A longitudinal mirror-image assessment of morbidity in bipolar disorder

Autores
Martino, Diego Javier; Samame, Cecilia; Marengo, E.; Igoa, A.; Scápola, M.; Strejilevich, S. A.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background Evidence about the clinical course of bipolar disorder is inconsistent and limited. The aim of this study was to assess changes in morbidity in patients with bipolar disorder along a mean follow-up period of 80 months. Methods Based on a mirror-image design, the follow-up period of each patient was divided into two halves. Then, three measures of morbidity — number of affective episodes, time spent ill, and cycle length — were recorded and compared between each half of the follow-up period. Results On average, there was a trend to a smaller amount of time spent with subclinical symptomatology during the second half of the follow-up period. In contrast, there were no differences in terms of number of episodes, time spent with clinical symptoms, or cycle length between the first and second half of the follow-up period. A subgroup analysis identified 21.9% of patients with consistent data of a worsening during follow-up. Conclusions The results suggest that, on average, there is stability or slight improvement of clinical morbidity over the course of BD. Then, worsening of the clinical course may be a feature of a subgroup of patients rather than an inherent characteristic of the disorder. These subgroups or patient profiles could represent an opportunity for further studies to assess clinical, pathophysiologic, and therapeutic features associated with them.
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Samame, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Marengo, E.. Universidad Favaloro; Argentina
Fil: Igoa, A.. Universidad Favaloro; Argentina
Fil: Scápola, M.. Universidad Favaloro; Argentina
Fil: Strejilevich, S. A.. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Materia
Cycle Length
Long-Term
Recurrences
Staging
Time Spent Ill
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66007
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A longitudinal mirror-image assessment of morbidity in bipolar disorderMartino, Diego JavierSamame, CeciliaMarengo, E.Igoa, A.Scápola, M.Strejilevich, S. A.Cycle LengthLong-TermRecurrencesStagingTime Spent Illhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background Evidence about the clinical course of bipolar disorder is inconsistent and limited. The aim of this study was to assess changes in morbidity in patients with bipolar disorder along a mean follow-up period of 80 months. Methods Based on a mirror-image design, the follow-up period of each patient was divided into two halves. Then, three measures of morbidity — number of affective episodes, time spent ill, and cycle length — were recorded and compared between each half of the follow-up period. Results On average, there was a trend to a smaller amount of time spent with subclinical symptomatology during the second half of the follow-up period. In contrast, there were no differences in terms of number of episodes, time spent with clinical symptoms, or cycle length between the first and second half of the follow-up period. A subgroup analysis identified 21.9% of patients with consistent data of a worsening during follow-up. Conclusions The results suggest that, on average, there is stability or slight improvement of clinical morbidity over the course of BD. Then, worsening of the clinical course may be a feature of a subgroup of patients rather than an inherent characteristic of the disorder. These subgroups or patient profiles could represent an opportunity for further studies to assess clinical, pathophysiologic, and therapeutic features associated with them.Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Samame, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Marengo, E.. Universidad Favaloro; ArgentinaFil: Igoa, A.. Universidad Favaloro; ArgentinaFil: Scápola, M.. Universidad Favaloro; ArgentinaFil: Strejilevich, S. A.. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaElsevier France-editions Scientifiques Medicales Elsevier2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66007Martino, Diego Javier; Samame, Cecilia; Marengo, E.; Igoa, A.; Scápola, M.; et al.; A longitudinal mirror-image assessment of morbidity in bipolar disorder; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 40; 2-2017; 55-590924-9338CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpsy.2016.06.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S092493381630075Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:00Zoai:ri.conicet.gov.ar:11336/66007instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:01.238CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A longitudinal mirror-image assessment of morbidity in bipolar disorder
title A longitudinal mirror-image assessment of morbidity in bipolar disorder
spellingShingle A longitudinal mirror-image assessment of morbidity in bipolar disorder
Martino, Diego Javier
Cycle Length
Long-Term
Recurrences
Staging
Time Spent Ill
title_short A longitudinal mirror-image assessment of morbidity in bipolar disorder
title_full A longitudinal mirror-image assessment of morbidity in bipolar disorder
title_fullStr A longitudinal mirror-image assessment of morbidity in bipolar disorder
title_full_unstemmed A longitudinal mirror-image assessment of morbidity in bipolar disorder
title_sort A longitudinal mirror-image assessment of morbidity in bipolar disorder
dc.creator.none.fl_str_mv Martino, Diego Javier
Samame, Cecilia
Marengo, E.
Igoa, A.
Scápola, M.
Strejilevich, S. A.
author Martino, Diego Javier
author_facet Martino, Diego Javier
Samame, Cecilia
Marengo, E.
Igoa, A.
Scápola, M.
Strejilevich, S. A.
author_role author
author2 Samame, Cecilia
Marengo, E.
Igoa, A.
Scápola, M.
Strejilevich, S. A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cycle Length
Long-Term
Recurrences
Staging
Time Spent Ill
topic Cycle Length
Long-Term
Recurrences
Staging
Time Spent Ill
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background Evidence about the clinical course of bipolar disorder is inconsistent and limited. The aim of this study was to assess changes in morbidity in patients with bipolar disorder along a mean follow-up period of 80 months. Methods Based on a mirror-image design, the follow-up period of each patient was divided into two halves. Then, three measures of morbidity — number of affective episodes, time spent ill, and cycle length — were recorded and compared between each half of the follow-up period. Results On average, there was a trend to a smaller amount of time spent with subclinical symptomatology during the second half of the follow-up period. In contrast, there were no differences in terms of number of episodes, time spent with clinical symptoms, or cycle length between the first and second half of the follow-up period. A subgroup analysis identified 21.9% of patients with consistent data of a worsening during follow-up. Conclusions The results suggest that, on average, there is stability or slight improvement of clinical morbidity over the course of BD. Then, worsening of the clinical course may be a feature of a subgroup of patients rather than an inherent characteristic of the disorder. These subgroups or patient profiles could represent an opportunity for further studies to assess clinical, pathophysiologic, and therapeutic features associated with them.
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Samame, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Marengo, E.. Universidad Favaloro; Argentina
Fil: Igoa, A.. Universidad Favaloro; Argentina
Fil: Scápola, M.. Universidad Favaloro; Argentina
Fil: Strejilevich, S. A.. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
description Background Evidence about the clinical course of bipolar disorder is inconsistent and limited. The aim of this study was to assess changes in morbidity in patients with bipolar disorder along a mean follow-up period of 80 months. Methods Based on a mirror-image design, the follow-up period of each patient was divided into two halves. Then, three measures of morbidity — number of affective episodes, time spent ill, and cycle length — were recorded and compared between each half of the follow-up period. Results On average, there was a trend to a smaller amount of time spent with subclinical symptomatology during the second half of the follow-up period. In contrast, there were no differences in terms of number of episodes, time spent with clinical symptoms, or cycle length between the first and second half of the follow-up period. A subgroup analysis identified 21.9% of patients with consistent data of a worsening during follow-up. Conclusions The results suggest that, on average, there is stability or slight improvement of clinical morbidity over the course of BD. Then, worsening of the clinical course may be a feature of a subgroup of patients rather than an inherent characteristic of the disorder. These subgroups or patient profiles could represent an opportunity for further studies to assess clinical, pathophysiologic, and therapeutic features associated with them.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66007
Martino, Diego Javier; Samame, Cecilia; Marengo, E.; Igoa, A.; Scápola, M.; et al.; A longitudinal mirror-image assessment of morbidity in bipolar disorder; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 40; 2-2017; 55-59
0924-9338
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66007
identifier_str_mv Martino, Diego Javier; Samame, Cecilia; Marengo, E.; Igoa, A.; Scápola, M.; et al.; A longitudinal mirror-image assessment of morbidity in bipolar disorder; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 40; 2-2017; 55-59
0924-9338
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpsy.2016.06.010
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S092493381630075X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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