Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation

Autores
Garrido Amaro, Cristina; Cardona, Maria Paula; Gassó, Diana; Arias, Lilibeth; Velarde, Roser; Tvarijonativiciute, Asta; Serrano, Emmanuel; Cardona, Pere Joan
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.
Fil: Garrido Amaro, Cristina. Universitat Autònoma de Barcelona; España
Fil: Cardona, Maria Paula. Universitat Autònoma de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Gassó, Diana. Universitat Autònoma de Barcelona; España
Fil: Arias, Lilibeth. Universitat Autònoma de Barcelona; España
Fil: Velarde, Roser. Universitat Autònoma de Barcelona; España
Fil: Tvarijonativiciute, Asta. Universidad de Murcia; España
Fil: Serrano, Emmanuel. Universitat Autònoma de Barcelona; España
Fil: Cardona, Pere Joan. Universitat Autònoma de Barcelona; España
Materia
C3HEB/FEJ
CO-INFECTION
ENVIRONMENTAL MYCOBACTERIA MYCOBACTERIUM MANRESENSIS
FASTING
HELIGMOSOMOIDES POLYGYRUS
TRICHURIS MURIS
TUBERCULOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169713
Acceder
id CONICETDig_2eaf8de62759fb9f4791fbc52fc5c301
oai_identifier_str oai:ri.conicet.gov.ar:11336/169713
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food DeprivationGarrido Amaro, CristinaCardona, Maria PaulaGassó, DianaArias, LilibethVelarde, RoserTvarijonativiciute, AstaSerrano, EmmanuelCardona, Pere JoanC3HEB/FEJCO-INFECTIONENVIRONMENTAL MYCOBACTERIA MYCOBACTERIUM MANRESENSISFASTINGHELIGMOSOMOIDES POLYGYRUSTRICHURIS MURISTUBERCULOSIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.Fil: Garrido Amaro, Cristina. Universitat Autònoma de Barcelona; EspañaFil: Cardona, Maria Paula. Universitat Autònoma de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Gassó, Diana. Universitat Autònoma de Barcelona; EspañaFil: Arias, Lilibeth. Universitat Autònoma de Barcelona; EspañaFil: Velarde, Roser. Universitat Autònoma de Barcelona; EspañaFil: Tvarijonativiciute, Asta. Universidad de Murcia; EspañaFil: Serrano, Emmanuel. Universitat Autònoma de Barcelona; EspañaFil: Cardona, Pere Joan. Universitat Autònoma de Barcelona; EspañaFrontiers Media2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169713Garrido Amaro, Cristina; Cardona, Maria Paula; Gassó, Diana; Arias, Lilibeth; Velarde, Roser; et al.; Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation; Frontiers Media; Frontiers in Immunology; 12; 4-2021; 1-101664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2021.627638info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:51Zoai:ri.conicet.gov.ar:11336/169713instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:52.136CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
spellingShingle Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
Garrido Amaro, Cristina
C3HEB/FEJ
CO-INFECTION
ENVIRONMENTAL MYCOBACTERIA MYCOBACTERIUM MANRESENSIS
FASTING
HELIGMOSOMOIDES POLYGYRUS
TRICHURIS MURIS
TUBERCULOSIS
title_short Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_full Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_fullStr Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_full_unstemmed Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
title_sort Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation
dc.creator.none.fl_str_mv Garrido Amaro, Cristina
Cardona, Maria Paula
Gassó, Diana
Arias, Lilibeth
Velarde, Roser
Tvarijonativiciute, Asta
Serrano, Emmanuel
Cardona, Pere Joan
author Garrido Amaro, Cristina
author_facet Garrido Amaro, Cristina
Cardona, Maria Paula
Gassó, Diana
Arias, Lilibeth
Velarde, Roser
Tvarijonativiciute, Asta
Serrano, Emmanuel
Cardona, Pere Joan
author_role author
author2 Cardona, Maria Paula
Gassó, Diana
Arias, Lilibeth
Velarde, Roser
Tvarijonativiciute, Asta
Serrano, Emmanuel
Cardona, Pere Joan
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv C3HEB/FEJ
CO-INFECTION
ENVIRONMENTAL MYCOBACTERIA MYCOBACTERIUM MANRESENSIS
FASTING
HELIGMOSOMOIDES POLYGYRUS
TRICHURIS MURIS
TUBERCULOSIS
topic C3HEB/FEJ
CO-INFECTION
ENVIRONMENTAL MYCOBACTERIA MYCOBACTERIUM MANRESENSIS
FASTING
HELIGMOSOMOIDES POLYGYRUS
TRICHURIS MURIS
TUBERCULOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.
Fil: Garrido Amaro, Cristina. Universitat Autònoma de Barcelona; España
Fil: Cardona, Maria Paula. Universitat Autònoma de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Gassó, Diana. Universitat Autònoma de Barcelona; España
Fil: Arias, Lilibeth. Universitat Autònoma de Barcelona; España
Fil: Velarde, Roser. Universitat Autònoma de Barcelona; España
Fil: Tvarijonativiciute, Asta. Universidad de Murcia; España
Fil: Serrano, Emmanuel. Universitat Autònoma de Barcelona; España
Fil: Cardona, Pere Joan. Universitat Autònoma de Barcelona; España
description Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169713
Garrido Amaro, Cristina; Cardona, Maria Paula; Gassó, Diana; Arias, Lilibeth; Velarde, Roser; et al.; Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation; Frontiers Media; Frontiers in Immunology; 12; 4-2021; 1-10
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169713
identifier_str_mv Garrido Amaro, Cristina; Cardona, Maria Paula; Gassó, Diana; Arias, Lilibeth; Velarde, Roser; et al.; Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation; Frontiers Media; Frontiers in Immunology; 12; 4-2021; 1-10
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2021.627638
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613859415949312
score 13.070432

Publicaciones similares