Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis

Autores
Verde, C.; Ferrante, M.; Simpson, M. I.; Babusci, M.; Broglia, G.; Landoni, Maria Fabiana
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Twelve healthy horses were subject to the monoioidoacetate (MIA) carpitis model, which was allowed to develop for 7 days. The horses were then randomly divided into two groups. Group A (control) received an intramuscular injection of normal saline every 4 days for a total of seven injections while group B received 500 mg of a PSGAG (SYNTEX CSY36) intramuscularly every 4 days for seven treatments. Efficacy of the PSGAG was evaluated by three clinical outcomes: lameness score, carpal circumference and maximum carpal flexion. Clinical outcomes were measured on days -8 (previous to carpitis induction), 0 (previous to drug treatment), 7, 14, 21, 28 and 35. Areas under the curve clinical outcome as function of time were built and used as variables for the statistical analysis. There was less joint circumference enlargement and lameness and greater carpal flexion in PSGAG-treated horses compared with that in controls. The studied compound has demonstrated to be efficacious on the treatment of a chemically induced carpitis in horses.
Fil: Verde, C.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Ferrante, M.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Simpson, M. I.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Babusci, M.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Broglia, G.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
PSGAGs
intramuscular
arthritis
horses
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242784
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitisVerde, C.Ferrante, M.Simpson, M. I.Babusci, M.Broglia, G.Landoni, Maria FabianaPSGAGsintramusculararthritishorseshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Twelve healthy horses were subject to the monoioidoacetate (MIA) carpitis model, which was allowed to develop for 7 days. The horses were then randomly divided into two groups. Group A (control) received an intramuscular injection of normal saline every 4 days for a total of seven injections while group B received 500 mg of a PSGAG (SYNTEX CSY36) intramuscularly every 4 days for seven treatments. Efficacy of the PSGAG was evaluated by three clinical outcomes: lameness score, carpal circumference and maximum carpal flexion. Clinical outcomes were measured on days -8 (previous to carpitis induction), 0 (previous to drug treatment), 7, 14, 21, 28 and 35. Areas under the curve clinical outcome as function of time were built and used as variables for the statistical analysis. There was less joint circumference enlargement and lameness and greater carpal flexion in PSGAG-treated horses compared with that in controls. The studied compound has demonstrated to be efficacious on the treatment of a chemically induced carpitis in horses.Fil: Verde, C.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Ferrante, M.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Simpson, M. I.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Babusci, M.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Broglia, G.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaWiley Blackwell Publishing, Inc2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242784Verde, C.; Ferrante, M.; Simpson, M. I.; Babusci, M.; Broglia, G.; et al.; Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 33; 4; 7-2010; 357-3620140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2885.2009.01154.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2009.01154.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:13:31Zoai:ri.conicet.gov.ar:11336/242784instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:13:32.141CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
title Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
spellingShingle Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
Verde, C.
PSGAGs
intramuscular
arthritis
horses
title_short Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
title_full Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
title_fullStr Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
title_full_unstemmed Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
title_sort Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis
dc.creator.none.fl_str_mv Verde, C.
Ferrante, M.
Simpson, M. I.
Babusci, M.
Broglia, G.
Landoni, Maria Fabiana
author Verde, C.
author_facet Verde, C.
Ferrante, M.
Simpson, M. I.
Babusci, M.
Broglia, G.
Landoni, Maria Fabiana
author_role author
author2 Ferrante, M.
Simpson, M. I.
Babusci, M.
Broglia, G.
Landoni, Maria Fabiana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv PSGAGs
intramuscular
arthritis
horses
topic PSGAGs
intramuscular
arthritis
horses
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Twelve healthy horses were subject to the monoioidoacetate (MIA) carpitis model, which was allowed to develop for 7 days. The horses were then randomly divided into two groups. Group A (control) received an intramuscular injection of normal saline every 4 days for a total of seven injections while group B received 500 mg of a PSGAG (SYNTEX CSY36) intramuscularly every 4 days for seven treatments. Efficacy of the PSGAG was evaluated by three clinical outcomes: lameness score, carpal circumference and maximum carpal flexion. Clinical outcomes were measured on days -8 (previous to carpitis induction), 0 (previous to drug treatment), 7, 14, 21, 28 and 35. Areas under the curve clinical outcome as function of time were built and used as variables for the statistical analysis. There was less joint circumference enlargement and lameness and greater carpal flexion in PSGAG-treated horses compared with that in controls. The studied compound has demonstrated to be efficacious on the treatment of a chemically induced carpitis in horses.
Fil: Verde, C.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Ferrante, M.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Simpson, M. I.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Babusci, M.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Broglia, G.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Twelve healthy horses were subject to the monoioidoacetate (MIA) carpitis model, which was allowed to develop for 7 days. The horses were then randomly divided into two groups. Group A (control) received an intramuscular injection of normal saline every 4 days for a total of seven injections while group B received 500 mg of a PSGAG (SYNTEX CSY36) intramuscularly every 4 days for seven treatments. Efficacy of the PSGAG was evaluated by three clinical outcomes: lameness score, carpal circumference and maximum carpal flexion. Clinical outcomes were measured on days -8 (previous to carpitis induction), 0 (previous to drug treatment), 7, 14, 21, 28 and 35. Areas under the curve clinical outcome as function of time were built and used as variables for the statistical analysis. There was less joint circumference enlargement and lameness and greater carpal flexion in PSGAG-treated horses compared with that in controls. The studied compound has demonstrated to be efficacious on the treatment of a chemically induced carpitis in horses.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242784
Verde, C.; Ferrante, M.; Simpson, M. I.; Babusci, M.; Broglia, G.; et al.; Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 33; 4; 7-2010; 357-362
0140-7783
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242784
identifier_str_mv Verde, C.; Ferrante, M.; Simpson, M. I.; Babusci, M.; Broglia, G.; et al.; Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 33; 4; 7-2010; 357-362
0140-7783
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2885.2009.01154.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2009.01154.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083282952781824
score 13.22299

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