Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster
- Autores
- Arora, Natasha; Schuenemann, Verena J.; Jäger, Hünter; Peltzer, Alexander; Seitz, Alexander; Herbig, Alexander; Strouhal, Michal; Grillová, Linda; Sánchez Busó, Leonor; Kühnert, Denise; Bos, Kirsten I.; Davis Rivero, Leyla; Mikalová, Lenka; Bruisten, Sylvia; Komericki, Peter; French, Patrick; Grant, Paul R.; Pando, María de los Ángeles; Gallo Vaulet, Maria Lucia; Rodríguez Fermepin, Marcelo; Martinez, Antonio; Lara, Arturo Centurión; Giacani, Lorenzo; Norris, Steven J.; Smajs, David; Bosshard, Philipp P.; González Candelas, Fernando; Nieselt, Kay; Krause, Johannes; Bagheri, Homayoun C.
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1 . Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster.
Fil: Arora, Natasha. Universitat Zurich; Suiza
Fil: Schuenemann, Verena J.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania
Fil: Jäger, Hünter. Eberhard Karls Universität Tübingen.; Alemania
Fil: Peltzer, Alexander. Eberhard Karls Universität Tübingen.; Alemania
Fil: Seitz, Alexander. Eberhard Karls Universität Tübingen.; Alemania
Fil: Herbig, Alexander. Eberhard Karls Universität Tübingen.; Alemania
Fil: Strouhal, Michal. Masaryk University; República Checa
Fil: Grillová, Linda. Masaryk University; República Checa
Fil: Sánchez Busó, Leonor. Universidad de Valencia; España. University of Cambridge; Reino Unido
Fil: Kühnert, Denise. Universitat Zurich; Suiza
Fil: Bos, Kirsten I.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania
Fil: Davis Rivero, Leyla. Universitat Zurich; Suiza
Fil: Mikalová, Lenka. Masaryk University; República Checa
Fil: Bruisten, Sylvia. Public Health Laboratory. Department of Infectious Diseases; Países Bajos
Fil: Komericki, Peter. Medical University of Graz; Austria
Fil: French, Patrick. The Mortimer Market Centre ; Reino Unido
Fil: Grant, Paul R.. University College London; Estados Unidos
Fil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; Argentina
Fil: Gallo Vaulet, Maria Lucia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Rodríguez Fermepin, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Martinez, Antonio. Hospital General Universitario de Valencia; España
Fil: Lara, Arturo Centurión. University of Washington; Estados Unidos
Fil: Giacani, Lorenzo. University of Washington; Estados Unidos
Fil: Norris, Steven J.. UTHealth McGovern Medical School. Department of Pathology and Laboratory Medicine; Estados Unidos
Fil: Smajs, David. Masaryk University; República Checa
Fil: Bosshard, Philipp P.. Universitat Zurich; Suiza
Fil: González Candelas, Fernando. Universidad de Valencia; España
Fil: Nieselt, Kay. Eberhard Karls Universität Tübingen.; Alemania
Fil: Krause, Johannes. Eberhard Karls Universität Tübingen.; Alemania
Fil: Bagheri, Homayoun C.. Universitat Zurich; Suiza - Materia
-
TREPONEMA PALLIDUM
ORIGIN OF SYPHILIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/112201
Ver los metadatos del registro completo
| id |
CONICETDig_208c801dce8ea2f7d63ff87172a94a6f |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/112201 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum clusterArora, NatashaSchuenemann, Verena J.Jäger, HünterPeltzer, AlexanderSeitz, AlexanderHerbig, AlexanderStrouhal, MichalGrillová, LindaSánchez Busó, LeonorKühnert, DeniseBos, Kirsten I.Davis Rivero, LeylaMikalová, LenkaBruisten, SylviaKomericki, PeterFrench, PatrickGrant, Paul R.Pando, María de los ÁngelesGallo Vaulet, Maria LuciaRodríguez Fermepin, MarceloMartinez, AntonioLara, Arturo CenturiónGiacani, LorenzoNorris, Steven J.Smajs, DavidBosshard, Philipp P.González Candelas, FernandoNieselt, KayKrause, JohannesBagheri, Homayoun C.TREPONEMA PALLIDUMORIGIN OF SYPHILIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1 . Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster.Fil: Arora, Natasha. Universitat Zurich; SuizaFil: Schuenemann, Verena J.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; AlemaniaFil: Jäger, Hünter. Eberhard Karls Universität Tübingen.; AlemaniaFil: Peltzer, Alexander. Eberhard Karls Universität Tübingen.; AlemaniaFil: Seitz, Alexander. Eberhard Karls Universität Tübingen.; AlemaniaFil: Herbig, Alexander. Eberhard Karls Universität Tübingen.; AlemaniaFil: Strouhal, Michal. Masaryk University; República ChecaFil: Grillová, Linda. Masaryk University; República ChecaFil: Sánchez Busó, Leonor. Universidad de Valencia; España. University of Cambridge; Reino UnidoFil: Kühnert, Denise. Universitat Zurich; SuizaFil: Bos, Kirsten I.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; AlemaniaFil: Davis Rivero, Leyla. Universitat Zurich; SuizaFil: Mikalová, Lenka. Masaryk University; República ChecaFil: Bruisten, Sylvia. Public Health Laboratory. Department of Infectious Diseases; Países BajosFil: Komericki, Peter. Medical University of Graz; AustriaFil: French, Patrick. The Mortimer Market Centre ; Reino UnidoFil: Grant, Paul R.. University College London; Estados UnidosFil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; ArgentinaFil: Gallo Vaulet, Maria Lucia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Rodríguez Fermepin, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Martinez, Antonio. Hospital General Universitario de Valencia; EspañaFil: Lara, Arturo Centurión. University of Washington; Estados UnidosFil: Giacani, Lorenzo. University of Washington; Estados UnidosFil: Norris, Steven J.. UTHealth McGovern Medical School. Department of Pathology and Laboratory Medicine; Estados UnidosFil: Smajs, David. Masaryk University; República ChecaFil: Bosshard, Philipp P.. Universitat Zurich; SuizaFil: González Candelas, Fernando. Universidad de Valencia; EspañaFil: Nieselt, Kay. Eberhard Karls Universität Tübingen.; AlemaniaFil: Krause, Johannes. Eberhard Karls Universität Tübingen.; AlemaniaFil: Bagheri, Homayoun C.. Universitat Zurich; SuizaSpringer2016-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112201Arora, Natasha; Schuenemann, Verena J.; Jäger, Hünter; Peltzer, Alexander; Seitz, Alexander; et al.; Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster; Springer; Nature Microbiology; 2; 16245; 11-2016; 1-62058-5276CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/NMICROBIOL.2016.245info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nmicrobiol2016245info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:10Zoai:ri.conicet.gov.ar:11336/112201instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:10.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| title |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| spellingShingle |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster Arora, Natasha TREPONEMA PALLIDUM ORIGIN OF SYPHILIS |
| title_short |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| title_full |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| title_fullStr |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| title_full_unstemmed |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| title_sort |
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster |
| dc.creator.none.fl_str_mv |
Arora, Natasha Schuenemann, Verena J. Jäger, Hünter Peltzer, Alexander Seitz, Alexander Herbig, Alexander Strouhal, Michal Grillová, Linda Sánchez Busó, Leonor Kühnert, Denise Bos, Kirsten I. Davis Rivero, Leyla Mikalová, Lenka Bruisten, Sylvia Komericki, Peter French, Patrick Grant, Paul R. Pando, María de los Ángeles Gallo Vaulet, Maria Lucia Rodríguez Fermepin, Marcelo Martinez, Antonio Lara, Arturo Centurión Giacani, Lorenzo Norris, Steven J. Smajs, David Bosshard, Philipp P. González Candelas, Fernando Nieselt, Kay Krause, Johannes Bagheri, Homayoun C. |
| author |
Arora, Natasha |
| author_facet |
Arora, Natasha Schuenemann, Verena J. Jäger, Hünter Peltzer, Alexander Seitz, Alexander Herbig, Alexander Strouhal, Michal Grillová, Linda Sánchez Busó, Leonor Kühnert, Denise Bos, Kirsten I. Davis Rivero, Leyla Mikalová, Lenka Bruisten, Sylvia Komericki, Peter French, Patrick Grant, Paul R. Pando, María de los Ángeles Gallo Vaulet, Maria Lucia Rodríguez Fermepin, Marcelo Martinez, Antonio Lara, Arturo Centurión Giacani, Lorenzo Norris, Steven J. Smajs, David Bosshard, Philipp P. González Candelas, Fernando Nieselt, Kay Krause, Johannes Bagheri, Homayoun C. |
| author_role |
author |
| author2 |
Schuenemann, Verena J. Jäger, Hünter Peltzer, Alexander Seitz, Alexander Herbig, Alexander Strouhal, Michal Grillová, Linda Sánchez Busó, Leonor Kühnert, Denise Bos, Kirsten I. Davis Rivero, Leyla Mikalová, Lenka Bruisten, Sylvia Komericki, Peter French, Patrick Grant, Paul R. Pando, María de los Ángeles Gallo Vaulet, Maria Lucia Rodríguez Fermepin, Marcelo Martinez, Antonio Lara, Arturo Centurión Giacani, Lorenzo Norris, Steven J. Smajs, David Bosshard, Philipp P. González Candelas, Fernando Nieselt, Kay Krause, Johannes Bagheri, Homayoun C. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
TREPONEMA PALLIDUM ORIGIN OF SYPHILIS |
| topic |
TREPONEMA PALLIDUM ORIGIN OF SYPHILIS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1 . Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster. Fil: Arora, Natasha. Universitat Zurich; Suiza Fil: Schuenemann, Verena J.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania Fil: Jäger, Hünter. Eberhard Karls Universität Tübingen.; Alemania Fil: Peltzer, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Seitz, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Herbig, Alexander. Eberhard Karls Universität Tübingen.; Alemania Fil: Strouhal, Michal. Masaryk University; República Checa Fil: Grillová, Linda. Masaryk University; República Checa Fil: Sánchez Busó, Leonor. Universidad de Valencia; España. University of Cambridge; Reino Unido Fil: Kühnert, Denise. Universitat Zurich; Suiza Fil: Bos, Kirsten I.. Eberhard Karls Universität Tübingen. Institute For Archaeological Sciences.; Alemania Fil: Davis Rivero, Leyla. Universitat Zurich; Suiza Fil: Mikalová, Lenka. Masaryk University; República Checa Fil: Bruisten, Sylvia. Public Health Laboratory. Department of Infectious Diseases; Países Bajos Fil: Komericki, Peter. Medical University of Graz; Austria Fil: French, Patrick. The Mortimer Market Centre ; Reino Unido Fil: Grant, Paul R.. University College London; Estados Unidos Fil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; Argentina Fil: Gallo Vaulet, Maria Lucia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Rodríguez Fermepin, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina Fil: Martinez, Antonio. Hospital General Universitario de Valencia; España Fil: Lara, Arturo Centurión. University of Washington; Estados Unidos Fil: Giacani, Lorenzo. University of Washington; Estados Unidos Fil: Norris, Steven J.. UTHealth McGovern Medical School. Department of Pathology and Laboratory Medicine; Estados Unidos Fil: Smajs, David. Masaryk University; República Checa Fil: Bosshard, Philipp P.. Universitat Zurich; Suiza Fil: González Candelas, Fernando. Universidad de Valencia; España Fil: Nieselt, Kay. Eberhard Karls Universität Tübingen.; Alemania Fil: Krause, Johannes. Eberhard Karls Universität Tübingen.; Alemania Fil: Bagheri, Homayoun C.. Universitat Zurich; Suiza |
| description |
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1 . Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the secondline antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-11 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/112201 Arora, Natasha; Schuenemann, Verena J.; Jäger, Hünter; Peltzer, Alexander; Seitz, Alexander; et al.; Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster; Springer; Nature Microbiology; 2; 16245; 11-2016; 1-6 2058-5276 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/112201 |
| identifier_str_mv |
Arora, Natasha; Schuenemann, Verena J.; Jäger, Hünter; Peltzer, Alexander; Seitz, Alexander; et al.; Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster; Springer; Nature Microbiology; 2; 16245; 11-2016; 1-6 2058-5276 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/NMICROBIOL.2016.245 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nmicrobiol2016245 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Springer |
| publisher.none.fl_str_mv |
Springer |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1842270148153573376 |
| score |
13.13397 |