In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride

Autores
Lombarte, Mercedes; Fina, Brenda Lorena; Lupión, Patricia Melina; Lupo, Maela; Rigalli, Alfredo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The fluoride ion (F) is a disturbing substance for the glucose-insulinsystem. The effects of F have been studied in various aspects. The chronic intake ofF generates hyperglycaemia with high plasma insulin levels. This effect is observedin several countries where the content of fluoride in drinking water is greater than theupper limit recommended by WHO (1.5 mg/L). The administration of a dose of Fcauses a decrease of insulin levels, which was attributed to a decrease in insulinsecretion through in vitro experiments. However, measurement of insulin secretionin vivo has not been done so far. Moreover, in endemic fluorosis areas children hadlower intelligence quotient (IQ) than children of areas with low F in drinking water.This decrease in IQ has also been observed in rats. In this work, the glucose uptakerate of insulin-independent tissues, insulin secretion, and insulin clearances weremeasured in vivo in rats that received a dose of F. A lower secretion and clearance ofinsulin were found in animals that received F. In addition, a decrease in glucoseuptake rate from insulin-independent tissues was observed. This glucose uptake ismainly the glucose consumed by the nervous system. As a consequence, thisdecrease could be associated with the effect of fluoride on IQ.
Fil: Lombarte, Mercedes. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Fina, Brenda Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Lupión, Patricia Melina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Lupo, Maela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Materia
GLUCOSE HOMEOSTASIS
INSULIN
IN VIVO EFFECTS
IQ
RATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180650
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/180650
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluorideLombarte, MercedesFina, Brenda LorenaLupión, Patricia MelinaLupo, MaelaRigalli, AlfredoGLUCOSE HOMEOSTASISINSULININ VIVO EFFECTSIQRATShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The fluoride ion (F) is a disturbing substance for the glucose-insulinsystem. The effects of F have been studied in various aspects. The chronic intake ofF generates hyperglycaemia with high plasma insulin levels. This effect is observedin several countries where the content of fluoride in drinking water is greater than theupper limit recommended by WHO (1.5 mg/L). The administration of a dose of Fcauses a decrease of insulin levels, which was attributed to a decrease in insulinsecretion through in vitro experiments. However, measurement of insulin secretionin vivo has not been done so far. Moreover, in endemic fluorosis areas children hadlower intelligence quotient (IQ) than children of areas with low F in drinking water.This decrease in IQ has also been observed in rats. In this work, the glucose uptakerate of insulin-independent tissues, insulin secretion, and insulin clearances weremeasured in vivo in rats that received a dose of F. A lower secretion and clearance ofinsulin were found in animals that received F. In addition, a decrease in glucoseuptake rate from insulin-independent tissues was observed. This glucose uptake ismainly the glucose consumed by the nervous system. As a consequence, thisdecrease could be associated with the effect of fluoride on IQ.Fil: Lombarte, Mercedes. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Fina, Brenda Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Lupión, Patricia Melina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Lupo, Maela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaInternational Society for Fluoride Research2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180650Lombarte, Mercedes; Fina, Brenda Lorena; Lupión, Patricia Melina; Lupo, Maela; Rigalli, Alfredo; In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride; International Society for Fluoride Research; Fluoride; 49; 1; 7-2016; 204-2100015-4725CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.fluorideresearch.org/493Pt1/files/FJ2016_v49_n3Pt1_p204-210_sfs.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:03Zoai:ri.conicet.gov.ar:11336/180650instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:03.483CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
title In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
spellingShingle In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
Lombarte, Mercedes
GLUCOSE HOMEOSTASIS
INSULIN
IN VIVO EFFECTS
IQ
RATS
title_short In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
title_full In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
title_fullStr In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
title_full_unstemmed In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
title_sort In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride
dc.creator.none.fl_str_mv Lombarte, Mercedes
Fina, Brenda Lorena
Lupión, Patricia Melina
Lupo, Maela
Rigalli, Alfredo
author Lombarte, Mercedes
author_facet Lombarte, Mercedes
Fina, Brenda Lorena
Lupión, Patricia Melina
Lupo, Maela
Rigalli, Alfredo
author_role author
author2 Fina, Brenda Lorena
Lupión, Patricia Melina
Lupo, Maela
Rigalli, Alfredo
author2_role author
author
author
author
dc.subject.none.fl_str_mv GLUCOSE HOMEOSTASIS
INSULIN
IN VIVO EFFECTS
IQ
RATS
topic GLUCOSE HOMEOSTASIS
INSULIN
IN VIVO EFFECTS
IQ
RATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The fluoride ion (F) is a disturbing substance for the glucose-insulinsystem. The effects of F have been studied in various aspects. The chronic intake ofF generates hyperglycaemia with high plasma insulin levels. This effect is observedin several countries where the content of fluoride in drinking water is greater than theupper limit recommended by WHO (1.5 mg/L). The administration of a dose of Fcauses a decrease of insulin levels, which was attributed to a decrease in insulinsecretion through in vitro experiments. However, measurement of insulin secretionin vivo has not been done so far. Moreover, in endemic fluorosis areas children hadlower intelligence quotient (IQ) than children of areas with low F in drinking water.This decrease in IQ has also been observed in rats. In this work, the glucose uptakerate of insulin-independent tissues, insulin secretion, and insulin clearances weremeasured in vivo in rats that received a dose of F. A lower secretion and clearance ofinsulin were found in animals that received F. In addition, a decrease in glucoseuptake rate from insulin-independent tissues was observed. This glucose uptake ismainly the glucose consumed by the nervous system. As a consequence, thisdecrease could be associated with the effect of fluoride on IQ.
Fil: Lombarte, Mercedes. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Fina, Brenda Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Lupión, Patricia Melina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Lupo, Maela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
description The fluoride ion (F) is a disturbing substance for the glucose-insulinsystem. The effects of F have been studied in various aspects. The chronic intake ofF generates hyperglycaemia with high plasma insulin levels. This effect is observedin several countries where the content of fluoride in drinking water is greater than theupper limit recommended by WHO (1.5 mg/L). The administration of a dose of Fcauses a decrease of insulin levels, which was attributed to a decrease in insulinsecretion through in vitro experiments. However, measurement of insulin secretionin vivo has not been done so far. Moreover, in endemic fluorosis areas children hadlower intelligence quotient (IQ) than children of areas with low F in drinking water.This decrease in IQ has also been observed in rats. In this work, the glucose uptakerate of insulin-independent tissues, insulin secretion, and insulin clearances weremeasured in vivo in rats that received a dose of F. A lower secretion and clearance ofinsulin were found in animals that received F. In addition, a decrease in glucoseuptake rate from insulin-independent tissues was observed. This glucose uptake ismainly the glucose consumed by the nervous system. As a consequence, thisdecrease could be associated with the effect of fluoride on IQ.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180650
Lombarte, Mercedes; Fina, Brenda Lorena; Lupión, Patricia Melina; Lupo, Maela; Rigalli, Alfredo; In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride; International Society for Fluoride Research; Fluoride; 49; 1; 7-2016; 204-210
0015-4725
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180650
identifier_str_mv Lombarte, Mercedes; Fina, Brenda Lorena; Lupión, Patricia Melina; Lupo, Maela; Rigalli, Alfredo; In vivo measurement of fluoride effects on glucose homeostasis: an explanation for the decrease in intelligence quotient and insulin resistance induced by fluoride; International Society for Fluoride Research; Fluoride; 49; 1; 7-2016; 204-210
0015-4725
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.fluorideresearch.org/493Pt1/files/FJ2016_v49_n3Pt1_p204-210_sfs.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Society for Fluoride Research
publisher.none.fl_str_mv International Society for Fluoride Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269734107611136
score 13.13397

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