Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of th...

Autores: Mura, Paola A.; Cirri, Marzia; Rossetti, Cristian Alan; Allemandi, Daniel Alberto; Paredes, Alejandro Javier; Palma, Santiago Daniel
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The effectiveness of dry-ball and wet-bead nano-milling methods in producing nanocrystals of glyburide with increased dissolution rate has been compared. A full factorial design was applied to both methods to systematically evaluate the effect of the most critical factors (milling time, milling speed, ball/bead volume, drug amount) on the responses to be optimized (particle size and dissolution rate). Different experimental conditions were found to obtain the best results: the dry-method required to increase frequency and milling time and reduce ball volume and drug amount, while the wet-method to increase milling rate and drug amount and reduce bead volume and milling time. The results obtained under the respective optimal conditions evidenced a similar performance in nanocrystal production (120 and 180 nm for dry-ball and wet-bead milling, respectively) while a higher % dissolved at 10 min (28 vs 14 %) was found for the wet-method, principally ascribed to the presence, in this case, of the solubilizing polymer P188, added as stabilizer. Differently from the wet-method, the dry-method showed no direct relationship between particle size reduction and drug dissolution rate increase. Solid-state studies evidenced a role of the drug crystallinity loss, caused by the dry-milling, in affecting dissolution rate and proved the stability of the drug under both the milling processes.
Fil: Mura, Paola A.. Università degli Studi di Firenze; Italia
Fil: Cirri, Marzia. Università degli Studi di Firenze; Italia
Fil: Rossetti, Cristian Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. The Queens University of Belfast; Irlanda
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia: Dry-milling rate
Glyburide
Wet-milling
Nanocrystals
Dissolution
Experimental design
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/261991

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network_name_str	CONICET Digital (CONICET)
spelling	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methodsMura, Paola A.Cirri, MarziaRossetti, Cristian AlanAllemandi, Daniel AlbertoParedes, Alejandro JavierPalma, Santiago DanielDry-milling rateGlyburideWet-millingNanocrystalsDissolutionExperimental designhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The effectiveness of dry-ball and wet-bead nano-milling methods in producing nanocrystals of glyburide with increased dissolution rate has been compared. A full factorial design was applied to both methods to systematically evaluate the effect of the most critical factors (milling time, milling speed, ball/bead volume, drug amount) on the responses to be optimized (particle size and dissolution rate). Different experimental conditions were found to obtain the best results: the dry-method required to increase frequency and milling time and reduce ball volume and drug amount, while the wet-method to increase milling rate and drug amount and reduce bead volume and milling time. The results obtained under the respective optimal conditions evidenced a similar performance in nanocrystal production (120 and 180 nm for dry-ball and wet-bead milling, respectively) while a higher % dissolved at 10 min (28 vs 14 %) was found for the wet-method, principally ascribed to the presence, in this case, of the solubilizing polymer P188, added as stabilizer. Differently from the wet-method, the dry-method showed no direct relationship between particle size reduction and drug dissolution rate increase. Solid-state studies evidenced a role of the drug crystallinity loss, caused by the dry-milling, in affecting dissolution rate and proved the stability of the drug under both the milling processes.Fil: Mura, Paola A.. Università degli Studi di Firenze; ItaliaFil: Cirri, Marzia. Università degli Studi di Firenze; ItaliaFil: Rossetti, Cristian Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. The Queens University of Belfast; IrlandaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaElsevier2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261991Mura, Paola A.; Cirri, Marzia; Rossetti, Cristian Alan; Allemandi, Daniel Alberto; Paredes, Alejandro Javier; et al.; Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods; Elsevier; Journal of Drug Delivery Science and Technology; 91; 1-2024; 1-121773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1773224723010742info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2023.105222info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:05Zoai:ri.conicet.gov.ar:11336/261991instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:05.587CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
title	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
spellingShingle	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods Mura, Paola A. Dry-milling rate Glyburide Wet-milling Nanocrystals Dissolution Experimental design
title_short	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
title_full	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
title_fullStr	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
title_full_unstemmed	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
title_sort	Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods
dc.creator.none.fl_str_mv	Mura, Paola A. Cirri, Marzia Rossetti, Cristian Alan Allemandi, Daniel Alberto Paredes, Alejandro Javier Palma, Santiago Daniel
author	Mura, Paola A.
author_facet	Mura, Paola A. Cirri, Marzia Rossetti, Cristian Alan Allemandi, Daniel Alberto Paredes, Alejandro Javier Palma, Santiago Daniel
author_role	author
author2	Cirri, Marzia Rossetti, Cristian Alan Allemandi, Daniel Alberto Paredes, Alejandro Javier Palma, Santiago Daniel
author2_role	author author author author author
dc.subject.none.fl_str_mv	Dry-milling rate Glyburide Wet-milling Nanocrystals Dissolution Experimental design
topic	Dry-milling rate Glyburide Wet-milling Nanocrystals Dissolution Experimental design
purl_subject.fl_str_mv	https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv	The effectiveness of dry-ball and wet-bead nano-milling methods in producing nanocrystals of glyburide with increased dissolution rate has been compared. A full factorial design was applied to both methods to systematically evaluate the effect of the most critical factors (milling time, milling speed, ball/bead volume, drug amount) on the responses to be optimized (particle size and dissolution rate). Different experimental conditions were found to obtain the best results: the dry-method required to increase frequency and milling time and reduce ball volume and drug amount, while the wet-method to increase milling rate and drug amount and reduce bead volume and milling time. The results obtained under the respective optimal conditions evidenced a similar performance in nanocrystal production (120 and 180 nm for dry-ball and wet-bead milling, respectively) while a higher % dissolved at 10 min (28 vs 14 %) was found for the wet-method, principally ascribed to the presence, in this case, of the solubilizing polymer P188, added as stabilizer. Differently from the wet-method, the dry-method showed no direct relationship between particle size reduction and drug dissolution rate increase. Solid-state studies evidenced a role of the drug crystallinity loss, caused by the dry-milling, in affecting dissolution rate and proved the stability of the drug under both the milling processes. Fil: Mura, Paola A.. Università degli Studi di Firenze; Italia Fil: Cirri, Marzia. Università degli Studi di Firenze; Italia Fil: Rossetti, Cristian Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Paredes, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. The Queens University of Belfast; Irlanda Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description	The effectiveness of dry-ball and wet-bead nano-milling methods in producing nanocrystals of glyburide with increased dissolution rate has been compared. A full factorial design was applied to both methods to systematically evaluate the effect of the most critical factors (milling time, milling speed, ball/bead volume, drug amount) on the responses to be optimized (particle size and dissolution rate). Different experimental conditions were found to obtain the best results: the dry-method required to increase frequency and milling time and reduce ball volume and drug amount, while the wet-method to increase milling rate and drug amount and reduce bead volume and milling time. The results obtained under the respective optimal conditions evidenced a similar performance in nanocrystal production (120 and 180 nm for dry-ball and wet-bead milling, respectively) while a higher % dissolved at 10 min (28 vs 14 %) was found for the wet-method, principally ascribed to the presence, in this case, of the solubilizing polymer P188, added as stabilizer. Differently from the wet-method, the dry-method showed no direct relationship between particle size reduction and drug dissolution rate increase. Solid-state studies evidenced a role of the drug crystallinity loss, caused by the dry-milling, in affecting dissolution rate and proved the stability of the drug under both the milling processes.
publishDate	2024
dc.date.none.fl_str_mv	2024-01
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/261991 Mura, Paola A.; Cirri, Marzia; Rossetti, Cristian Alan; Allemandi, Daniel Alberto; Paredes, Alejandro Javier; et al.; Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods; Elsevier; Journal of Drug Delivery Science and Technology; 91; 1-2024; 1-12 1773-2247 CONICET Digital CONICET
url	http://hdl.handle.net/11336/261991
identifier_str_mv	Mura, Paola A.; Cirri, Marzia; Rossetti, Cristian Alan; Allemandi, Daniel Alberto; Paredes, Alejandro Javier; et al.; Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods; Elsevier; Journal of Drug Delivery Science and Technology; 91; 1-2024; 1-12 1773-2247 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1773224723010742 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2023.105222
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
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instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	12.993085

Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of th...

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