Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations...

Autores: Oliveira, Rafael Gustavo; Schneck, Emanuel; Quinn, Bonnie E.; Konovalov, Oleg V.; Brandenburg, Klaus; Gutsmann, Thomas; Gill, Tom; Hanna, Charles B.; Pink, David A.; Tanaka, Motomu
Año de publicación: 2010
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Grazing incidence x-ray scattering techniques and Monte Carlo (MC) simulations are combined to reveal the influence of molecular structure (genetic mutation) and divalent cations on the survival of gram negative bacteria against cationic peptides such as protamine. The former yields detailed structures of bacterial lipopolysaccharide (LPS) membranes with minimized radiation damages, while the minimal computer model based on the linearized Poisson-Boltzmann theory allows for the simulation of conformational changes of macromolecules (LPSs and peptides) that occur in the time scale of ms. The complementary combination of the structural characterizations and MC simulation demonstrates that the condensations of divalent ions (Ca2+ or Mg2+) in the negatively charged core saccharides are crucial for bacterial survival. © 2010 The American Physical Society.
Fil: Oliveira, Rafael Gustavo. Technische Universitat München; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Schneck, Emanuel. Universität Heidelberg; Alemania. Technische Universitat München; Alemania
Fil: Quinn, Bonnie E.. St. Francis Xavier University; Canadá. Networks Of Centres Of Excellence; Canadá
Fil: Konovalov, Oleg V.. European Synchrotron Radiation; Francia
Fil: Brandenburg, Klaus. Research Center Borstel; Alemania
Fil: Gutsmann, Thomas. Research Center Borstel; Alemania
Fil: Gill, Tom. Dalhousie University Halifax; Canadá. Networks Of Centres Of Excellence; Canadá
Fil: Hanna, Charles B.. Advanced Foods and Materials Network of Centres of Excellen; Canadá. Boise State University; Alemania
Fil: Pink, David A.. St. Francis Xavier University; Canadá. Networks Of Centres Of Excellence; Canadá
Fil: Tanaka, Motomu. Universität Heidelberg; Alemania. Networks Of Centres Of Excellence; Canadá. Technische Universitat München; Alemania
Materia: LANGMUIR MONOLAYERS
LIPOPOLYSACHARIDES
GRAZING-INCIDENCE X-RAY DIFFRACTION
PROTAMINE
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/186593

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spelling	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulationsOliveira, Rafael GustavoSchneck, EmanuelQuinn, Bonnie E.Konovalov, Oleg V.Brandenburg, KlausGutsmann, ThomasGill, TomHanna, Charles B.Pink, David A.Tanaka, MotomuLANGMUIR MONOLAYERSLIPOPOLYSACHARIDESGRAZING-INCIDENCE X-RAY DIFFRACTIONPROTAMINEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Grazing incidence x-ray scattering techniques and Monte Carlo (MC) simulations are combined to reveal the influence of molecular structure (genetic mutation) and divalent cations on the survival of gram negative bacteria against cationic peptides such as protamine. The former yields detailed structures of bacterial lipopolysaccharide (LPS) membranes with minimized radiation damages, while the minimal computer model based on the linearized Poisson-Boltzmann theory allows for the simulation of conformational changes of macromolecules (LPSs and peptides) that occur in the time scale of ms. The complementary combination of the structural characterizations and MC simulation demonstrates that the condensations of divalent ions (Ca2+ or Mg2+) in the negatively charged core saccharides are crucial for bacterial survival. © 2010 The American Physical Society.Fil: Oliveira, Rafael Gustavo. Technische Universitat München; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Schneck, Emanuel. Universität Heidelberg; Alemania. Technische Universitat München; AlemaniaFil: Quinn, Bonnie E.. St. Francis Xavier University; Canadá. Networks Of Centres Of Excellence; CanadáFil: Konovalov, Oleg V.. European Synchrotron Radiation; FranciaFil: Brandenburg, Klaus. Research Center Borstel; AlemaniaFil: Gutsmann, Thomas. Research Center Borstel; AlemaniaFil: Gill, Tom. Dalhousie University Halifax; Canadá. Networks Of Centres Of Excellence; CanadáFil: Hanna, Charles B.. Advanced Foods and Materials Network of Centres of Excellen; Canadá. Boise State University; AlemaniaFil: Pink, David A.. St. Francis Xavier University; Canadá. Networks Of Centres Of Excellence; CanadáFil: Tanaka, Motomu. Universität Heidelberg; Alemania. Networks Of Centres Of Excellence; Canadá. Technische Universitat München; AlemaniaAmerican Physical Society2010-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186593Oliveira, Rafael Gustavo; Schneck, Emanuel; Quinn, Bonnie E.; Konovalov, Oleg V.; Brandenburg, Klaus; et al.; Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 81; 4; 4-2010; 4190101-41901121063-651XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.aps.org/doi/10.1103/PhysRevE.81.041901info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.81.041901info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:05Zoai:ri.conicet.gov.ar:11336/186593instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:05.945CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
title	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
spellingShingle	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations Oliveira, Rafael Gustavo LANGMUIR MONOLAYERS LIPOPOLYSACHARIDES GRAZING-INCIDENCE X-RAY DIFFRACTION PROTAMINE
title_short	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
title_full	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
title_fullStr	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
title_full_unstemmed	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
title_sort	Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations
dc.creator.none.fl_str_mv	Oliveira, Rafael Gustavo Schneck, Emanuel Quinn, Bonnie E. Konovalov, Oleg V. Brandenburg, Klaus Gutsmann, Thomas Gill, Tom Hanna, Charles B. Pink, David A. Tanaka, Motomu
author	Oliveira, Rafael Gustavo
author_facet	Oliveira, Rafael Gustavo Schneck, Emanuel Quinn, Bonnie E. Konovalov, Oleg V. Brandenburg, Klaus Gutsmann, Thomas Gill, Tom Hanna, Charles B. Pink, David A. Tanaka, Motomu
author_role	author
author2	Schneck, Emanuel Quinn, Bonnie E. Konovalov, Oleg V. Brandenburg, Klaus Gutsmann, Thomas Gill, Tom Hanna, Charles B. Pink, David A. Tanaka, Motomu
author2_role	author author author author author author author author author
dc.subject.none.fl_str_mv	LANGMUIR MONOLAYERS LIPOPOLYSACHARIDES GRAZING-INCIDENCE X-RAY DIFFRACTION PROTAMINE
topic	LANGMUIR MONOLAYERS LIPOPOLYSACHARIDES GRAZING-INCIDENCE X-RAY DIFFRACTION PROTAMINE
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	Grazing incidence x-ray scattering techniques and Monte Carlo (MC) simulations are combined to reveal the influence of molecular structure (genetic mutation) and divalent cations on the survival of gram negative bacteria against cationic peptides such as protamine. The former yields detailed structures of bacterial lipopolysaccharide (LPS) membranes with minimized radiation damages, while the minimal computer model based on the linearized Poisson-Boltzmann theory allows for the simulation of conformational changes of macromolecules (LPSs and peptides) that occur in the time scale of ms. The complementary combination of the structural characterizations and MC simulation demonstrates that the condensations of divalent ions (Ca2+ or Mg2+) in the negatively charged core saccharides are crucial for bacterial survival. © 2010 The American Physical Society. Fil: Oliveira, Rafael Gustavo. Technische Universitat München; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Schneck, Emanuel. Universität Heidelberg; Alemania. Technische Universitat München; Alemania Fil: Quinn, Bonnie E.. St. Francis Xavier University; Canadá. Networks Of Centres Of Excellence; Canadá Fil: Konovalov, Oleg V.. European Synchrotron Radiation; Francia Fil: Brandenburg, Klaus. Research Center Borstel; Alemania Fil: Gutsmann, Thomas. Research Center Borstel; Alemania Fil: Gill, Tom. Dalhousie University Halifax; Canadá. Networks Of Centres Of Excellence; Canadá Fil: Hanna, Charles B.. Advanced Foods and Materials Network of Centres of Excellen; Canadá. Boise State University; Alemania Fil: Pink, David A.. St. Francis Xavier University; Canadá. Networks Of Centres Of Excellence; Canadá Fil: Tanaka, Motomu. Universität Heidelberg; Alemania. Networks Of Centres Of Excellence; Canadá. Technische Universitat München; Alemania
description	Grazing incidence x-ray scattering techniques and Monte Carlo (MC) simulations are combined to reveal the influence of molecular structure (genetic mutation) and divalent cations on the survival of gram negative bacteria against cationic peptides such as protamine. The former yields detailed structures of bacterial lipopolysaccharide (LPS) membranes with minimized radiation damages, while the minimal computer model based on the linearized Poisson-Boltzmann theory allows for the simulation of conformational changes of macromolecules (LPSs and peptides) that occur in the time scale of ms. The complementary combination of the structural characterizations and MC simulation demonstrates that the condensations of divalent ions (Ca2+ or Mg2+) in the negatively charged core saccharides are crucial for bacterial survival. © 2010 The American Physical Society.
publishDate	2010
dc.date.none.fl_str_mv	2010-04
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/186593 Oliveira, Rafael Gustavo; Schneck, Emanuel; Quinn, Bonnie E.; Konovalov, Oleg V.; Brandenburg, Klaus; et al.; Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 81; 4; 4-2010; 4190101-4190112 1063-651X CONICET Digital CONICET
url	http://hdl.handle.net/11336/186593
identifier_str_mv	Oliveira, Rafael Gustavo; Schneck, Emanuel; Quinn, Bonnie E.; Konovalov, Oleg V.; Brandenburg, Klaus; et al.; Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 81; 4; 4-2010; 4190101-4190112 1063-651X CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/http://link.aps.org/doi/10.1103/PhysRevE.81.041901 info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.81.041901
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	American Physical Society
publisher.none.fl_str_mv	American Physical Society
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.13397

Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations...

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