Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices

Autores
Costa Carvalho, Beatriz Tavares; Sevciovic Grumach, Anete; Franco, José Luis; Espinosa Rosales, Francisco Javier; Leiva, Lily E.; King, Alejandra; Porras, Oscar; Bezrodnik, Liliana; Oleastro, Mathias; Sorensen, Ricardo U.; Condino Neto, Antonio
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and also increased cancer risk, particularly hematopoietic malignancies. The diversity of PIDD and the wide age range over which these clinical occurrences become apparent often make the identification of patients difficult for physicians other than immunologists. The aim of this report is to develop a tool for educative programs targeted to specialists and applied by clinical immunologists. Methods: Considering the data from national surveys and clinical reports of experiences with specific PIDD patients, an evidence-based list of symptoms, signs, and corresponding laboratory tests were elaborated to help physicians other than immunologists look for PIDD. Results: Tables including main clinical manifestations, restricted immunological evaluation, and possible related diagnosis were organized for general practitioners and 5 specialties. Tables include information on specific warning signs of PIDD for pulmonologists, gastroenterologists, dermatologists, hematologists, and infectious disease specialists. Conclusions: This report provides clinical immunologists with an instrument they can use to introduce specialists in other areas of medicine to the warning signs of PIDD and increase early diagnosis. Educational programs should be developed attending the needs of each specialty.
Fil: Costa Carvalho, Beatriz Tavares. Universidade Federal de São Paulo; Brasil
Fil: Sevciovic Grumach, Anete. Fundação ABC. Faculdade de Medicina; Brasil
Fil: Franco, José Luis. Universidad de Antioquia; Colombia
Fil: Espinosa Rosales, Francisco Javier. Instituto Nacional de Pediatría. Unidad de Investigación en Inmunodeficiencias; México
Fil: Leiva, Lily E.. State University of Louisiana; Estados Unidos
Fil: King, Alejandra. Hospital de Niños Doctor Luis Calvo Mackenna. Unidad de Inmunología; Chile
Fil: Porras, Oscar. Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”; Costa Rica
Fil: Bezrodnik, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Oleastro, Mathias. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sorensen, Ricardo U.. State University of Louisiana; Estados Unidos. Universidad de La Frontera. Facultad de Medicina; México
Fil: Condino Neto, Antonio. Universidade de Sao Paulo; Brasil
Materia
Primary Immunodeficiencies
Recurrent Infection
Cancer
Autoimmunity
Inflammation
Pidd
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32589
Acceder
id CONICETDig_310e57be951bbbb957dcc8a5cde30018
oai_identifier_str oai:ri.conicet.gov.ar:11336/32589
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Attending to warning signs of primary immunodeficiencies disease across the range of clinical practicesCosta Carvalho, Beatriz TavaresSevciovic Grumach, AneteFranco, José LuisEspinosa Rosales, Francisco JavierLeiva, Lily E.King, AlejandraPorras, OscarBezrodnik, LilianaOleastro, MathiasSorensen, Ricardo U.Condino Neto, AntonioPrimary ImmunodeficienciesRecurrent InfectionCancerAutoimmunityInflammationPiddhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and also increased cancer risk, particularly hematopoietic malignancies. The diversity of PIDD and the wide age range over which these clinical occurrences become apparent often make the identification of patients difficult for physicians other than immunologists. The aim of this report is to develop a tool for educative programs targeted to specialists and applied by clinical immunologists. Methods: Considering the data from national surveys and clinical reports of experiences with specific PIDD patients, an evidence-based list of symptoms, signs, and corresponding laboratory tests were elaborated to help physicians other than immunologists look for PIDD. Results: Tables including main clinical manifestations, restricted immunological evaluation, and possible related diagnosis were organized for general practitioners and 5 specialties. Tables include information on specific warning signs of PIDD for pulmonologists, gastroenterologists, dermatologists, hematologists, and infectious disease specialists. Conclusions: This report provides clinical immunologists with an instrument they can use to introduce specialists in other areas of medicine to the warning signs of PIDD and increase early diagnosis. Educational programs should be developed attending the needs of each specialty.Fil: Costa Carvalho, Beatriz Tavares. Universidade Federal de São Paulo; BrasilFil: Sevciovic Grumach, Anete. Fundação ABC. Faculdade de Medicina; BrasilFil: Franco, José Luis. Universidad de Antioquia; ColombiaFil: Espinosa Rosales, Francisco Javier. Instituto Nacional de Pediatría. Unidad de Investigación en Inmunodeficiencias; MéxicoFil: Leiva, Lily E.. State University of Louisiana; Estados UnidosFil: King, Alejandra. Hospital de Niños Doctor Luis Calvo Mackenna. Unidad de Inmunología; ChileFil: Porras, Oscar. Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”; Costa RicaFil: Bezrodnik, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Oleastro, Mathias. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Sorensen, Ricardo U.. State University of Louisiana; Estados Unidos. Universidad de La Frontera. Facultad de Medicina; MéxicoFil: Condino Neto, Antonio. Universidade de Sao Paulo; BrasilSpringer2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32589Costa Carvalho, Beatriz Tavares; Sevciovic Grumach, Anete; Franco, José Luis; Espinosa Rosales, Francisco Javier; Leiva, Lily E.; et al.; Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices; Springer; Journal of Clinical Immunology; 34; 1; 11-2013; 10-220271-91421573-2592CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10875-013-9954-6info:eu-repo/semantics/altIdentifier/doi/10.1007/s10875-013-9954-6info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930833/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:25Zoai:ri.conicet.gov.ar:11336/32589instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:26.108CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
title Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
spellingShingle Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
Costa Carvalho, Beatriz Tavares
Primary Immunodeficiencies
Recurrent Infection
Cancer
Autoimmunity
Inflammation
Pidd
title_short Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
title_full Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
title_fullStr Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
title_full_unstemmed Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
title_sort Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices
dc.creator.none.fl_str_mv Costa Carvalho, Beatriz Tavares
Sevciovic Grumach, Anete
Franco, José Luis
Espinosa Rosales, Francisco Javier
Leiva, Lily E.
King, Alejandra
Porras, Oscar
Bezrodnik, Liliana
Oleastro, Mathias
Sorensen, Ricardo U.
Condino Neto, Antonio
author Costa Carvalho, Beatriz Tavares
author_facet Costa Carvalho, Beatriz Tavares
Sevciovic Grumach, Anete
Franco, José Luis
Espinosa Rosales, Francisco Javier
Leiva, Lily E.
King, Alejandra
Porras, Oscar
Bezrodnik, Liliana
Oleastro, Mathias
Sorensen, Ricardo U.
Condino Neto, Antonio
author_role author
author2 Sevciovic Grumach, Anete
Franco, José Luis
Espinosa Rosales, Francisco Javier
Leiva, Lily E.
King, Alejandra
Porras, Oscar
Bezrodnik, Liliana
Oleastro, Mathias
Sorensen, Ricardo U.
Condino Neto, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Primary Immunodeficiencies
Recurrent Infection
Cancer
Autoimmunity
Inflammation
Pidd
topic Primary Immunodeficiencies
Recurrent Infection
Cancer
Autoimmunity
Inflammation
Pidd
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and also increased cancer risk, particularly hematopoietic malignancies. The diversity of PIDD and the wide age range over which these clinical occurrences become apparent often make the identification of patients difficult for physicians other than immunologists. The aim of this report is to develop a tool for educative programs targeted to specialists and applied by clinical immunologists. Methods: Considering the data from national surveys and clinical reports of experiences with specific PIDD patients, an evidence-based list of symptoms, signs, and corresponding laboratory tests were elaborated to help physicians other than immunologists look for PIDD. Results: Tables including main clinical manifestations, restricted immunological evaluation, and possible related diagnosis were organized for general practitioners and 5 specialties. Tables include information on specific warning signs of PIDD for pulmonologists, gastroenterologists, dermatologists, hematologists, and infectious disease specialists. Conclusions: This report provides clinical immunologists with an instrument they can use to introduce specialists in other areas of medicine to the warning signs of PIDD and increase early diagnosis. Educational programs should be developed attending the needs of each specialty.
Fil: Costa Carvalho, Beatriz Tavares. Universidade Federal de São Paulo; Brasil
Fil: Sevciovic Grumach, Anete. Fundação ABC. Faculdade de Medicina; Brasil
Fil: Franco, José Luis. Universidad de Antioquia; Colombia
Fil: Espinosa Rosales, Francisco Javier. Instituto Nacional de Pediatría. Unidad de Investigación en Inmunodeficiencias; México
Fil: Leiva, Lily E.. State University of Louisiana; Estados Unidos
Fil: King, Alejandra. Hospital de Niños Doctor Luis Calvo Mackenna. Unidad de Inmunología; Chile
Fil: Porras, Oscar. Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”; Costa Rica
Fil: Bezrodnik, Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Oleastro, Mathias. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sorensen, Ricardo U.. State University of Louisiana; Estados Unidos. Universidad de La Frontera. Facultad de Medicina; México
Fil: Condino Neto, Antonio. Universidade de Sao Paulo; Brasil
description Purpose: Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and also increased cancer risk, particularly hematopoietic malignancies. The diversity of PIDD and the wide age range over which these clinical occurrences become apparent often make the identification of patients difficult for physicians other than immunologists. The aim of this report is to develop a tool for educative programs targeted to specialists and applied by clinical immunologists. Methods: Considering the data from national surveys and clinical reports of experiences with specific PIDD patients, an evidence-based list of symptoms, signs, and corresponding laboratory tests were elaborated to help physicians other than immunologists look for PIDD. Results: Tables including main clinical manifestations, restricted immunological evaluation, and possible related diagnosis were organized for general practitioners and 5 specialties. Tables include information on specific warning signs of PIDD for pulmonologists, gastroenterologists, dermatologists, hematologists, and infectious disease specialists. Conclusions: This report provides clinical immunologists with an instrument they can use to introduce specialists in other areas of medicine to the warning signs of PIDD and increase early diagnosis. Educational programs should be developed attending the needs of each specialty.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32589
Costa Carvalho, Beatriz Tavares; Sevciovic Grumach, Anete; Franco, José Luis; Espinosa Rosales, Francisco Javier; Leiva, Lily E.; et al.; Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices; Springer; Journal of Clinical Immunology; 34; 1; 11-2013; 10-22
0271-9142
1573-2592
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32589
identifier_str_mv Costa Carvalho, Beatriz Tavares; Sevciovic Grumach, Anete; Franco, José Luis; Espinosa Rosales, Francisco Javier; Leiva, Lily E.; et al.; Attending to warning signs of primary immunodeficiencies disease across the range of clinical practices; Springer; Journal of Clinical Immunology; 34; 1; 11-2013; 10-22
0271-9142
1573-2592
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10875-013-9954-6
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10875-013-9954-6
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930833/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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