A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities

Autores
Nardi, Monica; Herrera Cano, Natividad Carolina; Simeonov, Svilen; Bence, Renata; Kurutos, Atanas; Scarpelli, Rosa; Wunderlin, Daniel Alberto; Procopio, Antonio
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs’ synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.
Fil: Nardi, Monica. Università Degli Studi Magna Graecia Di Catanzaro; Italia
Fil: Herrera Cano, Natividad Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Simeonov, Svilen. Universidade Nova de Lisboa; Portugal
Fil: Bence, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Kurutos, Atanas. Bulgarian Academy of Sciences; Bulgaria
Fil: Scarpelli, Rosa. Università Degli Studi Magna Graecia Di Catanzaro; Italia
Fil: Wunderlin, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Procopio, Antonio. Università Degli Studi Magna Graecia Di Catanzaro; Italia
Materia
BENZIMIDAZOLE
GREEN CHEMISTRY
PHARMACOLOGICAL ACTIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/230010
Acceder
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spelling A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological ActivitiesNardi, MonicaHerrera Cano, Natividad CarolinaSimeonov, SvilenBence, RenataKurutos, AtanasScarpelli, RosaWunderlin, Daniel AlbertoProcopio, AntonioBENZIMIDAZOLEGREEN CHEMISTRYPHARMACOLOGICAL ACTIVITYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs’ synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.Fil: Nardi, Monica. Università Degli Studi Magna Graecia Di Catanzaro; ItaliaFil: Herrera Cano, Natividad Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Simeonov, Svilen. Universidade Nova de Lisboa; PortugalFil: Bence, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Kurutos, Atanas. Bulgarian Academy of Sciences; BulgariaFil: Scarpelli, Rosa. Università Degli Studi Magna Graecia Di Catanzaro; ItaliaFil: Wunderlin, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Procopio, Antonio. Università Degli Studi Magna Graecia Di Catanzaro; ItaliaMDPI2023-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230010Nardi, Monica; Herrera Cano, Natividad Carolina; Simeonov, Svilen; Bence, Renata; Kurutos, Atanas; et al.; A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities; MDPI; Catalysts; 13; 2; 2-2023; 1-352073-4344CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4344/13/2/392info:eu-repo/semantics/altIdentifier/doi/10.3390/catal13020392info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:12:53Zoai:ri.conicet.gov.ar:11336/230010instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:12:53.7CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
title A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
spellingShingle A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
Nardi, Monica
BENZIMIDAZOLE
GREEN CHEMISTRY
PHARMACOLOGICAL ACTIVITY
title_short A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
title_full A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
title_fullStr A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
title_full_unstemmed A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
title_sort A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
dc.creator.none.fl_str_mv Nardi, Monica
Herrera Cano, Natividad Carolina
Simeonov, Svilen
Bence, Renata
Kurutos, Atanas
Scarpelli, Rosa
Wunderlin, Daniel Alberto
Procopio, Antonio
author Nardi, Monica
author_facet Nardi, Monica
Herrera Cano, Natividad Carolina
Simeonov, Svilen
Bence, Renata
Kurutos, Atanas
Scarpelli, Rosa
Wunderlin, Daniel Alberto
Procopio, Antonio
author_role author
author2 Herrera Cano, Natividad Carolina
Simeonov, Svilen
Bence, Renata
Kurutos, Atanas
Scarpelli, Rosa
Wunderlin, Daniel Alberto
Procopio, Antonio
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BENZIMIDAZOLE
GREEN CHEMISTRY
PHARMACOLOGICAL ACTIVITY
topic BENZIMIDAZOLE
GREEN CHEMISTRY
PHARMACOLOGICAL ACTIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs’ synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.
Fil: Nardi, Monica. Università Degli Studi Magna Graecia Di Catanzaro; Italia
Fil: Herrera Cano, Natividad Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Simeonov, Svilen. Universidade Nova de Lisboa; Portugal
Fil: Bence, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Kurutos, Atanas. Bulgarian Academy of Sciences; Bulgaria
Fil: Scarpelli, Rosa. Università Degli Studi Magna Graecia Di Catanzaro; Italia
Fil: Wunderlin, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Procopio, Antonio. Università Degli Studi Magna Graecia Di Catanzaro; Italia
description Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs’ synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.
publishDate 2023
dc.date.none.fl_str_mv 2023-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/230010
Nardi, Monica; Herrera Cano, Natividad Carolina; Simeonov, Svilen; Bence, Renata; Kurutos, Atanas; et al.; A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities; MDPI; Catalysts; 13; 2; 2-2023; 1-35
2073-4344
CONICET Digital
CONICET
url http://hdl.handle.net/11336/230010
identifier_str_mv Nardi, Monica; Herrera Cano, Natividad Carolina; Simeonov, Svilen; Bence, Renata; Kurutos, Atanas; et al.; A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities; MDPI; Catalysts; 13; 2; 2-2023; 1-35
2073-4344
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4344/13/2/392
info:eu-repo/semantics/altIdentifier/doi/10.3390/catal13020392
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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