Trace amines produced by skin bacteria accelerate wound healing in mice

Autores
Luqman, Arif; Muttaqin, Muhammad Zainul; Yulaipi, Sumah; Ebner, Patrick; Matsuo, Miki; Zabel, Susanne; Tribelli, Paula Maria; Nieselt, Kay; Hidayati, Dewi; Götz, Friedrich
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Certain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expect that such bacteria are able to produce TA on our skin. Here we show that TA-producing Staphylococcus epidermidis strains expressing SadA are predominant on human skin and that TA accelerate wound healing. In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by β2-adrenergic receptor (β2-AR) activation thus delay wound healing. As β2-AR antagonists, TA and dopamine (DOP) abrogate the effect of EPI thus accelerating wound healing both in vitro and in a mouse model. In the mouse model, the S. epidermidis wild type strain accelerates wound healing compared to its ΔsadA mutant. Our study demonstrates that TA-producing S. epidermidis strains present on our skin might be beneficial for wound healing.
Fil: Luqman, Arif. Eberhard Karls Universität Tübingen.; Alemania. Institut Teknologi Sepuluh Nopember; Indonesia
Fil: Muttaqin, Muhammad Zainul. Universitas Muhammadiyah Gresik; Indonesia
Fil: Yulaipi, Sumah. Institut Teknologi Sepuluh Nopember; Indonesia
Fil: Ebner, Patrick. Eberhard Karls Universität Tübingen.; Alemania
Fil: Matsuo, Miki. Eberhard Karls Universität Tübingen.; Alemania
Fil: Zabel, Susanne. Eberhard Karls Universität Tübingen.; Alemania
Fil: Tribelli, Paula Maria. Eberhard Karls Universität Tübingen.; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Nieselt, Kay. Universitas Muhammadiyah Gresik; Indonesia
Fil: Hidayati, Dewi. Institut Teknologi Sepuluh Nopember; Indonesia
Fil: Götz, Friedrich. Eberhard Karls Universität Tübingen.; Alemania
Materia
STAPHYLOCOCCUS
SKIN
HEALING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/143202
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/143202
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Trace amines produced by skin bacteria accelerate wound healing in miceLuqman, ArifMuttaqin, Muhammad ZainulYulaipi, SumahEbner, PatrickMatsuo, MikiZabel, SusanneTribelli, Paula MariaNieselt, KayHidayati, DewiGötz, FriedrichSTAPHYLOCOCCUSSKINHEALINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Certain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expect that such bacteria are able to produce TA on our skin. Here we show that TA-producing Staphylococcus epidermidis strains expressing SadA are predominant on human skin and that TA accelerate wound healing. In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by β2-adrenergic receptor (β2-AR) activation thus delay wound healing. As β2-AR antagonists, TA and dopamine (DOP) abrogate the effect of EPI thus accelerating wound healing both in vitro and in a mouse model. In the mouse model, the S. epidermidis wild type strain accelerates wound healing compared to its ΔsadA mutant. Our study demonstrates that TA-producing S. epidermidis strains present on our skin might be beneficial for wound healing.Fil: Luqman, Arif. Eberhard Karls Universität Tübingen.; Alemania. Institut Teknologi Sepuluh Nopember; IndonesiaFil: Muttaqin, Muhammad Zainul. Universitas Muhammadiyah Gresik; IndonesiaFil: Yulaipi, Sumah. Institut Teknologi Sepuluh Nopember; IndonesiaFil: Ebner, Patrick. Eberhard Karls Universität Tübingen.; AlemaniaFil: Matsuo, Miki. Eberhard Karls Universität Tübingen.; AlemaniaFil: Zabel, Susanne. Eberhard Karls Universität Tübingen.; AlemaniaFil: Tribelli, Paula Maria. Eberhard Karls Universität Tübingen.; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Nieselt, Kay. Universitas Muhammadiyah Gresik; IndonesiaFil: Hidayati, Dewi. Institut Teknologi Sepuluh Nopember; IndonesiaFil: Götz, Friedrich. Eberhard Karls Universität Tübingen.; AlemaniaNature2020-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/143202Luqman, Arif; Muttaqin, Muhammad Zainul; Yulaipi, Sumah; Ebner, Patrick; Matsuo, Miki; et al.; Trace amines produced by skin bacteria accelerate wound healing in mice; Nature; Communications Biology; 3; 277; 1-6-2020; 1-102399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s42003-020-1000-7info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-1000-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:30Zoai:ri.conicet.gov.ar:11336/143202instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:30.366CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Trace amines produced by skin bacteria accelerate wound healing in mice
title Trace amines produced by skin bacteria accelerate wound healing in mice
spellingShingle Trace amines produced by skin bacteria accelerate wound healing in mice
Luqman, Arif
STAPHYLOCOCCUS
SKIN
HEALING
title_short Trace amines produced by skin bacteria accelerate wound healing in mice
title_full Trace amines produced by skin bacteria accelerate wound healing in mice
title_fullStr Trace amines produced by skin bacteria accelerate wound healing in mice
title_full_unstemmed Trace amines produced by skin bacteria accelerate wound healing in mice
title_sort Trace amines produced by skin bacteria accelerate wound healing in mice
dc.creator.none.fl_str_mv Luqman, Arif
Muttaqin, Muhammad Zainul
Yulaipi, Sumah
Ebner, Patrick
Matsuo, Miki
Zabel, Susanne
Tribelli, Paula Maria
Nieselt, Kay
Hidayati, Dewi
Götz, Friedrich
author Luqman, Arif
author_facet Luqman, Arif
Muttaqin, Muhammad Zainul
Yulaipi, Sumah
Ebner, Patrick
Matsuo, Miki
Zabel, Susanne
Tribelli, Paula Maria
Nieselt, Kay
Hidayati, Dewi
Götz, Friedrich
author_role author
author2 Muttaqin, Muhammad Zainul
Yulaipi, Sumah
Ebner, Patrick
Matsuo, Miki
Zabel, Susanne
Tribelli, Paula Maria
Nieselt, Kay
Hidayati, Dewi
Götz, Friedrich
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv STAPHYLOCOCCUS
SKIN
HEALING
topic STAPHYLOCOCCUS
SKIN
HEALING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Certain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expect that such bacteria are able to produce TA on our skin. Here we show that TA-producing Staphylococcus epidermidis strains expressing SadA are predominant on human skin and that TA accelerate wound healing. In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by β2-adrenergic receptor (β2-AR) activation thus delay wound healing. As β2-AR antagonists, TA and dopamine (DOP) abrogate the effect of EPI thus accelerating wound healing both in vitro and in a mouse model. In the mouse model, the S. epidermidis wild type strain accelerates wound healing compared to its ΔsadA mutant. Our study demonstrates that TA-producing S. epidermidis strains present on our skin might be beneficial for wound healing.
Fil: Luqman, Arif. Eberhard Karls Universität Tübingen.; Alemania. Institut Teknologi Sepuluh Nopember; Indonesia
Fil: Muttaqin, Muhammad Zainul. Universitas Muhammadiyah Gresik; Indonesia
Fil: Yulaipi, Sumah. Institut Teknologi Sepuluh Nopember; Indonesia
Fil: Ebner, Patrick. Eberhard Karls Universität Tübingen.; Alemania
Fil: Matsuo, Miki. Eberhard Karls Universität Tübingen.; Alemania
Fil: Zabel, Susanne. Eberhard Karls Universität Tübingen.; Alemania
Fil: Tribelli, Paula Maria. Eberhard Karls Universität Tübingen.; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Nieselt, Kay. Universitas Muhammadiyah Gresik; Indonesia
Fil: Hidayati, Dewi. Institut Teknologi Sepuluh Nopember; Indonesia
Fil: Götz, Friedrich. Eberhard Karls Universität Tübingen.; Alemania
description Certain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expect that such bacteria are able to produce TA on our skin. Here we show that TA-producing Staphylococcus epidermidis strains expressing SadA are predominant on human skin and that TA accelerate wound healing. In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by β2-adrenergic receptor (β2-AR) activation thus delay wound healing. As β2-AR antagonists, TA and dopamine (DOP) abrogate the effect of EPI thus accelerating wound healing both in vitro and in a mouse model. In the mouse model, the S. epidermidis wild type strain accelerates wound healing compared to its ΔsadA mutant. Our study demonstrates that TA-producing S. epidermidis strains present on our skin might be beneficial for wound healing.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/143202
Luqman, Arif; Muttaqin, Muhammad Zainul; Yulaipi, Sumah; Ebner, Patrick; Matsuo, Miki; et al.; Trace amines produced by skin bacteria accelerate wound healing in mice; Nature; Communications Biology; 3; 277; 1-6-2020; 1-10
2399-3642
CONICET Digital
CONICET
url http://hdl.handle.net/11336/143202
identifier_str_mv Luqman, Arif; Muttaqin, Muhammad Zainul; Yulaipi, Sumah; Ebner, Patrick; Matsuo, Miki; et al.; Trace amines produced by skin bacteria accelerate wound healing in mice; Nature; Communications Biology; 3; 277; 1-6-2020; 1-10
2399-3642
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s42003-020-1000-7
info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-1000-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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