Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A

Autores
Socolsky, Cecilia; Rates, Stella Maris K.; Stein, Ana Cristina; Asakawa, Yoshinori; Bardon, Alicia del Valle
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nine new terpenylated acylphloroglucinols, crassipins A-I, were isolated from the rhizomes and roots of the fern Elaphoglossum crassipes, and their structures were elucidated by analysis of spectroscopic data and chemical derivatization. The absolute configurations of some of the compounds were established by CD and VCD in combination with a quantum mechanical method. Crassipin A (1), the major acylphloroglucinol of the Et2O extract of E. crassipes, as well as its peracetylated derivative (8), displayed antidepressantlike activity in a mouse forced-swimming test when administered orally at a dose of 15 mg/kg.
Fil: Socolsky, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Rates, Stella Maris K.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Stein, Ana Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Asakawa, Yoshinori. Tokushima Bunri University; Japón
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Materia
Acylphloroglucinols
Elaphoglossum Crassipes
Antidepressant-Like Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52491
Acceder
id CONICETDig_1d34f066807077cc0fdaa81e4873703f
oai_identifier_str oai:ri.conicet.gov.ar:11336/52491
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin ASocolsky, CeciliaRates, Stella Maris K.Stein, Ana CristinaAsakawa, YoshinoriBardon, Alicia del ValleAcylphloroglucinolsElaphoglossum CrassipesAntidepressant-Like Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Nine new terpenylated acylphloroglucinols, crassipins A-I, were isolated from the rhizomes and roots of the fern Elaphoglossum crassipes, and their structures were elucidated by analysis of spectroscopic data and chemical derivatization. The absolute configurations of some of the compounds were established by CD and VCD in combination with a quantum mechanical method. Crassipin A (1), the major acylphloroglucinol of the Et2O extract of E. crassipes, as well as its peracetylated derivative (8), displayed antidepressantlike activity in a mouse forced-swimming test when administered orally at a dose of 15 mg/kg.Fil: Socolsky, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Rates, Stella Maris K.. Universidade Federal do Rio Grande do Sul; BrasilFil: Stein, Ana Cristina. Universidade Federal do Rio Grande do Sul; BrasilFil: Asakawa, Yoshinori. Tokushima Bunri University; JapónFil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaAmerican Chemical Society2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52491Socolsky, Cecilia; Rates, Stella Maris K.; Stein, Ana Cristina; Asakawa, Yoshinori; Bardon, Alicia del Valle; Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A; American Chemical Society; Journal of Natural Products; 75; 6; 6-2012; 1007-10170163-3864CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/np200436hinfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/np200436hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:17Zoai:ri.conicet.gov.ar:11336/52491instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:17.41CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
title Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
spellingShingle Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
Socolsky, Cecilia
Acylphloroglucinols
Elaphoglossum Crassipes
Antidepressant-Like Activity
title_short Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
title_full Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
title_fullStr Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
title_full_unstemmed Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
title_sort Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A
dc.creator.none.fl_str_mv Socolsky, Cecilia
Rates, Stella Maris K.
Stein, Ana Cristina
Asakawa, Yoshinori
Bardon, Alicia del Valle
author Socolsky, Cecilia
author_facet Socolsky, Cecilia
Rates, Stella Maris K.
Stein, Ana Cristina
Asakawa, Yoshinori
Bardon, Alicia del Valle
author_role author
author2 Rates, Stella Maris K.
Stein, Ana Cristina
Asakawa, Yoshinori
Bardon, Alicia del Valle
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acylphloroglucinols
Elaphoglossum Crassipes
Antidepressant-Like Activity
topic Acylphloroglucinols
Elaphoglossum Crassipes
Antidepressant-Like Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nine new terpenylated acylphloroglucinols, crassipins A-I, were isolated from the rhizomes and roots of the fern Elaphoglossum crassipes, and their structures were elucidated by analysis of spectroscopic data and chemical derivatization. The absolute configurations of some of the compounds were established by CD and VCD in combination with a quantum mechanical method. Crassipin A (1), the major acylphloroglucinol of the Et2O extract of E. crassipes, as well as its peracetylated derivative (8), displayed antidepressantlike activity in a mouse forced-swimming test when administered orally at a dose of 15 mg/kg.
Fil: Socolsky, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Rates, Stella Maris K.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Stein, Ana Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Asakawa, Yoshinori. Tokushima Bunri University; Japón
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
description Nine new terpenylated acylphloroglucinols, crassipins A-I, were isolated from the rhizomes and roots of the fern Elaphoglossum crassipes, and their structures were elucidated by analysis of spectroscopic data and chemical derivatization. The absolute configurations of some of the compounds were established by CD and VCD in combination with a quantum mechanical method. Crassipin A (1), the major acylphloroglucinol of the Et2O extract of E. crassipes, as well as its peracetylated derivative (8), displayed antidepressantlike activity in a mouse forced-swimming test when administered orally at a dose of 15 mg/kg.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52491
Socolsky, Cecilia; Rates, Stella Maris K.; Stein, Ana Cristina; Asakawa, Yoshinori; Bardon, Alicia del Valle; Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A; American Chemical Society; Journal of Natural Products; 75; 6; 6-2012; 1007-1017
0163-3864
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52491
identifier_str_mv Socolsky, Cecilia; Rates, Stella Maris K.; Stein, Ana Cristina; Asakawa, Yoshinori; Bardon, Alicia del Valle; Acylphloroglucinols from Elaphoglossum crassipes: Antidepressant-like Activity of Crassipin A; American Chemical Society; Journal of Natural Products; 75; 6; 6-2012; 1007-1017
0163-3864
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/np200436h
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/np200436h
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614286766243840
score 13.070432

Publicaciones similares