Neuropathology of substance use disorders
- Autores
- Cadet, Jean Lud; Bisagno, Veronica; Milroy, Christopher Mark
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Addictions to licit and illicit drugs are chronic relapsing brain disorders that affect circuits that regulate reward, motivation, memory, and decision-making. Drug-induced pathological changes in these brain regions are associated with characteristic enduring behaviors that continue despite adverse biopsychosocial consequences. Repeated exposure to these substances leads to egocentric behaviors that focus on obtaining the drug by any means and on taking the drug under adverse psychosocial and medical conditions. Addiction also includes craving for the substances and, in some cases, involvement in risky behaviors that can cause death. These patterns of behaviors are associated with specific cognitive disturbances and neuroimaging evidence for brain dysfunctions in a diverse population of drug addicts. Postmortem studies have also revealed significant biochemical and/or structural abnormalities in some addicted individuals. The present review provides a summary of the evidence that has accumulated over the past few years to implicate brain dysfunctions in the varied manifestations of drug addiction. We thus review data on cerebrovascular alterations, brain structural abnormalities, and postmortem studies of patients who abuse cannabis, cocaine, amphetamines, heroin, and “bath salts”. We also discuss potential molecular, biochemical, and cellular bases for the varied clinical presentations of these patients. Elucidation of the biological bases of addiction will help to develop better therapeutic approaches to these patient populations.
Fil: Cadet, Jean Lud. Molecular Neuropsychiatry Research Branch; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Milroy, Christopher Mark. The Ottawa Hospital; Canadá - Materia
-
Cannabis
Cocaine
Methamphetamine
Mdma
Heroin
Cathinones
Bath Salts
Dopamine
Toxicitystriatum
Frontal Cortex
Hippocampus
Nucleus Accumbens
Reward Mechanisms - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/2326
Ver los metadatos del registro completo
id |
CONICETDig_2b99f2e9147c9b8b237d8841d4f41986 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/2326 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Neuropathology of substance use disordersCadet, Jean LudBisagno, VeronicaMilroy, Christopher MarkCannabisCocaineMethamphetamineMdmaHeroinCathinonesBath SaltsDopamineToxicitystriatumFrontal CortexHippocampusNucleus AccumbensReward Mechanismshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Addictions to licit and illicit drugs are chronic relapsing brain disorders that affect circuits that regulate reward, motivation, memory, and decision-making. Drug-induced pathological changes in these brain regions are associated with characteristic enduring behaviors that continue despite adverse biopsychosocial consequences. Repeated exposure to these substances leads to egocentric behaviors that focus on obtaining the drug by any means and on taking the drug under adverse psychosocial and medical conditions. Addiction also includes craving for the substances and, in some cases, involvement in risky behaviors that can cause death. These patterns of behaviors are associated with specific cognitive disturbances and neuroimaging evidence for brain dysfunctions in a diverse population of drug addicts. Postmortem studies have also revealed significant biochemical and/or structural abnormalities in some addicted individuals. The present review provides a summary of the evidence that has accumulated over the past few years to implicate brain dysfunctions in the varied manifestations of drug addiction. We thus review data on cerebrovascular alterations, brain structural abnormalities, and postmortem studies of patients who abuse cannabis, cocaine, amphetamines, heroin, and “bath salts”. We also discuss potential molecular, biochemical, and cellular bases for the varied clinical presentations of these patients. Elucidation of the biological bases of addiction will help to develop better therapeutic approaches to these patient populations.Fil: Cadet, Jean Lud. Molecular Neuropsychiatry Research Branch; Estados UnidosFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Milroy, Christopher Mark. The Ottawa Hospital; CanadáSpringer2013-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2326Cadet, Jean Lud; Bisagno, Veronica; Milroy, Christopher Mark; Neuropathology of substance use disorders; Springer; Acta Neuropathologica; 127; 1; 29-11-2013; 91-1070001-63221432-0533enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00401-013-1221-7info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s00401-013-1221-7info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453825/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:36Zoai:ri.conicet.gov.ar:11336/2326instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:36.36CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Neuropathology of substance use disorders |
title |
Neuropathology of substance use disorders |
spellingShingle |
Neuropathology of substance use disorders Cadet, Jean Lud Cannabis Cocaine Methamphetamine Mdma Heroin Cathinones Bath Salts Dopamine Toxicitystriatum Frontal Cortex Hippocampus Nucleus Accumbens Reward Mechanisms |
title_short |
Neuropathology of substance use disorders |
title_full |
Neuropathology of substance use disorders |
title_fullStr |
Neuropathology of substance use disorders |
title_full_unstemmed |
Neuropathology of substance use disorders |
title_sort |
Neuropathology of substance use disorders |
dc.creator.none.fl_str_mv |
Cadet, Jean Lud Bisagno, Veronica Milroy, Christopher Mark |
author |
Cadet, Jean Lud |
author_facet |
Cadet, Jean Lud Bisagno, Veronica Milroy, Christopher Mark |
author_role |
author |
author2 |
Bisagno, Veronica Milroy, Christopher Mark |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Cannabis Cocaine Methamphetamine Mdma Heroin Cathinones Bath Salts Dopamine Toxicitystriatum Frontal Cortex Hippocampus Nucleus Accumbens Reward Mechanisms |
topic |
Cannabis Cocaine Methamphetamine Mdma Heroin Cathinones Bath Salts Dopamine Toxicitystriatum Frontal Cortex Hippocampus Nucleus Accumbens Reward Mechanisms |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Addictions to licit and illicit drugs are chronic relapsing brain disorders that affect circuits that regulate reward, motivation, memory, and decision-making. Drug-induced pathological changes in these brain regions are associated with characteristic enduring behaviors that continue despite adverse biopsychosocial consequences. Repeated exposure to these substances leads to egocentric behaviors that focus on obtaining the drug by any means and on taking the drug under adverse psychosocial and medical conditions. Addiction also includes craving for the substances and, in some cases, involvement in risky behaviors that can cause death. These patterns of behaviors are associated with specific cognitive disturbances and neuroimaging evidence for brain dysfunctions in a diverse population of drug addicts. Postmortem studies have also revealed significant biochemical and/or structural abnormalities in some addicted individuals. The present review provides a summary of the evidence that has accumulated over the past few years to implicate brain dysfunctions in the varied manifestations of drug addiction. We thus review data on cerebrovascular alterations, brain structural abnormalities, and postmortem studies of patients who abuse cannabis, cocaine, amphetamines, heroin, and “bath salts”. We also discuss potential molecular, biochemical, and cellular bases for the varied clinical presentations of these patients. Elucidation of the biological bases of addiction will help to develop better therapeutic approaches to these patient populations. Fil: Cadet, Jean Lud. Molecular Neuropsychiatry Research Branch; Estados Unidos Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina Fil: Milroy, Christopher Mark. The Ottawa Hospital; Canadá |
description |
Addictions to licit and illicit drugs are chronic relapsing brain disorders that affect circuits that regulate reward, motivation, memory, and decision-making. Drug-induced pathological changes in these brain regions are associated with characteristic enduring behaviors that continue despite adverse biopsychosocial consequences. Repeated exposure to these substances leads to egocentric behaviors that focus on obtaining the drug by any means and on taking the drug under adverse psychosocial and medical conditions. Addiction also includes craving for the substances and, in some cases, involvement in risky behaviors that can cause death. These patterns of behaviors are associated with specific cognitive disturbances and neuroimaging evidence for brain dysfunctions in a diverse population of drug addicts. Postmortem studies have also revealed significant biochemical and/or structural abnormalities in some addicted individuals. The present review provides a summary of the evidence that has accumulated over the past few years to implicate brain dysfunctions in the varied manifestations of drug addiction. We thus review data on cerebrovascular alterations, brain structural abnormalities, and postmortem studies of patients who abuse cannabis, cocaine, amphetamines, heroin, and “bath salts”. We also discuss potential molecular, biochemical, and cellular bases for the varied clinical presentations of these patients. Elucidation of the biological bases of addiction will help to develop better therapeutic approaches to these patient populations. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-29 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/2326 Cadet, Jean Lud; Bisagno, Veronica; Milroy, Christopher Mark; Neuropathology of substance use disorders; Springer; Acta Neuropathologica; 127; 1; 29-11-2013; 91-107 0001-6322 1432-0533 |
url |
http://hdl.handle.net/11336/2326 |
identifier_str_mv |
Cadet, Jean Lud; Bisagno, Veronica; Milroy, Christopher Mark; Neuropathology of substance use disorders; Springer; Acta Neuropathologica; 127; 1; 29-11-2013; 91-107 0001-6322 1432-0533 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00401-013-1221-7 info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s00401-013-1221-7 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453825/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614034862637056 |
score |
13.070432 |