Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor

Autores
Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs.
Fil: Lopez Jimenez, Jimmy Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Materia
Poly(Beta-Hydroxybutyrate)
Fed-Batch Reactor
Optimization
Operating Conditions
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57682
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactorLopez Jimenez, Jimmy AndresBucala, VeronicaVillar, Marcelo ArmandoPoly(Beta-Hydroxybutyrate)Fed-Batch ReactorOptimizationOperating Conditionshttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs.Fil: Lopez Jimenez, Jimmy Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaAmerican Chemical Society2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57682Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando; Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor; American Chemical Society; Industrial & Engineering Chemical Research; 49; 4; 2-2010; 1762-17690888-5885CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/ie9006547info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ie9006547info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:27:47Zoai:ri.conicet.gov.ar:11336/57682instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:27:47.789CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
title Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
spellingShingle Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
Lopez Jimenez, Jimmy Andres
Poly(Beta-Hydroxybutyrate)
Fed-Batch Reactor
Optimization
Operating Conditions
title_short Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
title_full Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
title_fullStr Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
title_full_unstemmed Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
title_sort Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor
dc.creator.none.fl_str_mv Lopez Jimenez, Jimmy Andres
Bucala, Veronica
Villar, Marcelo Armando
author Lopez Jimenez, Jimmy Andres
author_facet Lopez Jimenez, Jimmy Andres
Bucala, Veronica
Villar, Marcelo Armando
author_role author
author2 Bucala, Veronica
Villar, Marcelo Armando
author2_role author
author
dc.subject.none.fl_str_mv Poly(Beta-Hydroxybutyrate)
Fed-Batch Reactor
Optimization
Operating Conditions
topic Poly(Beta-Hydroxybutyrate)
Fed-Batch Reactor
Optimization
Operating Conditions
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs.
Fil: Lopez Jimenez, Jimmy Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
description Poly(b̃-hydroxybutyrate), PHB, is a microbial biopolymer produced by bacteria under unbalanced culture conditions. Such unbalanced conditions can be easily reached in a fed-batch bioreactor; therefore, it is important to know the system's behavior as well as its constraints to induce unbalanced conditions that allow the optimization of feeding profiles and, consequently, PHB productivity. In this work, dynamic optimization has been applied to maximize PHB productivity in a fed-batch bioreactor. Optimal feeding profiles of carbon and nitrogen sources, as well as their respective concentrations, were obtained using gPROMS (generalized process modeling system). When there is reliable bioreaction kinetics available, dynamic optimization becomes a very valuable tool for predicting optimal operating conditions to maximize PHB productivity, with a considerable reduction in time and experimental costs.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57682
Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando; Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor; American Chemical Society; Industrial & Engineering Chemical Research; 49; 4; 2-2010; 1762-1769
0888-5885
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57682
identifier_str_mv Lopez Jimenez, Jimmy Andres; Bucala, Veronica; Villar, Marcelo Armando; Application of dynamic optimization techniques for poly(b̃- hydroxybutyrate) production in a fed-batch bioreactor; American Chemical Society; Industrial & Engineering Chemical Research; 49; 4; 2-2010; 1762-1769
0888-5885
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/ie9006547
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ie9006547
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083419419705344
score 13.22299

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