Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
- Autores
- Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs.
Fil: Lopez Jimenez, Jimmy Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina - Materia
-
Poly(Beta-Hydroxybutyrate)
Fed-Batch Reactor
Optimization
Operating Conditions - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/57682
Ver los metadatos del registro completo
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Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactorLopez Jimenez, Jimmy AndresBucala, VeronicaVillar, Marcelo ArmandoPoly(Beta-Hydroxybutyrate)Fed-Batch ReactorOptimizationOperating Conditionshttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs.Fil: Lopez Jimenez, Jimmy Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaAmerican Chemical Society2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57682Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando; Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor; American Chemical Society; Industrial & Engineering Chemical Research; 49; 4; 2-2010; 1762-17690888-5885CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/ie9006547info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ie9006547info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:34Zoai:ri.conicet.gov.ar:11336/57682instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:34.661CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
title |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
spellingShingle |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor Lopez Jimenez, Jimmy Andres Poly(Beta-Hydroxybutyrate) Fed-Batch Reactor Optimization Operating Conditions |
title_short |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
title_full |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
title_fullStr |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
title_full_unstemmed |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
title_sort |
Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor |
dc.creator.none.fl_str_mv |
Lopez Jimenez, Jimmy Andres Bucala, Veronica Villar, Marcelo Armando |
author |
Lopez Jimenez, Jimmy Andres |
author_facet |
Lopez Jimenez, Jimmy Andres Bucala, Veronica Villar, Marcelo Armando |
author_role |
author |
author2 |
Bucala, Veronica Villar, Marcelo Armando |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Poly(Beta-Hydroxybutyrate) Fed-Batch Reactor Optimization Operating Conditions |
topic |
Poly(Beta-Hydroxybutyrate) Fed-Batch Reactor Optimization Operating Conditions |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.4 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs. Fil: Lopez Jimenez, Jimmy Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina Fil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina |
description |
Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/57682 Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando; Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor; American Chemical Society; Industrial & Engineering Chemical Research; 49; 4; 2-2010; 1762-1769 0888-5885 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/57682 |
identifier_str_mv |
Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando; Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor; American Chemical Society; Industrial & Engineering Chemical Research; 49; 4; 2-2010; 1762-1769 0888-5885 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1021/ie9006547 info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ie9006547 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614314472767488 |
score |
13.070432 |