The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA

Autores
Ernst, Glenda Marina; Dalzotto, Pablo; Saban, Melina; Ferraro, Fernando M.; Salvado, Alejandro; Borsini, Eduardo Enrique
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective Obstructive sleep apnea (OSA) is a disorder characterized by recurrent pharyngeal obstruction during sleep, in which upper airway anatomy plays a key role in its pathogenesis. The aim of this study was to describe whether the quantification of cervical fat tissue volume (CFTV) obtained by Computed Tomography (CT)cephalometry is related to the severity of OSA. Methods Retrospective study between 2018 and 2020 in those patients > 18 years old, with diagnosis of OSA who performed a volumetric cephalometric imaging. Three-dimensional reconstruction of the images was performed and CFTV was measured. Results 91 patients were included in this study of which: without OSA (n: 7), mild (n: 19), moderate (n: 39) and severe OSA (n: 26). We observed a progressive increase of CFTV related to OSA severity has been observed (without OSA: 58.9 ml (47.9-87.5), mild: 59.1ml (48.4-78.3), moderate: 71 ml (42.6-127.1) and severe OSA 103.6 ml (81-153); p < 0.01); nevertheless, no differences were found in the airway volume and neck area. It was showed a significant correlation between CFTV and OSA indicators: AHI, ODI and T90 (Sp r: 0.48; 0.38 and 0.36; p < 0.01 respectively). CFTV cut-off value to discriminate AHI >15 ev/h with best sensitivity-specificity relationship was 64.1 ml with an area under the curve of 0.6 ± 0.06. Multivariate analysis showed that CFTV is a predictor for moderate to severe OSA (OR:3.05, IC95%: 1.14-8.17). Conclusion Cervical fat quantification by CT cephalometry correlates with OSA severity in adults. Fat volume > 64.1 ml increased more than three times the risk of OSA moderate to severe.
Fil: Ernst, Glenda Marina. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dalzotto, Pablo. Hospital Británico de Buenos Aires; Argentina
Fil: Saban, Melina. Hospital Británico de Buenos Aires; Argentina
Fil: Ferraro, Fernando M.. Hospital Británico de Buenos Aires; Argentina
Fil: Salvado, Alejandro. Hospital Británico de Buenos Aires; Argentina
Fil: Borsini, Eduardo Enrique. Hospital Británico de Buenos Aires; Argentina
Materia
adiposity
cephalometry
sleep apnea obstructive
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256741
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/256741
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSAErnst, Glenda MarinaDalzotto, PabloSaban, MelinaFerraro, Fernando M.Salvado, AlejandroBorsini, Eduardo Enriqueadipositycephalometrysleep apnea obstructivehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective Obstructive sleep apnea (OSA) is a disorder characterized by recurrent pharyngeal obstruction during sleep, in which upper airway anatomy plays a key role in its pathogenesis. The aim of this study was to describe whether the quantification of cervical fat tissue volume (CFTV) obtained by Computed Tomography (CT)cephalometry is related to the severity of OSA. Methods Retrospective study between 2018 and 2020 in those patients > 18 years old, with diagnosis of OSA who performed a volumetric cephalometric imaging. Three-dimensional reconstruction of the images was performed and CFTV was measured. Results 91 patients were included in this study of which: without OSA (n: 7), mild (n: 19), moderate (n: 39) and severe OSA (n: 26). We observed a progressive increase of CFTV related to OSA severity has been observed (without OSA: 58.9 ml (47.9-87.5), mild: 59.1ml (48.4-78.3), moderate: 71 ml (42.6-127.1) and severe OSA 103.6 ml (81-153); p < 0.01); nevertheless, no differences were found in the airway volume and neck area. It was showed a significant correlation between CFTV and OSA indicators: AHI, ODI and T90 (Sp r: 0.48; 0.38 and 0.36; p < 0.01 respectively). CFTV cut-off value to discriminate AHI >15 ev/h with best sensitivity-specificity relationship was 64.1 ml with an area under the curve of 0.6 ± 0.06. Multivariate analysis showed that CFTV is a predictor for moderate to severe OSA (OR:3.05, IC95%: 1.14-8.17). Conclusion Cervical fat quantification by CT cephalometry correlates with OSA severity in adults. Fat volume > 64.1 ml increased more than three times the risk of OSA moderate to severe.Fil: Ernst, Glenda Marina. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dalzotto, Pablo. Hospital Británico de Buenos Aires; ArgentinaFil: Saban, Melina. Hospital Británico de Buenos Aires; ArgentinaFil: Ferraro, Fernando M.. Hospital Británico de Buenos Aires; ArgentinaFil: Salvado, Alejandro. Hospital Británico de Buenos Aires; ArgentinaFil: Borsini, Eduardo Enrique. Hospital Británico de Buenos Aires; ArgentinaFederación Latinoamericana de Sociedades del Sueño2023-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256741Ernst, Glenda Marina; Dalzotto, Pablo; Saban, Melina; Ferraro, Fernando M.; Salvado, Alejandro; et al.; The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA; Federación Latinoamericana de Sociedades del Sueño; Sleep Science; 16; 03; 9-2023; 323-3281984-0063CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1772827info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0043-1772827info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:08Zoai:ri.conicet.gov.ar:11336/256741instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:09.157CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
title The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
spellingShingle The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
Ernst, Glenda Marina
adiposity
cephalometry
sleep apnea obstructive
title_short The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
title_full The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
title_fullStr The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
title_full_unstemmed The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
title_sort The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA
dc.creator.none.fl_str_mv Ernst, Glenda Marina
Dalzotto, Pablo
Saban, Melina
Ferraro, Fernando M.
Salvado, Alejandro
Borsini, Eduardo Enrique
author Ernst, Glenda Marina
author_facet Ernst, Glenda Marina
Dalzotto, Pablo
Saban, Melina
Ferraro, Fernando M.
Salvado, Alejandro
Borsini, Eduardo Enrique
author_role author
author2 Dalzotto, Pablo
Saban, Melina
Ferraro, Fernando M.
Salvado, Alejandro
Borsini, Eduardo Enrique
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv adiposity
cephalometry
sleep apnea obstructive
topic adiposity
cephalometry
sleep apnea obstructive
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective Obstructive sleep apnea (OSA) is a disorder characterized by recurrent pharyngeal obstruction during sleep, in which upper airway anatomy plays a key role in its pathogenesis. The aim of this study was to describe whether the quantification of cervical fat tissue volume (CFTV) obtained by Computed Tomography (CT)cephalometry is related to the severity of OSA. Methods Retrospective study between 2018 and 2020 in those patients > 18 years old, with diagnosis of OSA who performed a volumetric cephalometric imaging. Three-dimensional reconstruction of the images was performed and CFTV was measured. Results 91 patients were included in this study of which: without OSA (n: 7), mild (n: 19), moderate (n: 39) and severe OSA (n: 26). We observed a progressive increase of CFTV related to OSA severity has been observed (without OSA: 58.9 ml (47.9-87.5), mild: 59.1ml (48.4-78.3), moderate: 71 ml (42.6-127.1) and severe OSA 103.6 ml (81-153); p < 0.01); nevertheless, no differences were found in the airway volume and neck area. It was showed a significant correlation between CFTV and OSA indicators: AHI, ODI and T90 (Sp r: 0.48; 0.38 and 0.36; p < 0.01 respectively). CFTV cut-off value to discriminate AHI >15 ev/h with best sensitivity-specificity relationship was 64.1 ml with an area under the curve of 0.6 ± 0.06. Multivariate analysis showed that CFTV is a predictor for moderate to severe OSA (OR:3.05, IC95%: 1.14-8.17). Conclusion Cervical fat quantification by CT cephalometry correlates with OSA severity in adults. Fat volume > 64.1 ml increased more than three times the risk of OSA moderate to severe.
Fil: Ernst, Glenda Marina. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dalzotto, Pablo. Hospital Británico de Buenos Aires; Argentina
Fil: Saban, Melina. Hospital Británico de Buenos Aires; Argentina
Fil: Ferraro, Fernando M.. Hospital Británico de Buenos Aires; Argentina
Fil: Salvado, Alejandro. Hospital Británico de Buenos Aires; Argentina
Fil: Borsini, Eduardo Enrique. Hospital Británico de Buenos Aires; Argentina
description Objective Obstructive sleep apnea (OSA) is a disorder characterized by recurrent pharyngeal obstruction during sleep, in which upper airway anatomy plays a key role in its pathogenesis. The aim of this study was to describe whether the quantification of cervical fat tissue volume (CFTV) obtained by Computed Tomography (CT)cephalometry is related to the severity of OSA. Methods Retrospective study between 2018 and 2020 in those patients > 18 years old, with diagnosis of OSA who performed a volumetric cephalometric imaging. Three-dimensional reconstruction of the images was performed and CFTV was measured. Results 91 patients were included in this study of which: without OSA (n: 7), mild (n: 19), moderate (n: 39) and severe OSA (n: 26). We observed a progressive increase of CFTV related to OSA severity has been observed (without OSA: 58.9 ml (47.9-87.5), mild: 59.1ml (48.4-78.3), moderate: 71 ml (42.6-127.1) and severe OSA 103.6 ml (81-153); p < 0.01); nevertheless, no differences were found in the airway volume and neck area. It was showed a significant correlation between CFTV and OSA indicators: AHI, ODI and T90 (Sp r: 0.48; 0.38 and 0.36; p < 0.01 respectively). CFTV cut-off value to discriminate AHI >15 ev/h with best sensitivity-specificity relationship was 64.1 ml with an area under the curve of 0.6 ± 0.06. Multivariate analysis showed that CFTV is a predictor for moderate to severe OSA (OR:3.05, IC95%: 1.14-8.17). Conclusion Cervical fat quantification by CT cephalometry correlates with OSA severity in adults. Fat volume > 64.1 ml increased more than three times the risk of OSA moderate to severe.
publishDate 2023
dc.date.none.fl_str_mv 2023-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256741
Ernst, Glenda Marina; Dalzotto, Pablo; Saban, Melina; Ferraro, Fernando M.; Salvado, Alejandro; et al.; The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA; Federación Latinoamericana de Sociedades del Sueño; Sleep Science; 16; 03; 9-2023; 323-328
1984-0063
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256741
identifier_str_mv Ernst, Glenda Marina; Dalzotto, Pablo; Saban, Melina; Ferraro, Fernando M.; Salvado, Alejandro; et al.; The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA; Federación Latinoamericana de Sociedades del Sueño; Sleep Science; 16; 03; 9-2023; 323-328
1984-0063
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1772827
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0043-1772827
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Federación Latinoamericana de Sociedades del Sueño
publisher.none.fl_str_mv Federación Latinoamericana de Sociedades del Sueño
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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