Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum

Autores
Svartz, Gabriela Veronica; Hutler Wolkowicz, Ianina Ruth; Perez Coll, Cristina Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endosulfan is a widely used pesticide despite its extreme toxicity to a variety of taxa and its worldwide ban. The aim of the present study was to evaluate the acute and chronic toxicity of endosulfan on the embryonic-larval development of the common South American toad Rhinella arenarum. The results showed that lethal and sublethal effects increased with concentration and exposure time. The sensitivity to endosulfan increased during the larval period, the complete operculum stage (S.25) being the most sensitive (504-h median lethal concentration [LC50]=0.01mg endosulfan/L; 10% lethal concentration [LC10]=0.004mg endosulfan/L). Endosulfan exposure caused morphological abnormalities such as general underdevelopment, edema, gill malformations, and cellular dissociation as well as neurotoxicity. Our results also showed that larvae exposed to concentrations of 0.005mg endosulfan/L and 0.01mg endosulfan/L completed metamorphosis earlier than controls, but with underdevelopment. The 240-h teratogenic index was 6.13, implying a high risk for embryos to be malformed in the absence of significant embryonic lethality. Because the hazard quotients for chronic exposure were over 1, the level of concern value and toxicity endpoints obtained in the present study for R. arenarum occurred at concentrations lower than the levels of endosulfan reported in the environment, this pesticide should be considered a potential risk for this species. Environ Toxicol Chem 2014;33:875-881.
Fil: Svartz, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Hutler Wolkowicz, Ianina Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Materia
AMPHIBIANS
DEVELOPMENTAL TOXICITY
ECOLOGICAL RISK ASSESSMENT
ENDOSULFAN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89553
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/89553
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarumSvartz, Gabriela VeronicaHutler Wolkowicz, Ianina RuthPerez Coll, Cristina SilviaAMPHIBIANSDEVELOPMENTAL TOXICITYECOLOGICAL RISK ASSESSMENTENDOSULFANhttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1Endosulfan is a widely used pesticide despite its extreme toxicity to a variety of taxa and its worldwide ban. The aim of the present study was to evaluate the acute and chronic toxicity of endosulfan on the embryonic-larval development of the common South American toad Rhinella arenarum. The results showed that lethal and sublethal effects increased with concentration and exposure time. The sensitivity to endosulfan increased during the larval period, the complete operculum stage (S.25) being the most sensitive (504-h median lethal concentration [LC50]=0.01mg endosulfan/L; 10% lethal concentration [LC10]=0.004mg endosulfan/L). Endosulfan exposure caused morphological abnormalities such as general underdevelopment, edema, gill malformations, and cellular dissociation as well as neurotoxicity. Our results also showed that larvae exposed to concentrations of 0.005mg endosulfan/L and 0.01mg endosulfan/L completed metamorphosis earlier than controls, but with underdevelopment. The 240-h teratogenic index was 6.13, implying a high risk for embryos to be malformed in the absence of significant embryonic lethality. Because the hazard quotients for chronic exposure were over 1, the level of concern value and toxicity endpoints obtained in the present study for R. arenarum occurred at concentrations lower than the levels of endosulfan reported in the environment, this pesticide should be considered a potential risk for this species. Environ Toxicol Chem 2014;33:875-881.Fil: Svartz, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; ArgentinaFil: Hutler Wolkowicz, Ianina Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; ArgentinaFil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; ArgentinaSociety of Environmental Toxicology and Chemistry2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89553Svartz, Gabriela Veronica; Hutler Wolkowicz, Ianina Ruth; Perez Coll, Cristina Silvia; Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 33; 4; 4-2014; 875-8810730-7268CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/etc.2506info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.2506info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:01Zoai:ri.conicet.gov.ar:11336/89553instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:01.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
title Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
spellingShingle Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
Svartz, Gabriela Veronica
AMPHIBIANS
DEVELOPMENTAL TOXICITY
ECOLOGICAL RISK ASSESSMENT
ENDOSULFAN
title_short Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
title_full Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
title_fullStr Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
title_full_unstemmed Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
title_sort Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
dc.creator.none.fl_str_mv Svartz, Gabriela Veronica
Hutler Wolkowicz, Ianina Ruth
Perez Coll, Cristina Silvia
author Svartz, Gabriela Veronica
author_facet Svartz, Gabriela Veronica
Hutler Wolkowicz, Ianina Ruth
Perez Coll, Cristina Silvia
author_role author
author2 Hutler Wolkowicz, Ianina Ruth
Perez Coll, Cristina Silvia
author2_role author
author
dc.subject.none.fl_str_mv AMPHIBIANS
DEVELOPMENTAL TOXICITY
ECOLOGICAL RISK ASSESSMENT
ENDOSULFAN
topic AMPHIBIANS
DEVELOPMENTAL TOXICITY
ECOLOGICAL RISK ASSESSMENT
ENDOSULFAN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.5
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Endosulfan is a widely used pesticide despite its extreme toxicity to a variety of taxa and its worldwide ban. The aim of the present study was to evaluate the acute and chronic toxicity of endosulfan on the embryonic-larval development of the common South American toad Rhinella arenarum. The results showed that lethal and sublethal effects increased with concentration and exposure time. The sensitivity to endosulfan increased during the larval period, the complete operculum stage (S.25) being the most sensitive (504-h median lethal concentration [LC50]=0.01mg endosulfan/L; 10% lethal concentration [LC10]=0.004mg endosulfan/L). Endosulfan exposure caused morphological abnormalities such as general underdevelopment, edema, gill malformations, and cellular dissociation as well as neurotoxicity. Our results also showed that larvae exposed to concentrations of 0.005mg endosulfan/L and 0.01mg endosulfan/L completed metamorphosis earlier than controls, but with underdevelopment. The 240-h teratogenic index was 6.13, implying a high risk for embryos to be malformed in the absence of significant embryonic lethality. Because the hazard quotients for chronic exposure were over 1, the level of concern value and toxicity endpoints obtained in the present study for R. arenarum occurred at concentrations lower than the levels of endosulfan reported in the environment, this pesticide should be considered a potential risk for this species. Environ Toxicol Chem 2014;33:875-881.
Fil: Svartz, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Hutler Wolkowicz, Ianina Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
Fil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación en Ingeniería Ambiental; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
description Endosulfan is a widely used pesticide despite its extreme toxicity to a variety of taxa and its worldwide ban. The aim of the present study was to evaluate the acute and chronic toxicity of endosulfan on the embryonic-larval development of the common South American toad Rhinella arenarum. The results showed that lethal and sublethal effects increased with concentration and exposure time. The sensitivity to endosulfan increased during the larval period, the complete operculum stage (S.25) being the most sensitive (504-h median lethal concentration [LC50]=0.01mg endosulfan/L; 10% lethal concentration [LC10]=0.004mg endosulfan/L). Endosulfan exposure caused morphological abnormalities such as general underdevelopment, edema, gill malformations, and cellular dissociation as well as neurotoxicity. Our results also showed that larvae exposed to concentrations of 0.005mg endosulfan/L and 0.01mg endosulfan/L completed metamorphosis earlier than controls, but with underdevelopment. The 240-h teratogenic index was 6.13, implying a high risk for embryos to be malformed in the absence of significant embryonic lethality. Because the hazard quotients for chronic exposure were over 1, the level of concern value and toxicity endpoints obtained in the present study for R. arenarum occurred at concentrations lower than the levels of endosulfan reported in the environment, this pesticide should be considered a potential risk for this species. Environ Toxicol Chem 2014;33:875-881.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89553
Svartz, Gabriela Veronica; Hutler Wolkowicz, Ianina Ruth; Perez Coll, Cristina Silvia; Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 33; 4; 4-2014; 875-881
0730-7268
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89553
identifier_str_mv Svartz, Gabriela Veronica; Hutler Wolkowicz, Ianina Ruth; Perez Coll, Cristina Silvia; Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 33; 4; 4-2014; 875-881
0730-7268
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.2506
info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.2506
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society of Environmental Toxicology and Chemistry
publisher.none.fl_str_mv Society of Environmental Toxicology and Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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