Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity

Autores
Pirola, Carlos Jose; Sookoian, Silvia Cristina
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The knowledge accumulated over the past two decades has revealed that the natural history of metabolic dysfunction-associated steatotic liver disease (MASLD) and the drivers of the disease severity are not only complex but also exhibit variation among patients. This intricate clinical scenario entails major therapeutic and management implications. In this review, we provide a comprehensive examination of recent advancements in our understanding of MASLD heterogeneity, drawing insights from multiomics and panomics studies. The discussion herein explores the instrumental role of panomics in MASLD research, elucidating the potential for the identification of molecular subtypes that exhibit divergent survival outcomes or heterogeneous responses to various treatments. Furthermore, we provide insights into the challenges in addressing disease heterogeneity and potential solutions. Finally, the most advanced technological advancements and prospective research directions in the domain of MASLD research are delineated, with the objective of facilitating the implementation of personalized diagnosis and interventions.
Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides. Facultad de Ciencias de la Salud. Centro de Investigación Traslacional en Salud;
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides. Facultad de Ciencias de la Salud. Centro de Investigación Traslacional en Salud;
Materia
MASLD
MASH
OMICS
PANOMICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/285333
Acceder
id CONICETDig_20be2c7b5d08845184203b3f39353f47
oai_identifier_str oai:ri.conicet.gov.ar:11336/285333
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneityPirola, Carlos JoseSookoian, Silvia CristinaMASLDMASHOMICSPANOMICShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The knowledge accumulated over the past two decades has revealed that the natural history of metabolic dysfunction-associated steatotic liver disease (MASLD) and the drivers of the disease severity are not only complex but also exhibit variation among patients. This intricate clinical scenario entails major therapeutic and management implications. In this review, we provide a comprehensive examination of recent advancements in our understanding of MASLD heterogeneity, drawing insights from multiomics and panomics studies. The discussion herein explores the instrumental role of panomics in MASLD research, elucidating the potential for the identification of molecular subtypes that exhibit divergent survival outcomes or heterogeneous responses to various treatments. Furthermore, we provide insights into the challenges in addressing disease heterogeneity and potential solutions. Finally, the most advanced technological advancements and prospective research directions in the domain of MASLD research are delineated, with the objective of facilitating the implementation of personalized diagnosis and interventions.Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides. Facultad de Ciencias de la Salud. Centro de Investigación Traslacional en Salud;Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides. Facultad de Ciencias de la Salud. Centro de Investigación Traslacional en Salud;Korean Association for the Study of the Liver2026-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/285333Pirola, Carlos Jose; Sookoian, Silvia Cristina; Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity; Korean Association for the Study of the Liver; Clinical and Molecular Hepatology; 32; 1; 1-2026; 156-1692287-27282287-285XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.e-cmh.org/journal/view.php?doi=10.3350/cmh.2025.0960info:eu-repo/semantics/altIdentifier/doi/10.3350/cmh.2025.0960info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-06-17T09:41:10Zoai:ri.conicet.gov.ar:11336/285333instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-06-17 09:41:10.941CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
title Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
spellingShingle Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
Pirola, Carlos Jose
MASLD
MASH
OMICS
PANOMICS
title_short Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
title_full Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
title_fullStr Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
title_full_unstemmed Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
title_sort Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity
dc.creator.none.fl_str_mv Pirola, Carlos Jose
Sookoian, Silvia Cristina
author Pirola, Carlos Jose
author_facet Pirola, Carlos Jose
Sookoian, Silvia Cristina
author_role author
author2 Sookoian, Silvia Cristina
author2_role author
dc.subject.none.fl_str_mv MASLD
MASH
OMICS
PANOMICS
topic MASLD
MASH
OMICS
PANOMICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The knowledge accumulated over the past two decades has revealed that the natural history of metabolic dysfunction-associated steatotic liver disease (MASLD) and the drivers of the disease severity are not only complex but also exhibit variation among patients. This intricate clinical scenario entails major therapeutic and management implications. In this review, we provide a comprehensive examination of recent advancements in our understanding of MASLD heterogeneity, drawing insights from multiomics and panomics studies. The discussion herein explores the instrumental role of panomics in MASLD research, elucidating the potential for the identification of molecular subtypes that exhibit divergent survival outcomes or heterogeneous responses to various treatments. Furthermore, we provide insights into the challenges in addressing disease heterogeneity and potential solutions. Finally, the most advanced technological advancements and prospective research directions in the domain of MASLD research are delineated, with the objective of facilitating the implementation of personalized diagnosis and interventions.
Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides. Facultad de Ciencias de la Salud. Centro de Investigación Traslacional en Salud;
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides. Facultad de Ciencias de la Salud. Centro de Investigación Traslacional en Salud;
description The knowledge accumulated over the past two decades has revealed that the natural history of metabolic dysfunction-associated steatotic liver disease (MASLD) and the drivers of the disease severity are not only complex but also exhibit variation among patients. This intricate clinical scenario entails major therapeutic and management implications. In this review, we provide a comprehensive examination of recent advancements in our understanding of MASLD heterogeneity, drawing insights from multiomics and panomics studies. The discussion herein explores the instrumental role of panomics in MASLD research, elucidating the potential for the identification of molecular subtypes that exhibit divergent survival outcomes or heterogeneous responses to various treatments. Furthermore, we provide insights into the challenges in addressing disease heterogeneity and potential solutions. Finally, the most advanced technological advancements and prospective research directions in the domain of MASLD research are delineated, with the objective of facilitating the implementation of personalized diagnosis and interventions.
publishDate 2026
dc.date.none.fl_str_mv 2026-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/285333
Pirola, Carlos Jose; Sookoian, Silvia Cristina; Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity; Korean Association for the Study of the Liver; Clinical and Molecular Hepatology; 32; 1; 1-2026; 156-169
2287-2728
2287-285X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/285333
identifier_str_mv Pirola, Carlos Jose; Sookoian, Silvia Cristina; Panomics in metabolic dysfunction-associated steatotic liver disease: Unravelling the drivers of disease heterogeneity; Korean Association for the Study of the Liver; Clinical and Molecular Hepatology; 32; 1; 1-2026; 156-169
2287-2728
2287-285X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.e-cmh.org/journal/view.php?doi=10.3350/cmh.2025.0960
info:eu-repo/semantics/altIdentifier/doi/10.3350/cmh.2025.0960
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Korean Association for the Study of the Liver
publisher.none.fl_str_mv Korean Association for the Study of the Liver
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1868339015619444736
score 13.040872

Publicaciones similares