Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity

Autores
Miksztowicz, Veronica Julieta; Schreier, Laura Ester; McCoy, Mary; Lucero, Diego Martín; Fassio, Eduardo; Billheimer, Jeffrey; Rader, Daniel J.; Berg, Gabriela Alicia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective—To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic enzymes in the same patient. Approach and Results—Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. A trend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weight group (P=0.009) and was negatively associated with high-density lipoprotein–cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein–cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein–cholesterol (P=0.021) in control group. LPL was decreased in MS (P<0.001) as well as in overweight and obese compared with normal weight group (P=0.015 and P=0.004, respectively); inversely correlated %TG-very low-density lipoproteins (P=0.04) and TG/apolipoprotein B index (P=0.013) in control group. These associations were not found in MS. Conclusions—We describe for the first time EL and HL activity as phospholipases in MS/obesity, being both responsible for high-density lipoprotein catabolism. Our results elucidate part of the remaining controversies about SN1 lipases activity in MS and different grades of obesity. The impact of insulin resistance on the activity of the 3 enzymes determines the lipoprotein alterations observed in these states.
Fil: Miksztowicz, Veronica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: McCoy, Mary. University of Pennsylvania; Estados Unidos
Fil: Lucero, Diego Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fassio, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital "Prof. Alejandro Posadas"; Argentina
Fil: Billheimer, Jeffrey. University of Pennsylvania; Estados Unidos
Fil: Rader, Daniel J.. University of Pennsylvania; Estados Unidos
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Lipg Protein
Hepatic Lipase
Human
Lipoprotein Lipase
Metabolic Syndrome X
Obesity
Phospholipases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16847
Acceder
id CONICETDig_19b38618ab3dc8ded284a14c62bd2688
oai_identifier_str oai:ri.conicet.gov.ar:11336/16847
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of SN1 lipases on plasma lipids in metabolic syndrome and obesityMiksztowicz, Veronica JulietaSchreier, Laura EsterMcCoy, MaryLucero, Diego MartínFassio, EduardoBillheimer, JeffreyRader, Daniel J.Berg, Gabriela AliciaLipg ProteinHepatic LipaseHumanLipoprotein LipaseMetabolic Syndrome XObesityPhospholipaseshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective—To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic enzymes in the same patient. Approach and Results—Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. A trend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weight group (P=0.009) and was negatively associated with high-density lipoprotein–cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein–cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein–cholesterol (P=0.021) in control group. LPL was decreased in MS (P<0.001) as well as in overweight and obese compared with normal weight group (P=0.015 and P=0.004, respectively); inversely correlated %TG-very low-density lipoproteins (P=0.04) and TG/apolipoprotein B index (P=0.013) in control group. These associations were not found in MS. Conclusions—We describe for the first time EL and HL activity as phospholipases in MS/obesity, being both responsible for high-density lipoprotein catabolism. Our results elucidate part of the remaining controversies about SN1 lipases activity in MS and different grades of obesity. The impact of insulin resistance on the activity of the 3 enzymes determines the lipoprotein alterations observed in these states.Fil: Miksztowicz, Veronica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: McCoy, Mary. University of Pennsylvania; Estados UnidosFil: Lucero, Diego Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fassio, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital "Prof. Alejandro Posadas"; ArgentinaFil: Billheimer, Jeffrey. University of Pennsylvania; Estados UnidosFil: Rader, Daniel J.. University of Pennsylvania; Estados UnidosFil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Heart Association2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16847Miksztowicz, Veronica Julieta; Schreier, Laura Ester; McCoy, Mary; Lucero, Diego Martín; Fassio, Eduardo; et al.; Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity; American Heart Association; Arteriosclerosis Thrombosis And Vascular Biology; 34; 3; 3-2014; 669-6751079-56421524-4636enginfo:eu-repo/semantics/altIdentifier/doi/10.1161/ATVBAHA.113.303027info:eu-repo/semantics/altIdentifier/url/http://atvb.ahajournals.org/content/34/3/669info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:23Zoai:ri.conicet.gov.ar:11336/16847instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:23.821CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
title Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
spellingShingle Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
Miksztowicz, Veronica Julieta
Lipg Protein
Hepatic Lipase
Human
Lipoprotein Lipase
Metabolic Syndrome X
Obesity
Phospholipases
title_short Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
title_full Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
title_fullStr Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
title_full_unstemmed Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
title_sort Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
dc.creator.none.fl_str_mv Miksztowicz, Veronica Julieta
Schreier, Laura Ester
McCoy, Mary
Lucero, Diego Martín
Fassio, Eduardo
Billheimer, Jeffrey
Rader, Daniel J.
Berg, Gabriela Alicia
author Miksztowicz, Veronica Julieta
author_facet Miksztowicz, Veronica Julieta
Schreier, Laura Ester
McCoy, Mary
Lucero, Diego Martín
Fassio, Eduardo
Billheimer, Jeffrey
Rader, Daniel J.
Berg, Gabriela Alicia
author_role author
author2 Schreier, Laura Ester
McCoy, Mary
Lucero, Diego Martín
Fassio, Eduardo
Billheimer, Jeffrey
Rader, Daniel J.
Berg, Gabriela Alicia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lipg Protein
Hepatic Lipase
Human
Lipoprotein Lipase
Metabolic Syndrome X
Obesity
Phospholipases
topic Lipg Protein
Hepatic Lipase
Human
Lipoprotein Lipase
Metabolic Syndrome X
Obesity
Phospholipases
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective—To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic enzymes in the same patient. Approach and Results—Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. A trend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weight group (P=0.009) and was negatively associated with high-density lipoprotein–cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein–cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein–cholesterol (P=0.021) in control group. LPL was decreased in MS (P<0.001) as well as in overweight and obese compared with normal weight group (P=0.015 and P=0.004, respectively); inversely correlated %TG-very low-density lipoproteins (P=0.04) and TG/apolipoprotein B index (P=0.013) in control group. These associations were not found in MS. Conclusions—We describe for the first time EL and HL activity as phospholipases in MS/obesity, being both responsible for high-density lipoprotein catabolism. Our results elucidate part of the remaining controversies about SN1 lipases activity in MS and different grades of obesity. The impact of insulin resistance on the activity of the 3 enzymes determines the lipoprotein alterations observed in these states.
Fil: Miksztowicz, Veronica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: McCoy, Mary. University of Pennsylvania; Estados Unidos
Fil: Lucero, Diego Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fassio, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital "Prof. Alejandro Posadas"; Argentina
Fil: Billheimer, Jeffrey. University of Pennsylvania; Estados Unidos
Fil: Rader, Daniel J.. University of Pennsylvania; Estados Unidos
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Objective—To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic enzymes in the same patient. Approach and Results—Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. A trend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weight group (P=0.009) and was negatively associated with high-density lipoprotein–cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein–cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein–cholesterol (P=0.021) in control group. LPL was decreased in MS (P<0.001) as well as in overweight and obese compared with normal weight group (P=0.015 and P=0.004, respectively); inversely correlated %TG-very low-density lipoproteins (P=0.04) and TG/apolipoprotein B index (P=0.013) in control group. These associations were not found in MS. Conclusions—We describe for the first time EL and HL activity as phospholipases in MS/obesity, being both responsible for high-density lipoprotein catabolism. Our results elucidate part of the remaining controversies about SN1 lipases activity in MS and different grades of obesity. The impact of insulin resistance on the activity of the 3 enzymes determines the lipoprotein alterations observed in these states.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16847
Miksztowicz, Veronica Julieta; Schreier, Laura Ester; McCoy, Mary; Lucero, Diego Martín; Fassio, Eduardo; et al.; Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity; American Heart Association; Arteriosclerosis Thrombosis And Vascular Biology; 34; 3; 3-2014; 669-675
1079-5642
1524-4636
url http://hdl.handle.net/11336/16847
identifier_str_mv Miksztowicz, Veronica Julieta; Schreier, Laura Ester; McCoy, Mary; Lucero, Diego Martín; Fassio, Eduardo; et al.; Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity; American Heart Association; Arteriosclerosis Thrombosis And Vascular Biology; 34; 3; 3-2014; 669-675
1079-5642
1524-4636
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1161/ATVBAHA.113.303027
info:eu-repo/semantics/altIdentifier/url/http://atvb.ahajournals.org/content/34/3/669
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Heart Association
publisher.none.fl_str_mv American Heart Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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