Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis

Autores
Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; Alejandro de Nicola
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.
Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Sitruk Ware, Regine. Population Council’s Center for Biomedical Research; Estados Unidos. The Rockefeller University; Estados Unidos
Fil: Gennoun, Rachida. Inserm; Francia
Fil: Shumacher, Michael. Inserm; Francia
Fil: Alejandro de Nicola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Materia
Hippocampus
Gfap
Experimental Autoimmune Encephalomyelitis
Nestorone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6680
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitisGaray, Laura InesGonzalez Deniselle, Maria ClaudiaSitruk Ware, RegineGennoun, RachidaShumacher, MichaelAlejandro de NicolaHippocampusGfapExperimental Autoimmune EncephalomyelitisNestoronehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Sitruk Ware, Regine. Population Council’s Center for Biomedical Research; Estados Unidos. The Rockefeller University; Estados UnidosFil: Gennoun, Rachida. Inserm; FranciaFil: Shumacher, Michael. Inserm; FranciaFil: Alejandro de Nicola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaElsevier Inc2014-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6680Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-970165-5728enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jneuroim.2014.08.619info:eu-repo/semantics/altIdentifier/pmid/25200475info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0165572814008686info:eu-repo/semantics/altIdentifier/url/http://www.jni-journal.com/article/S0165-5728(14)00868-6/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:14Zoai:ri.conicet.gov.ar:11336/6680instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:14.745CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
title Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
spellingShingle Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
Garay, Laura Ines
Hippocampus
Gfap
Experimental Autoimmune Encephalomyelitis
Nestorone
title_short Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
title_full Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
title_fullStr Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
title_full_unstemmed Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
title_sort Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis
dc.creator.none.fl_str_mv Garay, Laura Ines
Gonzalez Deniselle, Maria Claudia
Sitruk Ware, Regine
Gennoun, Rachida
Shumacher, Michael
Alejandro de Nicola
author Garay, Laura Ines
author_facet Garay, Laura Ines
Gonzalez Deniselle, Maria Claudia
Sitruk Ware, Regine
Gennoun, Rachida
Shumacher, Michael
Alejandro de Nicola
author_role author
author2 Gonzalez Deniselle, Maria Claudia
Sitruk Ware, Regine
Gennoun, Rachida
Shumacher, Michael
Alejandro de Nicola
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hippocampus
Gfap
Experimental Autoimmune Encephalomyelitis
Nestorone
topic Hippocampus
Gfap
Experimental Autoimmune Encephalomyelitis
Nestorone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.
Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Sitruk Ware, Regine. Population Council’s Center for Biomedical Research; Estados Unidos. The Rockefeller University; Estados Unidos
Fil: Gennoun, Rachida. Inserm; Francia
Fil: Shumacher, Michael. Inserm; Francia
Fil: Alejandro de Nicola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
description Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1+ microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6680
Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-97
0165-5728
url http://hdl.handle.net/11336/6680
identifier_str_mv Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Sitruk Ware, Regine; Gennoun, Rachida; Shumacher, Michael; et al.; Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis; Elsevier Inc; Journal Of Neuroimmunology; 276; 1-2; 15-11-2014; 89-97
0165-5728
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jneuroim.2014.08.619
info:eu-repo/semantics/altIdentifier/pmid/25200475
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0165572814008686
info:eu-repo/semantics/altIdentifier/url/http://www.jni-journal.com/article/S0165-5728(14)00868-6/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614180950245376
score 13.070432

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