Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations

Autores
Molina, Sonia Jazmín; Buján, Gustavo Ezequiel; Rodriguez Gonzalez, Monserrat; Capani, Francisco; Gomez Casati, Maria Eugenia; Guelman, Laura Ruth
Año de publicación
2022
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
The perinatal temporal window is a highly vulnerable time in which environmental factors, such as nutrients, drugs, infections, chemicals, and stress, experienced by the mother can be communicated to the offspring and produce lasting consequences on the new-born brain, thus contributing the evolutionary origin of non-communicable neuropsychiatric diseases. Most of these disorders are preventable, since they are due to modifiable risk factors such as lifestyle and the environment.Nevertheless, the increase in perinatal exposure to drugs, substances of abuse, pathogens, nutritional deficits and in immune over-reactivity can partly explain the high prevalence of neuropsychiatric disorders over recent decades. They include teratogenesis, dysfunction of the reproductive, neurocognitive and immune systems, autism, and addiction, all of which may have a substantial economic and societal impact. Similarly, adolescence is truly a dynamic and unique period of one´s life. Adolescence is often considered to begin around the onset of puberty and culminate with the acquisition of adult social roles, although considerable inter-individual variability exists in these rough demarcations. During this time span, considerable change occurs across multiple domains (e.g., physical, cognitive, socio-emotional). Since adaptations to novelty and environmental challenges are prerequisites that make teenagers the most fully crucially adaptive human beings around, the relationship between exposure to environmental factors of vulnerability and onset of neuropsychiatric disturbances needs to be addressed.It is, therefore, necessary to take stock of the latest evidence regarding the underlying molecular mechanisms of epigenetics leading to vulnerability - or resilience - to neuropsychiatric diseases. On this basis, some of the major experts in the field will contribute to this Research Topic in order to share the most recent findings in the field.Covering the topic will have worldwide implications to orient the research towards the dimly addressed epigenetic mechanisms that underlie the perinatal origins of neuropsychiatric diseases and will help healthcare professionals towards a broader awareness, effective prevention and successful therapeutic strategies.
Fil: Molina, Sonia Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Buján, Gustavo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Rodriguez Gonzalez, Monserrat. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Gomez Casati, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
DEVELOPMENT
CRITICAL PERIODS
BRAIN
ADOLESCENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
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oai:ri.conicet.gov.ar:11336/245666
Acceder
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spelling Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral AlterationsMolina, Sonia JazmínBuján, Gustavo EzequielRodriguez Gonzalez, MonserratCapani, FranciscoGomez Casati, Maria EugeniaGuelman, Laura RuthDEVELOPMENTCRITICAL PERIODSBRAINADOLESCENCEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The perinatal temporal window is a highly vulnerable time in which environmental factors, such as nutrients, drugs, infections, chemicals, and stress, experienced by the mother can be communicated to the offspring and produce lasting consequences on the new-born brain, thus contributing the evolutionary origin of non-communicable neuropsychiatric diseases. Most of these disorders are preventable, since they are due to modifiable risk factors such as lifestyle and the environment.Nevertheless, the increase in perinatal exposure to drugs, substances of abuse, pathogens, nutritional deficits and in immune over-reactivity can partly explain the high prevalence of neuropsychiatric disorders over recent decades. They include teratogenesis, dysfunction of the reproductive, neurocognitive and immune systems, autism, and addiction, all of which may have a substantial economic and societal impact. Similarly, adolescence is truly a dynamic and unique period of one´s life. Adolescence is often considered to begin around the onset of puberty and culminate with the acquisition of adult social roles, although considerable inter-individual variability exists in these rough demarcations. During this time span, considerable change occurs across multiple domains (e.g., physical, cognitive, socio-emotional). Since adaptations to novelty and environmental challenges are prerequisites that make teenagers the most fully crucially adaptive human beings around, the relationship between exposure to environmental factors of vulnerability and onset of neuropsychiatric disturbances needs to be addressed.It is, therefore, necessary to take stock of the latest evidence regarding the underlying molecular mechanisms of epigenetics leading to vulnerability - or resilience - to neuropsychiatric diseases. On this basis, some of the major experts in the field will contribute to this Research Topic in order to share the most recent findings in the field.Covering the topic will have worldwide implications to orient the research towards the dimly addressed epigenetic mechanisms that underlie the perinatal origins of neuropsychiatric diseases and will help healthcare professionals towards a broader awareness, effective prevention and successful therapeutic strategies.Fil: Molina, Sonia Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Buján, Gustavo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Rodriguez Gonzalez, Monserrat. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Gomez Casati, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFrontiers Media2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245666Molina, Sonia Jazmín; Buján, Gustavo Ezequiel; Rodriguez Gonzalez, Monserrat; Capani, Francisco; Gomez Casati, Maria Eugenia; et al.; Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations; Frontiers Media; 2022; 5-23978-2-88974-617-0CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/research-topics/10252/developing-brain-in-danger-critical-periods-of-vulnerability-from-in-utero-to-adolescenceinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:54Zoai:ri.conicet.gov.ar:11336/245666instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:55.061CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
title Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
spellingShingle Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
Molina, Sonia Jazmín
DEVELOPMENT
CRITICAL PERIODS
BRAIN
ADOLESCENCE
title_short Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
title_full Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
title_fullStr Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
title_full_unstemmed Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
title_sort Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
dc.creator.none.fl_str_mv Molina, Sonia Jazmín
Buján, Gustavo Ezequiel
Rodriguez Gonzalez, Monserrat
Capani, Francisco
Gomez Casati, Maria Eugenia
Guelman, Laura Ruth
author Molina, Sonia Jazmín
author_facet Molina, Sonia Jazmín
Buján, Gustavo Ezequiel
Rodriguez Gonzalez, Monserrat
Capani, Francisco
Gomez Casati, Maria Eugenia
Guelman, Laura Ruth
author_role author
author2 Buján, Gustavo Ezequiel
Rodriguez Gonzalez, Monserrat
Capani, Francisco
Gomez Casati, Maria Eugenia
Guelman, Laura Ruth
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv DEVELOPMENT
CRITICAL PERIODS
BRAIN
ADOLESCENCE
topic DEVELOPMENT
CRITICAL PERIODS
BRAIN
ADOLESCENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The perinatal temporal window is a highly vulnerable time in which environmental factors, such as nutrients, drugs, infections, chemicals, and stress, experienced by the mother can be communicated to the offspring and produce lasting consequences on the new-born brain, thus contributing the evolutionary origin of non-communicable neuropsychiatric diseases. Most of these disorders are preventable, since they are due to modifiable risk factors such as lifestyle and the environment.Nevertheless, the increase in perinatal exposure to drugs, substances of abuse, pathogens, nutritional deficits and in immune over-reactivity can partly explain the high prevalence of neuropsychiatric disorders over recent decades. They include teratogenesis, dysfunction of the reproductive, neurocognitive and immune systems, autism, and addiction, all of which may have a substantial economic and societal impact. Similarly, adolescence is truly a dynamic and unique period of one´s life. Adolescence is often considered to begin around the onset of puberty and culminate with the acquisition of adult social roles, although considerable inter-individual variability exists in these rough demarcations. During this time span, considerable change occurs across multiple domains (e.g., physical, cognitive, socio-emotional). Since adaptations to novelty and environmental challenges are prerequisites that make teenagers the most fully crucially adaptive human beings around, the relationship between exposure to environmental factors of vulnerability and onset of neuropsychiatric disturbances needs to be addressed.It is, therefore, necessary to take stock of the latest evidence regarding the underlying molecular mechanisms of epigenetics leading to vulnerability - or resilience - to neuropsychiatric diseases. On this basis, some of the major experts in the field will contribute to this Research Topic in order to share the most recent findings in the field.Covering the topic will have worldwide implications to orient the research towards the dimly addressed epigenetic mechanisms that underlie the perinatal origins of neuropsychiatric diseases and will help healthcare professionals towards a broader awareness, effective prevention and successful therapeutic strategies.
Fil: Molina, Sonia Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Buján, Gustavo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Rodriguez Gonzalez, Monserrat. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Gomez Casati, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description The perinatal temporal window is a highly vulnerable time in which environmental factors, such as nutrients, drugs, infections, chemicals, and stress, experienced by the mother can be communicated to the offspring and produce lasting consequences on the new-born brain, thus contributing the evolutionary origin of non-communicable neuropsychiatric diseases. Most of these disorders are preventable, since they are due to modifiable risk factors such as lifestyle and the environment.Nevertheless, the increase in perinatal exposure to drugs, substances of abuse, pathogens, nutritional deficits and in immune over-reactivity can partly explain the high prevalence of neuropsychiatric disorders over recent decades. They include teratogenesis, dysfunction of the reproductive, neurocognitive and immune systems, autism, and addiction, all of which may have a substantial economic and societal impact. Similarly, adolescence is truly a dynamic and unique period of one´s life. Adolescence is often considered to begin around the onset of puberty and culminate with the acquisition of adult social roles, although considerable inter-individual variability exists in these rough demarcations. During this time span, considerable change occurs across multiple domains (e.g., physical, cognitive, socio-emotional). Since adaptations to novelty and environmental challenges are prerequisites that make teenagers the most fully crucially adaptive human beings around, the relationship between exposure to environmental factors of vulnerability and onset of neuropsychiatric disturbances needs to be addressed.It is, therefore, necessary to take stock of the latest evidence regarding the underlying molecular mechanisms of epigenetics leading to vulnerability - or resilience - to neuropsychiatric diseases. On this basis, some of the major experts in the field will contribute to this Research Topic in order to share the most recent findings in the field.Covering the topic will have worldwide implications to orient the research towards the dimly addressed epigenetic mechanisms that underlie the perinatal origins of neuropsychiatric diseases and will help healthcare professionals towards a broader awareness, effective prevention and successful therapeutic strategies.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/245666
Molina, Sonia Jazmín; Buján, Gustavo Ezequiel; Rodriguez Gonzalez, Monserrat; Capani, Francisco; Gomez Casati, Maria Eugenia; et al.; Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations; Frontiers Media; 2022; 5-23
978-2-88974-617-0
CONICET Digital
CONICET
url http://hdl.handle.net/11336/245666
identifier_str_mv Molina, Sonia Jazmín; Buján, Gustavo Ezequiel; Rodriguez Gonzalez, Monserrat; Capani, Francisco; Gomez Casati, Maria Eugenia; et al.; Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations; Frontiers Media; 2022; 5-23
978-2-88974-617-0
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/research-topics/10252/developing-brain-in-danger-critical-periods-of-vulnerability-from-in-utero-to-adolescence
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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