Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Met...

Autores: Yin Wu; Levis, Brooke; Daray, Federico Manuel; Ioannidis, John P. A.; Patten, Scott B.; Cuijpers, Pim; Ziegelstein, Roy C.; Gilbody, Simon; Fischer, Felix H.; Fan, Suiqiong; Sun, Ying; He, Chen; Krishnan, Ankur; Neupane, Dipika; Bhandari, Parash Mani; Negeri, Zelalem; Riehm, Kira E.; Rice, Danielle B.; Azar, Marleine; Yan, Xin Wei; Imran, Mahrukh; Chiovitti, Matthew J.; Boruff, Jill T.; McMillan, Dean; Kloda, Lorie A.; Wiese, Birgitt; Williams, Lana J.; Wong, Lai Yi; Benedetti, Andrea; Thombs, Brett D.
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item HADS (HADS-T) are both used for major depression screening. Compared to the HADS-D, the HADS-T includes anxiety items and requires more time to complete. We compared the screening accuracy of the HADS-D and HADS-T for major depression detection. We conducted an individual participant data metaanalysis and fit bivariate random effects models to assess diagnostic accuracy among participants with both HADS-D and HADS-T scores. We identified optimal cutoffs, estimated sensitivity and specificity with 95% confidence intervals, and compared screening accuracy across paired cutoffs via two-stage and individual-level models. We used a 0.05 equivalence margin to assess equivalency in sensitivity and specificity. 20,700 participants (2,285 major depression cases) from 98 studies were included. Cutoffs of ≥7 for the HADS-D (sensitivity 0.79 [0.75, 0.83], specificity 0.78 [0.75, 0.80]) and ≥15 for the HADS-T (sensitivity 0.79 [0.76, 0.82], specificity 0.81 [0.78, 0.83]) minimized the distance to the top-left corner of the receiver operating characteristic curve. Across all sets of paired cutoffs evaluated, differences of sensitivity between HADS-T and HADS-D ranged from −0.05 to 0.01 (0.00 at paired optimal cutoffs), and differences of specificity were within 0.03 for all cutoffs (0.02–0.03). The pattern was similar among outpatients, although the HADS-T was slightly (not nonequivalently) more specific among inpatients. The accuracy of HADS-T was equivalent to the HADSD for detecting major depression. In most settings, the shorter HADS-D would be preferred.
Fil: Yin Wu. Lady Davis Institute For Medical Research; Canadá. McGill University; Canadá
Fil: Levis, Brooke. Lady Davis Institute For Medical Research; Canadá. Keele University; Reino Unido
Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ioannidis, John P. A.. University of Stanford; Estados Unidos
Fil: Patten, Scott B.. University of Calgary; Canadá
Fil: Cuijpers, Pim. Vrije Universiteit Amsterdam; Países Bajos
Fil: Ziegelstein, Roy C.. University Johns Hopkins; Estados Unidos
Fil: Gilbody, Simon. University of York; Reino Unido
Fil: Fischer, Felix H.. Universität zu Berlin; Alemania
Fil: Fan, Suiqiong. Jewish General Hospital; Canadá
Fil: Sun, Ying. Jewish General Hospital; Canadá
Fil: He, Chen. Jewish General Hospital; Canadá
Fil: Krishnan, Ankur. Jewish General Hospital; Canadá
Fil: Neupane, Dipika. Jewish General Hospital; Canadá
Fil: Bhandari, Parash Mani. Jewish General Hospital; Canadá
Fil: Negeri, Zelalem. Jewish General Hospital; Canadá
Fil: Riehm, Kira E.. Jewish General Hospital; Canadá
Fil: Rice, Danielle B.. Jewish General Hospital; Canadá
Fil: Azar, Marleine. Jewish General Hospital; Canadá
Fil: Yan, Xin Wei. Jewish General Hospital; Canadá
Fil: Imran, Mahrukh. Jewish General Hospital; Canadá
Fil: Chiovitti, Matthew J.. Jewish General Hospital; Canadá
Fil: Boruff, Jill T.. McGill University; Canadá
Fil: McMillan, Dean. University of York; Reino Unido
Fil: Kloda, Lorie A.. Concordia University; Canadá
Fil: Wiese, Birgitt. Hannover Medical School; Alemania
Fil: Williams, Lana J.. Universidad Complutense de Madrid; España
Fil: Wong, Lai Yi. Kwai Chung Hospital; China
Fil: Benedetti, Andrea. McGill University; Canadá
Fil: Thombs, Brett D.. McGill University; Canadá. Jewish General Hospital; Canadá
Materia: HADS
Major Depression
Screening
Accuracy
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/239210

Acceder

id	CONICETDig_1b9f7e91c482d6023f82e810d9fb4813
oai_identifier_str	oai:ri.conicet.gov.ar:11336/239210
network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-AnalysisYin WuLevis, BrookeDaray, Federico ManuelIoannidis, John P. A.Patten, Scott B.Cuijpers, PimZiegelstein, Roy C.Gilbody, SimonFischer, Felix H.Fan, SuiqiongSun, YingHe, ChenKrishnan, AnkurNeupane, DipikaBhandari, Parash ManiNegeri, ZelalemRiehm, Kira E.Rice, Danielle B.Azar, MarleineYan, Xin WeiImran, MahrukhChiovitti, Matthew J.Boruff, Jill T.McMillan, DeanKloda, Lorie A.Wiese, BirgittWilliams, Lana J.Wong, Lai YiBenedetti, AndreaThombs, Brett D.HADSMajor DepressionScreeningAccuracyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item HADS (HADS-T) are both used for major depression screening. Compared to the HADS-D, the HADS-T includes anxiety items and requires more time to complete. We compared the screening accuracy of the HADS-D and HADS-T for major depression detection. We conducted an individual participant data metaanalysis and fit bivariate random effects models to assess diagnostic accuracy among participants with both HADS-D and HADS-T scores. We identified optimal cutoffs, estimated sensitivity and specificity with 95% confidence intervals, and compared screening accuracy across paired cutoffs via two-stage and individual-level models. We used a 0.05 equivalence margin to assess equivalency in sensitivity and specificity. 20,700 participants (2,285 major depression cases) from 98 studies were included. Cutoffs of ≥7 for the HADS-D (sensitivity 0.79 [0.75, 0.83], specificity 0.78 [0.75, 0.80]) and ≥15 for the HADS-T (sensitivity 0.79 [0.76, 0.82], specificity 0.81 [0.78, 0.83]) minimized the distance to the top-left corner of the receiver operating characteristic curve. Across all sets of paired cutoffs evaluated, differences of sensitivity between HADS-T and HADS-D ranged from −0.05 to 0.01 (0.00 at paired optimal cutoffs), and differences of specificity were within 0.03 for all cutoffs (0.02–0.03). The pattern was similar among outpatients, although the HADS-T was slightly (not nonequivalently) more specific among inpatients. The accuracy of HADS-T was equivalent to the HADSD for detecting major depression. In most settings, the shorter HADS-D would be preferred.Fil: Yin Wu. Lady Davis Institute For Medical Research; Canadá. McGill University; CanadáFil: Levis, Brooke. Lady Davis Institute For Medical Research; Canadá. Keele University; Reino UnidoFil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ioannidis, John P. A.. University of Stanford; Estados UnidosFil: Patten, Scott B.. University of Calgary; CanadáFil: Cuijpers, Pim. Vrije Universiteit Amsterdam; Países BajosFil: Ziegelstein, Roy C.. University Johns Hopkins; Estados UnidosFil: Gilbody, Simon. University of York; Reino UnidoFil: Fischer, Felix H.. Universität zu Berlin; AlemaniaFil: Fan, Suiqiong. Jewish General Hospital; CanadáFil: Sun, Ying. Jewish General Hospital; CanadáFil: He, Chen. Jewish General Hospital; CanadáFil: Krishnan, Ankur. Jewish General Hospital; CanadáFil: Neupane, Dipika. Jewish General Hospital; CanadáFil: Bhandari, Parash Mani. Jewish General Hospital; CanadáFil: Negeri, Zelalem. Jewish General Hospital; CanadáFil: Riehm, Kira E.. Jewish General Hospital; CanadáFil: Rice, Danielle B.. Jewish General Hospital; CanadáFil: Azar, Marleine. Jewish General Hospital; CanadáFil: Yan, Xin Wei. Jewish General Hospital; CanadáFil: Imran, Mahrukh. Jewish General Hospital; CanadáFil: Chiovitti, Matthew J.. Jewish General Hospital; CanadáFil: Boruff, Jill T.. McGill University; CanadáFil: McMillan, Dean. University of York; Reino UnidoFil: Kloda, Lorie A.. Concordia University; CanadáFil: Wiese, Birgitt. Hannover Medical School; AlemaniaFil: Williams, Lana J.. Universidad Complutense de Madrid; EspañaFil: Wong, Lai Yi. Kwai Chung Hospital; ChinaFil: Benedetti, Andrea. McGill University; CanadáFil: Thombs, Brett D.. McGill University; Canadá. Jewish General Hospital; CanadáAmerican Psychological Association2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239210Yin Wu; Levis, Brooke; Daray, Federico Manuel; Ioannidis, John P. A.; Patten, Scott B.; et al.; Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis; American Psychological Association; Psychological Assessment; 35; 2; 6-2024; 94-1141939-134XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1037/pas0001181info:eu-repo/semantics/altIdentifier/url/https://psycnet.apa.org/doiLanding?doi=10.1037%2Fpas0001181info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:01Zoai:ri.conicet.gov.ar:11336/239210instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:02.264CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
title	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
spellingShingle	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis Yin Wu HADS Major Depression Screening Accuracy
title_short	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
title_full	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
title_fullStr	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
title_full_unstemmed	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
title_sort	Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis
dc.creator.none.fl_str_mv	Yin Wu Levis, Brooke Daray, Federico Manuel Ioannidis, John P. A. Patten, Scott B. Cuijpers, Pim Ziegelstein, Roy C. Gilbody, Simon Fischer, Felix H. Fan, Suiqiong Sun, Ying He, Chen Krishnan, Ankur Neupane, Dipika Bhandari, Parash Mani Negeri, Zelalem Riehm, Kira E. Rice, Danielle B. Azar, Marleine Yan, Xin Wei Imran, Mahrukh Chiovitti, Matthew J. Boruff, Jill T. McMillan, Dean Kloda, Lorie A. Wiese, Birgitt Williams, Lana J. Wong, Lai Yi Benedetti, Andrea Thombs, Brett D.
author	Yin Wu
author_facet	Yin Wu Levis, Brooke Daray, Federico Manuel Ioannidis, John P. A. Patten, Scott B. Cuijpers, Pim Ziegelstein, Roy C. Gilbody, Simon Fischer, Felix H. Fan, Suiqiong Sun, Ying He, Chen Krishnan, Ankur Neupane, Dipika Bhandari, Parash Mani Negeri, Zelalem Riehm, Kira E. Rice, Danielle B. Azar, Marleine Yan, Xin Wei Imran, Mahrukh Chiovitti, Matthew J. Boruff, Jill T. McMillan, Dean Kloda, Lorie A. Wiese, Birgitt Williams, Lana J. Wong, Lai Yi Benedetti, Andrea Thombs, Brett D.
author_role	author
author2	Levis, Brooke Daray, Federico Manuel Ioannidis, John P. A. Patten, Scott B. Cuijpers, Pim Ziegelstein, Roy C. Gilbody, Simon Fischer, Felix H. Fan, Suiqiong Sun, Ying He, Chen Krishnan, Ankur Neupane, Dipika Bhandari, Parash Mani Negeri, Zelalem Riehm, Kira E. Rice, Danielle B. Azar, Marleine Yan, Xin Wei Imran, Mahrukh Chiovitti, Matthew J. Boruff, Jill T. McMillan, Dean Kloda, Lorie A. Wiese, Birgitt Williams, Lana J. Wong, Lai Yi Benedetti, Andrea Thombs, Brett D.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	HADS Major Depression Screening Accuracy
topic	HADS Major Depression Screening Accuracy
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	The seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item HADS (HADS-T) are both used for major depression screening. Compared to the HADS-D, the HADS-T includes anxiety items and requires more time to complete. We compared the screening accuracy of the HADS-D and HADS-T for major depression detection. We conducted an individual participant data metaanalysis and fit bivariate random effects models to assess diagnostic accuracy among participants with both HADS-D and HADS-T scores. We identified optimal cutoffs, estimated sensitivity and specificity with 95% confidence intervals, and compared screening accuracy across paired cutoffs via two-stage and individual-level models. We used a 0.05 equivalence margin to assess equivalency in sensitivity and specificity. 20,700 participants (2,285 major depression cases) from 98 studies were included. Cutoffs of ≥7 for the HADS-D (sensitivity 0.79 [0.75, 0.83], specificity 0.78 [0.75, 0.80]) and ≥15 for the HADS-T (sensitivity 0.79 [0.76, 0.82], specificity 0.81 [0.78, 0.83]) minimized the distance to the top-left corner of the receiver operating characteristic curve. Across all sets of paired cutoffs evaluated, differences of sensitivity between HADS-T and HADS-D ranged from −0.05 to 0.01 (0.00 at paired optimal cutoffs), and differences of specificity were within 0.03 for all cutoffs (0.02–0.03). The pattern was similar among outpatients, although the HADS-T was slightly (not nonequivalently) more specific among inpatients. The accuracy of HADS-T was equivalent to the HADSD for detecting major depression. In most settings, the shorter HADS-D would be preferred. Fil: Yin Wu. Lady Davis Institute For Medical Research; Canadá. McGill University; Canadá Fil: Levis, Brooke. Lady Davis Institute For Medical Research; Canadá. Keele University; Reino Unido Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ioannidis, John P. A.. University of Stanford; Estados Unidos Fil: Patten, Scott B.. University of Calgary; Canadá Fil: Cuijpers, Pim. Vrije Universiteit Amsterdam; Países Bajos Fil: Ziegelstein, Roy C.. University Johns Hopkins; Estados Unidos Fil: Gilbody, Simon. University of York; Reino Unido Fil: Fischer, Felix H.. Universität zu Berlin; Alemania Fil: Fan, Suiqiong. Jewish General Hospital; Canadá Fil: Sun, Ying. Jewish General Hospital; Canadá Fil: He, Chen. Jewish General Hospital; Canadá Fil: Krishnan, Ankur. Jewish General Hospital; Canadá Fil: Neupane, Dipika. Jewish General Hospital; Canadá Fil: Bhandari, Parash Mani. Jewish General Hospital; Canadá Fil: Negeri, Zelalem. Jewish General Hospital; Canadá Fil: Riehm, Kira E.. Jewish General Hospital; Canadá Fil: Rice, Danielle B.. Jewish General Hospital; Canadá Fil: Azar, Marleine. Jewish General Hospital; Canadá Fil: Yan, Xin Wei. Jewish General Hospital; Canadá Fil: Imran, Mahrukh. Jewish General Hospital; Canadá Fil: Chiovitti, Matthew J.. Jewish General Hospital; Canadá Fil: Boruff, Jill T.. McGill University; Canadá Fil: McMillan, Dean. University of York; Reino Unido Fil: Kloda, Lorie A.. Concordia University; Canadá Fil: Wiese, Birgitt. Hannover Medical School; Alemania Fil: Williams, Lana J.. Universidad Complutense de Madrid; España Fil: Wong, Lai Yi. Kwai Chung Hospital; China Fil: Benedetti, Andrea. McGill University; Canadá Fil: Thombs, Brett D.. McGill University; Canadá. Jewish General Hospital; Canadá
description	The seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item HADS (HADS-T) are both used for major depression screening. Compared to the HADS-D, the HADS-T includes anxiety items and requires more time to complete. We compared the screening accuracy of the HADS-D and HADS-T for major depression detection. We conducted an individual participant data metaanalysis and fit bivariate random effects models to assess diagnostic accuracy among participants with both HADS-D and HADS-T scores. We identified optimal cutoffs, estimated sensitivity and specificity with 95% confidence intervals, and compared screening accuracy across paired cutoffs via two-stage and individual-level models. We used a 0.05 equivalence margin to assess equivalency in sensitivity and specificity. 20,700 participants (2,285 major depression cases) from 98 studies were included. Cutoffs of ≥7 for the HADS-D (sensitivity 0.79 [0.75, 0.83], specificity 0.78 [0.75, 0.80]) and ≥15 for the HADS-T (sensitivity 0.79 [0.76, 0.82], specificity 0.81 [0.78, 0.83]) minimized the distance to the top-left corner of the receiver operating characteristic curve. Across all sets of paired cutoffs evaluated, differences of sensitivity between HADS-T and HADS-D ranged from −0.05 to 0.01 (0.00 at paired optimal cutoffs), and differences of specificity were within 0.03 for all cutoffs (0.02–0.03). The pattern was similar among outpatients, although the HADS-T was slightly (not nonequivalently) more specific among inpatients. The accuracy of HADS-T was equivalent to the HADSD for detecting major depression. In most settings, the shorter HADS-D would be preferred.
publishDate	2024
dc.date.none.fl_str_mv	2024-06
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/239210 Yin Wu; Levis, Brooke; Daray, Federico Manuel; Ioannidis, John P. A.; Patten, Scott B.; et al.; Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis; American Psychological Association; Psychological Assessment; 35; 2; 6-2024; 94-114 1939-134X CONICET Digital CONICET
url	http://hdl.handle.net/11336/239210
identifier_str_mv	Yin Wu; Levis, Brooke; Daray, Federico Manuel; Ioannidis, John P. A.; Patten, Scott B.; et al.; Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis; American Psychological Association; Psychological Assessment; 35; 2; 6-2024; 94-114 1939-134X CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1037/pas0001181 info:eu-repo/semantics/altIdentifier/url/https://psycnet.apa.org/doiLanding?doi=10.1037%2Fpas0001181
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	American Psychological Association
publisher.none.fl_str_mv	American Psychological Association
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_	1844613201023467520
score	13.070432

Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Met...

Publicaciones similares