Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus

Autores
Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; Rey, Rodolfo Alberto; Codner, Ethel
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian function in women with DM1 (n = 66) and healthy controls (n = 58), all <45 years old. Steroids, gonadotrophins, AMH and inhibin B levels were measured during the follicular phase.RESULTSPiece-wise regression analysis demonstrated that AMH levels begin to decrease at 33 years of age in both groups. This age limit was used to compare data in both groups. AMH levels were lower in DM1 women than in controls >33 years (4.1 ± 4.2 versus 9.5 ± 7.9 pmol/l, mean ± SD, P = 0.006). A higher proportion of women with DM1 showed AMH levels in the menopausal range compared with controls (16.7 versus 3.4, respectively, P = 0.02). For all patients, those with DM1 exhibited lower inhibin B levels than controls (89.3 ± 51.7 versus 113.2 ± 76.0 ng/ml, P < 0.05). FSH and estradiol were similar in both groups. Regression analysis showed an earlier decline in AMH levels in women with DM1 than controls. Even after age adjustment, DM1 was a significant factor for the determination of inhibin B and AMH levels.CONCLUSIONSLower AMH levels in women with DM1 during the fourth decade of life suggest the presence of an earlier decline in the ovarian follicle pool in these women. Further studies are needed to evaluate the mechanism of this complication.
Fil: Soto, Néstor. San Borja Arriarán Clinical Hospital; Chile
Fil: Iñiguez, Germán. Universidad de Chile; Chile
Fil: López, Patricia. Universidad de Chile; Chile
Fil: Larenas, Gladys. Universidad de La Frontera; Chile
Fil: Mujica, Verónica. Hospital Regional de Talca; Chile. Universidad de Talca; Chile
Fil: Rey, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Codner, Ethel. Universidad de Chile; Chile
Materia
ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194168
Acceder
id CONICETDig_1abe6f49d09e7d65ecb39fbbf892e19a
oai_identifier_str oai:ri.conicet.gov.ar:11336/194168
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitusSoto, NéstorIñiguez, GermánLópez, PatriciaLarenas, GladysMujica, VerónicaRey, Rodolfo AlbertoCodner, EthelANTI-MÜLLERIAN HORMONEINHIBIN BMENOPAUSEOVARIAN RESERVETYPE 1 DIABETES MELLITUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian function in women with DM1 (n = 66) and healthy controls (n = 58), all <45 years old. Steroids, gonadotrophins, AMH and inhibin B levels were measured during the follicular phase.RESULTSPiece-wise regression analysis demonstrated that AMH levels begin to decrease at 33 years of age in both groups. This age limit was used to compare data in both groups. AMH levels were lower in DM1 women than in controls >33 years (4.1 ± 4.2 versus 9.5 ± 7.9 pmol/l, mean ± SD, P = 0.006). A higher proportion of women with DM1 showed AMH levels in the menopausal range compared with controls (16.7 versus 3.4, respectively, P = 0.02). For all patients, those with DM1 exhibited lower inhibin B levels than controls (89.3 ± 51.7 versus 113.2 ± 76.0 ng/ml, P < 0.05). FSH and estradiol were similar in both groups. Regression analysis showed an earlier decline in AMH levels in women with DM1 than controls. Even after age adjustment, DM1 was a significant factor for the determination of inhibin B and AMH levels.CONCLUSIONSLower AMH levels in women with DM1 during the fourth decade of life suggest the presence of an earlier decline in the ovarian follicle pool in these women. Further studies are needed to evaluate the mechanism of this complication.Fil: Soto, Néstor. San Borja Arriarán Clinical Hospital; ChileFil: Iñiguez, Germán. Universidad de Chile; ChileFil: López, Patricia. Universidad de Chile; ChileFil: Larenas, Gladys. Universidad de La Frontera; ChileFil: Mujica, Verónica. Hospital Regional de Talca; Chile. Universidad de Talca; ChileFil: Rey, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Codner, Ethel. Universidad de Chile; ChileOxford University Press2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194168Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; et al.; Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus; Oxford University Press; Human Reproduction; 24; 11; 12-2009; 2838-28440268-1161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/dep276info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humrep/article/24/11/2838/627298info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:19Zoai:ri.conicet.gov.ar:11336/194168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:19.366CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
spellingShingle Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
Soto, Néstor
ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
title_short Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_full Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_fullStr Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_full_unstemmed Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
title_sort Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
dc.creator.none.fl_str_mv Soto, Néstor
Iñiguez, Germán
López, Patricia
Larenas, Gladys
Mujica, Verónica
Rey, Rodolfo Alberto
Codner, Ethel
author Soto, Néstor
author_facet Soto, Néstor
Iñiguez, Germán
López, Patricia
Larenas, Gladys
Mujica, Verónica
Rey, Rodolfo Alberto
Codner, Ethel
author_role author
author2 Iñiguez, Germán
López, Patricia
Larenas, Gladys
Mujica, Verónica
Rey, Rodolfo Alberto
Codner, Ethel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
topic ANTI-MÜLLERIAN HORMONE
INHIBIN B
MENOPAUSE
OVARIAN RESERVE
TYPE 1 DIABETES MELLITUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian function in women with DM1 (n = 66) and healthy controls (n = 58), all <45 years old. Steroids, gonadotrophins, AMH and inhibin B levels were measured during the follicular phase.RESULTSPiece-wise regression analysis demonstrated that AMH levels begin to decrease at 33 years of age in both groups. This age limit was used to compare data in both groups. AMH levels were lower in DM1 women than in controls >33 years (4.1 ± 4.2 versus 9.5 ± 7.9 pmol/l, mean ± SD, P = 0.006). A higher proportion of women with DM1 showed AMH levels in the menopausal range compared with controls (16.7 versus 3.4, respectively, P = 0.02). For all patients, those with DM1 exhibited lower inhibin B levels than controls (89.3 ± 51.7 versus 113.2 ± 76.0 ng/ml, P < 0.05). FSH and estradiol were similar in both groups. Regression analysis showed an earlier decline in AMH levels in women with DM1 than controls. Even after age adjustment, DM1 was a significant factor for the determination of inhibin B and AMH levels.CONCLUSIONSLower AMH levels in women with DM1 during the fourth decade of life suggest the presence of an earlier decline in the ovarian follicle pool in these women. Further studies are needed to evaluate the mechanism of this complication.
Fil: Soto, Néstor. San Borja Arriarán Clinical Hospital; Chile
Fil: Iñiguez, Germán. Universidad de Chile; Chile
Fil: López, Patricia. Universidad de Chile; Chile
Fil: Larenas, Gladys. Universidad de La Frontera; Chile
Fil: Mujica, Verónica. Hospital Regional de Talca; Chile. Universidad de Talca; Chile
Fil: Rey, Rodolfo Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Codner, Ethel. Universidad de Chile; Chile
description BACKGROUNDSerum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience menopause at a younger age. We hypothesized that older women with DM1 will have lower AMH levels than controls.METHODSWe studied ovarian function in women with DM1 (n = 66) and healthy controls (n = 58), all <45 years old. Steroids, gonadotrophins, AMH and inhibin B levels were measured during the follicular phase.RESULTSPiece-wise regression analysis demonstrated that AMH levels begin to decrease at 33 years of age in both groups. This age limit was used to compare data in both groups. AMH levels were lower in DM1 women than in controls >33 years (4.1 ± 4.2 versus 9.5 ± 7.9 pmol/l, mean ± SD, P = 0.006). A higher proportion of women with DM1 showed AMH levels in the menopausal range compared with controls (16.7 versus 3.4, respectively, P = 0.02). For all patients, those with DM1 exhibited lower inhibin B levels than controls (89.3 ± 51.7 versus 113.2 ± 76.0 ng/ml, P < 0.05). FSH and estradiol were similar in both groups. Regression analysis showed an earlier decline in AMH levels in women with DM1 than controls. Even after age adjustment, DM1 was a significant factor for the determination of inhibin B and AMH levels.CONCLUSIONSLower AMH levels in women with DM1 during the fourth decade of life suggest the presence of an earlier decline in the ovarian follicle pool in these women. Further studies are needed to evaluate the mechanism of this complication.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194168
Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; et al.; Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus; Oxford University Press; Human Reproduction; 24; 11; 12-2009; 2838-2844
0268-1161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194168
identifier_str_mv Soto, Néstor; Iñiguez, Germán; López, Patricia; Larenas, Gladys; Mujica, Verónica; et al.; Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus; Oxford University Press; Human Reproduction; 24; 11; 12-2009; 2838-2844
0268-1161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/dep276
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/humrep/article/24/11/2838/627298
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268966980943872
score 12.885934

Publicaciones similares