Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina
- Autores
- Alcaraz, Andrea; Pichón-riviere, Andres; Rojas Roque, Carlos; González, Juan Martín; Prina, Daniela Luciana; Solioz, Germán; Augustovski, Federico Ariel; Palacios, Alfredo
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background Centrifugal-flow pumps are novel treatment options for patients with advanced heart failure (HF). This study estimated the incremental cost-effectiveness ratio (ICER) of centrifugal-flow pumps for patients with advanced HF in Argentina. Methods Two Markov models were developed to estimate the cost-effectiveness of a centrifugal-flow pump as destination therapy (DT) in patients with contraindication for heart transplantation, and as bridge-to-transplant (BTT), with a lifetime horizon using the third-party payer Social Security (SS) and Private Sector (PS) perspectives. Clinical, epidemiological, and quality-adjusted life years (QALY) parameters were retrieved from the literature. Direct medical costs were estimated through a micro-costing approach (exchange rate USD 1 = ARS 59.95). Results The centrifugal-flow pump as a DT increased the per patient QALYs by 3.5 and costs by ARS 8.1 million in both the SS and PS, with an ICER of ARS 2.3 million per QALY. Corresponding values for a centrifugal-flow pump as BTT were 0.74 QALYs and more than ARS 8 million, yielding ICERs of ARS 11 million per QALY (highly dependent on waiting times). For the 1, 3, and 5 GDP per QALY thresholds, the probability of a centrifugal-flow pump to be cost-effective for DT/BTT was around 2%/0%, 40%/0%, and 80%/1%, respectively. Conclusion The centrifugal-flow pump prolongs life and improves the quality of life at significantly higher costs. As in Argentina there is no current explicit cost-effectiveness threshold, the final decision on reimbursement will depend on the willingness to pay in each subsector. Nevertheless, the centrifugal-flow pump as a DT was more cost-effective than as a BTT.
Fil: Alcaraz, Andrea. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Pichón-riviere, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: González, Juan Martín. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Prina, Daniela Luciana. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Solioz, Germán. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Augustovski, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palacios, Alfredo. Instituto de Efectividad Clínica y Sanitaria; Argentina - Materia
-
HEALTH ECONOMICS
CARDIAC TRANSPLANTATION
HEART FAILURE
COST-EFFECTIVENESS ANALYSIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/218165
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Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in ArgentinaAlcaraz, AndreaPichón-riviere, AndresRojas Roque, CarlosGonzález, Juan MartínPrina, Daniela LucianaSolioz, GermánAugustovski, Federico ArielPalacios, AlfredoHEALTH ECONOMICSCARDIAC TRANSPLANTATIONHEART FAILURECOST-EFFECTIVENESS ANALYSIShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background Centrifugal-flow pumps are novel treatment options for patients with advanced heart failure (HF). This study estimated the incremental cost-effectiveness ratio (ICER) of centrifugal-flow pumps for patients with advanced HF in Argentina. Methods Two Markov models were developed to estimate the cost-effectiveness of a centrifugal-flow pump as destination therapy (DT) in patients with contraindication for heart transplantation, and as bridge-to-transplant (BTT), with a lifetime horizon using the third-party payer Social Security (SS) and Private Sector (PS) perspectives. Clinical, epidemiological, and quality-adjusted life years (QALY) parameters were retrieved from the literature. Direct medical costs were estimated through a micro-costing approach (exchange rate USD 1 = ARS 59.95). Results The centrifugal-flow pump as a DT increased the per patient QALYs by 3.5 and costs by ARS 8.1 million in both the SS and PS, with an ICER of ARS 2.3 million per QALY. Corresponding values for a centrifugal-flow pump as BTT were 0.74 QALYs and more than ARS 8 million, yielding ICERs of ARS 11 million per QALY (highly dependent on waiting times). For the 1, 3, and 5 GDP per QALY thresholds, the probability of a centrifugal-flow pump to be cost-effective for DT/BTT was around 2%/0%, 40%/0%, and 80%/1%, respectively. Conclusion The centrifugal-flow pump prolongs life and improves the quality of life at significantly higher costs. As in Argentina there is no current explicit cost-effectiveness threshold, the final decision on reimbursement will depend on the willingness to pay in each subsector. Nevertheless, the centrifugal-flow pump as a DT was more cost-effective than as a BTT.Fil: Alcaraz, Andrea. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Pichón-riviere, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: González, Juan Martín. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Prina, Daniela Luciana. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Solioz, Germán. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Augustovski, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Palacios, Alfredo. Instituto de Efectividad Clínica y Sanitaria; ArgentinaPublic Library of Science2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218165Alcaraz, Andrea; Pichón-riviere, Andres; Rojas Roque, Carlos; González, Juan Martín; Prina, Daniela Luciana; et al.; Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina; Public Library of Science; Plos One; 17; 8 August; 8-2022; 1-181932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0271519info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271519info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:52Zoai:ri.conicet.gov.ar:11336/218165instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:53.241CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
title |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
spellingShingle |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina Alcaraz, Andrea HEALTH ECONOMICS CARDIAC TRANSPLANTATION HEART FAILURE COST-EFFECTIVENESS ANALYSIS |
title_short |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
title_full |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
title_fullStr |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
title_full_unstemmed |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
title_sort |
Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina |
dc.creator.none.fl_str_mv |
Alcaraz, Andrea Pichón-riviere, Andres Rojas Roque, Carlos González, Juan Martín Prina, Daniela Luciana Solioz, Germán Augustovski, Federico Ariel Palacios, Alfredo |
author |
Alcaraz, Andrea |
author_facet |
Alcaraz, Andrea Pichón-riviere, Andres Rojas Roque, Carlos González, Juan Martín Prina, Daniela Luciana Solioz, Germán Augustovski, Federico Ariel Palacios, Alfredo |
author_role |
author |
author2 |
Pichón-riviere, Andres Rojas Roque, Carlos González, Juan Martín Prina, Daniela Luciana Solioz, Germán Augustovski, Federico Ariel Palacios, Alfredo |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
HEALTH ECONOMICS CARDIAC TRANSPLANTATION HEART FAILURE COST-EFFECTIVENESS ANALYSIS |
topic |
HEALTH ECONOMICS CARDIAC TRANSPLANTATION HEART FAILURE COST-EFFECTIVENESS ANALYSIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background Centrifugal-flow pumps are novel treatment options for patients with advanced heart failure (HF). This study estimated the incremental cost-effectiveness ratio (ICER) of centrifugal-flow pumps for patients with advanced HF in Argentina. Methods Two Markov models were developed to estimate the cost-effectiveness of a centrifugal-flow pump as destination therapy (DT) in patients with contraindication for heart transplantation, and as bridge-to-transplant (BTT), with a lifetime horizon using the third-party payer Social Security (SS) and Private Sector (PS) perspectives. Clinical, epidemiological, and quality-adjusted life years (QALY) parameters were retrieved from the literature. Direct medical costs were estimated through a micro-costing approach (exchange rate USD 1 = ARS 59.95). Results The centrifugal-flow pump as a DT increased the per patient QALYs by 3.5 and costs by ARS 8.1 million in both the SS and PS, with an ICER of ARS 2.3 million per QALY. Corresponding values for a centrifugal-flow pump as BTT were 0.74 QALYs and more than ARS 8 million, yielding ICERs of ARS 11 million per QALY (highly dependent on waiting times). For the 1, 3, and 5 GDP per QALY thresholds, the probability of a centrifugal-flow pump to be cost-effective for DT/BTT was around 2%/0%, 40%/0%, and 80%/1%, respectively. Conclusion The centrifugal-flow pump prolongs life and improves the quality of life at significantly higher costs. As in Argentina there is no current explicit cost-effectiveness threshold, the final decision on reimbursement will depend on the willingness to pay in each subsector. Nevertheless, the centrifugal-flow pump as a DT was more cost-effective than as a BTT. Fil: Alcaraz, Andrea. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Pichón-riviere, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: González, Juan Martín. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Prina, Daniela Luciana. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Solioz, Germán. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Augustovski, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Palacios, Alfredo. Instituto de Efectividad Clínica y Sanitaria; Argentina |
description |
Background Centrifugal-flow pumps are novel treatment options for patients with advanced heart failure (HF). This study estimated the incremental cost-effectiveness ratio (ICER) of centrifugal-flow pumps for patients with advanced HF in Argentina. Methods Two Markov models were developed to estimate the cost-effectiveness of a centrifugal-flow pump as destination therapy (DT) in patients with contraindication for heart transplantation, and as bridge-to-transplant (BTT), with a lifetime horizon using the third-party payer Social Security (SS) and Private Sector (PS) perspectives. Clinical, epidemiological, and quality-adjusted life years (QALY) parameters were retrieved from the literature. Direct medical costs were estimated through a micro-costing approach (exchange rate USD 1 = ARS 59.95). Results The centrifugal-flow pump as a DT increased the per patient QALYs by 3.5 and costs by ARS 8.1 million in both the SS and PS, with an ICER of ARS 2.3 million per QALY. Corresponding values for a centrifugal-flow pump as BTT were 0.74 QALYs and more than ARS 8 million, yielding ICERs of ARS 11 million per QALY (highly dependent on waiting times). For the 1, 3, and 5 GDP per QALY thresholds, the probability of a centrifugal-flow pump to be cost-effective for DT/BTT was around 2%/0%, 40%/0%, and 80%/1%, respectively. Conclusion The centrifugal-flow pump prolongs life and improves the quality of life at significantly higher costs. As in Argentina there is no current explicit cost-effectiveness threshold, the final decision on reimbursement will depend on the willingness to pay in each subsector. Nevertheless, the centrifugal-flow pump as a DT was more cost-effective than as a BTT. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/218165 Alcaraz, Andrea; Pichón-riviere, Andres; Rojas Roque, Carlos; González, Juan Martín; Prina, Daniela Luciana; et al.; Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina; Public Library of Science; Plos One; 17; 8 August; 8-2022; 1-18 1932-6203 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/218165 |
identifier_str_mv |
Alcaraz, Andrea; Pichón-riviere, Andres; Rojas Roque, Carlos; González, Juan Martín; Prina, Daniela Luciana; et al.; Cost-effectiveness of a centrifugal-flow pump for patients with advanced heart failure in Argentina; Public Library of Science; Plos One; 17; 8 August; 8-2022; 1-18 1932-6203 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0271519 info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271519 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
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application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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