Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "...

Autores
Fernández, María Emilia; Kembro, Jackelyn Melissa; Nazar, Franco Nicolas; Moine, Luciana Beatriz; Jaime, Cristian Emanuel; Correa, Silvia Graciela
Año de publicación
2020
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Inflammatory bowel diseases (IBD) present a complex etiology associated with multiple factors interacting at different functional levels (i.e., risk genes, molecules, immune cells, biological processes and environment). The wide diversity of factors and associated variables studied over the last 3 decades in the context of IBD has challenged our ability to integrate the empirical information available in humans. Thus, our goal was to quantitatively analyze how representativeness of components of different functional levels and their interactions have changed over the last 30 years of IBD research in humans. A bibliographic search in Pubmed was performed aimed at extracting experimental studies on IBD in humans published between July 1990 and June 2020. This resulted in 25971 valid abstracts. A search for 1380 specific variables in these abstracts was conducted automatically using customized code in Matlab. The selection of these variables was based on recent reviews and, genetic and molecular catalogues. Publications showed a 5-fold annual rate increase from 1990 to the present. Representativeness of molecular and cellular components remained relatively constant over time, while genes showed a peak increase in publications between 1990 and 2005, with an increasing diversity of genes studied. Microbiota-sensing related variables showed a constant increase in publications. Specifically, components such as IL-1, IL-6, IL-10, NOD2, IFNγ, NF-κB, ATG16L1, TNF, T helper, Treg, macrophages and monocytes emerged as the most frequently studied elements. These components appear as integrative nodes in the network of variables involved in the manifestation of IBD. Our quantitative analysis with historical perspective supports the need to comprehend IBD as the resultant of an interactome or ‘network effect’. It also highlights the importance of elucidating the dynamic relations between nodes to comprise etiology and pathophysiology.
Fil: Fernández, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina
Fil: Nazar, Franco Nicolas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Moine, Luciana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Jaime, Cristian Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Reunión Anual de Sociedades de Biociencia 2020; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Argentina
Sociedad Argentina de Investigación Clínica (SAIC)
Sociedad Argentina de Biología (SAB)
Asociación Argentina de Farmacología Experimental (AAFE)
Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACYTAL)
Materia
Inflammatory bowel diseases
Network effect
Etiology
Pathophysiology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226921
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/226921
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"Fernández, María EmiliaKembro, Jackelyn MelissaNazar, Franco NicolasMoine, Luciana BeatrizJaime, Cristian EmanuelCorrea, Silvia GracielaInflammatory bowel diseasesNetwork effectEtiologyPathophysiologyhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Inflammatory bowel diseases (IBD) present a complex etiology associated with multiple factors interacting at different functional levels (i.e., risk genes, molecules, immune cells, biological processes and environment). The wide diversity of factors and associated variables studied over the last 3 decades in the context of IBD has challenged our ability to integrate the empirical information available in humans. Thus, our goal was to quantitatively analyze how representativeness of components of different functional levels and their interactions have changed over the last 30 years of IBD research in humans. A bibliographic search in Pubmed was performed aimed at extracting experimental studies on IBD in humans published between July 1990 and June 2020. This resulted in 25971 valid abstracts. A search for 1380 specific variables in these abstracts was conducted automatically using customized code in Matlab. The selection of these variables was based on recent reviews and, genetic and molecular catalogues. Publications showed a 5-fold annual rate increase from 1990 to the present. Representativeness of molecular and cellular components remained relatively constant over time, while genes showed a peak increase in publications between 1990 and 2005, with an increasing diversity of genes studied. Microbiota-sensing related variables showed a constant increase in publications. Specifically, components such as IL-1, IL-6, IL-10, NOD2, IFNγ, NF-κB, ATG16L1, TNF, T helper, Treg, macrophages and monocytes emerged as the most frequently studied elements. These components appear as integrative nodes in the network of variables involved in the manifestation of IBD. Our quantitative analysis with historical perspective supports the need to comprehend IBD as the resultant of an interactome or ‘network effect’. It also highlights the importance of elucidating the dynamic relations between nodes to comprise etiology and pathophysiology.Fil: Fernández, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; ArgentinaFil: Nazar, Franco Nicolas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Moine, Luciana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Jaime, Cristian Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaReunión Anual de Sociedades de Biociencia 2020; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de FisiologíaArgentinaSociedad Argentina de Investigación Clínica (SAIC)Sociedad Argentina de Biología (SAB)Asociación Argentina de Farmacología Experimental (AAFE)Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACYTAL)Fundación Revista MedicinaCarrillo, Maria CristinaTrevani, Analía SilvinaLarocca, Maria Cecilia2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226921Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"; Reunión Anual de Sociedades de Biociencia 2020; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 160-1610025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://inmunologia.org.ar/reunion-anual-de-sociedades-de-biociencia-2020/info:eu-repo/semantics/altIdentifier/url/https://www.reunionbiociencias.com.ar/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:36Zoai:ri.conicet.gov.ar:11336/226921instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:36.328CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
title Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
spellingShingle Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
Fernández, María Emilia
Inflammatory bowel diseases
Network effect
Etiology
Pathophysiology
title_short Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
title_full Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
title_fullStr Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
title_full_unstemmed Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
title_sort Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"
dc.creator.none.fl_str_mv Fernández, María Emilia
Kembro, Jackelyn Melissa
Nazar, Franco Nicolas
Moine, Luciana Beatriz
Jaime, Cristian Emanuel
Correa, Silvia Graciela
author Fernández, María Emilia
author_facet Fernández, María Emilia
Kembro, Jackelyn Melissa
Nazar, Franco Nicolas
Moine, Luciana Beatriz
Jaime, Cristian Emanuel
Correa, Silvia Graciela
author_role author
author2 Kembro, Jackelyn Melissa
Nazar, Franco Nicolas
Moine, Luciana Beatriz
Jaime, Cristian Emanuel
Correa, Silvia Graciela
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Carrillo, Maria Cristina
Trevani, Analía Silvina
Larocca, Maria Cecilia
dc.subject.none.fl_str_mv Inflammatory bowel diseases
Network effect
Etiology
Pathophysiology
topic Inflammatory bowel diseases
Network effect
Etiology
Pathophysiology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Inflammatory bowel diseases (IBD) present a complex etiology associated with multiple factors interacting at different functional levels (i.e., risk genes, molecules, immune cells, biological processes and environment). The wide diversity of factors and associated variables studied over the last 3 decades in the context of IBD has challenged our ability to integrate the empirical information available in humans. Thus, our goal was to quantitatively analyze how representativeness of components of different functional levels and their interactions have changed over the last 30 years of IBD research in humans. A bibliographic search in Pubmed was performed aimed at extracting experimental studies on IBD in humans published between July 1990 and June 2020. This resulted in 25971 valid abstracts. A search for 1380 specific variables in these abstracts was conducted automatically using customized code in Matlab. The selection of these variables was based on recent reviews and, genetic and molecular catalogues. Publications showed a 5-fold annual rate increase from 1990 to the present. Representativeness of molecular and cellular components remained relatively constant over time, while genes showed a peak increase in publications between 1990 and 2005, with an increasing diversity of genes studied. Microbiota-sensing related variables showed a constant increase in publications. Specifically, components such as IL-1, IL-6, IL-10, NOD2, IFNγ, NF-κB, ATG16L1, TNF, T helper, Treg, macrophages and monocytes emerged as the most frequently studied elements. These components appear as integrative nodes in the network of variables involved in the manifestation of IBD. Our quantitative analysis with historical perspective supports the need to comprehend IBD as the resultant of an interactome or ‘network effect’. It also highlights the importance of elucidating the dynamic relations between nodes to comprise etiology and pathophysiology.
Fil: Fernández, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina
Fil: Nazar, Franco Nicolas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Moine, Luciana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Jaime, Cristian Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Reunión Anual de Sociedades de Biociencia 2020; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Argentina
Sociedad Argentina de Investigación Clínica (SAIC)
Sociedad Argentina de Biología (SAB)
Asociación Argentina de Farmacología Experimental (AAFE)
Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACYTAL)
description Inflammatory bowel diseases (IBD) present a complex etiology associated with multiple factors interacting at different functional levels (i.e., risk genes, molecules, immune cells, biological processes and environment). The wide diversity of factors and associated variables studied over the last 3 decades in the context of IBD has challenged our ability to integrate the empirical information available in humans. Thus, our goal was to quantitatively analyze how representativeness of components of different functional levels and their interactions have changed over the last 30 years of IBD research in humans. A bibliographic search in Pubmed was performed aimed at extracting experimental studies on IBD in humans published between July 1990 and June 2020. This resulted in 25971 valid abstracts. A search for 1380 specific variables in these abstracts was conducted automatically using customized code in Matlab. The selection of these variables was based on recent reviews and, genetic and molecular catalogues. Publications showed a 5-fold annual rate increase from 1990 to the present. Representativeness of molecular and cellular components remained relatively constant over time, while genes showed a peak increase in publications between 1990 and 2005, with an increasing diversity of genes studied. Microbiota-sensing related variables showed a constant increase in publications. Specifically, components such as IL-1, IL-6, IL-10, NOD2, IFNγ, NF-κB, ATG16L1, TNF, T helper, Treg, macrophages and monocytes emerged as the most frequently studied elements. These components appear as integrative nodes in the network of variables involved in the manifestation of IBD. Our quantitative analysis with historical perspective supports the need to comprehend IBD as the resultant of an interactome or ‘network effect’. It also highlights the importance of elucidating the dynamic relations between nodes to comprise etiology and pathophysiology.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226921
Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"; Reunión Anual de Sociedades de Biociencia 2020; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 160-161
0025-7680
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226921
identifier_str_mv Quantitative and integrative analysis with historical perspective of inflammatory bowel disease research: Understanding etiology and pathogenesis as a result of an interactome or "network effect"; Reunión Anual de Sociedades de Biociencia 2020; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 160-161
0025-7680
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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application/pdf
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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