Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis

Autores
Abeldaño Zuñiga, Roberto Ariel; González Villoria, Ruth Ana María; Elizondo, María Vanesa; Osorio, Anel Yaneli Nicolás; Gómez Martínez, David; Coca, Silvia Mercedes
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: Given the variability of previously reported results, this systematic review aims to determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients diagnosed with COVID-19. Methods: We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, and ventilation requirement. Results: A total of 51 studies were retrieved from the databases. Five articles were finally included in the data extraction and qualitative and quantitative synthesis of results. The overall risk of bias in the reviewed articles was established at low-risk only in two trials. The meta-analysis suggests that there is no benefit of convalescent plasma compared with standard care or placebo in reducing the overall mortality and the ventilation requirement. However, there could be a benefit for the clinical improvement in patients treated with plasma. Conclusion: Current results led to assume that the convalescent plasma transfusion cannot reduce the mortality or ventilation requirement in hospitalized patients diagnosed with SARS-CoV-2 infection. More controlled clinical trials conducted with methodologies that ensure a low risk of bias are still needed. The reviews of this paper are available via the supplemental material section.
Fil: Abeldaño Zuñiga, Roberto Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de la Sierra Sur; México
Fil: González Villoria, Ruth Ana María. Universidad de la Sierra Sur; México
Fil: Elizondo, María Vanesa. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Osorio, Anel Yaneli Nicolás. Universidad de la Sierra Sur; México
Fil: Gómez Martínez, David. Universidad de la Sierra Sur; México
Fil: Coca, Silvia Mercedes. Universidad de la Sierra Sur; México
Materia
CLINICAL IMPROVEMENT
CONVALESCENT PLASMA
COVID-19
MORTALITY
SARS-COV-2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150530
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/150530
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysisAbeldaño Zuñiga, Roberto ArielGonzález Villoria, Ruth Ana MaríaElizondo, María VanesaOsorio, Anel Yaneli NicolásGómez Martínez, DavidCoca, Silvia MercedesCLINICAL IMPROVEMENTCONVALESCENT PLASMACOVID-19MORTALITYSARS-COV-2https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Aims: Given the variability of previously reported results, this systematic review aims to determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients diagnosed with COVID-19. Methods: We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, and ventilation requirement. Results: A total of 51 studies were retrieved from the databases. Five articles were finally included in the data extraction and qualitative and quantitative synthesis of results. The overall risk of bias in the reviewed articles was established at low-risk only in two trials. The meta-analysis suggests that there is no benefit of convalescent plasma compared with standard care or placebo in reducing the overall mortality and the ventilation requirement. However, there could be a benefit for the clinical improvement in patients treated with plasma. Conclusion: Current results led to assume that the convalescent plasma transfusion cannot reduce the mortality or ventilation requirement in hospitalized patients diagnosed with SARS-CoV-2 infection. More controlled clinical trials conducted with methodologies that ensure a low risk of bias are still needed. The reviews of this paper are available via the supplemental material section.Fil: Abeldaño Zuñiga, Roberto Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de la Sierra Sur; MéxicoFil: González Villoria, Ruth Ana María. Universidad de la Sierra Sur; MéxicoFil: Elizondo, María Vanesa. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Osorio, Anel Yaneli Nicolás. Universidad de la Sierra Sur; MéxicoFil: Gómez Martínez, David. Universidad de la Sierra Sur; MéxicoFil: Coca, Silvia Mercedes. Universidad de la Sierra Sur; MéxicoSAGE Publications2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150530Abeldaño Zuñiga, Roberto Ariel; González Villoria, Ruth Ana María; Elizondo, María Vanesa; Osorio, Anel Yaneli Nicolás; Gómez Martínez, David; et al.; Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis; SAGE Publications; Therapeutic Advances in Respiratory Disease; 15; 6-2021; 1-111753-46581753-4666CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/17534666211028077info:eu-repo/semantics/altIdentifier/doi/10.1177/17534666211028077info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:05Zoai:ri.conicet.gov.ar:11336/150530instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:06.001CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
title Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
spellingShingle Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
Abeldaño Zuñiga, Roberto Ariel
CLINICAL IMPROVEMENT
CONVALESCENT PLASMA
COVID-19
MORTALITY
SARS-COV-2
title_short Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
title_full Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
title_fullStr Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
title_full_unstemmed Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
title_sort Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
dc.creator.none.fl_str_mv Abeldaño Zuñiga, Roberto Ariel
González Villoria, Ruth Ana María
Elizondo, María Vanesa
Osorio, Anel Yaneli Nicolás
Gómez Martínez, David
Coca, Silvia Mercedes
author Abeldaño Zuñiga, Roberto Ariel
author_facet Abeldaño Zuñiga, Roberto Ariel
González Villoria, Ruth Ana María
Elizondo, María Vanesa
Osorio, Anel Yaneli Nicolás
Gómez Martínez, David
Coca, Silvia Mercedes
author_role author
author2 González Villoria, Ruth Ana María
Elizondo, María Vanesa
Osorio, Anel Yaneli Nicolás
Gómez Martínez, David
Coca, Silvia Mercedes
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CLINICAL IMPROVEMENT
CONVALESCENT PLASMA
COVID-19
MORTALITY
SARS-COV-2
topic CLINICAL IMPROVEMENT
CONVALESCENT PLASMA
COVID-19
MORTALITY
SARS-COV-2
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: Given the variability of previously reported results, this systematic review aims to determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients diagnosed with COVID-19. Methods: We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, and ventilation requirement. Results: A total of 51 studies were retrieved from the databases. Five articles were finally included in the data extraction and qualitative and quantitative synthesis of results. The overall risk of bias in the reviewed articles was established at low-risk only in two trials. The meta-analysis suggests that there is no benefit of convalescent plasma compared with standard care or placebo in reducing the overall mortality and the ventilation requirement. However, there could be a benefit for the clinical improvement in patients treated with plasma. Conclusion: Current results led to assume that the convalescent plasma transfusion cannot reduce the mortality or ventilation requirement in hospitalized patients diagnosed with SARS-CoV-2 infection. More controlled clinical trials conducted with methodologies that ensure a low risk of bias are still needed. The reviews of this paper are available via the supplemental material section.
Fil: Abeldaño Zuñiga, Roberto Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de la Sierra Sur; México
Fil: González Villoria, Ruth Ana María. Universidad de la Sierra Sur; México
Fil: Elizondo, María Vanesa. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Osorio, Anel Yaneli Nicolás. Universidad de la Sierra Sur; México
Fil: Gómez Martínez, David. Universidad de la Sierra Sur; México
Fil: Coca, Silvia Mercedes. Universidad de la Sierra Sur; México
description Aims: Given the variability of previously reported results, this systematic review aims to determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients diagnosed with COVID-19. Methods: We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, and ventilation requirement. Results: A total of 51 studies were retrieved from the databases. Five articles were finally included in the data extraction and qualitative and quantitative synthesis of results. The overall risk of bias in the reviewed articles was established at low-risk only in two trials. The meta-analysis suggests that there is no benefit of convalescent plasma compared with standard care or placebo in reducing the overall mortality and the ventilation requirement. However, there could be a benefit for the clinical improvement in patients treated with plasma. Conclusion: Current results led to assume that the convalescent plasma transfusion cannot reduce the mortality or ventilation requirement in hospitalized patients diagnosed with SARS-CoV-2 infection. More controlled clinical trials conducted with methodologies that ensure a low risk of bias are still needed. The reviews of this paper are available via the supplemental material section.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150530
Abeldaño Zuñiga, Roberto Ariel; González Villoria, Ruth Ana María; Elizondo, María Vanesa; Osorio, Anel Yaneli Nicolás; Gómez Martínez, David; et al.; Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis; SAGE Publications; Therapeutic Advances in Respiratory Disease; 15; 6-2021; 1-11
1753-4658
1753-4666
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150530
identifier_str_mv Abeldaño Zuñiga, Roberto Ariel; González Villoria, Ruth Ana María; Elizondo, María Vanesa; Osorio, Anel Yaneli Nicolás; Gómez Martínez, David; et al.; Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis; SAGE Publications; Therapeutic Advances in Respiratory Disease; 15; 6-2021; 1-11
1753-4658
1753-4666
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/17534666211028077
info:eu-repo/semantics/altIdentifier/doi/10.1177/17534666211028077
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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