Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela

Autores
Caraballo, Lizeth; Rangel, Yaritza; Reyna Bello, Armando; Muñoz, Mariana; Figueroa Espinosa, Roque Arnulfo; Sanz Rodríguez, Carlos E.; Guerrero, Elba; Loureiro, Carmen Luisa; Liu, Qingyun; Takiff, Howard Eugene
Año de publicación
2024
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leptospirosis is a common but underdiagnosed zoonosis. We conducted a 1-year prospective study in La Guaira State, Venezuela, analyzing 71 hospitalized patients who had possible leptospirosis and sampling local rodents and dairy cows. Leptospira rrs gene PCR test results were positive in blood or urine samples from 37/71 patients. Leptospira spp. were isolated from cultured blood or urine samples of 36/71 patients; 29 had L. interrogans, 3 L. noguchii, and 4 L. venezuelensis. Conjunctival suffusion was the most distinguishing clinical sign, many patients had liver involvement, and 8/30 patients with L. interrogans infections died. The Leptospira spp. found in humans were also isolated from local rodents; L. interrogans and L. venezuelensis were isolated from cows on a nearby, rodent-infested farm. Phylogenetic clustering of L. venezuelensis isolates suggested a recently expanded outbreak strain spread by rodents. Increased awareness of leptospirosis prevalence and rapid diagnostic tests are needed to improve patient outcomes.
Fil: Caraballo, Lizeth. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Rangel, Yaritza. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Reyna Bello, Armando. Universidad Nacional Experimental Simon Rodriguez  (unesr);
Fil: Muñoz, Mariana. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Figueroa Espinosa, Roque Arnulfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Sanz Rodríguez, Carlos E.. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Guerrero, Elba. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Loureiro, Carmen Luisa. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Liu, Qingyun. Harvard University; Estados Unidos
Fil: Takiff, Howard Eugene. Instituto Venezolano de Investigaciones Científicas; Venezuela
Materia
LEPTOSPIRA INTERROGANS
LEPTOSPIRA VENEZUELENSIS
LEPTOSPIROSIS
OUTBREAK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257005
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/257005
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, VenezuelaCaraballo, LizethRangel, YaritzaReyna Bello, ArmandoMuñoz, MarianaFigueroa Espinosa, Roque ArnulfoSanz Rodríguez, Carlos E.Guerrero, ElbaLoureiro, Carmen LuisaLiu, QingyunTakiff, Howard EugeneLEPTOSPIRA INTERROGANSLEPTOSPIRA VENEZUELENSISLEPTOSPIROSISOUTBREAKhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Leptospirosis is a common but underdiagnosed zoonosis. We conducted a 1-year prospective study in La Guaira State, Venezuela, analyzing 71 hospitalized patients who had possible leptospirosis and sampling local rodents and dairy cows. Leptospira rrs gene PCR test results were positive in blood or urine samples from 37/71 patients. Leptospira spp. were isolated from cultured blood or urine samples of 36/71 patients; 29 had L. interrogans, 3 L. noguchii, and 4 L. venezuelensis. Conjunctival suffusion was the most distinguishing clinical sign, many patients had liver involvement, and 8/30 patients with L. interrogans infections died. The Leptospira spp. found in humans were also isolated from local rodents; L. interrogans and L. venezuelensis were isolated from cows on a nearby, rodent-infested farm. Phylogenetic clustering of L. venezuelensis isolates suggested a recently expanded outbreak strain spread by rodents. Increased awareness of leptospirosis prevalence and rapid diagnostic tests are needed to improve patient outcomes.Fil: Caraballo, Lizeth. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Rangel, Yaritza. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Reyna Bello, Armando. Universidad Nacional Experimental Simon Rodriguez  (unesr);Fil: Muñoz, Mariana. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Figueroa Espinosa, Roque Arnulfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Sanz Rodríguez, Carlos E.. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Guerrero, Elba. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Loureiro, Carmen Luisa. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Liu, Qingyun. Harvard University; Estados UnidosFil: Takiff, Howard Eugene. Instituto Venezolano de Investigaciones Científicas; VenezuelaCenters Disease Control2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257005Caraballo, Lizeth; Rangel, Yaritza; Reyna Bello, Armando; Muñoz, Mariana; Figueroa Espinosa, Roque Arnulfo; et al.; Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela; Centers Disease Control; Emerging Infectious Diseases; 30; 8; 8-2024; 1514-15221080-6040CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/30/8/23-1562_articleinfo:eu-repo/semantics/altIdentifier/doi/10.3201/eid3008.231562info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:16Zoai:ri.conicet.gov.ar:11336/257005instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:16.591CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
title Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
spellingShingle Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
Caraballo, Lizeth
LEPTOSPIRA INTERROGANS
LEPTOSPIRA VENEZUELENSIS
LEPTOSPIROSIS
OUTBREAK
title_short Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
title_full Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
title_fullStr Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
title_full_unstemmed Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
title_sort Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela
dc.creator.none.fl_str_mv Caraballo, Lizeth
Rangel, Yaritza
Reyna Bello, Armando
Muñoz, Mariana
Figueroa Espinosa, Roque Arnulfo
Sanz Rodríguez, Carlos E.
Guerrero, Elba
Loureiro, Carmen Luisa
Liu, Qingyun
Takiff, Howard Eugene
author Caraballo, Lizeth
author_facet Caraballo, Lizeth
Rangel, Yaritza
Reyna Bello, Armando
Muñoz, Mariana
Figueroa Espinosa, Roque Arnulfo
Sanz Rodríguez, Carlos E.
Guerrero, Elba
Loureiro, Carmen Luisa
Liu, Qingyun
Takiff, Howard Eugene
author_role author
author2 Rangel, Yaritza
Reyna Bello, Armando
Muñoz, Mariana
Figueroa Espinosa, Roque Arnulfo
Sanz Rodríguez, Carlos E.
Guerrero, Elba
Loureiro, Carmen Luisa
Liu, Qingyun
Takiff, Howard Eugene
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LEPTOSPIRA INTERROGANS
LEPTOSPIRA VENEZUELENSIS
LEPTOSPIROSIS
OUTBREAK
topic LEPTOSPIRA INTERROGANS
LEPTOSPIRA VENEZUELENSIS
LEPTOSPIROSIS
OUTBREAK
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Leptospirosis is a common but underdiagnosed zoonosis. We conducted a 1-year prospective study in La Guaira State, Venezuela, analyzing 71 hospitalized patients who had possible leptospirosis and sampling local rodents and dairy cows. Leptospira rrs gene PCR test results were positive in blood or urine samples from 37/71 patients. Leptospira spp. were isolated from cultured blood or urine samples of 36/71 patients; 29 had L. interrogans, 3 L. noguchii, and 4 L. venezuelensis. Conjunctival suffusion was the most distinguishing clinical sign, many patients had liver involvement, and 8/30 patients with L. interrogans infections died. The Leptospira spp. found in humans were also isolated from local rodents; L. interrogans and L. venezuelensis were isolated from cows on a nearby, rodent-infested farm. Phylogenetic clustering of L. venezuelensis isolates suggested a recently expanded outbreak strain spread by rodents. Increased awareness of leptospirosis prevalence and rapid diagnostic tests are needed to improve patient outcomes.
Fil: Caraballo, Lizeth. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Rangel, Yaritza. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Reyna Bello, Armando. Universidad Nacional Experimental Simon Rodriguez  (unesr);
Fil: Muñoz, Mariana. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Figueroa Espinosa, Roque Arnulfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Sanz Rodríguez, Carlos E.. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Guerrero, Elba. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Loureiro, Carmen Luisa. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Liu, Qingyun. Harvard University; Estados Unidos
Fil: Takiff, Howard Eugene. Instituto Venezolano de Investigaciones Científicas; Venezuela
description Leptospirosis is a common but underdiagnosed zoonosis. We conducted a 1-year prospective study in La Guaira State, Venezuela, analyzing 71 hospitalized patients who had possible leptospirosis and sampling local rodents and dairy cows. Leptospira rrs gene PCR test results were positive in blood or urine samples from 37/71 patients. Leptospira spp. were isolated from cultured blood or urine samples of 36/71 patients; 29 had L. interrogans, 3 L. noguchii, and 4 L. venezuelensis. Conjunctival suffusion was the most distinguishing clinical sign, many patients had liver involvement, and 8/30 patients with L. interrogans infections died. The Leptospira spp. found in humans were also isolated from local rodents; L. interrogans and L. venezuelensis were isolated from cows on a nearby, rodent-infested farm. Phylogenetic clustering of L. venezuelensis isolates suggested a recently expanded outbreak strain spread by rodents. Increased awareness of leptospirosis prevalence and rapid diagnostic tests are needed to improve patient outcomes.
publishDate 2024
dc.date.none.fl_str_mv 2024-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257005
Caraballo, Lizeth; Rangel, Yaritza; Reyna Bello, Armando; Muñoz, Mariana; Figueroa Espinosa, Roque Arnulfo; et al.; Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela; Centers Disease Control; Emerging Infectious Diseases; 30; 8; 8-2024; 1514-1522
1080-6040
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257005
identifier_str_mv Caraballo, Lizeth; Rangel, Yaritza; Reyna Bello, Armando; Muñoz, Mariana; Figueroa Espinosa, Roque Arnulfo; et al.; Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans –Endemic Region, Venezuela; Centers Disease Control; Emerging Infectious Diseases; 30; 8; 8-2024; 1514-1522
1080-6040
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/30/8/23-1562_article
info:eu-repo/semantics/altIdentifier/doi/10.3201/eid3008.231562
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Centers Disease Control
publisher.none.fl_str_mv Centers Disease Control
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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