Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors

Autores
Gargiulo Monachelli, Gisella Mariana; Meyer, Maria; Rodríguez, Gabriel; Garay, Laura Ines; Sica, Roberto Ernesto Pedro; de Nicola, Alejandro Federico; Gonzalez Deniselle, Maria Claudia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder. Worse prognostic factors in ALS are: a) advanced age; b) bulbar onset; c) short time between onset and diagnosis. Progesterone (PROG) has been associated with neuroprotective and promyelinating activities in injury, ischemia and degeneration of the central and peripheral nervous system (CNS and PNS). Cortisol, is connected to the response to stress situations and might contribute to neuronal damage. The goals of the study were i) to investigate whether PROG levels are modified by ALS prognostic factors; ii) to determine whether cortisol follows the same pattern. We determined serum steroid levels in 27 patients with sporadic ALS (sALS) and 21 controls. Both steroid hormones showed significantly increased levels in ALS patients versus controls (mean ± SEM: PROG ALS vs control: 0.54 ± 0.05 vs 0.39 ± 0.04 ng/ml, p<0.05; cortisol ALS vs control: 17.02 ± 1.60 vs 11.83 ± 1.38 g/dl; p<0.05). A trend toward higher levels of PROG were demonstrated in spinal onset patients compared to bulbar onset (p=0.07), positive correlation with survival time (RRho=0.43, p=0.04) and a trend toward significance with time to diagnosis (RRho=0.36, p=0.06). These correlations have not been demonstrated for cortisol. Conclusion: Elevated serum steroid levels in sALS were probably due to hyperfunction of the HPA axis. However, only PROG correlated with better prognostic factors. Future studies will determine if the different behavior of PROG and cortisol relate to any particular role they may play during the course of this motor neuron degenerative disease.
Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rodríguez, Gabriel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Garay, Laura Ines. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Sica, Roberto Ernesto Pedro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: de Nicola, Alejandro Federico. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina
Materia
Esclerosis Lateral Amiotrófica
Hormonas
Sobrevida
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/277759
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/277759
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factorsGargiulo Monachelli, Gisella MarianaMeyer, MariaRodríguez, GabrielGaray, Laura InesSica, Roberto Ernesto Pedrode Nicola, Alejandro FedericoGonzalez Deniselle, Maria ClaudiaEsclerosis Lateral AmiotróficaHormonasSobrevidahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder. Worse prognostic factors in ALS are: a) advanced age; b) bulbar onset; c) short time between onset and diagnosis. Progesterone (PROG) has been associated with neuroprotective and promyelinating activities in injury, ischemia and degeneration of the central and peripheral nervous system (CNS and PNS). Cortisol, is connected to the response to stress situations and might contribute to neuronal damage. The goals of the study were i) to investigate whether PROG levels are modified by ALS prognostic factors; ii) to determine whether cortisol follows the same pattern. We determined serum steroid levels in 27 patients with sporadic ALS (sALS) and 21 controls. Both steroid hormones showed significantly increased levels in ALS patients versus controls (mean ± SEM: PROG ALS vs control: 0.54 ± 0.05 vs 0.39 ± 0.04 ng/ml, p<0.05; cortisol ALS vs control: 17.02 ± 1.60 vs 11.83 ± 1.38 g/dl; p<0.05). A trend toward higher levels of PROG were demonstrated in spinal onset patients compared to bulbar onset (p=0.07), positive correlation with survival time (RRho=0.43, p=0.04) and a trend toward significance with time to diagnosis (RRho=0.36, p=0.06). These correlations have not been demonstrated for cortisol. Conclusion: Elevated serum steroid levels in sALS were probably due to hyperfunction of the HPA axis. However, only PROG correlated with better prognostic factors. Future studies will determine if the different behavior of PROG and cortisol relate to any particular role they may play during the course of this motor neuron degenerative disease.Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rodríguez, Gabriel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Garay, Laura Ines. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sica, Roberto Ernesto Pedro. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: de Nicola, Alejandro Federico. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; ArgentinaDe Gruyter2011-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/277759Gargiulo Monachelli, Gisella Mariana; Meyer, Maria; Rodríguez, Gabriel; Garay, Laura Ines; Sica, Roberto Ernesto Pedro; et al.; Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 6; 1; 2-2011; 167-1731868-1891CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyterbrill.com/document/doi/10.1515/HMBCI.2011.006/htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/HMBCI.2011.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:14:41Zoai:ri.conicet.gov.ar:11336/277759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:14:41.692CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
title Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
spellingShingle Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
Gargiulo Monachelli, Gisella Mariana
Esclerosis Lateral Amiotrófica
Hormonas
Sobrevida
title_short Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
title_full Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
title_fullStr Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
title_full_unstemmed Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
title_sort Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors
dc.creator.none.fl_str_mv Gargiulo Monachelli, Gisella Mariana
Meyer, Maria
Rodríguez, Gabriel
Garay, Laura Ines
Sica, Roberto Ernesto Pedro
de Nicola, Alejandro Federico
Gonzalez Deniselle, Maria Claudia
author Gargiulo Monachelli, Gisella Mariana
author_facet Gargiulo Monachelli, Gisella Mariana
Meyer, Maria
Rodríguez, Gabriel
Garay, Laura Ines
Sica, Roberto Ernesto Pedro
de Nicola, Alejandro Federico
Gonzalez Deniselle, Maria Claudia
author_role author
author2 Meyer, Maria
Rodríguez, Gabriel
Garay, Laura Ines
Sica, Roberto Ernesto Pedro
de Nicola, Alejandro Federico
Gonzalez Deniselle, Maria Claudia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosis Lateral Amiotrófica
Hormonas
Sobrevida
topic Esclerosis Lateral Amiotrófica
Hormonas
Sobrevida
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder. Worse prognostic factors in ALS are: a) advanced age; b) bulbar onset; c) short time between onset and diagnosis. Progesterone (PROG) has been associated with neuroprotective and promyelinating activities in injury, ischemia and degeneration of the central and peripheral nervous system (CNS and PNS). Cortisol, is connected to the response to stress situations and might contribute to neuronal damage. The goals of the study were i) to investigate whether PROG levels are modified by ALS prognostic factors; ii) to determine whether cortisol follows the same pattern. We determined serum steroid levels in 27 patients with sporadic ALS (sALS) and 21 controls. Both steroid hormones showed significantly increased levels in ALS patients versus controls (mean ± SEM: PROG ALS vs control: 0.54 ± 0.05 vs 0.39 ± 0.04 ng/ml, p<0.05; cortisol ALS vs control: 17.02 ± 1.60 vs 11.83 ± 1.38 g/dl; p<0.05). A trend toward higher levels of PROG were demonstrated in spinal onset patients compared to bulbar onset (p=0.07), positive correlation with survival time (RRho=0.43, p=0.04) and a trend toward significance with time to diagnosis (RRho=0.36, p=0.06). These correlations have not been demonstrated for cortisol. Conclusion: Elevated serum steroid levels in sALS were probably due to hyperfunction of the HPA axis. However, only PROG correlated with better prognostic factors. Future studies will determine if the different behavior of PROG and cortisol relate to any particular role they may play during the course of this motor neuron degenerative disease.
Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rodríguez, Gabriel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Garay, Laura Ines. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Sica, Roberto Ernesto Pedro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: de Nicola, Alejandro Federico. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Cátedra de Química Biologica; Argentina
description Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder. Worse prognostic factors in ALS are: a) advanced age; b) bulbar onset; c) short time between onset and diagnosis. Progesterone (PROG) has been associated with neuroprotective and promyelinating activities in injury, ischemia and degeneration of the central and peripheral nervous system (CNS and PNS). Cortisol, is connected to the response to stress situations and might contribute to neuronal damage. The goals of the study were i) to investigate whether PROG levels are modified by ALS prognostic factors; ii) to determine whether cortisol follows the same pattern. We determined serum steroid levels in 27 patients with sporadic ALS (sALS) and 21 controls. Both steroid hormones showed significantly increased levels in ALS patients versus controls (mean ± SEM: PROG ALS vs control: 0.54 ± 0.05 vs 0.39 ± 0.04 ng/ml, p<0.05; cortisol ALS vs control: 17.02 ± 1.60 vs 11.83 ± 1.38 g/dl; p<0.05). A trend toward higher levels of PROG were demonstrated in spinal onset patients compared to bulbar onset (p=0.07), positive correlation with survival time (RRho=0.43, p=0.04) and a trend toward significance with time to diagnosis (RRho=0.36, p=0.06). These correlations have not been demonstrated for cortisol. Conclusion: Elevated serum steroid levels in sALS were probably due to hyperfunction of the HPA axis. However, only PROG correlated with better prognostic factors. Future studies will determine if the different behavior of PROG and cortisol relate to any particular role they may play during the course of this motor neuron degenerative disease.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/277759
Gargiulo Monachelli, Gisella Mariana; Meyer, Maria; Rodríguez, Gabriel; Garay, Laura Ines; Sica, Roberto Ernesto Pedro; et al.; Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 6; 1; 2-2011; 167-173
1868-1891
CONICET Digital
CONICET
url http://hdl.handle.net/11336/277759
identifier_str_mv Gargiulo Monachelli, Gisella Mariana; Meyer, Maria; Rodríguez, Gabriel; Garay, Laura Ines; Sica, Roberto Ernesto Pedro; et al.; Progesterone and cortisol levels in sporadic amyotrophic lateral sclerosis (sALS): correlation with prognostic factors; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 6; 1; 2-2011; 167-173
1868-1891
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyterbrill.com/document/doi/10.1515/HMBCI.2011.006/html
info:eu-repo/semantics/altIdentifier/doi/10.1515/HMBCI.2011.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.952241

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