Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observat...

Autores
Martín Rodríguez, Francisco; López Izquierdo, Raul; Delgado Benito, Juan F.; Sanz García, Ancor; Pozo Vegas, Carlos del; Castro Villamor, Miguel Ángel; Martín Conty, José Luis; Ortega, Guillermo José
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of this study was to assess whether the use of prehospital lactate (pLA) can increase the prognostic accuracy of the National Early Warning Score 2 (NEWS2) to detect the risk of death within 48 h. A prospective, multicenter study in adults treated consecutively by the emergency medical services (EMS) included six advanced life support (ALS) services and five hospitals. Patients were assigned to one of four groups according to their risk of mortality (low, low-medium, medium, and high), as determined by the NEWS2 score. For each group, the validity of pLA in our cohort was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. In this study, 3081 participants with a median age of 69 years (Interquartile range (IQR): 54–81) were included. The two-day mortality was 4.4% (137 cases). The scale derived from the implementation of the pLA improved the capacity of the NEWS2 to discriminate low risk of mortality, with an AUC of 0.910 (95% CI: 0.87–0.94; p < 0.001). The risk stratification provided by the NEWS2 can be improved by incorporating pLA measurement to more accurately predict the risk of mortality in patients with low risk.
Fil: Martín Rodríguez, Francisco. Universidad de Valladolid; España. Emergency Medical Services; España
Fil: López Izquierdo, Raul. Hospital Universitario Rio Hortega; España
Fil: Delgado Benito, Juan F.. Emergency Medical Services; España
Fil: Sanz García, Ancor. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España
Fil: Pozo Vegas, Carlos del. Hospital Clínico Universitario de Valladolid; España
Fil: Castro Villamor, Miguel Ángel. Universidad de Valladolid; España
Fil: Martín Conty, José Luis. Universidad de Castilla-La Mancha; España
Fil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España
Materia
BIOMARKERS
CLINICAL DECISION-MAKING
CLINICAL DETERIORATION
EARLY WARNING
EMERGENCY MEDICAL SERVICES
MORTALITY
PATIENT SAFETY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168664
Acceder
id CONICETDig_252907111f65c2de00ee24b961569991
oai_identifier_str oai:ri.conicet.gov.ar:11336/168664
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational studyMartín Rodríguez, FranciscoLópez Izquierdo, RaulDelgado Benito, Juan F.Sanz García, AncorPozo Vegas, Carlos delCastro Villamor, Miguel ÁngelMartín Conty, José LuisOrtega, Guillermo JoséBIOMARKERSCLINICAL DECISION-MAKINGCLINICAL DETERIORATIONEARLY WARNINGEMERGENCY MEDICAL SERVICESMORTALITYPATIENT SAFETYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The objective of this study was to assess whether the use of prehospital lactate (pLA) can increase the prognostic accuracy of the National Early Warning Score 2 (NEWS2) to detect the risk of death within 48 h. A prospective, multicenter study in adults treated consecutively by the emergency medical services (EMS) included six advanced life support (ALS) services and five hospitals. Patients were assigned to one of four groups according to their risk of mortality (low, low-medium, medium, and high), as determined by the NEWS2 score. For each group, the validity of pLA in our cohort was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. In this study, 3081 participants with a median age of 69 years (Interquartile range (IQR): 54–81) were included. The two-day mortality was 4.4% (137 cases). The scale derived from the implementation of the pLA improved the capacity of the NEWS2 to discriminate low risk of mortality, with an AUC of 0.910 (95% CI: 0.87–0.94; p < 0.001). The risk stratification provided by the NEWS2 can be improved by incorporating pLA measurement to more accurately predict the risk of mortality in patients with low risk.Fil: Martín Rodríguez, Francisco. Universidad de Valladolid; España. Emergency Medical Services; EspañaFil: López Izquierdo, Raul. Hospital Universitario Rio Hortega; EspañaFil: Delgado Benito, Juan F.. Emergency Medical Services; EspañaFil: Sanz García, Ancor. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; EspañaFil: Pozo Vegas, Carlos del. Hospital Clínico Universitario de Valladolid; EspañaFil: Castro Villamor, Miguel Ángel. Universidad de Valladolid; EspañaFil: Martín Conty, José Luis. Universidad de Castilla-La Mancha; EspañaFil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; EspañaMultidisciplinary Digital Publishing Institute2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168664Martín Rodríguez, Francisco; López Izquierdo, Raul; Delgado Benito, Juan F.; Sanz García, Ancor; Pozo Vegas, Carlos del; et al.; Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study; Multidisciplinary Digital Publishing Institute; Journal of Clinical Medicine; 9; 4; 4-2020; 1-142077-0383CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2077-0383/9/4/1156info:eu-repo/semantics/altIdentifier/doi/10.3390/jcm9041156info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:13:10Zoai:ri.conicet.gov.ar:11336/168664instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:13:10.519CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
title Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
spellingShingle Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
Martín Rodríguez, Francisco
BIOMARKERS
CLINICAL DECISION-MAKING
CLINICAL DETERIORATION
EARLY WARNING
EMERGENCY MEDICAL SERVICES
MORTALITY
PATIENT SAFETY
title_short Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
title_full Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
title_fullStr Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
title_full_unstemmed Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
title_sort Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study
dc.creator.none.fl_str_mv Martín Rodríguez, Francisco
López Izquierdo, Raul
Delgado Benito, Juan F.
Sanz García, Ancor
Pozo Vegas, Carlos del
Castro Villamor, Miguel Ángel
Martín Conty, José Luis
Ortega, Guillermo José
author Martín Rodríguez, Francisco
author_facet Martín Rodríguez, Francisco
López Izquierdo, Raul
Delgado Benito, Juan F.
Sanz García, Ancor
Pozo Vegas, Carlos del
Castro Villamor, Miguel Ángel
Martín Conty, José Luis
Ortega, Guillermo José
author_role author
author2 López Izquierdo, Raul
Delgado Benito, Juan F.
Sanz García, Ancor
Pozo Vegas, Carlos del
Castro Villamor, Miguel Ángel
Martín Conty, José Luis
Ortega, Guillermo José
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOMARKERS
CLINICAL DECISION-MAKING
CLINICAL DETERIORATION
EARLY WARNING
EMERGENCY MEDICAL SERVICES
MORTALITY
PATIENT SAFETY
topic BIOMARKERS
CLINICAL DECISION-MAKING
CLINICAL DETERIORATION
EARLY WARNING
EMERGENCY MEDICAL SERVICES
MORTALITY
PATIENT SAFETY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The objective of this study was to assess whether the use of prehospital lactate (pLA) can increase the prognostic accuracy of the National Early Warning Score 2 (NEWS2) to detect the risk of death within 48 h. A prospective, multicenter study in adults treated consecutively by the emergency medical services (EMS) included six advanced life support (ALS) services and five hospitals. Patients were assigned to one of four groups according to their risk of mortality (low, low-medium, medium, and high), as determined by the NEWS2 score. For each group, the validity of pLA in our cohort was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. In this study, 3081 participants with a median age of 69 years (Interquartile range (IQR): 54–81) were included. The two-day mortality was 4.4% (137 cases). The scale derived from the implementation of the pLA improved the capacity of the NEWS2 to discriminate low risk of mortality, with an AUC of 0.910 (95% CI: 0.87–0.94; p < 0.001). The risk stratification provided by the NEWS2 can be improved by incorporating pLA measurement to more accurately predict the risk of mortality in patients with low risk.
Fil: Martín Rodríguez, Francisco. Universidad de Valladolid; España. Emergency Medical Services; España
Fil: López Izquierdo, Raul. Hospital Universitario Rio Hortega; España
Fil: Delgado Benito, Juan F.. Emergency Medical Services; España
Fil: Sanz García, Ancor. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España
Fil: Pozo Vegas, Carlos del. Hospital Clínico Universitario de Valladolid; España
Fil: Castro Villamor, Miguel Ángel. Universidad de Valladolid; España
Fil: Martín Conty, José Luis. Universidad de Castilla-La Mancha; España
Fil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España
description The objective of this study was to assess whether the use of prehospital lactate (pLA) can increase the prognostic accuracy of the National Early Warning Score 2 (NEWS2) to detect the risk of death within 48 h. A prospective, multicenter study in adults treated consecutively by the emergency medical services (EMS) included six advanced life support (ALS) services and five hospitals. Patients were assigned to one of four groups according to their risk of mortality (low, low-medium, medium, and high), as determined by the NEWS2 score. For each group, the validity of pLA in our cohort was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. In this study, 3081 participants with a median age of 69 years (Interquartile range (IQR): 54–81) were included. The two-day mortality was 4.4% (137 cases). The scale derived from the implementation of the pLA improved the capacity of the NEWS2 to discriminate low risk of mortality, with an AUC of 0.910 (95% CI: 0.87–0.94; p < 0.001). The risk stratification provided by the NEWS2 can be improved by incorporating pLA measurement to more accurately predict the risk of mortality in patients with low risk.
publishDate 2020
dc.date.none.fl_str_mv 2020-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168664
Martín Rodríguez, Francisco; López Izquierdo, Raul; Delgado Benito, Juan F.; Sanz García, Ancor; Pozo Vegas, Carlos del; et al.; Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study; Multidisciplinary Digital Publishing Institute; Journal of Clinical Medicine; 9; 4; 4-2020; 1-14
2077-0383
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168664
identifier_str_mv Martín Rodríguez, Francisco; López Izquierdo, Raul; Delgado Benito, Juan F.; Sanz García, Ancor; Pozo Vegas, Carlos del; et al.; Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study; Multidisciplinary Digital Publishing Institute; Journal of Clinical Medicine; 9; 4; 4-2020; 1-14
2077-0383
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2077-0383/9/4/1156
info:eu-repo/semantics/altIdentifier/doi/10.3390/jcm9041156
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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