An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder

Autores
De la Peña Arteaga, Víctor; Berruga Sánchez, Mercedes; Steward, Trevor; Martínez Zalacaín, Ignacio; Goldberg, Ximena; Wainsztein, Agustina Edith; Abulafia, Carolina Andrea; Cardoner, Narcís; Castro, Mariana Nair; Villarreal, Mirta Fabiana; Menchón, José M.; Guinjoan, Salvador Martín; Soriano Mas, Carles
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background. One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations.Methods. In the present study we contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n=19), MDD patients (n=20) and healthy controls (HCs; n=19). Emotion regulation was assessed using an established functional magnetic resonance imaging (fMRI) cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity (i.e., Psychophysiological Interactions, PPI). Results. When compared to HCs, patients with BPD and MDD displayed a homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. Additionally, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions. Decreased activation of the vlPFC underlays emotion regulation deficits in MDD and BPD, although, beyond this finding, these groups are characterized by specific neurobiological underpinnings. Alterations in patients with MDD suggest a primary deficit in the strength of prefrontal activations, while patients with BPD are better characterized by connectivity disruptions between the prefrontal cortex and temporal emotion processing regions. These findings substantiate in neurobiological terms the different profiles of emotion regulation alteration observed in these disorders.
Fil: De la Peña Arteaga, Víctor. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Berruga Sánchez, Mercedes. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Steward, Trevor. University of Melbourne; Australia
Fil: Martínez Zalacaín, Ignacio. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Goldberg, Ximena. Parc Taulí University Hospital; España
Fil: Wainsztein, Agustina Edith. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cardoner, Narcís. Parc Taulí University Hospital; España
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Menchón, José M.. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Soriano Mas, Carles. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Materia
EMOTION REGULATION
BORDERLINE PERSONALITY DISORDER
MAJOR DEPRESSIVE DISORDER
FMRI
PREFRONTAL CORTEX
FUNCTIONAL CONNECTIVITY
COGNITIVE REAPPRAISAL
TRANSDIAGNOSTIC PSYCHIATRY
NEUROIMAGING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181643
Acceder
id CONICETDig_23b5dc1b1f40ba4e09d9209003fcea38
oai_identifier_str oai:ri.conicet.gov.ar:11336/181643
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorderDe la Peña Arteaga, VíctorBerruga Sánchez, MercedesSteward, TrevorMartínez Zalacaín, IgnacioGoldberg, XimenaWainsztein, Agustina EdithAbulafia, Carolina AndreaCardoner, NarcísCastro, Mariana NairVillarreal, Mirta FabianaMenchón, José M.Guinjoan, Salvador MartínSoriano Mas, CarlesEMOTION REGULATIONBORDERLINE PERSONALITY DISORDERMAJOR DEPRESSIVE DISORDERFMRIPREFRONTAL CORTEXFUNCTIONAL CONNECTIVITYCOGNITIVE REAPPRAISALTRANSDIAGNOSTIC PSYCHIATRYNEUROIMAGINGhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background. One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations.Methods. In the present study we contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n=19), MDD patients (n=20) and healthy controls (HCs; n=19). Emotion regulation was assessed using an established functional magnetic resonance imaging (fMRI) cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity (i.e., Psychophysiological Interactions, PPI). Results. When compared to HCs, patients with BPD and MDD displayed a homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. Additionally, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions. Decreased activation of the vlPFC underlays emotion regulation deficits in MDD and BPD, although, beyond this finding, these groups are characterized by specific neurobiological underpinnings. Alterations in patients with MDD suggest a primary deficit in the strength of prefrontal activations, while patients with BPD are better characterized by connectivity disruptions between the prefrontal cortex and temporal emotion processing regions. These findings substantiate in neurobiological terms the different profiles of emotion regulation alteration observed in these disorders.Fil: De la Peña Arteaga, Víctor. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; EspañaFil: Berruga Sánchez, Mercedes. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; EspañaFil: Steward, Trevor. University of Melbourne; AustraliaFil: Martínez Zalacaín, Ignacio. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; EspañaFil: Goldberg, Ximena. Parc Taulí University Hospital; EspañaFil: Wainsztein, Agustina Edith. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Cardoner, Narcís. Parc Taulí University Hospital; EspañaFil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Menchón, José M.. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; EspañaFil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; ArgentinaFil: Soriano Mas, Carles. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; EspañaElsevier France-Editions Scientifiques Medicales Elsevier2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181643De la Peña Arteaga, Víctor; Berruga Sánchez, Mercedes; Steward, Trevor; Martínez Zalacaín, Ignacio; Goldberg, Ximena; et al.; An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder; Elsevier France-Editions Scientifiques Medicales Elsevier; European Psychiatry; 64; 1; 9-2021; 1-200924-9338CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/product/identifier/S0924933821022318/type/journal_articleinfo:eu-repo/semantics/altIdentifier/doi/10.1192/j.eurpsy.2021.2231info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:05Zoai:ri.conicet.gov.ar:11336/181643instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:05.496CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
spellingShingle An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
De la Peña Arteaga, Víctor
EMOTION REGULATION
BORDERLINE PERSONALITY DISORDER
MAJOR DEPRESSIVE DISORDER
FMRI
PREFRONTAL CORTEX
FUNCTIONAL CONNECTIVITY
COGNITIVE REAPPRAISAL
TRANSDIAGNOSTIC PSYCHIATRY
NEUROIMAGING
title_short An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_full An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_fullStr An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_full_unstemmed An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
title_sort An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
dc.creator.none.fl_str_mv De la Peña Arteaga, Víctor
Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina Edith
Abulafia, Carolina Andrea
Cardoner, Narcís
Castro, Mariana Nair
Villarreal, Mirta Fabiana
Menchón, José M.
Guinjoan, Salvador Martín
Soriano Mas, Carles
author De la Peña Arteaga, Víctor
author_facet De la Peña Arteaga, Víctor
Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina Edith
Abulafia, Carolina Andrea
Cardoner, Narcís
Castro, Mariana Nair
Villarreal, Mirta Fabiana
Menchón, José M.
Guinjoan, Salvador Martín
Soriano Mas, Carles
author_role author
author2 Berruga Sánchez, Mercedes
Steward, Trevor
Martínez Zalacaín, Ignacio
Goldberg, Ximena
Wainsztein, Agustina Edith
Abulafia, Carolina Andrea
Cardoner, Narcís
Castro, Mariana Nair
Villarreal, Mirta Fabiana
Menchón, José M.
Guinjoan, Salvador Martín
Soriano Mas, Carles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EMOTION REGULATION
BORDERLINE PERSONALITY DISORDER
MAJOR DEPRESSIVE DISORDER
FMRI
PREFRONTAL CORTEX
FUNCTIONAL CONNECTIVITY
COGNITIVE REAPPRAISAL
TRANSDIAGNOSTIC PSYCHIATRY
NEUROIMAGING
topic EMOTION REGULATION
BORDERLINE PERSONALITY DISORDER
MAJOR DEPRESSIVE DISORDER
FMRI
PREFRONTAL CORTEX
FUNCTIONAL CONNECTIVITY
COGNITIVE REAPPRAISAL
TRANSDIAGNOSTIC PSYCHIATRY
NEUROIMAGING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background. One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations.Methods. In the present study we contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n=19), MDD patients (n=20) and healthy controls (HCs; n=19). Emotion regulation was assessed using an established functional magnetic resonance imaging (fMRI) cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity (i.e., Psychophysiological Interactions, PPI). Results. When compared to HCs, patients with BPD and MDD displayed a homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. Additionally, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions. Decreased activation of the vlPFC underlays emotion regulation deficits in MDD and BPD, although, beyond this finding, these groups are characterized by specific neurobiological underpinnings. Alterations in patients with MDD suggest a primary deficit in the strength of prefrontal activations, while patients with BPD are better characterized by connectivity disruptions between the prefrontal cortex and temporal emotion processing regions. These findings substantiate in neurobiological terms the different profiles of emotion regulation alteration observed in these disorders.
Fil: De la Peña Arteaga, Víctor. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Berruga Sánchez, Mercedes. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Steward, Trevor. University of Melbourne; Australia
Fil: Martínez Zalacaín, Ignacio. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Goldberg, Ximena. Parc Taulí University Hospital; España
Fil: Wainsztein, Agustina Edith. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Cardoner, Narcís. Parc Taulí University Hospital; España
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Menchón, José M.. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina
Fil: Soriano Mas, Carles. Universidad de Barcelona. Hospital Duran I Reynals. Instituto de Investigación Biomédica de Bellvitge; España
description Background. One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations.Methods. In the present study we contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n=19), MDD patients (n=20) and healthy controls (HCs; n=19). Emotion regulation was assessed using an established functional magnetic resonance imaging (fMRI) cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity (i.e., Psychophysiological Interactions, PPI). Results. When compared to HCs, patients with BPD and MDD displayed a homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. Additionally, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions. Decreased activation of the vlPFC underlays emotion regulation deficits in MDD and BPD, although, beyond this finding, these groups are characterized by specific neurobiological underpinnings. Alterations in patients with MDD suggest a primary deficit in the strength of prefrontal activations, while patients with BPD are better characterized by connectivity disruptions between the prefrontal cortex and temporal emotion processing regions. These findings substantiate in neurobiological terms the different profiles of emotion regulation alteration observed in these disorders.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181643
De la Peña Arteaga, Víctor; Berruga Sánchez, Mercedes; Steward, Trevor; Martínez Zalacaín, Ignacio; Goldberg, Ximena; et al.; An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder; Elsevier France-Editions Scientifiques Medicales Elsevier; European Psychiatry; 64; 1; 9-2021; 1-20
0924-9338
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181643
identifier_str_mv De la Peña Arteaga, Víctor; Berruga Sánchez, Mercedes; Steward, Trevor; Martínez Zalacaín, Ignacio; Goldberg, Ximena; et al.; An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder; Elsevier France-Editions Scientifiques Medicales Elsevier; European Psychiatry; 64; 1; 9-2021; 1-20
0924-9338
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/product/identifier/S0924933821022318/type/journal_article
info:eu-repo/semantics/altIdentifier/doi/10.1192/j.eurpsy.2021.2231
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier France-Editions Scientifiques Medicales Elsevier
publisher.none.fl_str_mv Elsevier France-Editions Scientifiques Medicales Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269012343390208
score 13.13397

Publicaciones similares