Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives

Autores
Labovsky, Vivian; Martinez, Leandro Marcelo; Calcagno, María; Davies, Kevin; Wenicke, Alejandra; Garcia Rivello, Hernan; Fernández Vallone, Valeria Beatriz; Chasseing, Norma Alejandra
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Despite recent major advance in the understanding of the mechanisms of breast cancer (BC) progression and in the development of novel therapeutic modalities, BC remains the second leading cause of mortality among women. Mortality is almost invariably due to metastasis. The different histological subtypes of BC and molecular maker expression (ER, PR and HER2) have strong prognostic and predictive values but are not enough to prevent that BC patients (BCP) develop a relapse and metastasis. So the aim of this work was the simultaneous evaluation of the expression of biomarkers related to BC progression and metastasis (OPG, TRAIL, TRAIL receptores (R) [R1, R2, R3 y R4], RANKL, RANK (RANKL-R), SDF-1, CXCR-4 (SDF-1-R), IL-6, IL-6-R, MCSF and M-CSF-R in BC cells together with the study of classic prognostic parameters (age, ER, PR, HER2, tumor size and histological grade) in BCP. Regarding the expression of these biomarkers in BC cells, the results are contradictory.
Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calcagno, María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Davies, Kevin. Hospital Italiano de La Plata; Argentina
Fil: Wenicke, Alejandra. Hospital Italiano; Argentina
Fil: Garcia Rivello, Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Fernández Vallone, Valeria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Special Conference on Tumor Invasion and Metastasis
Philadelphia
Estados Unidos
American Association for Cancer Research
Materia
BREAST CANCER
METASTAIS
BIOMARKERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/149760
Acceder
id CONICETDig_21ed7f5b9610e0c435f3ccc40124c8d1
oai_identifier_str oai:ri.conicet.gov.ar:11336/149760
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectivesLabovsky, VivianMartinez, Leandro MarceloCalcagno, MaríaDavies, KevinWenicke, AlejandraGarcia Rivello, HernanFernández Vallone, Valeria BeatrizChasseing, Norma AlejandraBREAST CANCERMETASTAISBIOMARKERShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Despite recent major advance in the understanding of the mechanisms of breast cancer (BC) progression and in the development of novel therapeutic modalities, BC remains the second leading cause of mortality among women. Mortality is almost invariably due to metastasis. The different histological subtypes of BC and molecular maker expression (ER, PR and HER2) have strong prognostic and predictive values but are not enough to prevent that BC patients (BCP) develop a relapse and metastasis. So the aim of this work was the simultaneous evaluation of the expression of biomarkers related to BC progression and metastasis (OPG, TRAIL, TRAIL receptores (R) [R1, R2, R3 y R4], RANKL, RANK (RANKL-R), SDF-1, CXCR-4 (SDF-1-R), IL-6, IL-6-R, MCSF and M-CSF-R in BC cells together with the study of classic prognostic parameters (age, ER, PR, HER2, tumor size and histological grade) in BCP. Regarding the expression of these biomarkers in BC cells, the results are contradictory.Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Calcagno, María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Davies, Kevin. Hospital Italiano de La Plata; ArgentinaFil: Wenicke, Alejandra. Hospital Italiano; ArgentinaFil: Garcia Rivello, Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Fernández Vallone, Valeria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaSpecial Conference on Tumor Invasion and MetastasisPhiladelphiaEstados UnidosAmerican Association for Cancer ResearchAmerican Association for Cancer Research2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/149760Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives; Special Conference on Tumor Invasion and Metastasis; Philadelphia; Estados Unidos; 2013; C16-C160008-54720008-5472CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://cancerres.aacrjournals.org/content/73/3_Supplement/C16info:eu-repo/semantics/altIdentifier/doi/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:11Zoai:ri.conicet.gov.ar:11336/149760instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:12.89CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
title Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
spellingShingle Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
Labovsky, Vivian
BREAST CANCER
METASTAIS
BIOMARKERS
title_short Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
title_full Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
title_fullStr Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
title_full_unstemmed Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
title_sort Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives
dc.creator.none.fl_str_mv Labovsky, Vivian
Martinez, Leandro Marcelo
Calcagno, María
Davies, Kevin
Wenicke, Alejandra
Garcia Rivello, Hernan
Fernández Vallone, Valeria Beatriz
Chasseing, Norma Alejandra
author Labovsky, Vivian
author_facet Labovsky, Vivian
Martinez, Leandro Marcelo
Calcagno, María
Davies, Kevin
Wenicke, Alejandra
Garcia Rivello, Hernan
Fernández Vallone, Valeria Beatriz
Chasseing, Norma Alejandra
author_role author
author2 Martinez, Leandro Marcelo
Calcagno, María
Davies, Kevin
Wenicke, Alejandra
Garcia Rivello, Hernan
Fernández Vallone, Valeria Beatriz
Chasseing, Norma Alejandra
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BREAST CANCER
METASTAIS
BIOMARKERS
topic BREAST CANCER
METASTAIS
BIOMARKERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Despite recent major advance in the understanding of the mechanisms of breast cancer (BC) progression and in the development of novel therapeutic modalities, BC remains the second leading cause of mortality among women. Mortality is almost invariably due to metastasis. The different histological subtypes of BC and molecular maker expression (ER, PR and HER2) have strong prognostic and predictive values but are not enough to prevent that BC patients (BCP) develop a relapse and metastasis. So the aim of this work was the simultaneous evaluation of the expression of biomarkers related to BC progression and metastasis (OPG, TRAIL, TRAIL receptores (R) [R1, R2, R3 y R4], RANKL, RANK (RANKL-R), SDF-1, CXCR-4 (SDF-1-R), IL-6, IL-6-R, MCSF and M-CSF-R in BC cells together with the study of classic prognostic parameters (age, ER, PR, HER2, tumor size and histological grade) in BCP. Regarding the expression of these biomarkers in BC cells, the results are contradictory.
Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calcagno, María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Davies, Kevin. Hospital Italiano de La Plata; Argentina
Fil: Wenicke, Alejandra. Hospital Italiano; Argentina
Fil: Garcia Rivello, Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Fernández Vallone, Valeria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Special Conference on Tumor Invasion and Metastasis
Philadelphia
Estados Unidos
American Association for Cancer Research
description Despite recent major advance in the understanding of the mechanisms of breast cancer (BC) progression and in the development of novel therapeutic modalities, BC remains the second leading cause of mortality among women. Mortality is almost invariably due to metastasis. The different histological subtypes of BC and molecular maker expression (ER, PR and HER2) have strong prognostic and predictive values but are not enough to prevent that BC patients (BCP) develop a relapse and metastasis. So the aim of this work was the simultaneous evaluation of the expression of biomarkers related to BC progression and metastasis (OPG, TRAIL, TRAIL receptores (R) [R1, R2, R3 y R4], RANKL, RANK (RANKL-R), SDF-1, CXCR-4 (SDF-1-R), IL-6, IL-6-R, MCSF and M-CSF-R in BC cells together with the study of classic prognostic parameters (age, ER, PR, HER2, tumor size and histological grade) in BCP. Regarding the expression of these biomarkers in BC cells, the results are contradictory.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Conferencia
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149760
Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives; Special Conference on Tumor Invasion and Metastasis; Philadelphia; Estados Unidos; 2013; C16-C16
0008-5472
0008-5472
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149760
identifier_str_mv Biomarkers of proliferation, survival, and migration of human breast tumor cells: future perspectives; Special Conference on Tumor Invasion and Metastasis; Philadelphia; Estados Unidos; 2013; C16-C16
0008-5472
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://cancerres.aacrjournals.org/content/73/3_Supplement/C16
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268777940516864
score 13.13397

Publicaciones similares