Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

Autores
Saiz, Juan Carlos; Martín Acebes, Miguel A.; Bueno Marí, Rubén; Salomón, Oscar Daniel; Villamil Jiménez, Luis Carlos; Heukelbach, Jorg; Alencar, Carlos H.; Armstrong, Paul K.; Ortiga Carvalho, Tania M.; Mendez Otero, Rosalia; Rosado de Castro, Paulo H.; Pimentel Coelho, Pedro M.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.
Fil: Saiz, Juan Carlos. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
Fil: Martín Acebes, Miguel A.. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
Fil: Bueno Marí, Rubén. Laboratorios Lokímica; España
Fil: Salomón, Oscar Daniel. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villamil Jiménez, Luis Carlos. Universidad de la Salle; Colombia
Fil: Heukelbach, Jorg. Universidad Federal de Ceará; Brasil. James Cook University; Australia
Fil: Alencar, Carlos H.. Universidad Federal de Ceará; Brasil
Fil: Armstrong, Paul K.. University of Western Australia; Australia
Fil: Ortiga Carvalho, Tania M.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Mendez Otero, Rosalia. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rosado de Castro, Paulo H.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Pimentel Coelho, Pedro M.. Universidade Federal do Rio de Janeiro; Brasil
Materia
FAVIVIRUS
EPIDEMIOLOGY
MICROCEPHALY
GUILLAIN-BARRÉ SYNDROME
ANTIVIRALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42270
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?Saiz, Juan CarlosMartín Acebes, Miguel A.Bueno Marí, RubénSalomón, Oscar DanielVillamil Jiménez, Luis CarlosHeukelbach, JorgAlencar, Carlos H.Armstrong, Paul K.Ortiga Carvalho, Tania M.Mendez Otero, RosaliaRosado de Castro, Paulo H.Pimentel Coelho, Pedro M.FAVIVIRUSEPIDEMIOLOGYMICROCEPHALYGUILLAIN-BARRÉ SYNDROMEANTIVIRALShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.Fil: Saiz, Juan Carlos. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; EspañaFil: Martín Acebes, Miguel A.. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; EspañaFil: Bueno Marí, Rubén. Laboratorios Lokímica; EspañaFil: Salomón, Oscar Daniel. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villamil Jiménez, Luis Carlos. Universidad de la Salle; ColombiaFil: Heukelbach, Jorg. Universidad Federal de Ceará; Brasil. James Cook University; AustraliaFil: Alencar, Carlos H.. Universidad Federal de Ceará; BrasilFil: Armstrong, Paul K.. University of Western Australia; AustraliaFil: Ortiga Carvalho, Tania M.. Universidade Federal do Rio de Janeiro; BrasilFil: Mendez Otero, Rosalia. Universidade Federal do Rio de Janeiro; BrasilFil: Rosado de Castro, Paulo H.. Universidade Federal do Rio de Janeiro; BrasilFil: Pimentel Coelho, Pedro M.. Universidade Federal do Rio de Janeiro; BrasilFrontiers Research Foundation2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42270Saiz, Juan Carlos; Martín Acebes, Miguel A.; Bueno Marí, Rubén; Salomón, Oscar Daniel; Villamil Jiménez, Luis Carlos; et al.; Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?; Frontiers Research Foundation; Frontiers in Microbiology; 8; 1554; 8-2017; 1-251664-302XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fmicb.2017.01554/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2017.01554info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:57Zoai:ri.conicet.gov.ar:11336/42270instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:18:57.58CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
title Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
spellingShingle Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
Saiz, Juan Carlos
FAVIVIRUS
EPIDEMIOLOGY
MICROCEPHALY
GUILLAIN-BARRÉ SYNDROME
ANTIVIRALS
title_short Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
title_full Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
title_fullStr Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
title_full_unstemmed Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
title_sort Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
dc.creator.none.fl_str_mv Saiz, Juan Carlos
Martín Acebes, Miguel A.
Bueno Marí, Rubén
Salomón, Oscar Daniel
Villamil Jiménez, Luis Carlos
Heukelbach, Jorg
Alencar, Carlos H.
Armstrong, Paul K.
Ortiga Carvalho, Tania M.
Mendez Otero, Rosalia
Rosado de Castro, Paulo H.
Pimentel Coelho, Pedro M.
author Saiz, Juan Carlos
author_facet Saiz, Juan Carlos
Martín Acebes, Miguel A.
Bueno Marí, Rubén
Salomón, Oscar Daniel
Villamil Jiménez, Luis Carlos
Heukelbach, Jorg
Alencar, Carlos H.
Armstrong, Paul K.
Ortiga Carvalho, Tania M.
Mendez Otero, Rosalia
Rosado de Castro, Paulo H.
Pimentel Coelho, Pedro M.
author_role author
author2 Martín Acebes, Miguel A.
Bueno Marí, Rubén
Salomón, Oscar Daniel
Villamil Jiménez, Luis Carlos
Heukelbach, Jorg
Alencar, Carlos H.
Armstrong, Paul K.
Ortiga Carvalho, Tania M.
Mendez Otero, Rosalia
Rosado de Castro, Paulo H.
Pimentel Coelho, Pedro M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FAVIVIRUS
EPIDEMIOLOGY
MICROCEPHALY
GUILLAIN-BARRÉ SYNDROME
ANTIVIRALS
topic FAVIVIRUS
EPIDEMIOLOGY
MICROCEPHALY
GUILLAIN-BARRÉ SYNDROME
ANTIVIRALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.
Fil: Saiz, Juan Carlos. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
Fil: Martín Acebes, Miguel A.. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; España
Fil: Bueno Marí, Rubén. Laboratorios Lokímica; España
Fil: Salomón, Oscar Daniel. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villamil Jiménez, Luis Carlos. Universidad de la Salle; Colombia
Fil: Heukelbach, Jorg. Universidad Federal de Ceará; Brasil. James Cook University; Australia
Fil: Alencar, Carlos H.. Universidad Federal de Ceará; Brasil
Fil: Armstrong, Paul K.. University of Western Australia; Australia
Fil: Ortiga Carvalho, Tania M.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Mendez Otero, Rosalia. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rosado de Castro, Paulo H.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Pimentel Coelho, Pedro M.. Universidade Federal do Rio de Janeiro; Brasil
description Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42270
Saiz, Juan Carlos; Martín Acebes, Miguel A.; Bueno Marí, Rubén; Salomón, Oscar Daniel; Villamil Jiménez, Luis Carlos; et al.; Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?; Frontiers Research Foundation; Frontiers in Microbiology; 8; 1554; 8-2017; 1-25
1664-302X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42270
identifier_str_mv Saiz, Juan Carlos; Martín Acebes, Miguel A.; Bueno Marí, Rubén; Salomón, Oscar Daniel; Villamil Jiménez, Luis Carlos; et al.; Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?; Frontiers Research Foundation; Frontiers in Microbiology; 8; 1554; 8-2017; 1-25
1664-302X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fmicb.2017.01554/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2017.01554
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.493442

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