Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries
- Autores
- García Betancur, Juan Carlos; De La Cadena, Elsa; Mojica, María F.; Hernández Gómez, Cristhian; Correa, Adriana; Radice, Marcela Alejandra; Castañeda Méndez, Paulo; Jaime Villalon, Diego A.; Gales, Ana C.; Munita, José M.; Villegas, María Virginia
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Ceftolozane/tazobactam (C/T) is a combination of an antipseudomonal oxyiminoaminothiazolyl cephalosporin with potent in vitro activity against Pseudomonas aeruginosa and tazobactam, a known β-lactamase inhibitor. The aim of this study was to evaluate the activity of C/T against clinical isolates of P. aeruginosa and Enterobacterales collected from five Latin American countries between 2016 and 2017, before its clinical use in Latin America, and to compare it with the activity of other available broad-spectrum antimicrobial agents. Methods: a total of 2760 clinical isolates (508 P. aeruginosa and 2252 Enterobacterales) were consecutively collected from 20 hospitals and susceptibility to C/T and comparator agents was tested and interpreted following the current guidelines. Results: according to the CLSI breakpoints, 68.1% (346/508) of P. aeruginosa and 83.9% (1889/2252) of Enterobacterales isolates were susceptible to C/T. Overall, C/T demonstrated higher in vitro activity than currently available cephalosporins, piperacillin/tazobactam and carbapenems when tested against P. aeruginosa, and its performance in vitro was comparable to fosfomycin. When tested against Enterobacterales, it showed higher activity than cephalosporins and piperacillin/tazobactam, and similar activity to ertapenem. Conclusions: these results show that C/T is an active β-lactam agent against clinical isolates of P. aeruginosa and Enterobacterales.
Fil: García Betancur, Juan Carlos. Universidad El Bosque;
Fil: De La Cadena, Elsa. Universidad El Bosque;
Fil: Mojica, María F.. Universidad El Bosque; . Case Western Reserve University; Estados Unidos
Fil: Hernández Gómez, Cristhian. Universidad El Bosque;
Fil: Correa, Adriana. Universidad Santiago de Cali; Colombia
Fil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquÍmica. Instituto de Investigaciones En Bacteriología y Virología Molecular (IBaViM); Argentina
Fil: Castañeda Méndez, Paulo. Fundacion Clinica Medica Sur; México
Fil: Jaime Villalon, Diego A.. Fundacion Clinica Medica Sur; México
Fil: Gales, Ana C.. Universidade Federal de Sao Paulo; Brasil
Fil: Munita, José M.. Universidad del Desarrollo; Chile
Fil: Villegas, María Virginia. Universidad El Bosque; - Materia
-
ANTIMICROBIAL RESISTANCE
CEFTOLOZANE/TAZOBACTAM
ENTEROBACTERALES
LATIN AMERICA
PSEUDOMONAS AERUGINOSA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/216748
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Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American CountriesGarcía Betancur, Juan CarlosDe La Cadena, ElsaMojica, María F.Hernández Gómez, CristhianCorrea, AdrianaRadice, Marcela AlejandraCastañeda Méndez, PauloJaime Villalon, Diego A.Gales, Ana C.Munita, José M.Villegas, María VirginiaANTIMICROBIAL RESISTANCECEFTOLOZANE/TAZOBACTAMENTEROBACTERALESLATIN AMERICAPSEUDOMONAS AERUGINOSAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Ceftolozane/tazobactam (C/T) is a combination of an antipseudomonal oxyiminoaminothiazolyl cephalosporin with potent in vitro activity against Pseudomonas aeruginosa and tazobactam, a known β-lactamase inhibitor. The aim of this study was to evaluate the activity of C/T against clinical isolates of P. aeruginosa and Enterobacterales collected from five Latin American countries between 2016 and 2017, before its clinical use in Latin America, and to compare it with the activity of other available broad-spectrum antimicrobial agents. Methods: a total of 2760 clinical isolates (508 P. aeruginosa and 2252 Enterobacterales) were consecutively collected from 20 hospitals and susceptibility to C/T and comparator agents was tested and interpreted following the current guidelines. Results: according to the CLSI breakpoints, 68.1% (346/508) of P. aeruginosa and 83.9% (1889/2252) of Enterobacterales isolates were susceptible to C/T. Overall, C/T demonstrated higher in vitro activity than currently available cephalosporins, piperacillin/tazobactam and carbapenems when tested against P. aeruginosa, and its performance in vitro was comparable to fosfomycin. When tested against Enterobacterales, it showed higher activity than cephalosporins and piperacillin/tazobactam, and similar activity to ertapenem. Conclusions: these results show that C/T is an active β-lactam agent against clinical isolates of P. aeruginosa and Enterobacterales.Fil: García Betancur, Juan Carlos. Universidad El Bosque;Fil: De La Cadena, Elsa. Universidad El Bosque;Fil: Mojica, María F.. Universidad El Bosque; . Case Western Reserve University; Estados UnidosFil: Hernández Gómez, Cristhian. Universidad El Bosque;Fil: Correa, Adriana. Universidad Santiago de Cali; ColombiaFil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquÍmica. Instituto de Investigaciones En Bacteriología y Virología Molecular (IBaViM); ArgentinaFil: Castañeda Méndez, Paulo. Fundacion Clinica Medica Sur; MéxicoFil: Jaime Villalon, Diego A.. Fundacion Clinica Medica Sur; MéxicoFil: Gales, Ana C.. Universidade Federal de Sao Paulo; BrasilFil: Munita, José M.. Universidad del Desarrollo; ChileFil: Villegas, María Virginia. Universidad El Bosque;MDPI2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216748García Betancur, Juan Carlos; De La Cadena, Elsa; Mojica, María F.; Hernández Gómez, Cristhian; Correa, Adriana; et al.; Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries; MDPI; Antibiotics; 11; 8; 8-2022; 1-112079-6382CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics11081101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:41Zoai:ri.conicet.gov.ar:11336/216748instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:41.433CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
title |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
spellingShingle |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries García Betancur, Juan Carlos ANTIMICROBIAL RESISTANCE CEFTOLOZANE/TAZOBACTAM ENTEROBACTERALES LATIN AMERICA PSEUDOMONAS AERUGINOSA |
title_short |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
title_full |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
title_fullStr |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
title_full_unstemmed |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
title_sort |
Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries |
dc.creator.none.fl_str_mv |
García Betancur, Juan Carlos De La Cadena, Elsa Mojica, María F. Hernández Gómez, Cristhian Correa, Adriana Radice, Marcela Alejandra Castañeda Méndez, Paulo Jaime Villalon, Diego A. Gales, Ana C. Munita, José M. Villegas, María Virginia |
author |
García Betancur, Juan Carlos |
author_facet |
García Betancur, Juan Carlos De La Cadena, Elsa Mojica, María F. Hernández Gómez, Cristhian Correa, Adriana Radice, Marcela Alejandra Castañeda Méndez, Paulo Jaime Villalon, Diego A. Gales, Ana C. Munita, José M. Villegas, María Virginia |
author_role |
author |
author2 |
De La Cadena, Elsa Mojica, María F. Hernández Gómez, Cristhian Correa, Adriana Radice, Marcela Alejandra Castañeda Méndez, Paulo Jaime Villalon, Diego A. Gales, Ana C. Munita, José M. Villegas, María Virginia |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ANTIMICROBIAL RESISTANCE CEFTOLOZANE/TAZOBACTAM ENTEROBACTERALES LATIN AMERICA PSEUDOMONAS AERUGINOSA |
topic |
ANTIMICROBIAL RESISTANCE CEFTOLOZANE/TAZOBACTAM ENTEROBACTERALES LATIN AMERICA PSEUDOMONAS AERUGINOSA |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Ceftolozane/tazobactam (C/T) is a combination of an antipseudomonal oxyiminoaminothiazolyl cephalosporin with potent in vitro activity against Pseudomonas aeruginosa and tazobactam, a known β-lactamase inhibitor. The aim of this study was to evaluate the activity of C/T against clinical isolates of P. aeruginosa and Enterobacterales collected from five Latin American countries between 2016 and 2017, before its clinical use in Latin America, and to compare it with the activity of other available broad-spectrum antimicrobial agents. Methods: a total of 2760 clinical isolates (508 P. aeruginosa and 2252 Enterobacterales) were consecutively collected from 20 hospitals and susceptibility to C/T and comparator agents was tested and interpreted following the current guidelines. Results: according to the CLSI breakpoints, 68.1% (346/508) of P. aeruginosa and 83.9% (1889/2252) of Enterobacterales isolates were susceptible to C/T. Overall, C/T demonstrated higher in vitro activity than currently available cephalosporins, piperacillin/tazobactam and carbapenems when tested against P. aeruginosa, and its performance in vitro was comparable to fosfomycin. When tested against Enterobacterales, it showed higher activity than cephalosporins and piperacillin/tazobactam, and similar activity to ertapenem. Conclusions: these results show that C/T is an active β-lactam agent against clinical isolates of P. aeruginosa and Enterobacterales. Fil: García Betancur, Juan Carlos. Universidad El Bosque; Fil: De La Cadena, Elsa. Universidad El Bosque; Fil: Mojica, María F.. Universidad El Bosque; . Case Western Reserve University; Estados Unidos Fil: Hernández Gómez, Cristhian. Universidad El Bosque; Fil: Correa, Adriana. Universidad Santiago de Cali; Colombia Fil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquÍmica. Instituto de Investigaciones En Bacteriología y Virología Molecular (IBaViM); Argentina Fil: Castañeda Méndez, Paulo. Fundacion Clinica Medica Sur; México Fil: Jaime Villalon, Diego A.. Fundacion Clinica Medica Sur; México Fil: Gales, Ana C.. Universidade Federal de Sao Paulo; Brasil Fil: Munita, José M.. Universidad del Desarrollo; Chile Fil: Villegas, María Virginia. Universidad El Bosque; |
description |
Background: Ceftolozane/tazobactam (C/T) is a combination of an antipseudomonal oxyiminoaminothiazolyl cephalosporin with potent in vitro activity against Pseudomonas aeruginosa and tazobactam, a known β-lactamase inhibitor. The aim of this study was to evaluate the activity of C/T against clinical isolates of P. aeruginosa and Enterobacterales collected from five Latin American countries between 2016 and 2017, before its clinical use in Latin America, and to compare it with the activity of other available broad-spectrum antimicrobial agents. Methods: a total of 2760 clinical isolates (508 P. aeruginosa and 2252 Enterobacterales) were consecutively collected from 20 hospitals and susceptibility to C/T and comparator agents was tested and interpreted following the current guidelines. Results: according to the CLSI breakpoints, 68.1% (346/508) of P. aeruginosa and 83.9% (1889/2252) of Enterobacterales isolates were susceptible to C/T. Overall, C/T demonstrated higher in vitro activity than currently available cephalosporins, piperacillin/tazobactam and carbapenems when tested against P. aeruginosa, and its performance in vitro was comparable to fosfomycin. When tested against Enterobacterales, it showed higher activity than cephalosporins and piperacillin/tazobactam, and similar activity to ertapenem. Conclusions: these results show that C/T is an active β-lactam agent against clinical isolates of P. aeruginosa and Enterobacterales. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/216748 García Betancur, Juan Carlos; De La Cadena, Elsa; Mojica, María F.; Hernández Gómez, Cristhian; Correa, Adriana; et al.; Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries; MDPI; Antibiotics; 11; 8; 8-2022; 1-11 2079-6382 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/216748 |
identifier_str_mv |
García Betancur, Juan Carlos; De La Cadena, Elsa; Mojica, María F.; Hernández Gómez, Cristhian; Correa, Adriana; et al.; Comparative In Vitro Activity of Ceftolozane/Tazobactam against Clinical Isolates of Pseudomonas aeruginosa and Enterobacterales from Five Latin American Countries; MDPI; Antibiotics; 11; 8; 8-2022; 1-11 2079-6382 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics11081101 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |