Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice
- Autores
- Brea, Rocío; Casanova, Natalia; Alvarez Lucena, Carlota; Fuertes Agudo, Marina; Luque Tevar, María; Cucarella, Carme; Capitani, María Celeste; Marinochi, María Virginia; Fusini, Matías E.; Lahoz, Agustín; Nogueroles, Marina López; Fraile, Juan; Ronco, Maria Teresa; Boscá, Lisardo; González Rodríguez, Águeda; García Monzón, Carmelo; Martín Sanz, Paloma; Casado, Marta; Frances, Daniel Eleazar Antonio
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background and Aims: Cyclooxygenase-2 (COX-2) is involved in different liver dis-eases, but little is known about the significance of COX-2 in cholestatic injury. Thisstudy was designed to elucidate the role of COX-2 expression in hepatocytes duringthe pathogenesis of obstructive cholestasis.Methods: We used genetically modified mice constitutively expressing human COX-2in hepatocytes. Transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates wereeither subjected to a mid-abdominal laparotomy or common bile duct ligation (BDL)for 2 or 5 days. Then, we explored the mechanisms underlying the role of COX-2 andits derived prostaglandins in liver function, and the synthesis and excretion of bileacids (BA) in response to cholestatic liver injury.Results: After BDL, hCOX-2-Tg mice showed lower grades of hepatic necrosis and in -flammation than Wt mice, in part by a reduced hepatic neutrophil recruitment associ-ated with lower mRNA levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tgmice displayed a differential metabolic pattern of BA synthesis that led to an improvedclearance after BDL-induced accumulation. In addition, an enhanced response to theBDL-induced oxidative stress and hepatic apoptosis was observed. In vitro experi-ments using hepatic cells that stably express hCOX-2 confirmed the cytoprotectiverole of prostaglandin E2 against BA toxicity.Conclusions: Taken together, our data indicate that constitutive expression of COX-2in hepatocytes ameliorates cholestatic liver injury in mice by reducing inflammationand cell damage and by modulating BA metabolism, pointing to a role for COX-2 as adefensive response against cholestasis-derived BA accumulation and injury.
Fil: Brea, Rocío. Instituto de Investigaciones Biomédicas Sols-Morreales; España
Fil: Casanova, Natalia. Instituto de Investigaciones Biomédicas Sols-Morreales; España
Fil: Alvarez Lucena, Carlota. Instituto de Investigaciones Biomédicas Sols-Morreales; España
Fil: Fuertes Agudo, Marina. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España
Fil: Luque Tevar, María. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España
Fil: Cucarella, Carme. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España
Fil: Capitani, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Marinochi, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Fusini, Matías E.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Lahoz, Agustín. IIS-Hospital La Fe; España
Fil: Nogueroles, Marina López. IIS-Hospital La Fe; España
Fil: Fraile, Juan. Instituto de Investigaciones Biomédicas Sols-Morreale; España
Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Boscá, Lisardo. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares; España. Instituto de Investigaciones Biomédicas Sols-Morreale; España
Fil: González Rodríguez, Águeda. Instituto de Investigaciones Biomédicas Sols-Morreale; España. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: García Monzón, Carmelo. Instituto de Investigación Sanitaria Princesa; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España
Fil: Martín Sanz, Paloma. Instituto de Investigaciones Biomédicas Sols-Morreale; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España
Fil: Casado, Marta. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España. Instituto de Biomedicina de Valencia; España
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina - Materia
-
BDL
BILE ACIDS
CHOLESTASIS
COX-2 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/268118
Ver los metadatos del registro completo
| id |
CONICETDig_1c253e0f13517fea0df51523075bf19c |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/268118 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in miceBrea, RocíoCasanova, NataliaAlvarez Lucena, CarlotaFuertes Agudo, MarinaLuque Tevar, MaríaCucarella, CarmeCapitani, María CelesteMarinochi, María VirginiaFusini, Matías E.Lahoz, AgustínNogueroles, Marina LópezFraile, JuanRonco, Maria TeresaBoscá, LisardoGonzález Rodríguez, ÁguedaGarcía Monzón, CarmeloMartín Sanz, PalomaCasado, MartaFrances, Daniel Eleazar AntonioBDLBILE ACIDSCHOLESTASISCOX-2https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background and Aims: Cyclooxygenase-2 (COX-2) is involved in different liver dis-eases, but little is known about the significance of COX-2 in cholestatic injury. Thisstudy was designed to elucidate the role of COX-2 expression in hepatocytes duringthe pathogenesis of obstructive cholestasis.Methods: We used genetically modified mice constitutively expressing human COX-2in hepatocytes. Transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates wereeither subjected to a mid-abdominal laparotomy or common bile duct ligation (BDL)for 2 or 5 days. Then, we explored the mechanisms underlying the role of COX-2 andits derived prostaglandins in liver function, and the synthesis and excretion of bileacids (BA) in response to cholestatic liver injury.Results: After BDL, hCOX-2-Tg mice showed lower grades of hepatic necrosis and in -flammation than Wt mice, in part by a reduced hepatic neutrophil recruitment associ-ated with lower mRNA levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tgmice displayed a differential metabolic pattern of BA synthesis that led to an improvedclearance after BDL-induced accumulation. In addition, an enhanced response to theBDL-induced oxidative stress and hepatic apoptosis was observed. In vitro experi-ments using hepatic cells that stably express hCOX-2 confirmed the cytoprotectiverole of prostaglandin E2 against BA toxicity.Conclusions: Taken together, our data indicate that constitutive expression of COX-2in hepatocytes ameliorates cholestatic liver injury in mice by reducing inflammationand cell damage and by modulating BA metabolism, pointing to a role for COX-2 as adefensive response against cholestasis-derived BA accumulation and injury.Fil: Brea, Rocío. Instituto de Investigaciones Biomédicas Sols-Morreales; EspañaFil: Casanova, Natalia. Instituto de Investigaciones Biomédicas Sols-Morreales; EspañaFil: Alvarez Lucena, Carlota. Instituto de Investigaciones Biomédicas Sols-Morreales; EspañaFil: Fuertes Agudo, Marina. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; EspañaFil: Luque Tevar, María. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; EspañaFil: Cucarella, Carme. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; EspañaFil: Capitani, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Marinochi, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Fusini, Matías E.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Lahoz, Agustín. IIS-Hospital La Fe; EspañaFil: Nogueroles, Marina López. IIS-Hospital La Fe; EspañaFil: Fraile, Juan. Instituto de Investigaciones Biomédicas Sols-Morreale; EspañaFil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Boscá, Lisardo. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares; España. Instituto de Investigaciones Biomédicas Sols-Morreale; EspañaFil: González Rodríguez, Águeda. Instituto de Investigaciones Biomédicas Sols-Morreale; España. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: García Monzón, Carmelo. Instituto de Investigación Sanitaria Princesa; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; EspañaFil: Martín Sanz, Paloma. Instituto de Investigaciones Biomédicas Sols-Morreale; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; EspañaFil: Casado, Marta. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España. Instituto de Biomedicina de Valencia; EspañaFil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaWiley Blackwell Publishing, Inc2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268118Brea, Rocío; Casanova, Natalia; Alvarez Lucena, Carlota; Fuertes Agudo, Marina; Luque Tevar, María; et al.; Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice; Wiley Blackwell Publishing, Inc; Liver International; 44; 9; 6-2024; 2409-24231478-3223CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/liv.16004info:eu-repo/semantics/altIdentifier/doi/10.1111/liv.16004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:31Zoai:ri.conicet.gov.ar:11336/268118instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:31.955CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| title |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| spellingShingle |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice Brea, Rocío BDL BILE ACIDS CHOLESTASIS COX-2 |
| title_short |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| title_full |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| title_fullStr |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| title_full_unstemmed |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| title_sort |
Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice |
| dc.creator.none.fl_str_mv |
Brea, Rocío Casanova, Natalia Alvarez Lucena, Carlota Fuertes Agudo, Marina Luque Tevar, María Cucarella, Carme Capitani, María Celeste Marinochi, María Virginia Fusini, Matías E. Lahoz, Agustín Nogueroles, Marina López Fraile, Juan Ronco, Maria Teresa Boscá, Lisardo González Rodríguez, Águeda García Monzón, Carmelo Martín Sanz, Paloma Casado, Marta Frances, Daniel Eleazar Antonio |
| author |
Brea, Rocío |
| author_facet |
Brea, Rocío Casanova, Natalia Alvarez Lucena, Carlota Fuertes Agudo, Marina Luque Tevar, María Cucarella, Carme Capitani, María Celeste Marinochi, María Virginia Fusini, Matías E. Lahoz, Agustín Nogueroles, Marina López Fraile, Juan Ronco, Maria Teresa Boscá, Lisardo González Rodríguez, Águeda García Monzón, Carmelo Martín Sanz, Paloma Casado, Marta Frances, Daniel Eleazar Antonio |
| author_role |
author |
| author2 |
Casanova, Natalia Alvarez Lucena, Carlota Fuertes Agudo, Marina Luque Tevar, María Cucarella, Carme Capitani, María Celeste Marinochi, María Virginia Fusini, Matías E. Lahoz, Agustín Nogueroles, Marina López Fraile, Juan Ronco, Maria Teresa Boscá, Lisardo González Rodríguez, Águeda García Monzón, Carmelo Martín Sanz, Paloma Casado, Marta Frances, Daniel Eleazar Antonio |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
BDL BILE ACIDS CHOLESTASIS COX-2 |
| topic |
BDL BILE ACIDS CHOLESTASIS COX-2 |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Background and Aims: Cyclooxygenase-2 (COX-2) is involved in different liver dis-eases, but little is known about the significance of COX-2 in cholestatic injury. Thisstudy was designed to elucidate the role of COX-2 expression in hepatocytes duringthe pathogenesis of obstructive cholestasis.Methods: We used genetically modified mice constitutively expressing human COX-2in hepatocytes. Transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates wereeither subjected to a mid-abdominal laparotomy or common bile duct ligation (BDL)for 2 or 5 days. Then, we explored the mechanisms underlying the role of COX-2 andits derived prostaglandins in liver function, and the synthesis and excretion of bileacids (BA) in response to cholestatic liver injury.Results: After BDL, hCOX-2-Tg mice showed lower grades of hepatic necrosis and in -flammation than Wt mice, in part by a reduced hepatic neutrophil recruitment associ-ated with lower mRNA levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tgmice displayed a differential metabolic pattern of BA synthesis that led to an improvedclearance after BDL-induced accumulation. In addition, an enhanced response to theBDL-induced oxidative stress and hepatic apoptosis was observed. In vitro experi-ments using hepatic cells that stably express hCOX-2 confirmed the cytoprotectiverole of prostaglandin E2 against BA toxicity.Conclusions: Taken together, our data indicate that constitutive expression of COX-2in hepatocytes ameliorates cholestatic liver injury in mice by reducing inflammationand cell damage and by modulating BA metabolism, pointing to a role for COX-2 as adefensive response against cholestasis-derived BA accumulation and injury. Fil: Brea, Rocío. Instituto de Investigaciones Biomédicas Sols-Morreales; España Fil: Casanova, Natalia. Instituto de Investigaciones Biomédicas Sols-Morreales; España Fil: Alvarez Lucena, Carlota. Instituto de Investigaciones Biomédicas Sols-Morreales; España Fil: Fuertes Agudo, Marina. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España Fil: Luque Tevar, María. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España Fil: Cucarella, Carme. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España Fil: Capitani, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Marinochi, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Fusini, Matías E.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: Lahoz, Agustín. IIS-Hospital La Fe; España Fil: Nogueroles, Marina López. IIS-Hospital La Fe; España Fil: Fraile, Juan. Instituto de Investigaciones Biomédicas Sols-Morreale; España Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Boscá, Lisardo. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares; España. Instituto de Investigaciones Biomédicas Sols-Morreale; España Fil: González Rodríguez, Águeda. Instituto de Investigaciones Biomédicas Sols-Morreale; España. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas; España Fil: García Monzón, Carmelo. Instituto de Investigación Sanitaria Princesa; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España Fil: Martín Sanz, Paloma. Instituto de Investigaciones Biomédicas Sols-Morreale; España. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España Fil: Casado, Marta. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España. Instituto de Biomedicina de Valencia; España Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina |
| description |
Background and Aims: Cyclooxygenase-2 (COX-2) is involved in different liver dis-eases, but little is known about the significance of COX-2 in cholestatic injury. Thisstudy was designed to elucidate the role of COX-2 expression in hepatocytes duringthe pathogenesis of obstructive cholestasis.Methods: We used genetically modified mice constitutively expressing human COX-2in hepatocytes. Transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates wereeither subjected to a mid-abdominal laparotomy or common bile duct ligation (BDL)for 2 or 5 days. Then, we explored the mechanisms underlying the role of COX-2 andits derived prostaglandins in liver function, and the synthesis and excretion of bileacids (BA) in response to cholestatic liver injury.Results: After BDL, hCOX-2-Tg mice showed lower grades of hepatic necrosis and in -flammation than Wt mice, in part by a reduced hepatic neutrophil recruitment associ-ated with lower mRNA levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tgmice displayed a differential metabolic pattern of BA synthesis that led to an improvedclearance after BDL-induced accumulation. In addition, an enhanced response to theBDL-induced oxidative stress and hepatic apoptosis was observed. In vitro experi-ments using hepatic cells that stably express hCOX-2 confirmed the cytoprotectiverole of prostaglandin E2 against BA toxicity.Conclusions: Taken together, our data indicate that constitutive expression of COX-2in hepatocytes ameliorates cholestatic liver injury in mice by reducing inflammationand cell damage and by modulating BA metabolism, pointing to a role for COX-2 as adefensive response against cholestasis-derived BA accumulation and injury. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-06 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/268118 Brea, Rocío; Casanova, Natalia; Alvarez Lucena, Carlota; Fuertes Agudo, Marina; Luque Tevar, María; et al.; Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice; Wiley Blackwell Publishing, Inc; Liver International; 44; 9; 6-2024; 2409-2423 1478-3223 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/268118 |
| identifier_str_mv |
Brea, Rocío; Casanova, Natalia; Alvarez Lucena, Carlota; Fuertes Agudo, Marina; Luque Tevar, María; et al.; Beneficial effects of hepatic cyclooxygenase‐2 expression against cholestatic injury after common bile duct ligation in mice; Wiley Blackwell Publishing, Inc; Liver International; 44; 9; 6-2024; 2409-2423 1478-3223 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/liv.16004 info:eu-repo/semantics/altIdentifier/doi/10.1111/liv.16004 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
| publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1844614254101004288 |
| score |
13.070432 |