Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water

Autores
Mozo, Joaquín; Decundo, Julieta María; Martínez, Guadalupe; Dieguez, Susana Nelly; Soraci, Alejandro Luis; Pérez, Denisa Soledad
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
In intensive pig farming, the irracional use of antibiotics has diminished their effectiveness and fostered the emergence and spread of antibiotic-resistant strains. Since these antibiotics are not completely metabolized, they can be released into the environment through animal waste, resulting in detectable levels in manure, soil, and both groundwater and surface waters. Nevertheless, thorough monitoring is still lacking. This study aimed to investigate the presence of residual amoxicillin (AMOXI) and oxytetracycline (OTC) which Transfer from pig feces to runoff water.Fecal samples (100 g) from untreated pigs were fortified by triplicate with AMOXI and OTC, considering therapeutic doses and bioavailability (20 mg/kg and 36% and 40 mg/kg and 6%, respectively) to simulate real levels. The excreta were left outdoors on a sloped area with natural vegetation for 30 days. Runoff water samples were collected alter precipitation events using passive collectors placed downslope. Analytical studies were conducted using HPLC-UV at the Toxicology Laboratory, Department of Physiopathology, CIVETAN.Five precipitation events occurred during the assay period on days 4, 8, 9, 11, and21. For AMOXI, average residual concentrations (0.06 pg/ml) were observed from day 4to 11, with the highest (0.10 pg/ml) on day 9. For OTC, residuals (0.13 pg/ml) were detected from the first rainfall through day 21, with peaks (0.14 pg/ml) on days 8, 9, and 11. Although AMOXI concentrations appea r lower than those of OTC, it is important to consider the different initial fortification doses; when adjusted for these differences, AMOXI levels are 2.36 times greater than those of OTC.Notably, AMOXI was present in higher proportions over a shorter period, while OTC persisted longer, being detected in the last rainfall sample. In conclusion, both antibiotics were found in runoff water, indicating potential risks to ecosystems and public health, emphasizing the need for systematic monitoring.
Fil: Mozo, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Decundo, Julieta María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Martínez, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dieguez, Susana Nelly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental
Bahía Blanca
Argentina
Asociación Argentina de Farmacología Experimental
Universidad Nacional del Sur
Materia
SWINE FACES
RESIDUAL ANTIBIOTICS
RUNOFF WATER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279426
Acceder
id CONICETDig_20a004a0123fabe485a536faa59ebe0e
oai_identifier_str oai:ri.conicet.gov.ar:11336/279426
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff waterMozo, JoaquínDecundo, Julieta MaríaMartínez, GuadalupeDieguez, Susana NellySoraci, Alejandro LuisPérez, Denisa SoledadSWINE FACESRESIDUAL ANTIBIOTICSRUNOFF WATERhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4In intensive pig farming, the irracional use of antibiotics has diminished their effectiveness and fostered the emergence and spread of antibiotic-resistant strains. Since these antibiotics are not completely metabolized, they can be released into the environment through animal waste, resulting in detectable levels in manure, soil, and both groundwater and surface waters. Nevertheless, thorough monitoring is still lacking. This study aimed to investigate the presence of residual amoxicillin (AMOXI) and oxytetracycline (OTC) which Transfer from pig feces to runoff water.Fecal samples (100 g) from untreated pigs were fortified by triplicate with AMOXI and OTC, considering therapeutic doses and bioavailability (20 mg/kg and 36% and 40 mg/kg and 6%, respectively) to simulate real levels. The excreta were left outdoors on a sloped area with natural vegetation for 30 days. Runoff water samples were collected alter precipitation events using passive collectors placed downslope. Analytical studies were conducted using HPLC-UV at the Toxicology Laboratory, Department of Physiopathology, CIVETAN.Five precipitation events occurred during the assay period on days 4, 8, 9, 11, and21. For AMOXI, average residual concentrations (0.06 pg/ml) were observed from day 4to 11, with the highest (0.10 pg/ml) on day 9. For OTC, residuals (0.13 pg/ml) were detected from the first rainfall through day 21, with peaks (0.14 pg/ml) on days 8, 9, and 11. Although AMOXI concentrations appea r lower than those of OTC, it is important to consider the different initial fortification doses; when adjusted for these differences, AMOXI levels are 2.36 times greater than those of OTC.Notably, AMOXI was present in higher proportions over a shorter period, while OTC persisted longer, being detected in the last rainfall sample. In conclusion, both antibiotics were found in runoff water, indicating potential risks to ecosystems and public health, emphasizing the need for systematic monitoring.Fil: Mozo, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Decundo, Julieta María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Martínez, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dieguez, Susana Nelly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaLVI Reunión Anual de la Asociación Argentina de Farmacología ExperimentalBahía BlancaArgentinaAsociación Argentina de Farmacología ExperimentalUniversidad Nacional del SurAsociación Argentina de Farmacología Experimental2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279426Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 101-101978-631-90806-0-5CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:22:21Zoai:ri.conicet.gov.ar:11336/279426instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:22:21.916CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
title Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
spellingShingle Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
Mozo, Joaquín
SWINE FACES
RESIDUAL ANTIBIOTICS
RUNOFF WATER
title_short Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
title_full Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
title_fullStr Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
title_full_unstemmed Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
title_sort Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water
dc.creator.none.fl_str_mv Mozo, Joaquín
Decundo, Julieta María
Martínez, Guadalupe
Dieguez, Susana Nelly
Soraci, Alejandro Luis
Pérez, Denisa Soledad
author Mozo, Joaquín
author_facet Mozo, Joaquín
Decundo, Julieta María
Martínez, Guadalupe
Dieguez, Susana Nelly
Soraci, Alejandro Luis
Pérez, Denisa Soledad
author_role author
author2 Decundo, Julieta María
Martínez, Guadalupe
Dieguez, Susana Nelly
Soraci, Alejandro Luis
Pérez, Denisa Soledad
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv SWINE FACES
RESIDUAL ANTIBIOTICS
RUNOFF WATER
topic SWINE FACES
RESIDUAL ANTIBIOTICS
RUNOFF WATER
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv In intensive pig farming, the irracional use of antibiotics has diminished their effectiveness and fostered the emergence and spread of antibiotic-resistant strains. Since these antibiotics are not completely metabolized, they can be released into the environment through animal waste, resulting in detectable levels in manure, soil, and both groundwater and surface waters. Nevertheless, thorough monitoring is still lacking. This study aimed to investigate the presence of residual amoxicillin (AMOXI) and oxytetracycline (OTC) which Transfer from pig feces to runoff water.Fecal samples (100 g) from untreated pigs were fortified by triplicate with AMOXI and OTC, considering therapeutic doses and bioavailability (20 mg/kg and 36% and 40 mg/kg and 6%, respectively) to simulate real levels. The excreta were left outdoors on a sloped area with natural vegetation for 30 days. Runoff water samples were collected alter precipitation events using passive collectors placed downslope. Analytical studies were conducted using HPLC-UV at the Toxicology Laboratory, Department of Physiopathology, CIVETAN.Five precipitation events occurred during the assay period on days 4, 8, 9, 11, and21. For AMOXI, average residual concentrations (0.06 pg/ml) were observed from day 4to 11, with the highest (0.10 pg/ml) on day 9. For OTC, residuals (0.13 pg/ml) were detected from the first rainfall through day 21, with peaks (0.14 pg/ml) on days 8, 9, and 11. Although AMOXI concentrations appea r lower than those of OTC, it is important to consider the different initial fortification doses; when adjusted for these differences, AMOXI levels are 2.36 times greater than those of OTC.Notably, AMOXI was present in higher proportions over a shorter period, while OTC persisted longer, being detected in the last rainfall sample. In conclusion, both antibiotics were found in runoff water, indicating potential risks to ecosystems and public health, emphasizing the need for systematic monitoring.
Fil: Mozo, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Decundo, Julieta María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Martínez, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dieguez, Susana Nelly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental
Bahía Blanca
Argentina
Asociación Argentina de Farmacología Experimental
Universidad Nacional del Sur
description In intensive pig farming, the irracional use of antibiotics has diminished their effectiveness and fostered the emergence and spread of antibiotic-resistant strains. Since these antibiotics are not completely metabolized, they can be released into the environment through animal waste, resulting in detectable levels in manure, soil, and both groundwater and surface waters. Nevertheless, thorough monitoring is still lacking. This study aimed to investigate the presence of residual amoxicillin (AMOXI) and oxytetracycline (OTC) which Transfer from pig feces to runoff water.Fecal samples (100 g) from untreated pigs were fortified by triplicate with AMOXI and OTC, considering therapeutic doses and bioavailability (20 mg/kg and 36% and 40 mg/kg and 6%, respectively) to simulate real levels. The excreta were left outdoors on a sloped area with natural vegetation for 30 days. Runoff water samples were collected alter precipitation events using passive collectors placed downslope. Analytical studies were conducted using HPLC-UV at the Toxicology Laboratory, Department of Physiopathology, CIVETAN.Five precipitation events occurred during the assay period on days 4, 8, 9, 11, and21. For AMOXI, average residual concentrations (0.06 pg/ml) were observed from day 4to 11, with the highest (0.10 pg/ml) on day 9. For OTC, residuals (0.13 pg/ml) were detected from the first rainfall through day 21, with peaks (0.14 pg/ml) on days 8, 9, and 11. Although AMOXI concentrations appea r lower than those of OTC, it is important to consider the different initial fortification doses; when adjusted for these differences, AMOXI levels are 2.36 times greater than those of OTC.Notably, AMOXI was present in higher proportions over a shorter period, while OTC persisted longer, being detected in the last rainfall sample. In conclusion, both antibiotics were found in runoff water, indicating potential risks to ecosystems and public health, emphasizing the need for systematic monitoring.
publishDate 2024
dc.date.none.fl_str_mv 2024
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info:eu-repo/semantics/conferenceObject
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Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279426
Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 101-101
978-631-90806-0-5
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279426
identifier_str_mv Swine faces as a source of residual amoxicillin and oxytetracycline concentrations in runoff water; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 101-101
978-631-90806-0-5
CONICET Digital
CONICET
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language eng
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dc.publisher.none.fl_str_mv Asociación Argentina de Farmacología Experimental
publisher.none.fl_str_mv Asociación Argentina de Farmacología Experimental
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