Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases

Autores
Veuthey, Tania Vanesa; Burkovski, Andras
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
As life expectancy increase, age-related disorders, such us neurodegenerative diseases (ND), have become more prevalent. Moreover, treatments only attenuate some symptoms, but fail to arrest characteristic neuronal proteotoxicity. Thus, new challenges emerge to science in order to understand molecular basis of these disorders. Lately, the gut-brain axis has gain attention and a close relation between gut microorganism and ND has been proposed. The aim of our work was to evaluate the relevance of the microbiota in the progression of proteotoxic-based disorders, assessing the impact of six non-pathogenic bacterial diets on life-history traits in C. elegans models of ND (vs standard OP50). In a first approach, we found 2 bacteria, Escherichia coli K12 and E. coli HB101, able to improve locomotion in liquid media, in worm’s model of Parkinson disease (PD) at adult day 4, versus E. coli OP50. Moreover, an age-dependent locomotion improvement, between larva-L4 and adult day 4, was observed in solid media after feeding PD model´s worms with 4 different bacteria versus E. coli OP50. We also observed an increase in the developmental timing of wild-type worms grown in 4 bacteria versus E. coli OP50, but more interesting was the accelerated developmental rate selectively found in models of PD and Huntington disease feed with E. coli BL21 (DE3). We are currently evaluating aggregate numbers, lifespan and mitochondrial morphology among others. Our results allowed us to identify bacteria with the ability to drive physiological outcomes and improve health status of C. elegans models of neurodegenerative diseases.
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Burkovski, Andras. Universitat Erlangen-nurnberg. Faculty Of Sciences.; Alemania
24th International C. elegans Conference
Glasgow
Reino Unido
Genetics Society of America
Materia
MICROBIOTA
C ELEGANS
DIETA
NEURIDEGENERATIVAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240063
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseasesVeuthey, Tania VanesaBurkovski, AndrasMICROBIOTAC ELEGANSDIETANEURIDEGENERATIVAShttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1As life expectancy increase, age-related disorders, such us neurodegenerative diseases (ND), have become more prevalent. Moreover, treatments only attenuate some symptoms, but fail to arrest characteristic neuronal proteotoxicity. Thus, new challenges emerge to science in order to understand molecular basis of these disorders. Lately, the gut-brain axis has gain attention and a close relation between gut microorganism and ND has been proposed. The aim of our work was to evaluate the relevance of the microbiota in the progression of proteotoxic-based disorders, assessing the impact of six non-pathogenic bacterial diets on life-history traits in C. elegans models of ND (vs standard OP50). In a first approach, we found 2 bacteria, Escherichia coli K12 and E. coli HB101, able to improve locomotion in liquid media, in worm’s model of Parkinson disease (PD) at adult day 4, versus E. coli OP50. Moreover, an age-dependent locomotion improvement, between larva-L4 and adult day 4, was observed in solid media after feeding PD model´s worms with 4 different bacteria versus E. coli OP50. We also observed an increase in the developmental timing of wild-type worms grown in 4 bacteria versus E. coli OP50, but more interesting was the accelerated developmental rate selectively found in models of PD and Huntington disease feed with E. coli BL21 (DE3). We are currently evaluating aggregate numbers, lifespan and mitochondrial morphology among others. Our results allowed us to identify bacteria with the ability to drive physiological outcomes and improve health status of C. elegans models of neurodegenerative diseases.Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Burkovski, Andras. Universitat Erlangen-nurnberg. Faculty Of Sciences.; Alemania24th International C. elegans ConferenceGlasgowReino UnidoGenetics Society of AmericaGenetics Society of America2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240063Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 392-392CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/program-and-abstract-books/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:38Zoai:ri.conicet.gov.ar:11336/240063instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:38.595CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
title Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
spellingShingle Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
Veuthey, Tania Vanesa
MICROBIOTA
C ELEGANS
DIETA
NEURIDEGENERATIVAS
title_short Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
title_full Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
title_fullStr Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
title_full_unstemmed Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
title_sort Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
dc.creator.none.fl_str_mv Veuthey, Tania Vanesa
Burkovski, Andras
author Veuthey, Tania Vanesa
author_facet Veuthey, Tania Vanesa
Burkovski, Andras
author_role author
author2 Burkovski, Andras
author2_role author
dc.subject.none.fl_str_mv MICROBIOTA
C ELEGANS
DIETA
NEURIDEGENERATIVAS
topic MICROBIOTA
C ELEGANS
DIETA
NEURIDEGENERATIVAS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv As life expectancy increase, age-related disorders, such us neurodegenerative diseases (ND), have become more prevalent. Moreover, treatments only attenuate some symptoms, but fail to arrest characteristic neuronal proteotoxicity. Thus, new challenges emerge to science in order to understand molecular basis of these disorders. Lately, the gut-brain axis has gain attention and a close relation between gut microorganism and ND has been proposed. The aim of our work was to evaluate the relevance of the microbiota in the progression of proteotoxic-based disorders, assessing the impact of six non-pathogenic bacterial diets on life-history traits in C. elegans models of ND (vs standard OP50). In a first approach, we found 2 bacteria, Escherichia coli K12 and E. coli HB101, able to improve locomotion in liquid media, in worm’s model of Parkinson disease (PD) at adult day 4, versus E. coli OP50. Moreover, an age-dependent locomotion improvement, between larva-L4 and adult day 4, was observed in solid media after feeding PD model´s worms with 4 different bacteria versus E. coli OP50. We also observed an increase in the developmental timing of wild-type worms grown in 4 bacteria versus E. coli OP50, but more interesting was the accelerated developmental rate selectively found in models of PD and Huntington disease feed with E. coli BL21 (DE3). We are currently evaluating aggregate numbers, lifespan and mitochondrial morphology among others. Our results allowed us to identify bacteria with the ability to drive physiological outcomes and improve health status of C. elegans models of neurodegenerative diseases.
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Burkovski, Andras. Universitat Erlangen-nurnberg. Faculty Of Sciences.; Alemania
24th International C. elegans Conference
Glasgow
Reino Unido
Genetics Society of America
description As life expectancy increase, age-related disorders, such us neurodegenerative diseases (ND), have become more prevalent. Moreover, treatments only attenuate some symptoms, but fail to arrest characteristic neuronal proteotoxicity. Thus, new challenges emerge to science in order to understand molecular basis of these disorders. Lately, the gut-brain axis has gain attention and a close relation between gut microorganism and ND has been proposed. The aim of our work was to evaluate the relevance of the microbiota in the progression of proteotoxic-based disorders, assessing the impact of six non-pathogenic bacterial diets on life-history traits in C. elegans models of ND (vs standard OP50). In a first approach, we found 2 bacteria, Escherichia coli K12 and E. coli HB101, able to improve locomotion in liquid media, in worm’s model of Parkinson disease (PD) at adult day 4, versus E. coli OP50. Moreover, an age-dependent locomotion improvement, between larva-L4 and adult day 4, was observed in solid media after feeding PD model´s worms with 4 different bacteria versus E. coli OP50. We also observed an increase in the developmental timing of wild-type worms grown in 4 bacteria versus E. coli OP50, but more interesting was the accelerated developmental rate selectively found in models of PD and Huntington disease feed with E. coli BL21 (DE3). We are currently evaluating aggregate numbers, lifespan and mitochondrial morphology among others. Our results allowed us to identify bacteria with the ability to drive physiological outcomes and improve health status of C. elegans models of neurodegenerative diseases.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240063
Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 392-392
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240063
identifier_str_mv Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 392-392
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/program-and-abstract-books/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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