Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin

Autores
Bach, Sandra M.; Fortuna, Antonio Mario; Attarian, Rodgoun; de Trimarco, Juliana T.; Catalan, Cesar Atilio Nazareno; Av Gay, Yossef; Bach, Horacio
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The antimicrobial and cytotoxic activities of chloroform extracts from the weeds Centaurea tweediei and C. diffusa, and the main sesquiterpene lactones isolated from these species, onopordopicrin and cnicin, respectively, were assayed. Results show that the chloroform extracts from both Centaurea species possess antibacterial activities against a panel of Gram-positive and Gram-negative bacteria. Remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus was also measured. Both the extracts and the purified sesquiterpene lactones show high cytotoxicity against human-derived macrophages. Despite this cytotoxicity, C. diffusa chloroform extract and cnicin are attractive candidates for evaluation as antibiotics in topical preparations against skin-associated pathogens.
Fil: Bach, Sandra M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. University of British Columbia; Canadá
Fil: Fortuna, Antonio Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia. Departamento de Biología; Argentina
Fil: Attarian, Rodgoun. University of British Columbia; Canadá
Fil: de Trimarco, Juliana T.. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Av Gay, Yossef. University of British Columbia; Canadá
Fil: Bach, Horacio. University of British Columbia; Canadá
Materia
Cnicin
Onopordopicrin
Cytotoxicity
Antibacterial Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52423
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrinBach, Sandra M.Fortuna, Antonio MarioAttarian, Rodgounde Trimarco, Juliana T.Catalan, Cesar Atilio NazarenoAv Gay, YossefBach, HoracioCnicinOnopordopicrinCytotoxicityAntibacterial Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The antimicrobial and cytotoxic activities of chloroform extracts from the weeds Centaurea tweediei and C. diffusa, and the main sesquiterpene lactones isolated from these species, onopordopicrin and cnicin, respectively, were assayed. Results show that the chloroform extracts from both Centaurea species possess antibacterial activities against a panel of Gram-positive and Gram-negative bacteria. Remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus was also measured. Both the extracts and the purified sesquiterpene lactones show high cytotoxicity against human-derived macrophages. Despite this cytotoxicity, C. diffusa chloroform extract and cnicin are attractive candidates for evaluation as antibiotics in topical preparations against skin-associated pathogens.Fil: Bach, Sandra M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. University of British Columbia; CanadáFil: Fortuna, Antonio Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia. Departamento de Biología; ArgentinaFil: Attarian, Rodgoun. University of British Columbia; CanadáFil: de Trimarco, Juliana T.. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Av Gay, Yossef. University of British Columbia; CanadáFil: Bach, Horacio. University of British Columbia; CanadáNatural Products2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52423Bach, Sandra M.; Fortuna, Antonio Mario; Attarian, Rodgoun; de Trimarco, Juliana T.; Catalan, Cesar Atilio Nazareno; et al.; Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin; Natural Products; Natural Product Communications; 6; 2; 1-2011; 163-1661934-578X1555-9475CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1100600202info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:46Zoai:ri.conicet.gov.ar:11336/52423instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:47.077CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
title Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
spellingShingle Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
Bach, Sandra M.
Cnicin
Onopordopicrin
Cytotoxicity
Antibacterial Activity
title_short Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
title_full Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
title_fullStr Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
title_full_unstemmed Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
title_sort Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin
dc.creator.none.fl_str_mv Bach, Sandra M.
Fortuna, Antonio Mario
Attarian, Rodgoun
de Trimarco, Juliana T.
Catalan, Cesar Atilio Nazareno
Av Gay, Yossef
Bach, Horacio
author Bach, Sandra M.
author_facet Bach, Sandra M.
Fortuna, Antonio Mario
Attarian, Rodgoun
de Trimarco, Juliana T.
Catalan, Cesar Atilio Nazareno
Av Gay, Yossef
Bach, Horacio
author_role author
author2 Fortuna, Antonio Mario
Attarian, Rodgoun
de Trimarco, Juliana T.
Catalan, Cesar Atilio Nazareno
Av Gay, Yossef
Bach, Horacio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cnicin
Onopordopicrin
Cytotoxicity
Antibacterial Activity
topic Cnicin
Onopordopicrin
Cytotoxicity
Antibacterial Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The antimicrobial and cytotoxic activities of chloroform extracts from the weeds Centaurea tweediei and C. diffusa, and the main sesquiterpene lactones isolated from these species, onopordopicrin and cnicin, respectively, were assayed. Results show that the chloroform extracts from both Centaurea species possess antibacterial activities against a panel of Gram-positive and Gram-negative bacteria. Remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus was also measured. Both the extracts and the purified sesquiterpene lactones show high cytotoxicity against human-derived macrophages. Despite this cytotoxicity, C. diffusa chloroform extract and cnicin are attractive candidates for evaluation as antibiotics in topical preparations against skin-associated pathogens.
Fil: Bach, Sandra M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. University of British Columbia; Canadá
Fil: Fortuna, Antonio Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia. Departamento de Biología; Argentina
Fil: Attarian, Rodgoun. University of British Columbia; Canadá
Fil: de Trimarco, Juliana T.. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Av Gay, Yossef. University of British Columbia; Canadá
Fil: Bach, Horacio. University of British Columbia; Canadá
description The antimicrobial and cytotoxic activities of chloroform extracts from the weeds Centaurea tweediei and C. diffusa, and the main sesquiterpene lactones isolated from these species, onopordopicrin and cnicin, respectively, were assayed. Results show that the chloroform extracts from both Centaurea species possess antibacterial activities against a panel of Gram-positive and Gram-negative bacteria. Remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus was also measured. Both the extracts and the purified sesquiterpene lactones show high cytotoxicity against human-derived macrophages. Despite this cytotoxicity, C. diffusa chloroform extract and cnicin are attractive candidates for evaluation as antibiotics in topical preparations against skin-associated pathogens.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52423
Bach, Sandra M.; Fortuna, Antonio Mario; Attarian, Rodgoun; de Trimarco, Juliana T.; Catalan, Cesar Atilio Nazareno; et al.; Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin; Natural Products; Natural Product Communications; 6; 2; 1-2011; 163-166
1934-578X
1555-9475
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52423
identifier_str_mv Bach, Sandra M.; Fortuna, Antonio Mario; Attarian, Rodgoun; de Trimarco, Juliana T.; Catalan, Cesar Atilio Nazareno; et al.; Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin; Natural Products; Natural Product Communications; 6; 2; 1-2011; 163-166
1934-578X
1555-9475
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/1934578X1100600202
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Natural Products
publisher.none.fl_str_mv Natural Products
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613835367907328
score 13.070432

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