Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis

Autores
Sandoval, María Macarena; Ruvinsky, Silvina Denise; Palermo, María Carolina; Alconada, Tomás; Brizuela, Martín Eduardo; Wierzbicki, Eugenia Ramirez; Cantos, Joaquín; Bardach, Ariel Esteban; Ciapponi, Agustín; Gagetti, Paula Silvana
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Invasive pneumococcal disease has declined since pneumococcal conjugate vaccine introduction in Latin America and the Caribbean (LAC). However, serotype distribution and antimicrobial resistance patterns have changed. Methods: We conducted a systematic review to evaluate the frequency of antimicrobial resistance of Streptococcus pneumoniae from invasive disease in LAC. Articles published between 1 January 2000, and 27 December 2022, with no language restriction, were searched in major databases and gray literature. Pairs of reviewers independently selected extracted data and assessed the risk of bias in the studies. The quality of antimicrobial resistance (AMR) studies was evaluated according to WHO recommendations (PROSPERO CRD42023392097). Results: From 8,600 records identified, 103 studies were included, with 49,660 positive samples of S. pneumoniae for AMR analysis processed. Most studies were from Brazil (29.1%) and Argentina (18.4%), were cross-sectional (57.3%), reported data on AMR from IPD cases (52.4%), and were classified as moderate risk of bias (50.5%). Resistance to penicillin was 21.7% (95%IC 18.7–25.0, I2: 95.9), and for ceftriaxone/cefotaxime it was 4.7% (95%IC 3.2–6.9, I2: 96.1). The highest resistance for both penicillin and ceftriaxone/cefotaxime was in the age group of 0 to 5 years (32.1% [95%IC 28.2–36.4, I2: 87.7], and 9.7% [95%IC 5.9–15.6, I2: 96.9] respectively). The most frequent serotypes associated with resistance were 14 for penicillin and 19A for ceftriaxone/cefotaxime. Conclusion: Approximately one-quarter of invasive pneumococcal disease isolates in Latin America and the Caribbean displayed penicillin resistance, with higher rates in young children. Ongoing surveillance is essential to monitor serotype evolution and antimicrobial resistance patterns following pneumococcal conjugate vaccine introduction.
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Palermo, María Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Brizuela, Martín Eduardo. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dalmacio Vélez Sarsfield";
Fil: Wierzbicki, Eugenia Ramirez. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Cantos, Joaquín. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Gagetti, Paula Silvana. Instituto de Efectividad Clínica y Sanitaria; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Materia
STREPTOCOCCUS PNEUMONIAE
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265326
Acceder
id CONICETDig_2b1adb764623fef8d8970e777d4cfa50
oai_identifier_str oai:ri.conicet.gov.ar:11336/265326
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysisSandoval, María MacarenaRuvinsky, Silvina DenisePalermo, María CarolinaAlconada, TomásBrizuela, Martín EduardoWierzbicki, Eugenia RamirezCantos, JoaquínBardach, Ariel EstebanCiapponi, AgustínGagetti, Paula SilvanaSTREPTOCOCCUS PNEUMONIAELATIN AMERICASYSTEMATIC REVIEWMETA-ANALYSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Invasive pneumococcal disease has declined since pneumococcal conjugate vaccine introduction in Latin America and the Caribbean (LAC). However, serotype distribution and antimicrobial resistance patterns have changed. Methods: We conducted a systematic review to evaluate the frequency of antimicrobial resistance of Streptococcus pneumoniae from invasive disease in LAC. Articles published between 1 January 2000, and 27 December 2022, with no language restriction, were searched in major databases and gray literature. Pairs of reviewers independently selected extracted data and assessed the risk of bias in the studies. The quality of antimicrobial resistance (AMR) studies was evaluated according to WHO recommendations (PROSPERO CRD42023392097). Results: From 8,600 records identified, 103 studies were included, with 49,660 positive samples of S. pneumoniae for AMR analysis processed. Most studies were from Brazil (29.1%) and Argentina (18.4%), were cross-sectional (57.3%), reported data on AMR from IPD cases (52.4%), and were classified as moderate risk of bias (50.5%). Resistance to penicillin was 21.7% (95%IC 18.7–25.0, I2: 95.9), and for ceftriaxone/cefotaxime it was 4.7% (95%IC 3.2–6.9, I2: 96.1). The highest resistance for both penicillin and ceftriaxone/cefotaxime was in the age group of 0 to 5 years (32.1% [95%IC 28.2–36.4, I2: 87.7], and 9.7% [95%IC 5.9–15.6, I2: 96.9] respectively). The most frequent serotypes associated with resistance were 14 for penicillin and 19A for ceftriaxone/cefotaxime. Conclusion: Approximately one-quarter of invasive pneumococcal disease isolates in Latin America and the Caribbean displayed penicillin resistance, with higher rates in young children. Ongoing surveillance is essential to monitor serotype evolution and antimicrobial resistance patterns following pneumococcal conjugate vaccine introduction.Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Palermo, María Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Brizuela, Martín Eduardo. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dalmacio Vélez Sarsfield";Fil: Wierzbicki, Eugenia Ramirez. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Cantos, Joaquín. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Gagetti, Paula Silvana. Instituto de Efectividad Clínica y Sanitaria; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFrontiers Media2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265326Sandoval, María Macarena; Ruvinsky, Silvina Denise; Palermo, María Carolina; Alconada, Tomás; Brizuela, Martín Eduardo; et al.; Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis; Frontiers Media; Frontiers in Public Health; 12; 1-2024; 1-122296-2565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1337276/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fpubh.2024.1337276info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:14Zoai:ri.conicet.gov.ar:11336/265326instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:14.857CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
title Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
spellingShingle Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
Sandoval, María Macarena
STREPTOCOCCUS PNEUMONIAE
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
title_short Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
title_full Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
title_fullStr Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
title_full_unstemmed Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
title_sort Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis
dc.creator.none.fl_str_mv Sandoval, María Macarena
Ruvinsky, Silvina Denise
Palermo, María Carolina
Alconada, Tomás
Brizuela, Martín Eduardo
Wierzbicki, Eugenia Ramirez
Cantos, Joaquín
Bardach, Ariel Esteban
Ciapponi, Agustín
Gagetti, Paula Silvana
author Sandoval, María Macarena
author_facet Sandoval, María Macarena
Ruvinsky, Silvina Denise
Palermo, María Carolina
Alconada, Tomás
Brizuela, Martín Eduardo
Wierzbicki, Eugenia Ramirez
Cantos, Joaquín
Bardach, Ariel Esteban
Ciapponi, Agustín
Gagetti, Paula Silvana
author_role author
author2 Ruvinsky, Silvina Denise
Palermo, María Carolina
Alconada, Tomás
Brizuela, Martín Eduardo
Wierzbicki, Eugenia Ramirez
Cantos, Joaquín
Bardach, Ariel Esteban
Ciapponi, Agustín
Gagetti, Paula Silvana
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv STREPTOCOCCUS PNEUMONIAE
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
topic STREPTOCOCCUS PNEUMONIAE
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Invasive pneumococcal disease has declined since pneumococcal conjugate vaccine introduction in Latin America and the Caribbean (LAC). However, serotype distribution and antimicrobial resistance patterns have changed. Methods: We conducted a systematic review to evaluate the frequency of antimicrobial resistance of Streptococcus pneumoniae from invasive disease in LAC. Articles published between 1 January 2000, and 27 December 2022, with no language restriction, were searched in major databases and gray literature. Pairs of reviewers independently selected extracted data and assessed the risk of bias in the studies. The quality of antimicrobial resistance (AMR) studies was evaluated according to WHO recommendations (PROSPERO CRD42023392097). Results: From 8,600 records identified, 103 studies were included, with 49,660 positive samples of S. pneumoniae for AMR analysis processed. Most studies were from Brazil (29.1%) and Argentina (18.4%), were cross-sectional (57.3%), reported data on AMR from IPD cases (52.4%), and were classified as moderate risk of bias (50.5%). Resistance to penicillin was 21.7% (95%IC 18.7–25.0, I2: 95.9), and for ceftriaxone/cefotaxime it was 4.7% (95%IC 3.2–6.9, I2: 96.1). The highest resistance for both penicillin and ceftriaxone/cefotaxime was in the age group of 0 to 5 years (32.1% [95%IC 28.2–36.4, I2: 87.7], and 9.7% [95%IC 5.9–15.6, I2: 96.9] respectively). The most frequent serotypes associated with resistance were 14 for penicillin and 19A for ceftriaxone/cefotaxime. Conclusion: Approximately one-quarter of invasive pneumococcal disease isolates in Latin America and the Caribbean displayed penicillin resistance, with higher rates in young children. Ongoing surveillance is essential to monitor serotype evolution and antimicrobial resistance patterns following pneumococcal conjugate vaccine introduction.
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Palermo, María Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Brizuela, Martín Eduardo. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dalmacio Vélez Sarsfield";
Fil: Wierzbicki, Eugenia Ramirez. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Cantos, Joaquín. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Gagetti, Paula Silvana. Instituto de Efectividad Clínica y Sanitaria; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
description Background: Invasive pneumococcal disease has declined since pneumococcal conjugate vaccine introduction in Latin America and the Caribbean (LAC). However, serotype distribution and antimicrobial resistance patterns have changed. Methods: We conducted a systematic review to evaluate the frequency of antimicrobial resistance of Streptococcus pneumoniae from invasive disease in LAC. Articles published between 1 January 2000, and 27 December 2022, with no language restriction, were searched in major databases and gray literature. Pairs of reviewers independently selected extracted data and assessed the risk of bias in the studies. The quality of antimicrobial resistance (AMR) studies was evaluated according to WHO recommendations (PROSPERO CRD42023392097). Results: From 8,600 records identified, 103 studies were included, with 49,660 positive samples of S. pneumoniae for AMR analysis processed. Most studies were from Brazil (29.1%) and Argentina (18.4%), were cross-sectional (57.3%), reported data on AMR from IPD cases (52.4%), and were classified as moderate risk of bias (50.5%). Resistance to penicillin was 21.7% (95%IC 18.7–25.0, I2: 95.9), and for ceftriaxone/cefotaxime it was 4.7% (95%IC 3.2–6.9, I2: 96.1). The highest resistance for both penicillin and ceftriaxone/cefotaxime was in the age group of 0 to 5 years (32.1% [95%IC 28.2–36.4, I2: 87.7], and 9.7% [95%IC 5.9–15.6, I2: 96.9] respectively). The most frequent serotypes associated with resistance were 14 for penicillin and 19A for ceftriaxone/cefotaxime. Conclusion: Approximately one-quarter of invasive pneumococcal disease isolates in Latin America and the Caribbean displayed penicillin resistance, with higher rates in young children. Ongoing surveillance is essential to monitor serotype evolution and antimicrobial resistance patterns following pneumococcal conjugate vaccine introduction.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265326
Sandoval, María Macarena; Ruvinsky, Silvina Denise; Palermo, María Carolina; Alconada, Tomás; Brizuela, Martín Eduardo; et al.; Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis; Frontiers Media; Frontiers in Public Health; 12; 1-2024; 1-12
2296-2565
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265326
identifier_str_mv Sandoval, María Macarena; Ruvinsky, Silvina Denise; Palermo, María Carolina; Alconada, Tomás; Brizuela, Martín Eduardo; et al.; Antimicrobial resistance of Streptococcus pneumoniae from invasive pneumococcal diseases in Latin American countries: a systematic review and meta-analysis; Frontiers Media; Frontiers in Public Health; 12; 1-2024; 1-12
2296-2565
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1337276/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fpubh.2024.1337276
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268779792302080
score 13.13397

Publicaciones similares