Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels

Autores
Sosa, Emiliano; Liaudat, Ana Cecilia; Becerra, Karen; Huck, Guillermo; Rodriguez, Nancy
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The study of stress physiological consequences has gained importance since last five decades. Accordingly, prenatal stress is a contributing factor on mammal gestation, causing adaptive disturbances during offspring adult life. The aim of this study was to analyze the physiological effects of prenatal stress rats on some skeletal muscle and liver parameters after forced swimming (FS) exposition. Pregnant Wistar rats were stressed by immobilization (IMO) during the two last week of pregnancy and male offspring raised in bioterium standard conditions until 90 days old. Corticosterone (COR), glycemia and malondialdehyde (MDA) levels were studied in all experimental group: Control animals, forced swimming stressed rats and prenatal stressed animals rats with and without FS stress. The results show that in basal conditions COR and glycemia levels were increased in prenatal stressed animals. After an acute exposition to FS, COR significantly increased in prenatal stress and control groups (without prenatal stress). Glycemia levels had similar values in all experimental conditions; however, hepatic MDA levels showed a significant increase in prenatal stressed rats and the effect was maintained in FS animals. MDA values analyzed in grooved muscle were higher in prenatal stressed groups, but after FS acute stress, MDA levels increased in control animals too. In conclusion, IMO prenatal stress causes a change in the regulation of hypothalamic-pituitary-adrenal axis (HPA), reflected in high basal levels of plasmatic COR and hyperglycemia. Moreover, it causes a hyper sensibility to acute stressors caused in post birth life. Also, prenatal stress produces oxidative stress in liver cells while FS stimulates this process in grooved voluntary muscle.
Fil: Sosa, Emiliano. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Becerra, Karen. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Huck, Guillermo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Rodriguez, Nancy. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Materia
PRENATAL STRESS
FORCED SWIMMING
MUSCLE
RATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129877
Acceder
id CONICETDig_263838070a4264b603576eb2bbace1a4
oai_identifier_str oai:ri.conicet.gov.ar:11336/129877
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levelsSosa, EmilianoLiaudat, Ana CeciliaBecerra, KarenHuck, GuillermoRodriguez, NancyPRENATAL STRESSFORCED SWIMMINGMUSCLERATShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The study of stress physiological consequences has gained importance since last five decades. Accordingly, prenatal stress is a contributing factor on mammal gestation, causing adaptive disturbances during offspring adult life. The aim of this study was to analyze the physiological effects of prenatal stress rats on some skeletal muscle and liver parameters after forced swimming (FS) exposition. Pregnant Wistar rats were stressed by immobilization (IMO) during the two last week of pregnancy and male offspring raised in bioterium standard conditions until 90 days old. Corticosterone (COR), glycemia and malondialdehyde (MDA) levels were studied in all experimental group: Control animals, forced swimming stressed rats and prenatal stressed animals rats with and without FS stress. The results show that in basal conditions COR and glycemia levels were increased in prenatal stressed animals. After an acute exposition to FS, COR significantly increased in prenatal stress and control groups (without prenatal stress). Glycemia levels had similar values in all experimental conditions; however, hepatic MDA levels showed a significant increase in prenatal stressed rats and the effect was maintained in FS animals. MDA values analyzed in grooved muscle were higher in prenatal stressed groups, but after FS acute stress, MDA levels increased in control animals too. In conclusion, IMO prenatal stress causes a change in the regulation of hypothalamic-pituitary-adrenal axis (HPA), reflected in high basal levels of plasmatic COR and hyperglycemia. Moreover, it causes a hyper sensibility to acute stressors caused in post birth life. Also, prenatal stress produces oxidative stress in liver cells while FS stimulates this process in grooved voluntary muscle.Fil: Sosa, Emiliano. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Becerra, Karen. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Huck, Guillermo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaFil: Rodriguez, Nancy. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; ArgentinaMedCrave Group2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129877Sosa, Emiliano; Liaudat, Ana Cecilia; Becerra, Karen; Huck, Guillermo; Rodriguez, Nancy; Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels; MedCrave Group; MOJ Anatomy and Physiology; 6; 6; 12-2019; 226-2312471-139XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/MOJAP/volume_issues?issueId=2959&volumeId=648info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:24Zoai:ri.conicet.gov.ar:11336/129877instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:24.318CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
title Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
spellingShingle Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
Sosa, Emiliano
PRENATAL STRESS
FORCED SWIMMING
MUSCLE
RATS
title_short Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
title_full Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
title_fullStr Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
title_full_unstemmed Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
title_sort Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels
dc.creator.none.fl_str_mv Sosa, Emiliano
Liaudat, Ana Cecilia
Becerra, Karen
Huck, Guillermo
Rodriguez, Nancy
author Sosa, Emiliano
author_facet Sosa, Emiliano
Liaudat, Ana Cecilia
Becerra, Karen
Huck, Guillermo
Rodriguez, Nancy
author_role author
author2 Liaudat, Ana Cecilia
Becerra, Karen
Huck, Guillermo
Rodriguez, Nancy
author2_role author
author
author
author
dc.subject.none.fl_str_mv PRENATAL STRESS
FORCED SWIMMING
MUSCLE
RATS
topic PRENATAL STRESS
FORCED SWIMMING
MUSCLE
RATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The study of stress physiological consequences has gained importance since last five decades. Accordingly, prenatal stress is a contributing factor on mammal gestation, causing adaptive disturbances during offspring adult life. The aim of this study was to analyze the physiological effects of prenatal stress rats on some skeletal muscle and liver parameters after forced swimming (FS) exposition. Pregnant Wistar rats were stressed by immobilization (IMO) during the two last week of pregnancy and male offspring raised in bioterium standard conditions until 90 days old. Corticosterone (COR), glycemia and malondialdehyde (MDA) levels were studied in all experimental group: Control animals, forced swimming stressed rats and prenatal stressed animals rats with and without FS stress. The results show that in basal conditions COR and glycemia levels were increased in prenatal stressed animals. After an acute exposition to FS, COR significantly increased in prenatal stress and control groups (without prenatal stress). Glycemia levels had similar values in all experimental conditions; however, hepatic MDA levels showed a significant increase in prenatal stressed rats and the effect was maintained in FS animals. MDA values analyzed in grooved muscle were higher in prenatal stressed groups, but after FS acute stress, MDA levels increased in control animals too. In conclusion, IMO prenatal stress causes a change in the regulation of hypothalamic-pituitary-adrenal axis (HPA), reflected in high basal levels of plasmatic COR and hyperglycemia. Moreover, it causes a hyper sensibility to acute stressors caused in post birth life. Also, prenatal stress produces oxidative stress in liver cells while FS stimulates this process in grooved voluntary muscle.
Fil: Sosa, Emiliano. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Becerra, Karen. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Huck, Guillermo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
Fil: Rodriguez, Nancy. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina
description The study of stress physiological consequences has gained importance since last five decades. Accordingly, prenatal stress is a contributing factor on mammal gestation, causing adaptive disturbances during offspring adult life. The aim of this study was to analyze the physiological effects of prenatal stress rats on some skeletal muscle and liver parameters after forced swimming (FS) exposition. Pregnant Wistar rats were stressed by immobilization (IMO) during the two last week of pregnancy and male offspring raised in bioterium standard conditions until 90 days old. Corticosterone (COR), glycemia and malondialdehyde (MDA) levels were studied in all experimental group: Control animals, forced swimming stressed rats and prenatal stressed animals rats with and without FS stress. The results show that in basal conditions COR and glycemia levels were increased in prenatal stressed animals. After an acute exposition to FS, COR significantly increased in prenatal stress and control groups (without prenatal stress). Glycemia levels had similar values in all experimental conditions; however, hepatic MDA levels showed a significant increase in prenatal stressed rats and the effect was maintained in FS animals. MDA values analyzed in grooved muscle were higher in prenatal stressed groups, but after FS acute stress, MDA levels increased in control animals too. In conclusion, IMO prenatal stress causes a change in the regulation of hypothalamic-pituitary-adrenal axis (HPA), reflected in high basal levels of plasmatic COR and hyperglycemia. Moreover, it causes a hyper sensibility to acute stressors caused in post birth life. Also, prenatal stress produces oxidative stress in liver cells while FS stimulates this process in grooved voluntary muscle.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129877
Sosa, Emiliano; Liaudat, Ana Cecilia; Becerra, Karen; Huck, Guillermo; Rodriguez, Nancy; Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels; MedCrave Group; MOJ Anatomy and Physiology; 6; 6; 12-2019; 226-231
2471-139X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129877
identifier_str_mv Sosa, Emiliano; Liaudat, Ana Cecilia; Becerra, Karen; Huck, Guillermo; Rodriguez, Nancy; Effect of prenatal stress and forced swimming acute stress on adult rat's skeletal muscle and liver MDA levels; MedCrave Group; MOJ Anatomy and Physiology; 6; 6; 12-2019; 226-231
2471-139X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/MOJAP/volume_issues?issueId=2959&volumeId=648
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MedCrave Group
publisher.none.fl_str_mv MedCrave Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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