RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity

Autores
Filevich, Oscar; Etchenique, Roberto Argentino
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This photo-trigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photo-cleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient epsilon(MAX) = 5300 M-1 cm(-1) at 447 nm and a quantum efficiency phi similar to 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons.
Fil: Filevich, Oscar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Etchenique, Roberto Argentino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Quimica Fisica; Argentina
Materia
Ruthenium
Gaba
Caged Compound
Neurotransmitter
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8108
Acceder
id CONICETDig_2f75092e1e7c69140167721044c81651
oai_identifier_str oai:ri.conicet.gov.ar:11336/8108
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivityFilevich, OscarEtchenique, Roberto ArgentinoRutheniumGabaCaged CompoundNeurotransmitterhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This photo-trigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photo-cleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient epsilon(MAX) = 5300 M-1 cm(-1) at 447 nm and a quantum efficiency phi similar to 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons.Fil: Filevich, Oscar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Etchenique, Roberto Argentino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Quimica Fisica; ArgentinaRoyal Society Of Chemistry2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8108Filevich, Oscar; Etchenique, Roberto Argentino; RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity; Royal Society Of Chemistry; Photochemical And Photobiological Sciences; 12; 9; 4-2013; 1565-15701474-905Xenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c3pp25248einfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2013/pp/c3pp25248e#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:56:04Zoai:ri.conicet.gov.ar:11336/8108instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:56:04.681CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
title RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
spellingShingle RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
Filevich, Oscar
Ruthenium
Gaba
Caged Compound
Neurotransmitter
title_short RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
title_full RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
title_fullStr RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
title_full_unstemmed RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
title_sort RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity
dc.creator.none.fl_str_mv Filevich, Oscar
Etchenique, Roberto Argentino
author Filevich, Oscar
author_facet Filevich, Oscar
Etchenique, Roberto Argentino
author_role author
author2 Etchenique, Roberto Argentino
author2_role author
dc.subject.none.fl_str_mv Ruthenium
Gaba
Caged Compound
Neurotransmitter
topic Ruthenium
Gaba
Caged Compound
Neurotransmitter
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This photo-trigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photo-cleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient epsilon(MAX) = 5300 M-1 cm(-1) at 447 nm and a quantum efficiency phi similar to 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons.
Fil: Filevich, Oscar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Etchenique, Roberto Argentino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de Los Materiales, Medioambiente y Energía; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Quimica Fisica; Argentina
description We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This photo-trigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photo-cleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient epsilon(MAX) = 5300 M-1 cm(-1) at 447 nm and a quantum efficiency phi similar to 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8108
Filevich, Oscar; Etchenique, Roberto Argentino; RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity; Royal Society Of Chemistry; Photochemical And Photobiological Sciences; 12; 9; 4-2013; 1565-1570
1474-905X
url http://hdl.handle.net/11336/8108
identifier_str_mv Filevich, Oscar; Etchenique, Roberto Argentino; RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity; Royal Society Of Chemistry; Photochemical And Photobiological Sciences; 12; 9; 4-2013; 1565-1570
1474-905X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c3pp25248e
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2013/pp/c3pp25248e#!divAbstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society Of Chemistry
publisher.none.fl_str_mv Royal Society Of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847426676731936768
score 13.10058

Publicaciones similares