Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes

Autores
Valenzuela Alvarez, Matias Juan Pablo; Gutierrez, Luciana Mariel; Correa, Alejandro; Lazarowski, Alberto Jorge; Bolontrade, Marcela Fabiana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mesenchymal stem cells (MSCs) represent an interesting population due to their capacity to release a variety of cytokines, chemokines, and growth factors, and due to their motile nature and homing ability. MSCs can be isolated from dierent sources, like adipose tissue or bone marrow, and have the capacity to dierentiate, both in vivo and in vitro, into adipocytes,chondrocytes, and osteoblasts, making them even more interesting in the regenerative medicinefield. Tumor associated stroma has been recognized as a key element in tumor progression, necessary for the biological success of the tumor, and MSCs represent a functionally fundamental part of this associated stroma. Exosomes represent one of the dominant signaling pathways within the tumor microenvironment. Their biology raises high interest, with implications in dierent biological processes involved in cancer progression, such as the formation of the pre-metastatic niche. This is critical during the metastatic cascade, given that it is the formation of a permissive context that wouldallow metastatic tumor cells survival within the new environment. In this context, we explored the role of exosomes, particularly MSCs-derived exosomes as direct or indirect modulators. All this points out a possible new tool useful for designing better treatment and detection strategies for metastatic progression, including the management of chemoresistance.
Fil: Valenzuela Alvarez, Matias Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Gutierrez, Luciana Mariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Correa, Alejandro. Instituto Carlos Chagas Fiocruz; Brasil
Fil: Lazarowski, Alberto Jorge. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Materia
MESENCHYMAL STEM CELLS
EXOSOMES
PRE-METASTATIC NICHE
METASTASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117497
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/117497
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its ExosomesValenzuela Alvarez, Matias Juan PabloGutierrez, Luciana MarielCorrea, AlejandroLazarowski, Alberto JorgeBolontrade, Marcela FabianaMESENCHYMAL STEM CELLSEXOSOMESPRE-METASTATIC NICHEMETASTASIShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Mesenchymal stem cells (MSCs) represent an interesting population due to their capacity to release a variety of cytokines, chemokines, and growth factors, and due to their motile nature and homing ability. MSCs can be isolated from dierent sources, like adipose tissue or bone marrow, and have the capacity to dierentiate, both in vivo and in vitro, into adipocytes,chondrocytes, and osteoblasts, making them even more interesting in the regenerative medicinefield. Tumor associated stroma has been recognized as a key element in tumor progression, necessary for the biological success of the tumor, and MSCs represent a functionally fundamental part of this associated stroma. Exosomes represent one of the dominant signaling pathways within the tumor microenvironment. Their biology raises high interest, with implications in dierent biological processes involved in cancer progression, such as the formation of the pre-metastatic niche. This is critical during the metastatic cascade, given that it is the formation of a permissive context that wouldallow metastatic tumor cells survival within the new environment. In this context, we explored the role of exosomes, particularly MSCs-derived exosomes as direct or indirect modulators. All this points out a possible new tool useful for designing better treatment and detection strategies for metastatic progression, including the management of chemoresistance.Fil: Valenzuela Alvarez, Matias Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Gutierrez, Luciana Mariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Correa, Alejandro. Instituto Carlos Chagas Fiocruz; BrasilFil: Lazarowski, Alberto Jorge. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaMolecular Diversity Preservation International2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117497Valenzuela Alvarez, Matias Juan Pablo; Gutierrez, Luciana Mariel; Correa, Alejandro; Lazarowski, Alberto Jorge; Bolontrade, Marcela Fabiana; Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 4-2019; 1-171422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/20/8/1946info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:39Zoai:ri.conicet.gov.ar:11336/117497instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:39.866CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
title Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
spellingShingle Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
Valenzuela Alvarez, Matias Juan Pablo
MESENCHYMAL STEM CELLS
EXOSOMES
PRE-METASTATIC NICHE
METASTASIS
title_short Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
title_full Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
title_fullStr Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
title_full_unstemmed Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
title_sort Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes
dc.creator.none.fl_str_mv Valenzuela Alvarez, Matias Juan Pablo
Gutierrez, Luciana Mariel
Correa, Alejandro
Lazarowski, Alberto Jorge
Bolontrade, Marcela Fabiana
author Valenzuela Alvarez, Matias Juan Pablo
author_facet Valenzuela Alvarez, Matias Juan Pablo
Gutierrez, Luciana Mariel
Correa, Alejandro
Lazarowski, Alberto Jorge
Bolontrade, Marcela Fabiana
author_role author
author2 Gutierrez, Luciana Mariel
Correa, Alejandro
Lazarowski, Alberto Jorge
Bolontrade, Marcela Fabiana
author2_role author
author
author
author
dc.subject.none.fl_str_mv MESENCHYMAL STEM CELLS
EXOSOMES
PRE-METASTATIC NICHE
METASTASIS
topic MESENCHYMAL STEM CELLS
EXOSOMES
PRE-METASTATIC NICHE
METASTASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mesenchymal stem cells (MSCs) represent an interesting population due to their capacity to release a variety of cytokines, chemokines, and growth factors, and due to their motile nature and homing ability. MSCs can be isolated from dierent sources, like adipose tissue or bone marrow, and have the capacity to dierentiate, both in vivo and in vitro, into adipocytes,chondrocytes, and osteoblasts, making them even more interesting in the regenerative medicinefield. Tumor associated stroma has been recognized as a key element in tumor progression, necessary for the biological success of the tumor, and MSCs represent a functionally fundamental part of this associated stroma. Exosomes represent one of the dominant signaling pathways within the tumor microenvironment. Their biology raises high interest, with implications in dierent biological processes involved in cancer progression, such as the formation of the pre-metastatic niche. This is critical during the metastatic cascade, given that it is the formation of a permissive context that wouldallow metastatic tumor cells survival within the new environment. In this context, we explored the role of exosomes, particularly MSCs-derived exosomes as direct or indirect modulators. All this points out a possible new tool useful for designing better treatment and detection strategies for metastatic progression, including the management of chemoresistance.
Fil: Valenzuela Alvarez, Matias Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Gutierrez, Luciana Mariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Correa, Alejandro. Instituto Carlos Chagas Fiocruz; Brasil
Fil: Lazarowski, Alberto Jorge. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
description Mesenchymal stem cells (MSCs) represent an interesting population due to their capacity to release a variety of cytokines, chemokines, and growth factors, and due to their motile nature and homing ability. MSCs can be isolated from dierent sources, like adipose tissue or bone marrow, and have the capacity to dierentiate, both in vivo and in vitro, into adipocytes,chondrocytes, and osteoblasts, making them even more interesting in the regenerative medicinefield. Tumor associated stroma has been recognized as a key element in tumor progression, necessary for the biological success of the tumor, and MSCs represent a functionally fundamental part of this associated stroma. Exosomes represent one of the dominant signaling pathways within the tumor microenvironment. Their biology raises high interest, with implications in dierent biological processes involved in cancer progression, such as the formation of the pre-metastatic niche. This is critical during the metastatic cascade, given that it is the formation of a permissive context that wouldallow metastatic tumor cells survival within the new environment. In this context, we explored the role of exosomes, particularly MSCs-derived exosomes as direct or indirect modulators. All this points out a possible new tool useful for designing better treatment and detection strategies for metastatic progression, including the management of chemoresistance.
publishDate 2019
dc.date.none.fl_str_mv 2019-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117497
Valenzuela Alvarez, Matias Juan Pablo; Gutierrez, Luciana Mariel; Correa, Alejandro; Lazarowski, Alberto Jorge; Bolontrade, Marcela Fabiana; Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 4-2019; 1-17
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117497
identifier_str_mv Valenzuela Alvarez, Matias Juan Pablo; Gutierrez, Luciana Mariel; Correa, Alejandro; Lazarowski, Alberto Jorge; Bolontrade, Marcela Fabiana; Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 4-2019; 1-17
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/20/8/1946
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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