Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
- Autores
- Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; Alejandro de Nicola
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.
Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Sitruk Ware, Regine. Population Council’s Center for Biomedical Research; Estados Unidos. The Rockefeller University; Estados Unidos
Fil: Gennoun, Rachida. Inserm; Francia
Fil: Shumacher, Michael. Inserm; Francia
Fil: Alejandro de Nicola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina - Materia
-
Hippocampus
Gfap
Experimental Autoimmune Encephalomyelitis
Nestorone - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/6680
Ver los metadatos del registro completo
id |
CONICETDig_238fa17517b72ff3c04406a0754772fd |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/6680 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitisGaray, Laura InesGonzalez Deniselle, Maria ClaudiaSitruk Ware, RegineGennoun, RachidaShumacher, MichaelAlejandro de NicolaHippocampusGfapExperimental Autoimmune EncephalomyelitisNestoronehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Sitruk Ware, Regine. Population Council’s Center for Biomedical Research; Estados Unidos. The Rockefeller University; Estados UnidosFil: Gennoun, Rachida. Inserm; FranciaFil: Shumacher, Michael. Inserm; FranciaFil: Alejandro de Nicola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaElsevier Inc2014-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6680Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-970165-5728enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jneuroim.2014.08.619info:eu-repo/semantics/altIdentifier/pmid/25200475info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0165572814008686info:eu-repo/semantics/altIdentifier/url/http://www.jni-journal.com/article/S0165-5728(14)00868-6/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:17Zoai:ri.conicet.gov.ar:11336/6680instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:17.928CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
title |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
spellingShingle |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis Garay, Laura Ines Hippocampus Gfap Experimental Autoimmune Encephalomyelitis Nestorone |
title_short |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
title_full |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
title_fullStr |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
title_full_unstemmed |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
title_sort |
Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis |
dc.creator.none.fl_str_mv |
Garay, Laura Ines Gonzalez Deniselle, Maria Claudia Sitruk Ware, Regine Gennoun, Rachida Shumacher, Michael Alejandro de Nicola |
author |
Garay, Laura Ines |
author_facet |
Garay, Laura Ines Gonzalez Deniselle, Maria Claudia Sitruk Ware, Regine Gennoun, Rachida Shumacher, Michael Alejandro de Nicola |
author_role |
author |
author2 |
Gonzalez Deniselle, Maria Claudia Sitruk Ware, Regine Gennoun, Rachida Shumacher, Michael Alejandro de Nicola |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Hippocampus Gfap Experimental Autoimmune Encephalomyelitis Nestorone |
topic |
Hippocampus Gfap Experimental Autoimmune Encephalomyelitis Nestorone |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS. Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Sitruk Ware, Regine. Population Council’s Center for Biomedical Research; Estados Unidos. The Rockefeller University; Estados Unidos Fil: Gennoun, Rachida. Inserm; Francia Fil: Shumacher, Michael. Inserm; Francia Fil: Alejandro de Nicola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina |
description |
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/6680 Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-97 0165-5728 |
url |
http://hdl.handle.net/11336/6680 |
identifier_str_mv |
Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-97 0165-5728 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jneuroim.2014.08.619 info:eu-repo/semantics/altIdentifier/pmid/25200475 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0165572814008686 info:eu-repo/semantics/altIdentifier/url/http://www.jni-journal.com/article/S0165-5728(14)00868-6/abstract |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Inc |
publisher.none.fl_str_mv |
Elsevier Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269794060992512 |
score |
13.13397 |