Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues

Autores
Maffia Bizzozero, Santiago; Cevallos, Cintia Gisela; Remes Lenicov, Federico; Freiberger, Rosa Nicole; López, Cinthya Alicia Marcela; Guano Toaquiza, Alex; Sviercz, Franco Agustin; Jarmoluk, Patricio; Bustos, Cristina; D’Addario, Adriana Claudia; Quarleri, Jorge Fabian; Delpino, María Victoria
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent ofcoronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due to its tropism for several tissues.However, previous reports were unable to provide definitive information about whether the virus is viable and transmissible. Ithas been hypothesized that the persisting reservoirs of SARS-CoV-2 in tissues could be one of the multiple potentially overlappingcauses of long COVID. In the present study, we investigated autopsy materials obtained from 21 cadaveric donors with documentedfirst infection or reinfection at the time of death. Among the cases, there were COVID-19 vaccine recipients including differentformulations and doses received. The aim was to find the presence of SARS-CoV-2 in the lungs, heart, liver, kidneys, and intestines.We used two technical approaches: the detection and quantification of viral genomic RNA using RT-qPCR, and virus infectivity usingpermissive in vitro Vero E6 culture. All tissues analyzed showed the presence of SARS-CoV-2 genomic RNA, but at dissimilar levelsranging from 1.01x102 copies/mL to 1.14x108 copies/mL, even among those cases who had been COVID-19 vaccinated. Importantly,different amounts of replication-competent virus were detected in the culture media from the studied tissues. The highest viralload levels were measured in the lung (~1.4x106 copies/mL) and heart (~1.9x106 copies/mL) samples. Additionally, based on partialSpike gene sequences, SARS-CoV-2 characterization revealed the presence of multiple Omicron sub-variants exhibiting a high levelof nucleotide and amino acid identity among them. These findings highlight that SARS-CoV-2 can spread to multiple tissue locationssuch as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections with the Omicronvariant, contributing to extending knowledge about the pathogenesis of acute infection, and understand the sequelae clinicalmanifestations that are observed during post-acute COVID.
Fil: Maffia Bizzozero, Santiago. Poder Judicial de la Nacion.; Argentina
Fil: Cevallos, Cintia Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Remes Lenicov, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Freiberger, Rosa Nicole. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: López, Cinthya Alicia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Guano Toaquiza, Alex. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Sviercz, Franco Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Jarmoluk, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Bustos, Cristina. Poder Judicial de la Nacion.; Argentina
Fil: D’Addario, Adriana Claudia. Poder Judicial de la Nacion.; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
OMICRON VARIANTS
POSTMORTEM TISSUE
SARS-COV-2
VERO E6 CELL LINE
VIRUS ISOLATION
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227975
Acceder
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spelling Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissuesMaffia Bizzozero, SantiagoCevallos, Cintia GiselaRemes Lenicov, FedericoFreiberger, Rosa NicoleLópez, Cinthya Alicia MarcelaGuano Toaquiza, AlexSviercz, Franco AgustinJarmoluk, PatricioBustos, CristinaD’Addario, Adriana ClaudiaQuarleri, Jorge FabianDelpino, María VictoriaOMICRON VARIANTSPOSTMORTEM TISSUESARS-COV-2VERO E6 CELL LINEVIRUS ISOLATIONCOVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent ofcoronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due to its tropism for several tissues.However, previous reports were unable to provide definitive information about whether the virus is viable and transmissible. Ithas been hypothesized that the persisting reservoirs of SARS-CoV-2 in tissues could be one of the multiple potentially overlappingcauses of long COVID. In the present study, we investigated autopsy materials obtained from 21 cadaveric donors with documentedfirst infection or reinfection at the time of death. Among the cases, there were COVID-19 vaccine recipients including differentformulations and doses received. The aim was to find the presence of SARS-CoV-2 in the lungs, heart, liver, kidneys, and intestines.We used two technical approaches: the detection and quantification of viral genomic RNA using RT-qPCR, and virus infectivity usingpermissive in vitro Vero E6 culture. All tissues analyzed showed the presence of SARS-CoV-2 genomic RNA, but at dissimilar levelsranging from 1.01x102 copies/mL to 1.14x108 copies/mL, even among those cases who had been COVID-19 vaccinated. Importantly,different amounts of replication-competent virus were detected in the culture media from the studied tissues. The highest viralload levels were measured in the lung (~1.4x106 copies/mL) and heart (~1.9x106 copies/mL) samples. Additionally, based on partialSpike gene sequences, SARS-CoV-2 characterization revealed the presence of multiple Omicron sub-variants exhibiting a high levelof nucleotide and amino acid identity among them. These findings highlight that SARS-CoV-2 can spread to multiple tissue locationssuch as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections with the Omicronvariant, contributing to extending knowledge about the pathogenesis of acute infection, and understand the sequelae clinicalmanifestations that are observed during post-acute COVID.Fil: Maffia Bizzozero, Santiago. Poder Judicial de la Nacion.; ArgentinaFil: Cevallos, Cintia Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Remes Lenicov, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Freiberger, Rosa Nicole. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: López, Cinthya Alicia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Guano Toaquiza, Alex. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Sviercz, Franco Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Jarmoluk, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Bustos, Cristina. Poder Judicial de la Nacion.; ArgentinaFil: D’Addario, Adriana Claudia. Poder Judicial de la Nacion.; ArgentinaFil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFrontiers Media2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227975Maffia Bizzozero, Santiago; Cevallos, Cintia Gisela; Remes Lenicov, Federico; Freiberger, Rosa Nicole; López, Cinthya Alicia Marcela; et al.; Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues; Frontiers Media; Frontiers in Microbiology; 14; 5-2023; 1-111664-302XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2023.1192832/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2023.1192832info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:29:34Zoai:ri.conicet.gov.ar:11336/227975instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:29:35.031CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
title Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
spellingShingle Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
Maffia Bizzozero, Santiago
OMICRON VARIANTS
POSTMORTEM TISSUE
SARS-COV-2
VERO E6 CELL LINE
VIRUS ISOLATION
COVID-19
title_short Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
title_full Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
title_fullStr Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
title_full_unstemmed Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
title_sort Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues
dc.creator.none.fl_str_mv Maffia Bizzozero, Santiago
Cevallos, Cintia Gisela
Remes Lenicov, Federico
Freiberger, Rosa Nicole
López, Cinthya Alicia Marcela
Guano Toaquiza, Alex
Sviercz, Franco Agustin
Jarmoluk, Patricio
Bustos, Cristina
D’Addario, Adriana Claudia
Quarleri, Jorge Fabian
Delpino, María Victoria
author Maffia Bizzozero, Santiago
author_facet Maffia Bizzozero, Santiago
Cevallos, Cintia Gisela
Remes Lenicov, Federico
Freiberger, Rosa Nicole
López, Cinthya Alicia Marcela
Guano Toaquiza, Alex
Sviercz, Franco Agustin
Jarmoluk, Patricio
Bustos, Cristina
D’Addario, Adriana Claudia
Quarleri, Jorge Fabian
Delpino, María Victoria
author_role author
author2 Cevallos, Cintia Gisela
Remes Lenicov, Federico
Freiberger, Rosa Nicole
López, Cinthya Alicia Marcela
Guano Toaquiza, Alex
Sviercz, Franco Agustin
Jarmoluk, Patricio
Bustos, Cristina
D’Addario, Adriana Claudia
Quarleri, Jorge Fabian
Delpino, María Victoria
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv OMICRON VARIANTS
POSTMORTEM TISSUE
SARS-COV-2
VERO E6 CELL LINE
VIRUS ISOLATION
COVID-19
topic OMICRON VARIANTS
POSTMORTEM TISSUE
SARS-COV-2
VERO E6 CELL LINE
VIRUS ISOLATION
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent ofcoronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due to its tropism for several tissues.However, previous reports were unable to provide definitive information about whether the virus is viable and transmissible. Ithas been hypothesized that the persisting reservoirs of SARS-CoV-2 in tissues could be one of the multiple potentially overlappingcauses of long COVID. In the present study, we investigated autopsy materials obtained from 21 cadaveric donors with documentedfirst infection or reinfection at the time of death. Among the cases, there were COVID-19 vaccine recipients including differentformulations and doses received. The aim was to find the presence of SARS-CoV-2 in the lungs, heart, liver, kidneys, and intestines.We used two technical approaches: the detection and quantification of viral genomic RNA using RT-qPCR, and virus infectivity usingpermissive in vitro Vero E6 culture. All tissues analyzed showed the presence of SARS-CoV-2 genomic RNA, but at dissimilar levelsranging from 1.01x102 copies/mL to 1.14x108 copies/mL, even among those cases who had been COVID-19 vaccinated. Importantly,different amounts of replication-competent virus were detected in the culture media from the studied tissues. The highest viralload levels were measured in the lung (~1.4x106 copies/mL) and heart (~1.9x106 copies/mL) samples. Additionally, based on partialSpike gene sequences, SARS-CoV-2 characterization revealed the presence of multiple Omicron sub-variants exhibiting a high levelof nucleotide and amino acid identity among them. These findings highlight that SARS-CoV-2 can spread to multiple tissue locationssuch as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections with the Omicronvariant, contributing to extending knowledge about the pathogenesis of acute infection, and understand the sequelae clinicalmanifestations that are observed during post-acute COVID.
Fil: Maffia Bizzozero, Santiago. Poder Judicial de la Nacion.; Argentina
Fil: Cevallos, Cintia Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Remes Lenicov, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Freiberger, Rosa Nicole. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: López, Cinthya Alicia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Guano Toaquiza, Alex. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Sviercz, Franco Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Jarmoluk, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Bustos, Cristina. Poder Judicial de la Nacion.; Argentina
Fil: D’Addario, Adriana Claudia. Poder Judicial de la Nacion.; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent ofcoronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due to its tropism for several tissues.However, previous reports were unable to provide definitive information about whether the virus is viable and transmissible. Ithas been hypothesized that the persisting reservoirs of SARS-CoV-2 in tissues could be one of the multiple potentially overlappingcauses of long COVID. In the present study, we investigated autopsy materials obtained from 21 cadaveric donors with documentedfirst infection or reinfection at the time of death. Among the cases, there were COVID-19 vaccine recipients including differentformulations and doses received. The aim was to find the presence of SARS-CoV-2 in the lungs, heart, liver, kidneys, and intestines.We used two technical approaches: the detection and quantification of viral genomic RNA using RT-qPCR, and virus infectivity usingpermissive in vitro Vero E6 culture. All tissues analyzed showed the presence of SARS-CoV-2 genomic RNA, but at dissimilar levelsranging from 1.01x102 copies/mL to 1.14x108 copies/mL, even among those cases who had been COVID-19 vaccinated. Importantly,different amounts of replication-competent virus were detected in the culture media from the studied tissues. The highest viralload levels were measured in the lung (~1.4x106 copies/mL) and heart (~1.9x106 copies/mL) samples. Additionally, based on partialSpike gene sequences, SARS-CoV-2 characterization revealed the presence of multiple Omicron sub-variants exhibiting a high levelof nucleotide and amino acid identity among them. These findings highlight that SARS-CoV-2 can spread to multiple tissue locationssuch as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections with the Omicronvariant, contributing to extending knowledge about the pathogenesis of acute infection, and understand the sequelae clinicalmanifestations that are observed during post-acute COVID.
publishDate 2023
dc.date.none.fl_str_mv 2023-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227975
Maffia Bizzozero, Santiago; Cevallos, Cintia Gisela; Remes Lenicov, Federico; Freiberger, Rosa Nicole; López, Cinthya Alicia Marcela; et al.; Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues; Frontiers Media; Frontiers in Microbiology; 14; 5-2023; 1-11
1664-302X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227975
identifier_str_mv Maffia Bizzozero, Santiago; Cevallos, Cintia Gisela; Remes Lenicov, Federico; Freiberger, Rosa Nicole; López, Cinthya Alicia Marcela; et al.; Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues; Frontiers Media; Frontiers in Microbiology; 14; 5-2023; 1-11
1664-302X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2023.1192832/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2023.1192832
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
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