Formaldehyde metabolism and its impact on human health

Autores
Reingruber, Hernán; Pontel, Lucas Blas
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Human health is threatened by exposure to reactive toxins that can damage fundamental biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest and one of the most reactive aldehydes. Formaldehyde is ubiquitous in the environment, and can be derived from some food components. However, a great burden of formaldehyde is also generated endogenously as a result of cellular meta- bolism. In fact, recent work has shown that endogenous formaldehyde is produced at sufficient levels to pose a signif- icant threat to genome stability. To counteract this reactive molecule, organisms have evolved a detoxification system centered on the enzyme alcohol dehydrogenase 5 (ADH5). This system converts formaldehyde to formate, a less reactive molecule that can be used for nucleotide biosynthesis. The Fanconi Anemia (FA) DNA repair pathway guarantees addi- tional protection against formaldehyde by alleviating DNA damage. Indeed, the simultaneous inactivation of both ADH5 and the FA DNA repair pathway in mice leads to dysfunction of vital organs and cancer. These findings suggest that formal- dehyde might be a driver of the human disease FA. Additional work also links this genotoxin to the etiology of other human illnesses, such as the Ruijs-Aalfs syndrome and the cancer predisposition of BRCA2 mutation carriers. This review dis- cusses the recent advances in formaldehyde biology and the impact of this toxic metabolite on human health.
Fil: Reingruber, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Pontel, Lucas Blas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Materia
FORMALDEHYDE
FANCONI ANEMIA
CANCER
ADH5
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88240
Acceder
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spelling Formaldehyde metabolism and its impact on human healthReingruber, HernánPontel, Lucas BlasFORMALDEHYDEFANCONI ANEMIACANCERADH5https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Human health is threatened by exposure to reactive toxins that can damage fundamental biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest and one of the most reactive aldehydes. Formaldehyde is ubiquitous in the environment, and can be derived from some food components. However, a great burden of formaldehyde is also generated endogenously as a result of cellular meta- bolism. In fact, recent work has shown that endogenous formaldehyde is produced at sufficient levels to pose a signif- icant threat to genome stability. To counteract this reactive molecule, organisms have evolved a detoxification system centered on the enzyme alcohol dehydrogenase 5 (ADH5). This system converts formaldehyde to formate, a less reactive molecule that can be used for nucleotide biosynthesis. The Fanconi Anemia (FA) DNA repair pathway guarantees addi- tional protection against formaldehyde by alleviating DNA damage. Indeed, the simultaneous inactivation of both ADH5 and the FA DNA repair pathway in mice leads to dysfunction of vital organs and cancer. These findings suggest that formal- dehyde might be a driver of the human disease FA. Additional work also links this genotoxin to the etiology of other human illnesses, such as the Ruijs-Aalfs syndrome and the cancer predisposition of BRCA2 mutation carriers. This review dis- cusses the recent advances in formaldehyde biology and the impact of this toxic metabolite on human health.Fil: Reingruber, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Pontel, Lucas Blas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaElsevier2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88240Reingruber, Hernán; Pontel, Lucas Blas; Formaldehyde metabolism and its impact on human health ; Elsevier; Current Opinion in Toxicology; 9; 6-2018; 28-342468-2020CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468202017301456info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cotox.2018.07.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:22Zoai:ri.conicet.gov.ar:11336/88240instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:22.713CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Formaldehyde metabolism and its impact on human health
title Formaldehyde metabolism and its impact on human health
spellingShingle Formaldehyde metabolism and its impact on human health
Reingruber, Hernán
FORMALDEHYDE
FANCONI ANEMIA
CANCER
ADH5
title_short Formaldehyde metabolism and its impact on human health
title_full Formaldehyde metabolism and its impact on human health
title_fullStr Formaldehyde metabolism and its impact on human health
title_full_unstemmed Formaldehyde metabolism and its impact on human health
title_sort Formaldehyde metabolism and its impact on human health
dc.creator.none.fl_str_mv Reingruber, Hernán
Pontel, Lucas Blas
author Reingruber, Hernán
author_facet Reingruber, Hernán
Pontel, Lucas Blas
author_role author
author2 Pontel, Lucas Blas
author2_role author
dc.subject.none.fl_str_mv FORMALDEHYDE
FANCONI ANEMIA
CANCER
ADH5
topic FORMALDEHYDE
FANCONI ANEMIA
CANCER
ADH5
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Human health is threatened by exposure to reactive toxins that can damage fundamental biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest and one of the most reactive aldehydes. Formaldehyde is ubiquitous in the environment, and can be derived from some food components. However, a great burden of formaldehyde is also generated endogenously as a result of cellular meta- bolism. In fact, recent work has shown that endogenous formaldehyde is produced at sufficient levels to pose a signif- icant threat to genome stability. To counteract this reactive molecule, organisms have evolved a detoxification system centered on the enzyme alcohol dehydrogenase 5 (ADH5). This system converts formaldehyde to formate, a less reactive molecule that can be used for nucleotide biosynthesis. The Fanconi Anemia (FA) DNA repair pathway guarantees addi- tional protection against formaldehyde by alleviating DNA damage. Indeed, the simultaneous inactivation of both ADH5 and the FA DNA repair pathway in mice leads to dysfunction of vital organs and cancer. These findings suggest that formal- dehyde might be a driver of the human disease FA. Additional work also links this genotoxin to the etiology of other human illnesses, such as the Ruijs-Aalfs syndrome and the cancer predisposition of BRCA2 mutation carriers. This review dis- cusses the recent advances in formaldehyde biology and the impact of this toxic metabolite on human health.
Fil: Reingruber, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Pontel, Lucas Blas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
description Human health is threatened by exposure to reactive toxins that can damage fundamental biomolecules such as DNA and proteins. One of these molecules is formaldehyde, the simplest and one of the most reactive aldehydes. Formaldehyde is ubiquitous in the environment, and can be derived from some food components. However, a great burden of formaldehyde is also generated endogenously as a result of cellular meta- bolism. In fact, recent work has shown that endogenous formaldehyde is produced at sufficient levels to pose a signif- icant threat to genome stability. To counteract this reactive molecule, organisms have evolved a detoxification system centered on the enzyme alcohol dehydrogenase 5 (ADH5). This system converts formaldehyde to formate, a less reactive molecule that can be used for nucleotide biosynthesis. The Fanconi Anemia (FA) DNA repair pathway guarantees addi- tional protection against formaldehyde by alleviating DNA damage. Indeed, the simultaneous inactivation of both ADH5 and the FA DNA repair pathway in mice leads to dysfunction of vital organs and cancer. These findings suggest that formal- dehyde might be a driver of the human disease FA. Additional work also links this genotoxin to the etiology of other human illnesses, such as the Ruijs-Aalfs syndrome and the cancer predisposition of BRCA2 mutation carriers. This review dis- cusses the recent advances in formaldehyde biology and the impact of this toxic metabolite on human health.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88240
Reingruber, Hernán; Pontel, Lucas Blas; Formaldehyde metabolism and its impact on human health ; Elsevier; Current Opinion in Toxicology; 9; 6-2018; 28-34
2468-2020
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88240
identifier_str_mv Reingruber, Hernán; Pontel, Lucas Blas; Formaldehyde metabolism and its impact on human health ; Elsevier; Current Opinion in Toxicology; 9; 6-2018; 28-34
2468-2020
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468202017301456
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cotox.2018.07.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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