Androgens and androgen receptor action in skin and hair follicles

Autores
Ceruti, Julieta María; Leiros, Gustavo Jose; Balaña, Maria Eugenia
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Beyond sexual functions, androgens exert their action in skin physiology andpathophysiology. Skin cells are able to synthesize most of active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we go over recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of its molecular mechanisms in androgenetic alopecia (AGA). We review on the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrinefactors deregulated in dermal papilla (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.
Fil: Ceruti, Julieta María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
Fil: Leiros, Gustavo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
Fil: Balaña, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
Materia
ANDROGENETIC ALOPECIA
DERMAL PAPILLA
EPITHELIAL-MESENCHYMAL INTERACTIONS
SKIN STEROIDOGENESIS IN HEALTH AND DISEASE
WNT/Β-CATENIN SIGNALING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88192
Acceder
id CONICETDig_1d5de58ea3d284f3874f358631d9284a
oai_identifier_str oai:ri.conicet.gov.ar:11336/88192
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Androgens and androgen receptor action in skin and hair folliclesCeruti, Julieta MaríaLeiros, Gustavo JoseBalaña, Maria EugeniaANDROGENETIC ALOPECIADERMAL PAPILLAEPITHELIAL-MESENCHYMAL INTERACTIONSSKIN STEROIDOGENESIS IN HEALTH AND DISEASEWNT/Β-CATENIN SIGNALINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Beyond sexual functions, androgens exert their action in skin physiology andpathophysiology. Skin cells are able to synthesize most of active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we go over recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of its molecular mechanisms in androgenetic alopecia (AGA). We review on the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrinefactors deregulated in dermal papilla (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.Fil: Ceruti, Julieta María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; ArgentinaFil: Leiros, Gustavo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; ArgentinaFil: Balaña, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; ArgentinaElsevier Ireland2018-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88192Ceruti, Julieta María; Leiros, Gustavo Jose; Balaña, Maria Eugenia; Androgens and androgen receptor action in skin and hair follicles; Elsevier Ireland; Molecular and Cellular Endocrinology; 465; 15-4-2018; 122-1330303-7207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2017.09.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720717304926info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:07Zoai:ri.conicet.gov.ar:11336/88192instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:07.648CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Androgens and androgen receptor action in skin and hair follicles
title Androgens and androgen receptor action in skin and hair follicles
spellingShingle Androgens and androgen receptor action in skin and hair follicles
Ceruti, Julieta María
ANDROGENETIC ALOPECIA
DERMAL PAPILLA
EPITHELIAL-MESENCHYMAL INTERACTIONS
SKIN STEROIDOGENESIS IN HEALTH AND DISEASE
WNT/Β-CATENIN SIGNALING
title_short Androgens and androgen receptor action in skin and hair follicles
title_full Androgens and androgen receptor action in skin and hair follicles
title_fullStr Androgens and androgen receptor action in skin and hair follicles
title_full_unstemmed Androgens and androgen receptor action in skin and hair follicles
title_sort Androgens and androgen receptor action in skin and hair follicles
dc.creator.none.fl_str_mv Ceruti, Julieta María
Leiros, Gustavo Jose
Balaña, Maria Eugenia
author Ceruti, Julieta María
author_facet Ceruti, Julieta María
Leiros, Gustavo Jose
Balaña, Maria Eugenia
author_role author
author2 Leiros, Gustavo Jose
Balaña, Maria Eugenia
author2_role author
author
dc.subject.none.fl_str_mv ANDROGENETIC ALOPECIA
DERMAL PAPILLA
EPITHELIAL-MESENCHYMAL INTERACTIONS
SKIN STEROIDOGENESIS IN HEALTH AND DISEASE
WNT/Β-CATENIN SIGNALING
topic ANDROGENETIC ALOPECIA
DERMAL PAPILLA
EPITHELIAL-MESENCHYMAL INTERACTIONS
SKIN STEROIDOGENESIS IN HEALTH AND DISEASE
WNT/Β-CATENIN SIGNALING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Beyond sexual functions, androgens exert their action in skin physiology andpathophysiology. Skin cells are able to synthesize most of active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we go over recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of its molecular mechanisms in androgenetic alopecia (AGA). We review on the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrinefactors deregulated in dermal papilla (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.
Fil: Ceruti, Julieta María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
Fil: Leiros, Gustavo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
Fil: Balaña, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; Argentina
description Beyond sexual functions, androgens exert their action in skin physiology andpathophysiology. Skin cells are able to synthesize most of active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we go over recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of its molecular mechanisms in androgenetic alopecia (AGA). We review on the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrinefactors deregulated in dermal papilla (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88192
Ceruti, Julieta María; Leiros, Gustavo Jose; Balaña, Maria Eugenia; Androgens and androgen receptor action in skin and hair follicles; Elsevier Ireland; Molecular and Cellular Endocrinology; 465; 15-4-2018; 122-133
0303-7207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88192
identifier_str_mv Ceruti, Julieta María; Leiros, Gustavo Jose; Balaña, Maria Eugenia; Androgens and androgen receptor action in skin and hair follicles; Elsevier Ireland; Molecular and Cellular Endocrinology; 465; 15-4-2018; 122-133
0303-7207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2017.09.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720717304926
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268838619512832
score 13.13397

Publicaciones similares