p21 regulates the cell cycle...or the other way around?

Autores
Speroni, Juliana; Gottifredi, Vanesa
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
For many years, the upregulation of the p53- p21 pathway was supposed to represent the universal response to genotoxic stress. i n triguingly, many genotoxic agents (hydroxy - urea, aphidicolin, hypoxia, cisplatinun and U v irradiation) do not upregulate p21 despite p53 activation. 1 Remarkably, in the August 15th issue of Cell Cycle , Ciznadija and colleagues 2 showed that g i R (gamma ionizing radiation), a D n A damaging agent which was previously characterized as a bona fide inducer of p21, fails to promote such accumulation in s phase. Remarkably, this happens in the context of high p53 levels demonstrating that also in the context of g i R, as well as signals downstream of p53 specifically prevent p21 accumulation during s phase.
Fil: Speroni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
P21
Cell Cycle
P53
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48756
Acceder
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network_name_str CONICET Digital (CONICET)
spelling p21 regulates the cell cycle...or the other way around?Speroni, JulianaGottifredi, VanesaP21Cell CycleP53https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1For many years, the upregulation of the p53- p21 pathway was supposed to represent the universal response to genotoxic stress. i n triguingly, many genotoxic agents (hydroxy - urea, aphidicolin, hypoxia, cisplatinun and U v irradiation) do not upregulate p21 despite p53 activation. 1 Remarkably, in the August 15th issue of Cell Cycle , Ciznadija and colleagues 2 showed that g i R (gamma ionizing radiation), a D n A damaging agent which was previously characterized as a bona fide inducer of p21, fails to promote such accumulation in s phase. Remarkably, this happens in the context of high p53 levels demonstrating that also in the context of g i R, as well as signals downstream of p53 specifically prevent p21 accumulation during s phase.Fil: Speroni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaLandes Bioscience2011-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48756Speroni, Juliana; Gottifredi, Vanesa; p21 regulates the cell cycle...or the other way around?; Landes Bioscience; Cell Cycle; 10; 20; 10-2011; 3430-34311538-41011551-4005CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4161/cc.10.20.17530info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.4161/cc.10.20.17530info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:57:59Zoai:ri.conicet.gov.ar:11336/48756instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:57:59.347CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv p21 regulates the cell cycle...or the other way around?
title p21 regulates the cell cycle...or the other way around?
spellingShingle p21 regulates the cell cycle...or the other way around?
Speroni, Juliana
P21
Cell Cycle
P53
title_short p21 regulates the cell cycle...or the other way around?
title_full p21 regulates the cell cycle...or the other way around?
title_fullStr p21 regulates the cell cycle...or the other way around?
title_full_unstemmed p21 regulates the cell cycle...or the other way around?
title_sort p21 regulates the cell cycle...or the other way around?
dc.creator.none.fl_str_mv Speroni, Juliana
Gottifredi, Vanesa
author Speroni, Juliana
author_facet Speroni, Juliana
Gottifredi, Vanesa
author_role author
author2 Gottifredi, Vanesa
author2_role author
dc.subject.none.fl_str_mv P21
Cell Cycle
P53
topic P21
Cell Cycle
P53
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv For many years, the upregulation of the p53- p21 pathway was supposed to represent the universal response to genotoxic stress. i n triguingly, many genotoxic agents (hydroxy - urea, aphidicolin, hypoxia, cisplatinun and U v irradiation) do not upregulate p21 despite p53 activation. 1 Remarkably, in the August 15th issue of Cell Cycle , Ciznadija and colleagues 2 showed that g i R (gamma ionizing radiation), a D n A damaging agent which was previously characterized as a bona fide inducer of p21, fails to promote such accumulation in s phase. Remarkably, this happens in the context of high p53 levels demonstrating that also in the context of g i R, as well as signals downstream of p53 specifically prevent p21 accumulation during s phase.
Fil: Speroni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description For many years, the upregulation of the p53- p21 pathway was supposed to represent the universal response to genotoxic stress. i n triguingly, many genotoxic agents (hydroxy - urea, aphidicolin, hypoxia, cisplatinun and U v irradiation) do not upregulate p21 despite p53 activation. 1 Remarkably, in the August 15th issue of Cell Cycle , Ciznadija and colleagues 2 showed that g i R (gamma ionizing radiation), a D n A damaging agent which was previously characterized as a bona fide inducer of p21, fails to promote such accumulation in s phase. Remarkably, this happens in the context of high p53 levels demonstrating that also in the context of g i R, as well as signals downstream of p53 specifically prevent p21 accumulation during s phase.
publishDate 2011
dc.date.none.fl_str_mv 2011-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48756
Speroni, Juliana; Gottifredi, Vanesa; p21 regulates the cell cycle...or the other way around?; Landes Bioscience; Cell Cycle; 10; 20; 10-2011; 3430-3431
1538-4101
1551-4005
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48756
identifier_str_mv Speroni, Juliana; Gottifredi, Vanesa; p21 regulates the cell cycle...or the other way around?; Landes Bioscience; Cell Cycle; 10; 20; 10-2011; 3430-3431
1538-4101
1551-4005
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4161/cc.10.20.17530
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.4161/cc.10.20.17530
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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