Time course changes of oxidative stress markers in a rat experimental glaucoma model

Autores
Ferreira, Sandra María; Fabián Lerner, S.; Brunzini, Ricardo; Reides, Claudia Gabriela; Evelson, Pablo Andrés; Llesuy, Susana Francisca
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
PURPOSE. To evaluate the relationship between oxidative stress arkers and increased intraocular pressure in experimental laucoma. METHODS. In vivo chemiluminescence (CL), total antioxidant apacity (TRAP), nitrite concentration (NC), and lipid peroxidation arkers (TBARS) were evaluated. Wistar rats (n = 18 for ach time point) underwent operation, and two episcleral eins were cauterized. ESULTS. Decreases of 22%, 35%, and 27% at 7, 15, and 30 days nd an increase of 22% at 60 days in CL were observed in laucomatous eyes. In optic nerve, TBARS values were 6.9 ± 0.5 nmol/mg protein (7 days), 9.4 ± 0.4 nmol/mg protein (15 ays), 18.0 ±1.2 nmol/mg protein (30 days), and 43.1 ± 5.3 nmol/mg protein (60 days) (control, 6.2 ± 0.4 nmol/mg protein; P < 0.001). NC was 37.0 ± 1.8 μM (7 days), 31.4 ± 1.2 μM (15 days), 39.6 ± 1.3 μM (30 days), and 40.0 ± 1.3 μM (60 days) (control, 21.1 ± 1.7 μM; P < 0.001). In glaucomatous vitreous humor, TRAP decreased by 42% at 15 days and 78% at 60 days (control, 414 ± 29 μM; P < 0.001). In glaucomatous aqueous humor, TRAP values were 75 ± 7 μM (7 days), 54 ±4 μM (15 days), 25 ± 4 μM (30 days), and 50 ± 3 μM (60 days) (control, 90 ±10 μM; P < 0.001). CONCLUSIONS. Reactive species were increased in glaucoma, as evidenced by the increases in CL, TBARS, and NC. The decrease in the antioxidant levels may be a consequence of an increase in oxidative processes.
Fil: Ferreira, Sandra María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Fabián Lerner, S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Brunzini, Ricardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Reides, Claudia Gabriela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
glaucoma
OXIDATIVE STRESS
antioxidant
modelo experimental
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/151539

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Time course changes of oxidative stress markers in a rat experimental glaucoma modelFerreira, Sandra MaríaFabián Lerner, S.Brunzini, RicardoReides, Claudia GabrielaEvelson, Pablo AndrésLlesuy, Susana FranciscaglaucomaOXIDATIVE STRESSantioxidantmodelo experimentalhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3PURPOSE. To evaluate the relationship between oxidative stress arkers and increased intraocular pressure in experimental laucoma. METHODS. In vivo chemiluminescence (CL), total antioxidant apacity (TRAP), nitrite concentration (NC), and lipid peroxidation arkers (TBARS) were evaluated. Wistar rats (n = 18 for ach time point) underwent operation, and two episcleral eins were cauterized. ESULTS. Decreases of 22%, 35%, and 27% at 7, 15, and 30 days nd an increase of 22% at 60 days in CL were observed in laucomatous eyes. In optic nerve, TBARS values were 6.9 ± 0.5 nmol/mg protein (7 days), 9.4 ± 0.4 nmol/mg protein (15 ays), 18.0 ±1.2 nmol/mg protein (30 days), and 43.1 ± 5.3 nmol/mg protein (60 days) (control, 6.2 ± 0.4 nmol/mg protein; P < 0.001). NC was 37.0 ± 1.8 μM (7 days), 31.4 ± 1.2 μM (15 days), 39.6 ± 1.3 μM (30 days), and 40.0 ± 1.3 μM (60 days) (control, 21.1 ± 1.7 μM; P < 0.001). In glaucomatous vitreous humor, TRAP decreased by 42% at 15 days and 78% at 60 days (control, 414 ± 29 μM; P < 0.001). In glaucomatous aqueous humor, TRAP values were 75 ± 7 μM (7 days), 54 ±4 μM (15 days), 25 ± 4 μM (30 days), and 50 ± 3 μM (60 days) (control, 90 ±10 μM; P < 0.001). CONCLUSIONS. Reactive species were increased in glaucoma, as evidenced by the increases in CL, TBARS, and NC. The decrease in the antioxidant levels may be a consequence of an increase in oxidative processes.Fil: Ferreira, Sandra María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Fabián Lerner, S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Brunzini, Ricardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Reides, Claudia Gabriela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaAssociation for Research in Vision and Ophthalmology2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/151539Ferreira, Sandra María; Fabián Lerner, S.; Brunzini, Ricardo; Reides, Claudia Gabriela; Evelson, Pablo Andrés; et al.; Time course changes of oxidative stress markers in a rat experimental glaucoma model; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 51; 9; 9-2010; 4635-46400146-0404CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://iovs.arvojournals.org/article.aspx?articleid=2126746info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.09-5044info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:28Zoai:ri.conicet.gov.ar:11336/151539instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:29.249CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Time course changes of oxidative stress markers in a rat experimental glaucoma model
title Time course changes of oxidative stress markers in a rat experimental glaucoma model
spellingShingle Time course changes of oxidative stress markers in a rat experimental glaucoma model
Ferreira, Sandra María
glaucoma
OXIDATIVE STRESS
antioxidant
modelo experimental
title_short Time course changes of oxidative stress markers in a rat experimental glaucoma model
title_full Time course changes of oxidative stress markers in a rat experimental glaucoma model
title_fullStr Time course changes of oxidative stress markers in a rat experimental glaucoma model
title_full_unstemmed Time course changes of oxidative stress markers in a rat experimental glaucoma model
title_sort Time course changes of oxidative stress markers in a rat experimental glaucoma model
dc.creator.none.fl_str_mv Ferreira, Sandra María
Fabián Lerner, S.
Brunzini, Ricardo
Reides, Claudia Gabriela
Evelson, Pablo Andrés
Llesuy, Susana Francisca
author Ferreira, Sandra María
author_facet Ferreira, Sandra María
Fabián Lerner, S.
Brunzini, Ricardo
Reides, Claudia Gabriela
Evelson, Pablo Andrés
Llesuy, Susana Francisca
author_role author
author2 Fabián Lerner, S.
Brunzini, Ricardo
Reides, Claudia Gabriela
Evelson, Pablo Andrés
Llesuy, Susana Francisca
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv glaucoma
OXIDATIVE STRESS
antioxidant
modelo experimental
topic glaucoma
OXIDATIVE STRESS
antioxidant
modelo experimental
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv PURPOSE. To evaluate the relationship between oxidative stress arkers and increased intraocular pressure in experimental laucoma. METHODS. In vivo chemiluminescence (CL), total antioxidant apacity (TRAP), nitrite concentration (NC), and lipid peroxidation arkers (TBARS) were evaluated. Wistar rats (n = 18 for ach time point) underwent operation, and two episcleral eins were cauterized. ESULTS. Decreases of 22%, 35%, and 27% at 7, 15, and 30 days nd an increase of 22% at 60 days in CL were observed in laucomatous eyes. In optic nerve, TBARS values were 6.9 ± 0.5 nmol/mg protein (7 days), 9.4 ± 0.4 nmol/mg protein (15 ays), 18.0 ±1.2 nmol/mg protein (30 days), and 43.1 ± 5.3 nmol/mg protein (60 days) (control, 6.2 ± 0.4 nmol/mg protein; P < 0.001). NC was 37.0 ± 1.8 μM (7 days), 31.4 ± 1.2 μM (15 days), 39.6 ± 1.3 μM (30 days), and 40.0 ± 1.3 μM (60 days) (control, 21.1 ± 1.7 μM; P < 0.001). In glaucomatous vitreous humor, TRAP decreased by 42% at 15 days and 78% at 60 days (control, 414 ± 29 μM; P < 0.001). In glaucomatous aqueous humor, TRAP values were 75 ± 7 μM (7 days), 54 ±4 μM (15 days), 25 ± 4 μM (30 days), and 50 ± 3 μM (60 days) (control, 90 ±10 μM; P < 0.001). CONCLUSIONS. Reactive species were increased in glaucoma, as evidenced by the increases in CL, TBARS, and NC. The decrease in the antioxidant levels may be a consequence of an increase in oxidative processes.
Fil: Ferreira, Sandra María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Fabián Lerner, S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Brunzini, Ricardo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Reides, Claudia Gabriela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
description PURPOSE. To evaluate the relationship between oxidative stress arkers and increased intraocular pressure in experimental laucoma. METHODS. In vivo chemiluminescence (CL), total antioxidant apacity (TRAP), nitrite concentration (NC), and lipid peroxidation arkers (TBARS) were evaluated. Wistar rats (n = 18 for ach time point) underwent operation, and two episcleral eins were cauterized. ESULTS. Decreases of 22%, 35%, and 27% at 7, 15, and 30 days nd an increase of 22% at 60 days in CL were observed in laucomatous eyes. In optic nerve, TBARS values were 6.9 ± 0.5 nmol/mg protein (7 days), 9.4 ± 0.4 nmol/mg protein (15 ays), 18.0 ±1.2 nmol/mg protein (30 days), and 43.1 ± 5.3 nmol/mg protein (60 days) (control, 6.2 ± 0.4 nmol/mg protein; P < 0.001). NC was 37.0 ± 1.8 μM (7 days), 31.4 ± 1.2 μM (15 days), 39.6 ± 1.3 μM (30 days), and 40.0 ± 1.3 μM (60 days) (control, 21.1 ± 1.7 μM; P < 0.001). In glaucomatous vitreous humor, TRAP decreased by 42% at 15 days and 78% at 60 days (control, 414 ± 29 μM; P < 0.001). In glaucomatous aqueous humor, TRAP values were 75 ± 7 μM (7 days), 54 ±4 μM (15 days), 25 ± 4 μM (30 days), and 50 ± 3 μM (60 days) (control, 90 ±10 μM; P < 0.001). CONCLUSIONS. Reactive species were increased in glaucoma, as evidenced by the increases in CL, TBARS, and NC. The decrease in the antioxidant levels may be a consequence of an increase in oxidative processes.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/151539
Ferreira, Sandra María; Fabián Lerner, S.; Brunzini, Ricardo; Reides, Claudia Gabriela; Evelson, Pablo Andrés; et al.; Time course changes of oxidative stress markers in a rat experimental glaucoma model; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 51; 9; 9-2010; 4635-4640
0146-0404
CONICET Digital
CONICET
url http://hdl.handle.net/11336/151539
identifier_str_mv Ferreira, Sandra María; Fabián Lerner, S.; Brunzini, Ricardo; Reides, Claudia Gabriela; Evelson, Pablo Andrés; et al.; Time course changes of oxidative stress markers in a rat experimental glaucoma model; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 51; 9; 9-2010; 4635-4640
0146-0404
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://iovs.arvojournals.org/article.aspx?articleid=2126746
info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.09-5044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology
publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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