A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions

Autores
Bianchini, Romina Marcela; Kaufman, Teodoro Saul
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The analysis of UV-spectrophotometric data with second-order chemometrics techniques, including multivariate curve resolution with alternating least-squares (MCR-ALS) and hybrid hard- and soft MCR (HS-MCR), was examined as an alternative tool for studying the kinetics of drug degradation under stress conditions, employing valsartan (VAL) as a model drug. Despite small structural and spectroscopic differences between VAL and its degradation products, MCR-ALS and HS-MCR were able to detect the generation of two photoneutral degradation products (DP-1 and DP-2) and a single acid hydrolysis product (DP-3), providing good approximations to their pure spectra and concentration profiles, from which estimations of the kinetic profiles and rate constants were obtained. Kinetic models based on first-order reactions explained the degradation processes. MCR-ALS and HS-MCR analyses yielded similar rate constants; however, the latter was capable of more properly fitting the experimental data to a kinetic model in the case of drug photolysis. The results were confirmed by comparison with data obtained by HPLC analysis of the degraded samples.
Fil: Bianchini, Romina Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Materia
Valsartan
Mcr-Als
Kinetics
Degradation Products
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6082
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6082
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditionsBianchini, Romina MarcelaKaufman, Teodoro SaulValsartanMcr-AlsKineticsDegradation Productshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The analysis of UV-spectrophotometric data with second-order chemometrics techniques, including multivariate curve resolution with alternating least-squares (MCR-ALS) and hybrid hard- and soft MCR (HS-MCR), was examined as an alternative tool for studying the kinetics of drug degradation under stress conditions, employing valsartan (VAL) as a model drug. Despite small structural and spectroscopic differences between VAL and its degradation products, MCR-ALS and HS-MCR were able to detect the generation of two photoneutral degradation products (DP-1 and DP-2) and a single acid hydrolysis product (DP-3), providing good approximations to their pure spectra and concentration profiles, from which estimations of the kinetic profiles and rate constants were obtained. Kinetic models based on first-order reactions explained the degradation processes. MCR-ALS and HS-MCR analyses yielded similar rate constants; however, the latter was capable of more properly fitting the experimental data to a kinetic model in the case of drug photolysis. The results were confirmed by comparison with data obtained by HPLC analysis of the degraded samples.Fil: Bianchini, Romina Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaWiley2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6082Bianchini, Romina Marcela; Kaufman, Teodoro Saul; A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions; Wiley; International Journal of Chemical Kinetics; 45; 11; 6-2013; 734-7450538-8066enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/kin.20808/abstractinfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1002/kin.20808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:04Zoai:ri.conicet.gov.ar:11336/6082instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:05.123CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
title A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
spellingShingle A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
Bianchini, Romina Marcela
Valsartan
Mcr-Als
Kinetics
Degradation Products
title_short A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
title_full A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
title_fullStr A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
title_full_unstemmed A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
title_sort A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
dc.creator.none.fl_str_mv Bianchini, Romina Marcela
Kaufman, Teodoro Saul
author Bianchini, Romina Marcela
author_facet Bianchini, Romina Marcela
Kaufman, Teodoro Saul
author_role author
author2 Kaufman, Teodoro Saul
author2_role author
dc.subject.none.fl_str_mv Valsartan
Mcr-Als
Kinetics
Degradation Products
topic Valsartan
Mcr-Als
Kinetics
Degradation Products
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The analysis of UV-spectrophotometric data with second-order chemometrics techniques, including multivariate curve resolution with alternating least-squares (MCR-ALS) and hybrid hard- and soft MCR (HS-MCR), was examined as an alternative tool for studying the kinetics of drug degradation under stress conditions, employing valsartan (VAL) as a model drug. Despite small structural and spectroscopic differences between VAL and its degradation products, MCR-ALS and HS-MCR were able to detect the generation of two photoneutral degradation products (DP-1 and DP-2) and a single acid hydrolysis product (DP-3), providing good approximations to their pure spectra and concentration profiles, from which estimations of the kinetic profiles and rate constants were obtained. Kinetic models based on first-order reactions explained the degradation processes. MCR-ALS and HS-MCR analyses yielded similar rate constants; however, the latter was capable of more properly fitting the experimental data to a kinetic model in the case of drug photolysis. The results were confirmed by comparison with data obtained by HPLC analysis of the degraded samples.
Fil: Bianchini, Romina Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
description The analysis of UV-spectrophotometric data with second-order chemometrics techniques, including multivariate curve resolution with alternating least-squares (MCR-ALS) and hybrid hard- and soft MCR (HS-MCR), was examined as an alternative tool for studying the kinetics of drug degradation under stress conditions, employing valsartan (VAL) as a model drug. Despite small structural and spectroscopic differences between VAL and its degradation products, MCR-ALS and HS-MCR were able to detect the generation of two photoneutral degradation products (DP-1 and DP-2) and a single acid hydrolysis product (DP-3), providing good approximations to their pure spectra and concentration profiles, from which estimations of the kinetic profiles and rate constants were obtained. Kinetic models based on first-order reactions explained the degradation processes. MCR-ALS and HS-MCR analyses yielded similar rate constants; however, the latter was capable of more properly fitting the experimental data to a kinetic model in the case of drug photolysis. The results were confirmed by comparison with data obtained by HPLC analysis of the degraded samples.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6082
Bianchini, Romina Marcela; Kaufman, Teodoro Saul; A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions; Wiley; International Journal of Chemical Kinetics; 45; 11; 6-2013; 734-745
0538-8066
url http://hdl.handle.net/11336/6082
identifier_str_mv Bianchini, Romina Marcela; Kaufman, Teodoro Saul; A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions; Wiley; International Journal of Chemical Kinetics; 45; 11; 6-2013; 734-745
0538-8066
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/kin.20808/abstract
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1002/kin.20808
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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