Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis

Autores
Carrillo Muñoz, Alfonso Javier; Tur Tur, Cristina; Giusiano, Gustavo Emilio; Marcos Arias, Cristina; Eraso, Elena; Jauregizar, Nerea; Quindós, Guillermo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptoms
Fil: Carrillo Muñoz, Alfonso Javier. Departamento de Microbiología-Micología, ACIAM,; España
Fil: Tur Tur, Cristina. SDPI CAP Manso; España
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marcos Arias, Cristina. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Eraso, Elena. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Jauregizar, Nerea. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Quindós, Guillermo. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Materia
Antifungal
Azoles
Candida
Sertaconazole
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8943
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8943
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasisCarrillo Muñoz, Alfonso JavierTur Tur, CristinaGiusiano, Gustavo EmilioMarcos Arias, CristinaEraso, ElenaJauregizar, NereaQuindós, GuillermoAntifungalAzolesCandidaSertaconazolehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptomsFil: Carrillo Muñoz, Alfonso Javier. Departamento de Microbiología-Micología, ACIAM,; EspañaFil: Tur Tur, Cristina. SDPI CAP Manso; EspañaFil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marcos Arias, Cristina. Universidad del País Vasco-Euskal Herriko Unibertsitatea; EspañaFil: Eraso, Elena. Universidad del País Vasco-Euskal Herriko Unibertsitatea; EspañaFil: Jauregizar, Nerea. Universidad del País Vasco-Euskal Herriko Unibertsitatea; EspañaFil: Quindós, Guillermo. Universidad del País Vasco-Euskal Herriko Unibertsitatea; EspañaExpert Reviews2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8943Carrillo Muñoz, Alfonso Javier; Tur Tur, Cristina; Giusiano, Gustavo Emilio; Marcos Arias, Cristina; Eraso, Elena; et al.; Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis; Expert Reviews; Expert Review Of Anti-infective Therapy; 11; 4; 2-2013; 477-4811478-72101744-8336enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1586/eri.13.17?journalCode=ierz20info:eu-repo/semantics/altIdentifier/doi/10.1586/eri.13.17info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:35Zoai:ri.conicet.gov.ar:11336/8943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:36.068CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
title Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
spellingShingle Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
Carrillo Muñoz, Alfonso Javier
Antifungal
Azoles
Candida
Sertaconazole
title_short Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
title_full Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
title_fullStr Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
title_full_unstemmed Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
title_sort Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
dc.creator.none.fl_str_mv Carrillo Muñoz, Alfonso Javier
Tur Tur, Cristina
Giusiano, Gustavo Emilio
Marcos Arias, Cristina
Eraso, Elena
Jauregizar, Nerea
Quindós, Guillermo
author Carrillo Muñoz, Alfonso Javier
author_facet Carrillo Muñoz, Alfonso Javier
Tur Tur, Cristina
Giusiano, Gustavo Emilio
Marcos Arias, Cristina
Eraso, Elena
Jauregizar, Nerea
Quindós, Guillermo
author_role author
author2 Tur Tur, Cristina
Giusiano, Gustavo Emilio
Marcos Arias, Cristina
Eraso, Elena
Jauregizar, Nerea
Quindós, Guillermo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Antifungal
Azoles
Candida
Sertaconazole
topic Antifungal
Azoles
Candida
Sertaconazole
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptoms
Fil: Carrillo Muñoz, Alfonso Javier. Departamento de Microbiología-Micología, ACIAM,; España
Fil: Tur Tur, Cristina. SDPI CAP Manso; España
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marcos Arias, Cristina. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Eraso, Elena. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Jauregizar, Nerea. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
Fil: Quindós, Guillermo. Universidad del País Vasco-Euskal Herriko Unibertsitatea; España
description Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptoms
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8943
Carrillo Muñoz, Alfonso Javier; Tur Tur, Cristina; Giusiano, Gustavo Emilio; Marcos Arias, Cristina; Eraso, Elena; et al.; Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis; Expert Reviews; Expert Review Of Anti-infective Therapy; 11; 4; 2-2013; 477-481
1478-7210
1744-8336
url http://hdl.handle.net/11336/8943
identifier_str_mv Carrillo Muñoz, Alfonso Javier; Tur Tur, Cristina; Giusiano, Gustavo Emilio; Marcos Arias, Cristina; Eraso, Elena; et al.; Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis; Expert Reviews; Expert Review Of Anti-infective Therapy; 11; 4; 2-2013; 477-481
1478-7210
1744-8336
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1586/eri.13.17?journalCode=ierz20
info:eu-repo/semantics/altIdentifier/doi/10.1586/eri.13.17
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Expert Reviews
publisher.none.fl_str_mv Expert Reviews
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083314561056768
score 13.22299

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