The person-to-person transmission landscape of the gut and oral microbiomes
- Autores
- Valles Colomer, M.; Blanco Míguez, A.; Manghi, P.; Asnicar, F.; Dubois, L.; Golzato, D.; Armanini, F.; Cumbo, F.; Huang, K.; Manara, S.; Masetti, G.; Pinto, F.; Piperni, E.; Punčochář, M.; Ricci, L.; Zolfo, M.; Farrant, O.; Goncalves, Adriana; Selma-Royo, M.; Binetti, Ana Griselda; Becerra, J.; Han, B.; Lusingu, J.; Amuasi, J.; Ponzoni., M.; Pasolli, E.; Spector, T.; Domenici, E.; Collado, M. C.; Segata, N.
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The human microbiome is an integral component of the human body and a co-determinant of several health conditions1,2. However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown3,4. Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies5, especially those on non-infectious, microbiome-associated diseases.
Fil: Valles Colomer, M.. University of Trento; Italia
Fil: Blanco Míguez, A.. University of Trento; Italia
Fil: Manghi, P.. University of Trento; Italia
Fil: Asnicar, F.. University of Trento; Italia
Fil: Dubois, L.. University of Trento; Italia
Fil: Golzato, D.. University of Trento; Italia
Fil: Armanini, F.. University of Trento; Italia
Fil: Cumbo, F.. University of Trento; Italia
Fil: Huang, K.. University of Trento; Italia
Fil: Manara, S.. University of Trento; Italia
Fil: Masetti, G.. University of Trento; Italia
Fil: Pinto, F.. University of Trento; Italia
Fil: Piperni, E.. Ieo European Institute of Oncology Irccs; Italia
Fil: Punčochář, M.. University of Trento; Italia
Fil: Ricci, L.. University of Trento; Italia
Fil: Zolfo, M.. University of Trento; Italia
Fil: Farrant, O.. London School Of Hygiene And Tropical Medicine; Reino Unido
Fil: Goncalves, Adriana. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Selma-Royo, M.. University Of Trento; Italia
Fil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Becerra, J.. Universidad Metropolitana; Colombia
Fil: Han, B.. Xian Jiaotong University; China
Fil: Lusingu, J.. National Institute For Medical Research; Tanzania
Fil: Amuasi, J.. Kwame Nkrumah University Of Science; Ghana
Fil: Ponzoni., M.. Laboratory Of Experimental Therapies In Oncology; Italia
Fil: Pasolli, E.. University of Naples ‘Federico II’; Italia
Fil: Spector, T.. Kings College London; Reino Unido
Fil: Domenici, E.. University of Trento; Italia
Fil: Collado, M. C.. Consejo Superior de Investigaciones Científicas; España
Fil: Segata, N.. University of Trento; Italia - Materia
-
HUMAN MICROBIOME
TRANSMISSION
INTERPERSONAL RELATIONSHIP
MOTHER-TO-INFANT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/219306
Ver los metadatos del registro completo
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The person-to-person transmission landscape of the gut and oral microbiomesValles Colomer, M.Blanco Míguez, A.Manghi, P.Asnicar, F.Dubois, L.Golzato, D.Armanini, F.Cumbo, F.Huang, K.Manara, S.Masetti, G.Pinto, F.Piperni, E.Punčochář, M.Ricci, L.Zolfo, M.Farrant, O.Goncalves, AdrianaSelma-Royo, M.Binetti, Ana GriseldaBecerra, J.Han, B.Lusingu, J.Amuasi, J.Ponzoni., M.Pasolli, E.Spector, T.Domenici, E.Collado, M. C.Segata, N.HUMAN MICROBIOMETRANSMISSIONINTERPERSONAL RELATIONSHIPMOTHER-TO-INFANThttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3The human microbiome is an integral component of the human body and a co-determinant of several health conditions1,2. However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown3,4. Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies5, especially those on non-infectious, microbiome-associated diseases.Fil: Valles Colomer, M.. University of Trento; ItaliaFil: Blanco Míguez, A.. University of Trento; ItaliaFil: Manghi, P.. University of Trento; ItaliaFil: Asnicar, F.. University of Trento; ItaliaFil: Dubois, L.. University of Trento; ItaliaFil: Golzato, D.. University of Trento; ItaliaFil: Armanini, F.. University of Trento; ItaliaFil: Cumbo, F.. University of Trento; ItaliaFil: Huang, K.. University of Trento; ItaliaFil: Manara, S.. University of Trento; ItaliaFil: Masetti, G.. University of Trento; ItaliaFil: Pinto, F.. University of Trento; ItaliaFil: Piperni, E.. Ieo European Institute of Oncology Irccs; ItaliaFil: Punčochář, M.. University of Trento; ItaliaFil: Ricci, L.. University of Trento; ItaliaFil: Zolfo, M.. University of Trento; ItaliaFil: Farrant, O.. London School Of Hygiene And Tropical Medicine; Reino UnidoFil: Goncalves, Adriana. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Selma-Royo, M.. University Of Trento; ItaliaFil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Becerra, J.. Universidad Metropolitana; ColombiaFil: Han, B.. Xian Jiaotong University; ChinaFil: Lusingu, J.. National Institute For Medical Research; TanzaniaFil: Amuasi, J.. Kwame Nkrumah University Of Science; GhanaFil: Ponzoni., M.. Laboratory Of Experimental Therapies In Oncology; ItaliaFil: Pasolli, E.. University of Naples ‘Federico II’; ItaliaFil: Spector, T.. Kings College London; Reino UnidoFil: Domenici, E.. University of Trento; ItaliaFil: Collado, M. C.. Consejo Superior de Investigaciones Científicas; EspañaFil: Segata, N.. University of Trento; ItaliaNature Publishing Group2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/219306Valles Colomer, M.; Blanco Míguez, A.; Manghi, P.; Asnicar, F.; Dubois, L.; et al.; The person-to-person transmission landscape of the gut and oral microbiomes; Nature Publishing Group; Nature; 614; 7946; 1-2023; 125-1350028-0836CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-022-05620-1info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41586-022-05620-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:49Zoai:ri.conicet.gov.ar:11336/219306instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:49.44CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
The person-to-person transmission landscape of the gut and oral microbiomes |
| title |
The person-to-person transmission landscape of the gut and oral microbiomes |
| spellingShingle |
The person-to-person transmission landscape of the gut and oral microbiomes Valles Colomer, M. HUMAN MICROBIOME TRANSMISSION INTERPERSONAL RELATIONSHIP MOTHER-TO-INFANT |
| title_short |
The person-to-person transmission landscape of the gut and oral microbiomes |
| title_full |
The person-to-person transmission landscape of the gut and oral microbiomes |
| title_fullStr |
The person-to-person transmission landscape of the gut and oral microbiomes |
| title_full_unstemmed |
The person-to-person transmission landscape of the gut and oral microbiomes |
| title_sort |
The person-to-person transmission landscape of the gut and oral microbiomes |
| dc.creator.none.fl_str_mv |
Valles Colomer, M. Blanco Míguez, A. Manghi, P. Asnicar, F. Dubois, L. Golzato, D. Armanini, F. Cumbo, F. Huang, K. Manara, S. Masetti, G. Pinto, F. Piperni, E. Punčochář, M. Ricci, L. Zolfo, M. Farrant, O. Goncalves, Adriana Selma-Royo, M. Binetti, Ana Griselda Becerra, J. Han, B. Lusingu, J. Amuasi, J. Ponzoni., M. Pasolli, E. Spector, T. Domenici, E. Collado, M. C. Segata, N. |
| author |
Valles Colomer, M. |
| author_facet |
Valles Colomer, M. Blanco Míguez, A. Manghi, P. Asnicar, F. Dubois, L. Golzato, D. Armanini, F. Cumbo, F. Huang, K. Manara, S. Masetti, G. Pinto, F. Piperni, E. Punčochář, M. Ricci, L. Zolfo, M. Farrant, O. Goncalves, Adriana Selma-Royo, M. Binetti, Ana Griselda Becerra, J. Han, B. Lusingu, J. Amuasi, J. Ponzoni., M. Pasolli, E. Spector, T. Domenici, E. Collado, M. C. Segata, N. |
| author_role |
author |
| author2 |
Blanco Míguez, A. Manghi, P. Asnicar, F. Dubois, L. Golzato, D. Armanini, F. Cumbo, F. Huang, K. Manara, S. Masetti, G. Pinto, F. Piperni, E. Punčochář, M. Ricci, L. Zolfo, M. Farrant, O. Goncalves, Adriana Selma-Royo, M. Binetti, Ana Griselda Becerra, J. Han, B. Lusingu, J. Amuasi, J. Ponzoni., M. Pasolli, E. Spector, T. Domenici, E. Collado, M. C. Segata, N. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
HUMAN MICROBIOME TRANSMISSION INTERPERSONAL RELATIONSHIP MOTHER-TO-INFANT |
| topic |
HUMAN MICROBIOME TRANSMISSION INTERPERSONAL RELATIONSHIP MOTHER-TO-INFANT |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
The human microbiome is an integral component of the human body and a co-determinant of several health conditions1,2. However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown3,4. Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies5, especially those on non-infectious, microbiome-associated diseases. Fil: Valles Colomer, M.. University of Trento; Italia Fil: Blanco Míguez, A.. University of Trento; Italia Fil: Manghi, P.. University of Trento; Italia Fil: Asnicar, F.. University of Trento; Italia Fil: Dubois, L.. University of Trento; Italia Fil: Golzato, D.. University of Trento; Italia Fil: Armanini, F.. University of Trento; Italia Fil: Cumbo, F.. University of Trento; Italia Fil: Huang, K.. University of Trento; Italia Fil: Manara, S.. University of Trento; Italia Fil: Masetti, G.. University of Trento; Italia Fil: Pinto, F.. University of Trento; Italia Fil: Piperni, E.. Ieo European Institute of Oncology Irccs; Italia Fil: Punčochář, M.. University of Trento; Italia Fil: Ricci, L.. University of Trento; Italia Fil: Zolfo, M.. University of Trento; Italia Fil: Farrant, O.. London School Of Hygiene And Tropical Medicine; Reino Unido Fil: Goncalves, Adriana. London School of Hygiene and Tropical Medicine; Reino Unido Fil: Selma-Royo, M.. University Of Trento; Italia Fil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Becerra, J.. Universidad Metropolitana; Colombia Fil: Han, B.. Xian Jiaotong University; China Fil: Lusingu, J.. National Institute For Medical Research; Tanzania Fil: Amuasi, J.. Kwame Nkrumah University Of Science; Ghana Fil: Ponzoni., M.. Laboratory Of Experimental Therapies In Oncology; Italia Fil: Pasolli, E.. University of Naples ‘Federico II’; Italia Fil: Spector, T.. Kings College London; Reino Unido Fil: Domenici, E.. University of Trento; Italia Fil: Collado, M. C.. Consejo Superior de Investigaciones Científicas; España Fil: Segata, N.. University of Trento; Italia |
| description |
The human microbiome is an integral component of the human body and a co-determinant of several health conditions1,2. However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown3,4. Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies5, especially those on non-infectious, microbiome-associated diseases. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-01 |
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article |
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http://hdl.handle.net/11336/219306 Valles Colomer, M.; Blanco Míguez, A.; Manghi, P.; Asnicar, F.; Dubois, L.; et al.; The person-to-person transmission landscape of the gut and oral microbiomes; Nature Publishing Group; Nature; 614; 7946; 1-2023; 125-135 0028-0836 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/219306 |
| identifier_str_mv |
Valles Colomer, M.; Blanco Míguez, A.; Manghi, P.; Asnicar, F.; Dubois, L.; et al.; The person-to-person transmission landscape of the gut and oral microbiomes; Nature Publishing Group; Nature; 614; 7946; 1-2023; 125-135 0028-0836 CONICET Digital CONICET |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-022-05620-1 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41586-022-05620-1 |
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Nature Publishing Group |
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Nature Publishing Group |
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