Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity
- Autores
- Lardone, Ricardo Dante; Yuki, Nobuhiro; Odaka, Masaaki; Daniotti, Jose Luis; Irazoqui, Fernando Jose; Nores, Gustavo Alejandro
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. Objective: The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Methods: Thirty-four GBS patients with anti-GM1 IgG antibodies were grouped into two categories according to disease severity at nadir: mild (grades 1-3 by Hughes functional scale, n=13) and severe (grades 4 and 5, n=21). Titre, affinity, fine specificity and cell binding of anti-GM1 antibodies were obtained and compared between the two groups. Results: No differences in antibody titre (GM1-ELISA) or affinity were found between the two patient groups. In contrast, the severe group showed a significantly higher frequency (95%, vs 46% in the mild group, p=0.002) of specific (not cross-reacting with GD1b) anti-GM1 antibodies. In addition, the severe group also exhibited a higher antibody binding titre to cellular GM1. Conclusions: Differences in fine specificity of antibodies are strong indications that different regions of the GM 1-oligosaccharide are involved in antibody binding. High titres of specific anti-GM1 antibody binding to cellular GM1 can be explained by antigen exposure, that is, GM1 exposes or forms mainly epitopes recognised by specific antibodies, and 'hides' those involved in binding of crossreacting antibodies. Thus, the fine specificity of anti-GM 1 antibodies may influence disease severity by affecting antibody binding to cellular targets. Additionally, since antibody specificity studies are relatively easy to implement, fine specificity could be considered a useful predictor of disease severity.
Fil: Lardone, Ricardo Dante. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Yuki, Nobuhiro. Niigata National Hospital; Japón
Fil: Odaka, Masaaki. Dokkyo Medical University; Japón
Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Irazoqui, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Nores, Gustavo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina - Materia
-
Gangliosides
Guillaine Barré
Antibodies
Autoimmune - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/186923
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Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severityLardone, Ricardo DanteYuki, NobuhiroOdaka, MasaakiDaniotti, Jose LuisIrazoqui, Fernando JoseNores, Gustavo AlejandroGangliosidesGuillaine BarréAntibodiesAutoimmunehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. Objective: The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Methods: Thirty-four GBS patients with anti-GM1 IgG antibodies were grouped into two categories according to disease severity at nadir: mild (grades 1-3 by Hughes functional scale, n=13) and severe (grades 4 and 5, n=21). Titre, affinity, fine specificity and cell binding of anti-GM1 antibodies were obtained and compared between the two groups. Results: No differences in antibody titre (GM1-ELISA) or affinity were found between the two patient groups. In contrast, the severe group showed a significantly higher frequency (95%, vs 46% in the mild group, p=0.002) of specific (not cross-reacting with GD1b) anti-GM1 antibodies. In addition, the severe group also exhibited a higher antibody binding titre to cellular GM1. Conclusions: Differences in fine specificity of antibodies are strong indications that different regions of the GM 1-oligosaccharide are involved in antibody binding. High titres of specific anti-GM1 antibody binding to cellular GM1 can be explained by antigen exposure, that is, GM1 exposes or forms mainly epitopes recognised by specific antibodies, and 'hides' those involved in binding of crossreacting antibodies. Thus, the fine specificity of anti-GM 1 antibodies may influence disease severity by affecting antibody binding to cellular targets. Additionally, since antibody specificity studies are relatively easy to implement, fine specificity could be considered a useful predictor of disease severity.Fil: Lardone, Ricardo Dante. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Yuki, Nobuhiro. Niigata National Hospital; JapónFil: Odaka, Masaaki. Dokkyo Medical University; JapónFil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Irazoqui, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Nores, Gustavo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaB M J Publishing Group2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186923Lardone, Ricardo Dante; Yuki, Nobuhiro; Odaka, Masaaki; Daniotti, Jose Luis; Irazoqui, Fernando Jose; et al.; Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 81; 6; 6-2010; 629-6330022-30501468-330XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jnnp.bmj.com/content/81/6/629info:eu-repo/semantics/altIdentifier/doi/10.1136/jnnp.2009.183665info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:32Zoai:ri.conicet.gov.ar:11336/186923instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:33.161CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
title |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
spellingShingle |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity Lardone, Ricardo Dante Gangliosides Guillaine Barré Antibodies Autoimmune |
title_short |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
title_full |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
title_fullStr |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
title_full_unstemmed |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
title_sort |
Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity |
dc.creator.none.fl_str_mv |
Lardone, Ricardo Dante Yuki, Nobuhiro Odaka, Masaaki Daniotti, Jose Luis Irazoqui, Fernando Jose Nores, Gustavo Alejandro |
author |
Lardone, Ricardo Dante |
author_facet |
Lardone, Ricardo Dante Yuki, Nobuhiro Odaka, Masaaki Daniotti, Jose Luis Irazoqui, Fernando Jose Nores, Gustavo Alejandro |
author_role |
author |
author2 |
Yuki, Nobuhiro Odaka, Masaaki Daniotti, Jose Luis Irazoqui, Fernando Jose Nores, Gustavo Alejandro |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Gangliosides Guillaine Barré Antibodies Autoimmune |
topic |
Gangliosides Guillaine Barré Antibodies Autoimmune |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Background: Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. Objective: The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Methods: Thirty-four GBS patients with anti-GM1 IgG antibodies were grouped into two categories according to disease severity at nadir: mild (grades 1-3 by Hughes functional scale, n=13) and severe (grades 4 and 5, n=21). Titre, affinity, fine specificity and cell binding of anti-GM1 antibodies were obtained and compared between the two groups. Results: No differences in antibody titre (GM1-ELISA) or affinity were found between the two patient groups. In contrast, the severe group showed a significantly higher frequency (95%, vs 46% in the mild group, p=0.002) of specific (not cross-reacting with GD1b) anti-GM1 antibodies. In addition, the severe group also exhibited a higher antibody binding titre to cellular GM1. Conclusions: Differences in fine specificity of antibodies are strong indications that different regions of the GM 1-oligosaccharide are involved in antibody binding. High titres of specific anti-GM1 antibody binding to cellular GM1 can be explained by antigen exposure, that is, GM1 exposes or forms mainly epitopes recognised by specific antibodies, and 'hides' those involved in binding of crossreacting antibodies. Thus, the fine specificity of anti-GM 1 antibodies may influence disease severity by affecting antibody binding to cellular targets. Additionally, since antibody specificity studies are relatively easy to implement, fine specificity could be considered a useful predictor of disease severity. Fil: Lardone, Ricardo Dante. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Yuki, Nobuhiro. Niigata National Hospital; Japón Fil: Odaka, Masaaki. Dokkyo Medical University; Japón Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Irazoqui, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Nores, Gustavo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina |
description |
Background: Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. Objective: The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Methods: Thirty-four GBS patients with anti-GM1 IgG antibodies were grouped into two categories according to disease severity at nadir: mild (grades 1-3 by Hughes functional scale, n=13) and severe (grades 4 and 5, n=21). Titre, affinity, fine specificity and cell binding of anti-GM1 antibodies were obtained and compared between the two groups. Results: No differences in antibody titre (GM1-ELISA) or affinity were found between the two patient groups. In contrast, the severe group showed a significantly higher frequency (95%, vs 46% in the mild group, p=0.002) of specific (not cross-reacting with GD1b) anti-GM1 antibodies. In addition, the severe group also exhibited a higher antibody binding titre to cellular GM1. Conclusions: Differences in fine specificity of antibodies are strong indications that different regions of the GM 1-oligosaccharide are involved in antibody binding. High titres of specific anti-GM1 antibody binding to cellular GM1 can be explained by antigen exposure, that is, GM1 exposes or forms mainly epitopes recognised by specific antibodies, and 'hides' those involved in binding of crossreacting antibodies. Thus, the fine specificity of anti-GM 1 antibodies may influence disease severity by affecting antibody binding to cellular targets. Additionally, since antibody specificity studies are relatively easy to implement, fine specificity could be considered a useful predictor of disease severity. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/186923 Lardone, Ricardo Dante; Yuki, Nobuhiro; Odaka, Masaaki; Daniotti, Jose Luis; Irazoqui, Fernando Jose; et al.; Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 81; 6; 6-2010; 629-633 0022-3050 1468-330X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/186923 |
identifier_str_mv |
Lardone, Ricardo Dante; Yuki, Nobuhiro; Odaka, Masaaki; Daniotti, Jose Luis; Irazoqui, Fernando Jose; et al.; Anti-GM1 IgG antibodies in Guillain-Barré syndrome: Fine specificity is associated with disease severity; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 81; 6; 6-2010; 629-633 0022-3050 1468-330X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://jnnp.bmj.com/content/81/6/629 info:eu-repo/semantics/altIdentifier/doi/10.1136/jnnp.2009.183665 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
B M J Publishing Group |
publisher.none.fl_str_mv |
B M J Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269232779231232 |
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13.13397 |