Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion

Autores
Garcia Ovejero, Daniel; Gonzalez, Susana Laura; Paniagua Torija, Beatriz; Lima, Analia Ethel; Molina Holgado, Eduardo; de Nicola, Alejandro Federico; Labombarda, Maria Florencia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury.
Fil: Garcia Ovejero, Daniel. Hospital Nacional de Paraplejicos; España
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Paniagua Torija, Beatriz. Hospital Nacional de Paraplejicos; España
Fil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Molina Holgado, Eduardo. Hospital Nacional de Paraplejicos; España
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Materia
Catwalk
Oligodendrocytes
Progesterone
Spare White Matter
Spinal Cord Injury
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6285
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6285
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusionGarcia Ovejero, DanielGonzalez, Susana LauraPaniagua Torija, BeatrizLima, Analia EthelMolina Holgado, Eduardode Nicola, Alejandro FedericoLabombarda, Maria FlorenciaCatwalkOligodendrocytesProgesteroneSpare White MatterSpinal Cord Injuryhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury.Fil: Garcia Ovejero, Daniel. Hospital Nacional de Paraplejicos; EspañaFil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Paniagua Torija, Beatriz. Hospital Nacional de Paraplejicos; EspañaFil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Molina Holgado, Eduardo. Hospital Nacional de Paraplejicos; EspañaFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaMary Ann Liebert Inc2014-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/mswordhttp://hdl.handle.net/11336/6285Garcia Ovejero, Daniel; Gonzalez, Susana Laura; Paniagua Torija, Beatriz; Lima, Analia Ethel; Molina Holgado, Eduardo; et al.; Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion; Mary Ann Liebert Inc; Journal of Neurotrauma; 31; 9; 1-5-2014; 857-8710897-71511557-9042enginfo:eu-repo/semantics/altIdentifier/doi/10.1089/neu.2013.3162info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/neu.2013.3162info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:17Zoai:ri.conicet.gov.ar:11336/6285instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:17.536CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
title Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
spellingShingle Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
Garcia Ovejero, Daniel
Catwalk
Oligodendrocytes
Progesterone
Spare White Matter
Spinal Cord Injury
title_short Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
title_full Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
title_fullStr Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
title_full_unstemmed Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
title_sort Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion
dc.creator.none.fl_str_mv Garcia Ovejero, Daniel
Gonzalez, Susana Laura
Paniagua Torija, Beatriz
Lima, Analia Ethel
Molina Holgado, Eduardo
de Nicola, Alejandro Federico
Labombarda, Maria Florencia
author Garcia Ovejero, Daniel
author_facet Garcia Ovejero, Daniel
Gonzalez, Susana Laura
Paniagua Torija, Beatriz
Lima, Analia Ethel
Molina Holgado, Eduardo
de Nicola, Alejandro Federico
Labombarda, Maria Florencia
author_role author
author2 Gonzalez, Susana Laura
Paniagua Torija, Beatriz
Lima, Analia Ethel
Molina Holgado, Eduardo
de Nicola, Alejandro Federico
Labombarda, Maria Florencia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Catwalk
Oligodendrocytes
Progesterone
Spare White Matter
Spinal Cord Injury
topic Catwalk
Oligodendrocytes
Progesterone
Spare White Matter
Spinal Cord Injury
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury.
Fil: Garcia Ovejero, Daniel. Hospital Nacional de Paraplejicos; España
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Paniagua Torija, Beatriz. Hospital Nacional de Paraplejicos; España
Fil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Molina Holgado, Eduardo. Hospital Nacional de Paraplejicos; España
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
description Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury.
publishDate 2014
dc.date.none.fl_str_mv 2014-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6285
Garcia Ovejero, Daniel; Gonzalez, Susana Laura; Paniagua Torija, Beatriz; Lima, Analia Ethel; Molina Holgado, Eduardo; et al.; Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion; Mary Ann Liebert Inc; Journal of Neurotrauma; 31; 9; 1-5-2014; 857-871
0897-7151
1557-9042
url http://hdl.handle.net/11336/6285
identifier_str_mv Garcia Ovejero, Daniel; Gonzalez, Susana Laura; Paniagua Torija, Beatriz; Lima, Analia Ethel; Molina Holgado, Eduardo; et al.; Progesterone reduces secondary damage, preserves white matter and improves locomotor outcome after spinal cord contusion; Mary Ann Liebert Inc; Journal of Neurotrauma; 31; 9; 1-5-2014; 857-871
0897-7151
1557-9042
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1089/neu.2013.3162
info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/neu.2013.3162
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/msword
dc.publisher.none.fl_str_mv Mary Ann Liebert Inc
publisher.none.fl_str_mv Mary Ann Liebert Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613332250656768
score 13.070432

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