Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa

Autores
Veaute, Carolina Melania Isabel; Liu, D. Y.; Furlong, L. I.; Biancotti, J. C.; Baker, H.; Vazquez, Monica Hebe
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)-induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin-acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP.
Fil: Veaute, Carolina Melania Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Liu, D. Y.. The University Of Melbourne; Australia
Fil: Furlong, L. I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Biancotti, J. C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Baker, H. . The University Of Melbourne; Australia
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Materia
Human
Fertilization
Spermatozoa
Oocyte
Proacrosin
Acrosin
Antibodies
Acrosome Reaction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14258
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14258
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoaVeaute, Carolina Melania IsabelLiu, D. Y.Furlong, L. I.Biancotti, J. C.Baker, H. Vazquez, Monica HebeHumanFertilizationSpermatozoaOocyteProacrosinAcrosinAntibodiesAcrosome Reactionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)-induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin-acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP.Fil: Veaute, Carolina Melania Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Liu, D. Y.. The University Of Melbourne; AustraliaFil: Furlong, L. I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Biancotti, J. C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Baker, H. . The University Of Melbourne; AustraliaFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaElsevier Inc2010-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14258Veaute, Carolina Melania Isabel; Liu, D. Y.; Furlong, L. I.; Biancotti, J. C.; Baker, H. ; et al.; Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa; Elsevier Inc; Fertility And Sterility; 93; 7; 1-5-2010; 2456-24590015-02821556-5653enginfo:eu-repo/semantics/altIdentifier/url/http://www.fertstert.org/article/S0015-0282(09)03518-3/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2009.08.040info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:36Zoai:ri.conicet.gov.ar:11336/14258instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:37.168CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
title Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
spellingShingle Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
Veaute, Carolina Melania Isabel
Human
Fertilization
Spermatozoa
Oocyte
Proacrosin
Acrosin
Antibodies
Acrosome Reaction
title_short Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
title_full Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
title_fullStr Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
title_full_unstemmed Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
title_sort Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
dc.creator.none.fl_str_mv Veaute, Carolina Melania Isabel
Liu, D. Y.
Furlong, L. I.
Biancotti, J. C.
Baker, H.
Vazquez, Monica Hebe
author Veaute, Carolina Melania Isabel
author_facet Veaute, Carolina Melania Isabel
Liu, D. Y.
Furlong, L. I.
Biancotti, J. C.
Baker, H.
Vazquez, Monica Hebe
author_role author
author2 Liu, D. Y.
Furlong, L. I.
Biancotti, J. C.
Baker, H.
Vazquez, Monica Hebe
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Human
Fertilization
Spermatozoa
Oocyte
Proacrosin
Acrosin
Antibodies
Acrosome Reaction
topic Human
Fertilization
Spermatozoa
Oocyte
Proacrosin
Acrosin
Antibodies
Acrosome Reaction
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)-induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin-acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP.
Fil: Veaute, Carolina Melania Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Liu, D. Y.. The University Of Melbourne; Australia
Fil: Furlong, L. I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Biancotti, J. C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Baker, H. . The University Of Melbourne; Australia
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
description The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)-induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin-acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP.
publishDate 2010
dc.date.none.fl_str_mv 2010-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14258
Veaute, Carolina Melania Isabel; Liu, D. Y.; Furlong, L. I.; Biancotti, J. C.; Baker, H. ; et al.; Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa; Elsevier Inc; Fertility And Sterility; 93; 7; 1-5-2010; 2456-2459
0015-0282
1556-5653
url http://hdl.handle.net/11336/14258
identifier_str_mv Veaute, Carolina Melania Isabel; Liu, D. Y.; Furlong, L. I.; Biancotti, J. C.; Baker, H. ; et al.; Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa; Elsevier Inc; Fertility And Sterility; 93; 7; 1-5-2010; 2456-2459
0015-0282
1556-5653
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.fertstert.org/article/S0015-0282(09)03518-3/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2009.08.040
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614218127507456
score 13.070432

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